SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ee2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EE2_A_CHDA1150_0
(ALCOHOL
DEHYDROGENASE)		 1ee2 ALCOHOL
DEHYDROGENASE
(Equus
caballus) 		11 / 11 CYH A  46
SER A  48
LEU A  57
HIS A  67
LEU A 110
SER A 116
MET A 117
LEU A 140
CYH A 173
VAL A 293
ILE A 317
 ZN  A1300 ( 2.3A)
CHD  A1150 ( 2.5A)
CHD  A1150 (-4.5A)
ZN  A1300 ( 3.2A)
None
CHD  A1150 (-2.8A)
CHD  A1150 (-4.2A)
None
ZN  A1300 (-2.2A)
NAD  A1100 ( 4.0A)
CHD  A1150 ( 4.3A)
 0.02A 1ee2A-1ee2A:
71.0		 1ee2A-1ee2A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EE2_A_CHDA1150_1
(ALCOHOL
DEHYDROGENASE)		 1ee2 ALCOHOL
DEHYDROGENASE
(Equus
caballus) 		4 / 4 GLU A 283
MET A 305
LEU A 308
SER A 309
 None
 0.07A 1ee2B-1ee2A:
68.6		 1ee2B-1ee2A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EE2_B_CHDB1250_0
(ALCOHOL
DEHYDROGENASE)		 1ee2 ALCOHOL
DEHYDROGENASE
(Equus
caballus) 		3 / 3 MET A 305
LEU A 308
SER A 309
 None
 0.00A 1ee2A-1ee2A:
71.0		 1ee2A-1ee2A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EE2_B_CHDB1250_1
(ALCOHOL
DEHYDROGENASE)		 1ee2 ALCOHOL
DEHYDROGENASE
(Equus
caballus) 		11 / 11 CYH A  46
SER A  48
LEU A  57
HIS A  67
LEU A 110
SER A 116
MET A 117
LEU A 140
CYH A 173
VAL A 293
ILE A 317
 ZN  A1300 ( 2.3A)
CHD  A1150 ( 2.5A)
CHD  A1150 (-4.5A)
ZN  A1300 ( 3.2A)
None
CHD  A1150 (-2.8A)
CHD  A1150 (-4.2A)
None
ZN  A1300 (-2.2A)
NAD  A1100 ( 4.0A)
CHD  A1150 ( 4.3A)
 0.12A 1ee2B-1ee2A:
68.6		 1ee2B-1ee2A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBY_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1ee2 ALCOHOL
DEHYDROGENASE
(Equus
caballus) 		5 / 12 CYH A 210
ALA A 213
ALA A 215
GLN A 190
VAL A 289
 None
 1.04A 1fbyA-1ee2A:
undetectable		 1fbyA-1ee2A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHO_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1ee2 ALCOHOL
DEHYDROGENASE
(Equus
caballus) 		5 / 9 THR A 369
GLY A 357
GLY A 364
SER A 363
ARG A 362
 None
 1.33A 1jhoA-1ee2A:
3.6		 1jhoA-1ee2A:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 1ee2 ALCOHOL
DEHYDROGENASE
(Equus
caballus) 		4 / 6 ARG A  84
ILE A  76
GLY A  77
ALA A  33
 None
 0.94A 1wmqA-1ee2A:
0.0		 1wmqA-1ee2A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 1ee2 ALCOHOL
DEHYDROGENASE
(Equus
caballus) 		4 / 6 ARG A  84
ILE A  76
GLY A  77
ALA A  33
 None
 0.94A 1wmqB-1ee2A:
0.0		 1wmqB-1ee2A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 1ee2 ALCOHOL
DEHYDROGENASE
(Equus
caballus) 		4 / 6 ARG A  84
ILE A  76
GLY A  77
ALA A  33
 None
 0.93A 1wpuA-1ee2A:
0.0		 1wpuA-1ee2A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 1ee2 ALCOHOL
DEHYDROGENASE
(Equus
caballus) 		4 / 6 ARG A  84
ILE A  76
GLY A  77
ALA A  33
 None
 0.94A 1wpuB-1ee2A:
undetectable		 1wpuB-1ee2A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 1ee2 ALCOHOL
DEHYDROGENASE
(Equus
caballus) 		4 / 6 ARG A  84
ILE A  76
GLY A  77
ALA A  33
 None
 0.92A 1wrqA-1ee2A:
0.0		 1wrqA-1ee2A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 1ee2 ALCOHOL
DEHYDROGENASE
(Equus
caballus) 		4 / 6 ARG A  84
ILE A  76
GLY A  77
ALA A  33
 None
 0.94A 1wrqB-1ee2A:
0.0		 1wrqB-1ee2A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B17_A_DIFA701_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 1ee2 ALCOHOL
DEHYDROGENASE
(Equus
caballus) 		5 / 10 LEU A 170
ALA A  70
ILE A  90
ASP A  49
PHE A 373
 None
 1.41A 2b17A-1ee2A:
undetectable		 2b17A-1ee2A:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8G_B_017B401_2
(POL POLYPROTEIN)		 1ee2 ALCOHOL
DEHYDROGENASE
(Equus
caballus) 		6 / 12 GLY A  71
ALA A  70
VAL A 168
PRO A 328
VAL A 327
ILE A  90
 None
 1.48A 2f8gB-1ee2A:
undetectable		 2f8gB-1ee2A:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1003_0
(ALDEHYDE
DEHYDROGENASE A)		 1ee2 ALCOHOL
DEHYDROGENASE
(Equus
caballus) 		4 / 5 LEU A 371
ASP A  49
ALA A  69
PHE A 358
 None
 1.00A 2opxA-1ee2A:
4.2		 2opxA-1ee2A:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_A_SAMA1248_0
(NON-STRUCTURAL
PROTEIN 5)		 1ee2 ALCOHOL
DEHYDROGENASE
(Equus
caballus) 		5 / 12 GLY A 174
GLY A 198
GLY A 200
SER A 205
ILE A 268
 None
NAD  A1100 (-3.7A)
NAD  A1100 (-3.4A)
None
NAD  A1100 (-3.9A)
 1.20A 2wa2A-1ee2A:
5.3		 2wa2A-1ee2A:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_A_SAMA1248_0
(NON-STRUCTURAL
PROTEIN 5)		 1ee2 ALCOHOL
DEHYDROGENASE
(Equus
caballus) 		5 / 12 GLY A 178
GLY A 198
GLY A 200
SER A 205
ILE A 268
 None
NAD  A1100 (-3.7A)
NAD  A1100 (-3.4A)
None
NAD  A1100 (-3.9A)
 0.69A 2wa2A-1ee2A:
5.3		 2wa2A-1ee2A:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA606_1
(CHITINASE A)		 1ee2 ALCOHOL
DEHYDROGENASE
(Equus
caballus) 		4 / 7 PHE A  21
GLY A  66
ASP A  50
ARG A  47
 None
None
None
NAD  A1100 (-3.7A)
 1.23A 3aruA-1ee2A:
undetectable		 3aruA-1ee2A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_B_478B200_1
(PROTEASE)		 1ee2 ALCOHOL
DEHYDROGENASE
(Equus
caballus) 		5 / 8 LEU A 110
GLY A 315
ALA A 316
GLY A 292
ILE A 317
 None
None
None
NAD  A1100 (-3.5A)
CHD  A1150 ( 4.3A)
 1.22A 3ekpA-1ee2A:
0.0		 3ekpA-1ee2A:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC6_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1ee2 ALCOHOL
DEHYDROGENASE
(Equus
caballus) 		5 / 12 VAL A 206
CYH A 210
ALA A 212
ALA A 213
VAL A 291
 None
None
None
None
NAD  A1100 (-4.2A)
 0.87A 3fc6C-1ee2A:
undetectable		 3fc6C-1ee2A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N23_A_OBNA1_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 1ee2 ALCOHOL
DEHYDROGENASE
(Equus
caballus) 		5 / 11 PRO A 248
VAL A 261
PHE A 197
ILE A 219
ARG A 270
 None
None
None
None
NAD  A1100 (-4.4A)
 1.41A 3n23A-1ee2A:
5.2		 3n23A-1ee2A:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_C_BEZC264_0
(CARNITINYL-COA
DEHYDRATASE)		 1ee2 ALCOHOL
DEHYDROGENASE
(Equus
caballus) 		4 / 6 ILE A 345
LEU A 170
GLU A 166
ALA A  70
 None
 0.89A 3r9sC-1ee2A:
undetectable		 3r9sC-1ee2A:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQI_A_NIOA403_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1ee2 ALCOHOL
DEHYDROGENASE
(Equus
caballus) 		5 / 9 THR A 369
GLY A 357
GLY A 364
SER A 363
ARG A 362
 None
 1.30A 4kqiA-1ee2A:
undetectable		 4kqiA-1ee2A:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1A_A_AB1A101_1
(MDR769 HIV-1
PROTEASE)		 1ee2 ALCOHOL
DEHYDROGENASE
(Equus
caballus) 		5 / 11 ARG A  47
GLY A  66
ALA A  65
ILE A  23
VAL A  52
 NAD  A1100 (-3.7A)
None
None
None
None
 0.87A 4l1aA-1ee2A:
undetectable		 4l1aA-1ee2A:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_B_STRB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 1ee2 ALCOHOL
DEHYDROGENASE
(Equus
caballus) 		4 / 6 VAL A  83
VAL A  73
ILE A  38
LEU A  92
 None
 0.87A 4l1wB-1ee2A:
undetectable		 4l1wB-1ee2A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 1ee2 ALCOHOL
DEHYDROGENASE
(Equus
caballus) 		3 / 3 ASP A 226
ASN A 241
SER A 363
 None
 0.77A 4obwA-1ee2A:
7.5		 4obwA-1ee2A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_MTLA501_0
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 1ee2 ALCOHOL
DEHYDROGENASE
(Equus
caballus) 		5 / 12 GLY A 315
ALA A 316
PHE A 265
ALA A 182
VAL A 188
 None
 1.32A 4ryaA-1ee2A:
0.0		 4ryaA-1ee2A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XNX_A_41XA707_1
(TRANSPORTER)		 1ee2 ALCOHOL
DEHYDROGENASE
(Equus
caballus) 		5 / 11 PHE A 175
ALA A 182
VAL A 183
SER A 176
GLY A 178
 None
 1.23A 4xnxA-1ee2A:
undetectable		 4xnxA-1ee2A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP1_A_LDPA708_1
(DOPAMINE
TRANSPORTER, ISOFORM
B)		 1ee2 ALCOHOL
DEHYDROGENASE
(Equus
caballus) 		5 / 10 PHE A 175
ALA A 182
VAL A 183
SER A 176
GLY A 178
 None
 1.37A 4xp1A-1ee2A:
0.0		 4xp1A-1ee2A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 1ee2 ALCOHOL
DEHYDROGENASE
(Equus
caballus) 		4 / 7 ASN A 224
LYS A 225
LYS A 227
PHE A 265
 None
None
NAD  A1100 (-4.4A)
None
 1.17A 4yv5A-1ee2A:
undetectable		 4yv5A-1ee2A:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 1ee2 ALCOHOL
DEHYDROGENASE
(Equus
caballus) 		5 / 12 ILE A  64
VAL A  63
GLY A  66
SER A 143
PRO A  20
 None
 1.03A 5ergB-1ee2A:
7.0		 5ergB-1ee2A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 1ee2 ALCOHOL
DEHYDROGENASE
(Equus
caballus) 		5 / 12 ILE A  64
VAL A  63
SER A 143
PHE A 139
PRO A  20
 None
 1.20A 5ergB-1ee2A:
7.0		 5ergB-1ee2A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5INZ_D_DVAD15_0
(THETA DEFENSIN-2,
D-PEPTIDE
THETA DEFENSIN-2,
L-PEPTIDE)		 1ee2 ALCOHOL
DEHYDROGENASE
(Equus
caballus) 		3 / 3 GLY A  98
CYH A 103
CYH A 100
 None
ZN  A1301 (-2.3A)
ZN  A1301 (-2.3A)
 0.96A 5inzB-1ee2A:
undetectable		 5inzB-1ee2A:
5.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K4P_A_SORA611_0
(PROBABLE
PHOSPHATIDYLETHANOLA
MINE TRANSFERASE
MCR-1)		 1ee2 ALCOHOL
DEHYDROGENASE
(Equus
caballus) 		4 / 6 GLY A 319
THR A 177
SER A 176
GLY A 174
 None
NAD  A1100 (-3.3A)
None
None
 0.90A 5k4pA-1ee2A:
0.0		 5k4pA-1ee2A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1ee2 ALCOHOL
DEHYDROGENASE
(Equus
caballus) 		5 / 9 GLY A 120
VAL A  52
GLY A 141
PHE A 358
ILE A 354
 None
 0.96A 5vkqC-1ee2A:
0.0
5vkqD-1ee2A:
0.0		 5vkqC-1ee2A:
12.89
5vkqD-1ee2A:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WY0_A_SAMA800_0
(SMALL RNA
2'-O-METHYLTRANSFERA
SE)		 1ee2 ALCOHOL
DEHYDROGENASE
(Equus
caballus) 		5 / 12 GLY A 198
ASP A 222
ILE A 223
ASN A 224
LYS A 227
 NAD  A1100 (-3.7A)
NAD  A1100 (-2.9A)
NAD  A1100 (-4.0A)
None
NAD  A1100 (-4.4A)
 0.73A 5wy0A-1ee2A:
undetectable		 5wy0A-1ee2A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_1
(-)		 1ee2 ALCOHOL
DEHYDROGENASE
(Equus
caballus) 		5 / 12 VAL A 289
THR A  56
PRO A 118
VAL A 185
GLY A 178
 None
 1.43A 6gngB-1ee2A:
3.8		 6gngB-1ee2A:
21.10