SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ee6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_C_DVAC6_0
(GRAMICIDIN A)		 1ee6 PECTATE LYASE
(Bacillus
sp.
KSM-P15) 		3 / 3 ALA A  59
VAL A  81
TRP A  78
 None
CA  A 300 (-4.9A)
None
 0.92A 1c4dC-1ee6A:
undetectable
1c4dD-1ee6A:
undetectable		 1c4dC-1ee6A:
7.75
1c4dD-1ee6A:
7.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_B_RTLB501_0
(RETINOL DEHYDRATASE)		 1ee6 PECTATE LYASE
(Bacillus
sp.
KSM-P15) 		5 / 12 ILE A 111
LEU A 130
LEU A 158
HIS A  66
ILE A 119
 None
 1.17A 1fmlB-1ee6A:
undetectable		 1fmlB-1ee6A:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JR1_A_MOAA1332_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 1ee6 PECTATE LYASE
(Bacillus
sp.
KSM-P15) 		5 / 11 SER A 165
ASN A 188
GLY A 183
THR A 160
GLN A 133
 None
 1.47A 1jr1A-1ee6A:
undetectable		 1jr1A-1ee6A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC685_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 1ee6 PECTATE LYASE
(Bacillus
sp.
KSM-P15) 		4 / 8 HIS A  66
PRO A  42
LYS A  89
SER A  90
 None
 1.22A 1p7lC-1ee6A:
undetectable		 1p7lC-1ee6A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_A_SAMA385_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 1ee6 PECTATE LYASE
(Bacillus
sp.
KSM-P15) 		4 / 8 HIS A  66
PRO A  42
LYS A  89
SER A  90
 None
 1.21A 1rg9A-1ee6A:
undetectable		 1rg9A-1ee6A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_D_DVAD6_0
(GRAMICIDIN D)		 1ee6 PECTATE LYASE
(Bacillus
sp.
KSM-P15) 		3 / 3 TRP A  78
ALA A  59
VAL A  81
 None
None
CA  A 300 (-4.9A)
 0.98A 2izqC-1ee6A:
undetectable
2izqD-1ee6A:
undetectable		 2izqC-1ee6A:
7.75
2izqD-1ee6A:
7.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OBV_A_SAMA501_0
(S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-1)		 1ee6 PECTATE LYASE
(Bacillus
sp.
KSM-P15) 		4 / 8 HIS A  66
PRO A  42
LYS A  89
SER A  90
 None
 1.19A 2obvA-1ee6A:
undetectable		 2obvA-1ee6A:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P02_A_SAMA2_0
(S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-2)		 1ee6 PECTATE LYASE
(Bacillus
sp.
KSM-P15) 		4 / 8 HIS A  66
PRO A  42
LYS A  89
SER A  90
 None
 1.22A 2p02A-1ee6A:
undetectable		 2p02A-1ee6A:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_K_BO2K1402_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 1ee6 PECTATE LYASE
(Bacillus
sp.
KSM-P15) 		5 / 11 ALA A 101
ALA A 124
ALA A  61
GLY A  82
ALA A  85
 None
None
None
CA  A 300 ( 4.5A)
None
 0.90A 3mg0K-1ee6A:
0.0
3mg0L-1ee6A:
0.0		 3mg0K-1ee6A:
22.13
3mg0L-1ee6A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_Y_BO2Y1403_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 1ee6 PECTATE LYASE
(Bacillus
sp.
KSM-P15) 		5 / 12 ALA A 101
ALA A 124
ALA A  61
GLY A  82
ALA A  85
 None
None
None
CA  A 300 ( 4.5A)
None
 0.85A 3mg0Y-1ee6A:
0.0
3mg0Z-1ee6A:
undetectable		 3mg0Y-1ee6A:
22.13
3mg0Z-1ee6A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RET_A_SALA201_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 1ee6 PECTATE LYASE
(Bacillus
sp.
KSM-P15) 		5 / 10 VAL A   5
VAL A  65
TYR A  24
ILE A  57
ILE A   9
 None
 1.26A 3retA-1ee6A:
undetectable
3retB-1ee6A:
undetectable		 3retA-1ee6A:
18.59
3retB-1ee6A:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1ee6 PECTATE LYASE
(Bacillus
sp.
KSM-P15) 		5 / 12 ILE A 150
GLY A 128
ALA A 104
ALA A 101
ALA A 124
 None
 1.00A 3sudC-1ee6A:
undetectable		 3sudC-1ee6A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_A_SAMA407_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1ee6 PECTATE LYASE
(Bacillus
sp.
KSM-P15) 		4 / 8 HIS A  66
PRO A  42
LYS A  89
SER A  90
 None
 1.20A 4ndnA-1ee6A:
undetectable		 4ndnA-1ee6A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQY_A_BEZA401_0
(THIOREDOXIN)		 1ee6 PECTATE LYASE
(Bacillus
sp.
KSM-P15) 		4 / 8 ILE A 117
PHE A 109
VAL A  94
GLN A 110
 None
 1.02A 5dqyA-1ee6A:
0.0		 5dqyA-1ee6A:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GSN_A_MMZA503_1
(FLAVIN-CONTAINING
MONOOXYGENASE)		 1ee6 PECTATE LYASE
(Bacillus
sp.
KSM-P15) 		3 / 3 ASN A 149
SER A 151
SER A 175
 None
 0.71A 5gsnA-1ee6A:
undetectable		 5gsnA-1ee6A:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGY_A_ERYA403_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 1ee6 PECTATE LYASE
(Bacillus
sp.
KSM-P15) 		5 / 12 ILE A  57
GLY A  64
PHE A  17
SER A  97
ILE A  96
 None
 1.01A 5igyA-1ee6A:
0.0		 5igyA-1ee6A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 1ee6 PECTATE LYASE
(Bacillus
sp.
KSM-P15) 		5 / 12 ILE A  57
GLY A  64
PHE A  17
SER A  97
ILE A  96
 None
 1.05A 5ih0A-1ee6A:
0.0		 5ih0A-1ee6A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8S_B_SAMB402_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 1ee6 PECTATE LYASE
(Bacillus
sp.
KSM-P15) 		4 / 8 HIS A  66
PRO A  42
LYS A  89
SER A  90
 None
 1.23A 5t8sB-1ee6A:
undetectable		 5t8sB-1ee6A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_A_SAMA501_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 1ee6 PECTATE LYASE
(Bacillus
sp.
KSM-P15) 		5 / 12 ILE A 119
ILE A 169
ILE A 111
VAL A 141
ILE A 117
 None
 0.92A 6emuA-1ee6A:
undetectable		 6emuA-1ee6A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBN_B_SAMB401_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1ee6 PECTATE LYASE
(Bacillus
sp.
KSM-P15) 		4 / 8 HIS A  66
PRO A  42
LYS A  89
SER A  90
 None
 1.20A 6fbnB-1ee6A:
undetectable		 6fbnB-1ee6A:
18.99