SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ee8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_A_ESTA1_1
(ESTROGEN RECEPTOR)		 1ee8 MUTM (FPG) PROTEIN
(Thermus
thermophilus) 		5 / 10 ALA A 156
LEU A 150
LEU A 151
ILE A 162
LEU A 198
 None
 1.44A 1a52A-1ee8A:
undetectable		 1a52A-1ee8A:
26.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TBF_A_VIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1ee8 MUTM (FPG) PROTEIN
(Thermus
thermophilus) 		5 / 9 LEU A 146
LEU A 190
VAL A 159
ALA A 157
PHE A 135
 None
 1.24A 1tbfA-1ee8A:
undetectable		 1tbfA-1ee8A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_F_CLMF1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1ee8 MUTM (FPG) PROTEIN
(Thermus
thermophilus) 		5 / 7 PRO A   1
PRO A   4
THR A   8
GLY A 206
TYR A 214
 None
 1.49A 1usqF-1ee8A:
0.0		 1usqF-1ee8A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRE_D_CHDD702_0
(FERROCHELATASE)		 1ee8 MUTM (FPG) PROTEIN
(Thermus
thermophilus) 		3 / 3 ARG A 154
GLY A 122
PRO A 123
 None
 0.66A 2hreD-1ee8A:
0.0		 2hreD-1ee8A:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_A_ACTA1117_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 1ee8 MUTM (FPG) PROTEIN
(Thermus
thermophilus) 		3 / 3 ASP A  48
ARG A  49
ARG A  10
 None
 1.01A 2j9dA-1ee8A:
0.0
2j9dC-1ee8A:
0.2		 2j9dA-1ee8A:
18.96
2j9dC-1ee8A:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_D_CLMD1142_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1ee8 MUTM (FPG) PROTEIN
(Thermus
thermophilus) 		4 / 5 PRO A   1
PRO A   4
GLY A 206
TYR A 214
 None
 1.18A 2jkjD-1ee8A:
0.0		 2jkjD-1ee8A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_F_CLMF1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1ee8 MUTM (FPG) PROTEIN
(Thermus
thermophilus) 		4 / 5 PRO A   1
PRO A   4
GLY A 206
TYR A 214
 None
 1.17A 2jkjF-1ee8A:
0.0		 2jkjF-1ee8A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQ5_B_LDPB1197_1
(S-NORCOCLAURINE
SYNTHASE)		 1ee8 MUTM (FPG) PROTEIN
(Thermus
thermophilus) 		4 / 7 LEU A 190
LEU A 194
PHE A 135
LEU A 182
 None
 0.88A 2vq5B-1ee8A:
0.7		 2vq5B-1ee8A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN6_A_T44A1370_1
(THYROXINE-BINDING
GLOBULIN)		 1ee8 MUTM (FPG) PROTEIN
(Thermus
thermophilus) 		5 / 10 LEU A 173
LEU A 146
LEU A 139
LEU A 190
ARG A 189
 None
 1.19A 2xn6A-1ee8A:
0.0
2xn6B-1ee8A:
0.0		 2xn6A-1ee8A:
21.22
2xn6B-1ee8A:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEH_B_DAHB786_1
(PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN)		 1ee8 MUTM (FPG) PROTEIN
(Thermus
thermophilus) 		4 / 7 PRO A 125
LEU A 118
GLY A 122
ALA A 157
 None
 0.82A 3tehB-1ee8A:
0.0		 3tehB-1ee8A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1005_1
(HEMOLYTIC LECTIN
CEL-III)		 1ee8 MUTM (FPG) PROTEIN
(Thermus
thermophilus) 		3 / 3 ASP A 165
GLY A 254
TYR A 231
 None
 0.61A 3w9tC-1ee8A:
undetectable		 3w9tC-1ee8A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG503_1
(HEMOLYTIC LECTIN
CEL-III)		 1ee8 MUTM (FPG) PROTEIN
(Thermus
thermophilus) 		3 / 3 ASP A 165
GLY A 254
TYR A 231
 None
 0.61A 3w9tG-1ee8A:
undetectable		 3w9tG-1ee8A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A84_A_DXCA1161_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 1ee8 MUTM (FPG) PROTEIN
(Thermus
thermophilus) 		5 / 12 PHE A 135
PHE A 132
PRO A 125
LEU A   3
ALA A 193
 None
 1.49A 4a84A-1ee8A:
1.1		 4a84A-1ee8A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 1ee8 MUTM (FPG) PROTEIN
(Thermus
thermophilus) 		5 / 12 LEU A   3
HIS A  67
LEU A 104
GLY A  73
GLY A 206
 None
 1.14A 5d4uA-1ee8A:
undetectable		 5d4uA-1ee8A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 1ee8 MUTM (FPG) PROTEIN
(Thermus
thermophilus) 		5 / 12 LEU A   3
HIS A  67
LEU A 104
GLY A  73
GLY A 206
 None
 1.10A 5d4uB-1ee8A:
undetectable		 5d4uB-1ee8A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQB_B_IBPB706_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)		 1ee8 MUTM (FPG) PROTEIN
(Thermus
thermophilus) 		4 / 8 ALA A 171
LEU A 146
LEU A 150
LEU A 182
 None
 0.68A 5jqbA-1ee8A:
0.0
5jqbB-1ee8A:
0.0		 5jqbA-1ee8A:
23.43
5jqbB-1ee8A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJB_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 1ee8 MUTM (FPG) PROTEIN
(Thermus
thermophilus) 		5 / 12 PHE A  56
LEU A 104
ALA A  66
TYR A  94
LEU A  16
 None
 1.40A 5ljbA-1ee8A:
undetectable		 5ljbA-1ee8A:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 1ee8 MUTM (FPG) PROTEIN
(Thermus
thermophilus) 		5 / 12 PHE A 135
LEU A 139
LEU A 182
ALA A 187
LEU A 198
 None
 0.85A 5ljeA-1ee8A:
0.0		 5ljeA-1ee8A:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1103_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 1ee8 MUTM (FPG) PROTEIN
(Thermus
thermophilus) 		4 / 8 THR A 260
GLN A 262
ASP A 165
GLY A 235
 None
 0.98A 5nzyA-1ee8A:
undetectable		 5nzyA-1ee8A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_F_BEZF201_0
(NS3 PROTEASE)		 1ee8 MUTM (FPG) PROTEIN
(Thermus
thermophilus) 		4 / 5 HIS A 228
ALA A 201
SER A 207
TYR A 214
 None
 1.40A 5yodF-1ee8A:
undetectable		 5yodF-1ee8A:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 1ee8 MUTM (FPG) PROTEIN
(Thermus
thermophilus) 		4 / 8 ASP A  29
ARG A 100
VAL A 107
GLN A 153
 None
 1.24A 6fbvD-1ee8A:
0.0		 6fbvD-1ee8A:
13.20