SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1eep'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_C_ADNC603_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 1eep INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE
(Borreliella
burgdorferi) 		5 / 12 THR A  54
ASP A 172
ASP A 262
GLY A 285
MET A 283
 None
None
None
SO4  A 600 (-3.4A)
None
 1.36A 1d4fC-1eepA:
undetectable		 1d4fC-1eepA:
23.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JR1_A_MOAA1332_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 1eep INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE
(Borreliella
burgdorferi) 		5 / 11 ASP A 172
SER A 173
ASN A 201
GLY A 224
THR A 231
 None
 1.02A 1jr1A-1eepA:
44.8		 1jr1A-1eepA:
33.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ME7_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1eep INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE
(Borreliella
burgdorferi) 		5 / 8 ASP A 172
SER A 173
ASN A 201
ILE A 223
GLY A 224
 None
 0.81A 1me7A-1eepA:
44.3		 1me7A-1eepA:
33.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MEH_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1eep INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE
(Borreliella
burgdorferi) 		5 / 10 ASP A 172
SER A 173
ASN A 201
ILE A 223
GLY A 224
 None
 0.78A 1mehA-1eepA:
43.8		 1mehA-1eepA:
33.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MEI_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1eep INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE
(Borreliella
burgdorferi) 		4 / 8 ASP A 172
SER A 173
ASN A 201
ILE A 223
 None
 0.59A 1meiA-1eepA:
44.3		 1meiA-1eepA:
33.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SH9_B_RITB301_1
(POL POLYPROTEIN)		 1eep INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE
(Borreliella
burgdorferi) 		5 / 8 ASP A 172
ILE A 198
ILE A 260
GLY A 222
ILE A 223
 None
 1.10A 1sh9A-1eepA:
undetectable		 1sh9A-1eepA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_A_SALA506_1
(SALICYLATE
SYNTHETASE, IRP9)		 1eep INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE
(Borreliella
burgdorferi) 		5 / 11 ILE A 284
GLY A 290
THR A 291
LEU A 356
GLY A 285
 None
None
None
None
SO4  A 600 (-3.4A)
 1.33A 2fn1A-1eepA:
undetectable		 2fn1A-1eepA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ4_X_DXCX75_0
(CYTOCHROME C7)		 1eep INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE
(Borreliella
burgdorferi) 		5 / 9 ILE A 242
LYS A 220
ILE A 259
MET A 283
GLY A 263
 None
None
None
None
SO4  A 600 (-3.4A)
 1.37A 3sj4X-1eepA:
undetectable		 3sj4X-1eepA:
11.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FO4_A_MOAA502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 1eep INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE
(Borreliella
burgdorferi) 		4 / 8 ASP A 172
SER A 173
ASN A 201
THR A 231
 None
 0.83A 4fo4A-1eepA:
44.8		 4fo4A-1eepA:
50.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FO4_B_MOAB502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 1eep INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE
(Borreliella
burgdorferi) 		4 / 8 SER A 173
ASN A 201
GLY A 224
THR A 231
 None
 0.67A 4fo4B-1eepA:
44.3		 4fo4B-1eepA:
50.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FXS_A_MOAA702_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1eep INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE
(Borreliella
burgdorferi) 		6 / 9 ASP A 172
SER A 173
ASN A 201
ILE A 223
THR A 231
ASP A 262
 None
 0.68A 4fxsA-1eepA:
47.6		 4fxsA-1eepA:
48.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FXS_A_MOAA702_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1eep INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE
(Borreliella
burgdorferi) 		6 / 9 SER A 173
ASN A 201
ILE A 223
GLY A 224
THR A 231
ASP A 262
 None
 0.65A 4fxsA-1eepA:
47.6		 4fxsA-1eepA:
48.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HB8_A_DXCA75_0
(PPCA)		 1eep INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE
(Borreliella
burgdorferi) 		5 / 8 ILE A 242
LYS A 220
ILE A 259
MET A 283
GLY A 263
 None
None
None
None
SO4  A 600 (-3.4A)
 1.37A 4hb8A-1eepA:
undetectable		 4hb8A-1eepA:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_A_LURA201_1
(TRANSTHYRETIN)		 1eep INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE
(Borreliella
burgdorferi) 		3 / 3 LYS A  64
LEU A 142
ALA A 134
 None
 0.81A 4iizA-1eepA:
0.0		 4iizA-1eepA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLB_A_TRPA901_0
(PROTEIN ARGONAUTE-2)		 1eep INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE
(Borreliella
burgdorferi) 		3 / 3 VAL A 271
ALA A 261
PHE A  12
 None
 0.89A 4olbA-1eepA:
2.4		 4olbA-1eepA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_A_SAMA301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 1eep INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE
(Borreliella
burgdorferi) 		5 / 12 LEU A 356
GLY A  69
PHE A  45
ASP A 167
ALA A  59
 None
 1.11A 4pclA-1eepA:
2.1		 4pclA-1eepA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 1eep INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE
(Borreliella
burgdorferi) 		3 / 3 VAL A 271
ALA A 261
PHE A  12
 None
 0.88A 4w5nA-1eepA:
0.0		 4w5nA-1eepA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_D_29SD601_2
(ESTROGEN RECEPTOR)		 1eep INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE
(Borreliella
burgdorferi) 		3 / 3 LEU A 169
ASP A 217
ILE A 155
 None
 0.62A 4xi3D-1eepA:
undetectable		 4xi3D-1eepA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 1eep INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE
(Borreliella
burgdorferi) 		3 / 3 VAL A 271
ALA A 261
PHE A  12
 None
 0.91A 4z4iA-1eepA:
undetectable		 4z4iA-1eepA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_A_4TXA201_1
(TRANSTHYRETIN)		 1eep INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE
(Borreliella
burgdorferi) 		4 / 6 LEU A 287
ALA A 289
SER A  48
THR A  52
 None
 1.08A 5bojA-1eepA:
undetectable		 5bojA-1eepA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_2_BEZ2801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 1eep INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE
(Borreliella
burgdorferi) 		4 / 4 LEU A 195
ARG A 143
ILE A 168
ILE A  39
 None
 1.10A 5dzk2-1eepA:
undetectable
5dzkM-1eepA:
1.2
5dzkN-1eepA:
1.4		 5dzk2-1eepA:
11.76
5dzkM-1eepA:
19.55
5dzkN-1eepA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_V_BEZV801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 1eep INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE
(Borreliella
burgdorferi) 		4 / 4 ILE A 168
ILE A  39
ARG A 143
LEU A 195
 None
 1.18A 5dzkh-1eepA:
1.7
5dzkn-1eepA:
1.6
5dzkv-1eepA:
undetectable		 5dzkh-1eepA:
19.55
5dzkn-1eepA:
19.55
5dzkv-1eepA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1eep INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE
(Borreliella
burgdorferi) 		5 / 8 ILE A  60
VAL A  87
VAL A 158
ILE A 188
ILE A 198
 None
 1.29A 5hi2A-1eepA:
undetectable		 5hi2A-1eepA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS1_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 1eep INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE
(Borreliella
burgdorferi) 		3 / 3 VAL A 271
ALA A 261
PHE A  12
 None
 0.89A 5js1A-1eepA:
1.8		 5js1A-1eepA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MXB_A_ML1A222_1
(CLASS 10 PLANT
PATHOGENESIS-RELATED
PROTEIN)		 1eep INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE
(Borreliella
burgdorferi) 		5 / 10 ILE A 355
LEU A 359
GLY A 285
ALA A 289
PHE A 288
 None
None
SO4  A 600 (-3.4A)
None
None
 1.20A 5mxbA-1eepA:
0.0		 5mxbA-1eepA:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA312_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1eep INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE
(Borreliella
burgdorferi) 		3 / 3 ILE A 265
VAL A 282
PRO A  44
 None
 0.69A 5uunA-1eepA:
undetectable		 5uunA-1eepA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_A_HFGA1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 1eep INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE
(Borreliella
burgdorferi) 		5 / 12 LEU A 363
PRO A  44
PHE A 288
THR A  54
GLY A  69
 None
 1.34A 5xiqA-1eepA:
undetectable		 5xiqA-1eepA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 1eep INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE
(Borreliella
burgdorferi) 		5 / 12 LEU A 363
PRO A  44
PHE A 288
THR A  54
GLY A  69
 None
 1.32A 5xiqD-1eepA:
undetectable		 5xiqD-1eepA:
19.73