SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ef1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AGM_A_ACRA495_1
(GLUCOAMYLASE-471)		 1ef1 MOESIN
(Homo
sapiens) 		5 / 12 ALA A 222
TYR A 291
ASP A 221
GLU A 244
GLU C 505
 None
 1.18A 1agmA-1ef1A:
undetectable		 1agmA-1ef1A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AGM_A_ACRA496_1
(GLUCOAMYLASE-471)		 1ef1 MOESIN
(Homo
sapiens) 		5 / 12 ALA A 222
TYR A 291
ASP A 221
GLU A 244
GLU C 505
 None
 1.18A 1agmA-1ef1A:
undetectable		 1agmA-1ef1A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_A_ESTA351_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 1ef1 MOESIN
(Homo
sapiens) 		5 / 12 VAL A 220
GLY A 219
LEU A 218
TYR A 228
GLY A 224
 None
 1.09A 1fduA-1ef1A:
undetectable		 1fduA-1ef1A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_C_ESTC353_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 1ef1 MOESIN
(Homo
sapiens) 		5 / 12 VAL A 220
GLY A 219
LEU A 218
TYR A 228
GLY A 224
 None
 1.08A 1fduC-1ef1A:
undetectable		 1fduC-1ef1A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1871_0
(FPRA)		 1ef1 MOESIN
(Homo
sapiens) 		4 / 7 PRO A  86
ALA A  82
PHE A  45
PHE A  44
 None
 1.21A 1lqtA-1ef1A:
undetectable		 1lqtA-1ef1A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_A_ACTA1428_0
(FPRA)		 1ef1 MOESIN
(Homo
sapiens) 		4 / 7 PRO A  86
ALA A  82
PHE A  45
PHE A  44
 None
 1.21A 1lquA-1ef1A:
undetectable		 1lquA-1ef1A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_A_DEXA1999_1
(GLUCOCORTICOID
RECEPTOR)		 1ef1 MOESIN
(Homo
sapiens) 		5 / 12 ASN A 226
LEU A 218
GLY A 219
THR C 558
ILE C 562
 None
 1.43A 1p93A-1ef1A:
undetectable		 1p93A-1ef1A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PCG_A_ESTA1_1
(ESTROGEN RECEPTOR)		 1ef1 MOESIN
(Homo
sapiens) 		5 / 10 LEU A 125
ALA A 129
LEU A 192
ILE A 115
LEU A 111
 None
 1.34A 1pcgA-1ef1A:
undetectable		 1pcgA-1ef1A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UUJ_B_ACTB1077_0
(PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE IB
ALPHA SUBUNIT)		 1ef1 MOESIN
(Homo
sapiens) 		3 / 3 ARG C 508
TYR C 556
LYS C 555
 None
 1.01A 1uujB-1ef1C:
undetectable		 1uujB-1ef1C:
28.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_0
(UNCHARACTERIZED
PROTEIN RPA2492)		 1ef1 MOESIN
(Homo
sapiens) 		5 / 12 LEU A 225
GLY A 202
GLY A 219
LEU A 218
PHE A 206
 None
 1.19A 3e23A-1ef1A:
undetectable		 3e23A-1ef1A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 1ef1 MOESIN
(Homo
sapiens) 		5 / 10 VAL A   7
LEU A  59
VAL A  70
VAL A  65
LEU A  29
 None
 1.00A 3gwxA-1ef1A:
undetectable		 3gwxA-1ef1A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3007_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1ef1 MOESIN
(Homo
sapiens) 		5 / 9 THR A 121
ALA A 122
LEU A 124
ALA A 126
SER A 127
 None
 1.47A 3kp6B-1ef1A:
0.0		 3kp6B-1ef1A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_A_ESLA700_1
(ESTROGEN RECEPTOR)		 1ef1 MOESIN
(Homo
sapiens) 		6 / 12 LEU A 125
ALA A 129
LEU A 192
ILE A 115
GLY A 109
LEU A 111
 None
 1.28A 3q95A-1ef1A:
undetectable		 3q95A-1ef1A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_B_ESLB700_1
(ESTROGEN RECEPTOR)		 1ef1 MOESIN
(Homo
sapiens) 		5 / 12 LEU A 125
ALA A 129
ILE A 115
GLY A 109
LEU A 111
 None
 0.93A 3q95B-1ef1A:
undetectable		 3q95B-1ef1A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UUD_A_ESTA600_1
(ESTROGEN RECEPTOR)		 1ef1 MOESIN
(Homo
sapiens) 		5 / 11 LEU A 125
ALA A 129
LEU A 192
GLY A 109
LEU A 111
 None
 1.17A 3uudA-1ef1A:
0.1		 3uudA-1ef1A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WSJ_A_MK1A201_2
(PROTEASE)		 1ef1 MOESIN
(Homo
sapiens) 		4 / 7 LEU A 104
ASP A  13
ALA A  14
VAL A  33
 None
 0.95A 3wsjB-1ef1A:
0.4		 3wsjB-1ef1A:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_B_ML1B302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1ef1 MOESIN
(Homo
sapiens) 		4 / 6 GLY A 213
PHE C 574
ILE A 208
PHE A 267
 None
 1.10A 4qogA-1ef1A:
0.0
4qogB-1ef1A:
0.0		 4qogA-1ef1A:
22.00
4qogB-1ef1A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1ef1 MOESIN
(Homo
sapiens) 		4 / 5 SER A 127
ALA A 126
HIS A 179
LEU A 124
 None
 1.23A 5dzkb-1ef1A:
0.0
5dzkp-1ef1A:
undetectable		 5dzkb-1ef1A:
20.81
5dzkp-1ef1A:
2.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Q_BEZQ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1ef1 MOESIN
(Homo
sapiens) 		4 / 5 SER A 127
ALA A 126
HIS A 179
LEU A 124
 None
 1.26A 5dzkc-1ef1A:
0.0
5dzkq-1ef1A:
undetectable		 5dzkc-1ef1A:
20.81
5dzkq-1ef1A:
2.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_U_BEZU801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1ef1 MOESIN
(Homo
sapiens) 		4 / 6 SER A 127
ALA A 126
HIS A 179
LEU A 124
 None
 1.26A 5dzkg-1ef1A:
undetectable
5dzku-1ef1A:
undetectable		 5dzkg-1ef1A:
20.81
5dzku-1ef1A:
2.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 1ef1 MOESIN
(Homo
sapiens) 		4 / 7 PHE A  45
ARG A  81
GLN A  95
GLN A  48
 None
None
SO4  A2001 (-3.8A)
None
 1.28A 6b89A-1ef1A:
undetectable		 6b89A-1ef1A:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G1P_A_ACTA403_0
(ADP-RIBOSYLHYDROLASE
LIKE 2)		 1ef1 MOESIN
(Homo
sapiens) 		3 / 3 TYR A 201
ASP A 197
GLN A 196
 None
 0.62A 6g1pA-1ef1A:
0.0		 6g1pA-1ef1A:
21.98