SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ef4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3U5J_A_08HA1_1 (BROMODOMAIN-CONTAINI NG PROTEIN 4)	1ef4	DNA-DIRECTED RNA POLYMERASE (Methanothermobac ter thermautotrophic us)	4 / 7	PRO A 30 LEU A 37 LEU A 39 ILE A 49	None	0.92A	3u5jA-1ef4A: undetectable	3u5jA-1ef4A: 14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HRQ_G_IPHG101_0 (INSULIN A-CHAIN INSULIN B-CHAIN)	1ef4	DNA-DIRECTED RNA POLYMERASE (Methanothermobac ter thermautotrophic us)	4 / 6	CYH A 44 CYH A 6 HIS A 51 LEU A 48	ZN A 56 (-2.3A) ZN A 56 (-2.2A) None None	1.28A	5hrqD-1ef4A: undetectable 5hrqG-1ef4A: undetectable 5hrqH-1ef4A: undetectable	5hrqD-1ef4A: 18.18 5hrqG-1ef4A: 20.45 5hrqH-1ef4A: 18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HRQ_K_IPHK101_0 (INSULIN A-CHAIN INSULIN B-CHAIN)	1ef4	DNA-DIRECTED RNA POLYMERASE (Methanothermobac ter thermautotrophic us)	4 / 6	CYH A 44 CYH A 6 HIS A 51 LEU A 48	ZN A 56 (-2.3A) ZN A 56 (-2.2A) None None	1.29A	5hrqH-1ef4A: undetectable 5hrqK-1ef4A: undetectable 5hrqL-1ef4A: undetectable	5hrqH-1ef4A: 18.18 5hrqK-1ef4A: 20.45 5hrqL-1ef4A: 18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5Y1Y_A_HNQA201_1 (BROMODOMAIN-CONTAINI NG PROTEIN 4)	1ef4	DNA-DIRECTED RNA POLYMERASE (Methanothermobac ter thermautotrophic us)	4 / 8	PRO A 30 LEU A 37 LEU A 39 ILE A 49	None	0.91A	5y1yA-1ef4A: undetectable	5y1yA-1ef4A: 14.96

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3U5J_A_08HA1_1","BROMODOMAIN-CONTAINING PROTEIN 4","1ef4","DNA-DIRECTED RNA POLYMERASE","Methanothermobacter thermautotrophicus",4,"PRO A  30;LEU A  37;LEU A  39;ILE A  49","None","0.92A","3u5jA-1ef4A:undetectable","3u5jA-1ef4A:14.29"],["5HRQ_G_IPHG101_0","INSULIN A-CHAIN;INSULIN B-CHAIN","1ef4","DNA-DIRECTED RNA POLYMERASE","Methanothermobacter thermautotrophicus",4,"CYH A  44;CYH A   6;HIS A  51;LEU A  48"," ZN A  56 (-2.3A); ZN A  56 (-2.2A);None;None","1.28A","5hrqD-1ef4A:undetectable;5hrqG-1ef4A:undetectable;5hrqH-1ef4A:undetectable","5hrqD-1ef4A:18.18;5hrqG-1ef4A:20.45;5hrqH-1ef4A:18.18"],["5HRQ_K_IPHK101_0","INSULIN A-CHAIN;INSULIN B-CHAIN","1ef4","DNA-DIRECTED RNA POLYMERASE","Methanothermobacter thermautotrophicus",4,"CYH A  44;CYH A   6;HIS A  51;LEU A  48"," ZN A  56 (-2.3A); ZN A  56 (-2.2A);None;None","1.29A","5hrqH-1ef4A:undetectable;5hrqK-1ef4A:undetectable;5hrqL-1ef4A:undetectable","5hrqH-1ef4A:18.18;5hrqK-1ef4A:20.45;5hrqL-1ef4A:18.18"],["5Y1Y_A_HNQA201_1","BROMODOMAIN-CONTAINING PROTEIN 4","1ef4","DNA-DIRECTED RNA POLYMERASE","Methanothermobacter thermautotrophicus",4,"PRO A  30;LEU A  37;LEU A  39;ILE A  49","None","0.91A","5y1yA-1ef4A:undetectable","5y1yA-1ef4A:14.96"]]