SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ef7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_C_DVAC8_0
(GRAMICIDIN A)		 1ef7 CATHEPSIN X
(Homo
sapiens) 		3 / 4 VAL A 184
TRP A   5
TRP A 196
 None
 1.35A 1gmkC-1ef7A:
undetectable
1gmkD-1ef7A:
undetectable		 1gmkC-1ef7A:
6.34
1gmkD-1ef7A:
6.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_C_NIOC708_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1ef7 CATHEPSIN X
(Homo
sapiens) 		4 / 5 SER A 217
THR A 218
GLU A 232
GLY A 137
 None
 1.27A 1icvC-1ef7A:
0.0
1icvD-1ef7A:
0.0		 1icvC-1ef7A:
20.77
1icvD-1ef7A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_B_BEZB525_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1ef7 CATHEPSIN X
(Homo
sapiens) 		4 / 5 GLU A 232
GLY A 137
SER A 217
THR A 218
 None
 1.29A 1kqbA-1ef7A:
0.0
1kqbB-1ef7A:
0.0		 1kqbA-1ef7A:
22.80
1kqbB-1ef7A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7J_A_478A200_1
(POL POLYPROTEIN)		 1ef7 CATHEPSIN X
(Homo
sapiens) 		6 / 11 LEU A  57
GLY A  87
ALA A  83
ASP A  81
GLY A 130
ILE A 241
 None
 1.27A 1t7jA-1ef7A:
undetectable		 1t7jA-1ef7A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_B_SAMB301_0
(HYPOTHETICAL PROTEIN
PH0226)		 1ef7 CATHEPSIN X
(Homo
sapiens) 		5 / 12 ALA A 185
GLY A 186
ALA A  16
ILE A 151
SER A 183
 None
 1.15A 1ve3B-1ef7A:
undetectable		 1ve3B-1ef7A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2887_1
(AMINOMETHYLTRANSFERA
SE)		 1ef7 CATHEPSIN X
(Homo
sapiens) 		3 / 3 ASP A 191
GLU A 208
ARG A 160
 None
 0.79A 1wopA-1ef7A:
0.0		 1wopA-1ef7A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRD_A_MIYA2001_1
(ACRB)		 1ef7 CATHEPSIN X
(Homo
sapiens) 		5 / 9 GLY A  29
GLU A  72
ILE A  63
ALA A  33
VAL A  59
 None
 1.04A 2drdA-1ef7A:
0.0		 2drdA-1ef7A:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_X_CPFX1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 1ef7 CATHEPSIN X
(Homo
sapiens) 		4 / 4 ARG A 138
GLY A 137
GLU A 139
SER A 183
 None
 1.42A 2xctS-1ef7A:
undetectable
2xctU-1ef7A:
undetectable		 2xctS-1ef7A:
16.26
2xctU-1ef7A:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_D_TC9D1206_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1ef7 CATHEPSIN X
(Homo
sapiens) 		4 / 7 TRP A 202
TYR A 169
GLU A 208
TYR A 164
 None
 1.28A 2xytD-1ef7A:
0.0		 2xytD-1ef7A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI8_A_HNQA255_1
(CATHEPSIN B)		 1ef7 CATHEPSIN X
(Homo
sapiens) 		4 / 7 GLN A  22
GLY A  29
HIS A 180
TRP A 202
 None
 0.46A 3ai8A-1ef7A:
28.0		 3ai8A-1ef7A:
29.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AV6_A_SAMA1_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1)		 1ef7 CATHEPSIN X
(Homo
sapiens) 		5 / 12 PHE A 237
GLY A 149
GLY A 186
ALA A 185
VAL A 184
 None
 1.08A 3av6A-1ef7A:
undetectable		 3av6A-1ef7A:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_B_DVAB8_0
(VAL-GRAMICIDIN A)		 1ef7 CATHEPSIN X
(Homo
sapiens) 		3 / 3 TRP A   7
VAL A 184
TRP A   5
 None
 1.43A 3zq8A-1ef7A:
undetectable
3zq8B-1ef7A:
undetectable		 3zq8A-1ef7A:
6.34
3zq8B-1ef7A:
6.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_B_478B101_2
(HIV-1 PROTEASE)		 1ef7 CATHEPSIN X
(Homo
sapiens) 		6 / 9 LEU A  57
GLY A  87
ALA A  83
ASP A  81
GLY A 130
ILE A 241
 None
 1.28A 4rvjB-1ef7A:
undetectable		 4rvjB-1ef7A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_D_478D101_2
(HIV-1 PROTEASE)		 1ef7 CATHEPSIN X
(Homo
sapiens) 		6 / 9 LEU A  57
GLY A  87
ALA A  83
ASP A  81
GLY A 130
ILE A 241
 None
 1.28A 4rvjD-1ef7A:
undetectable		 4rvjD-1ef7A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1ef7 CATHEPSIN X
(Homo
sapiens) 		4 / 7 SER A 183
ARG A 138
GLY A 137
GLU A 139
 None
 0.94A 5btaA-1ef7A:
0.0
5btaC-1ef7A:
0.0
5btaD-1ef7A:
undetectable		 5btaA-1ef7A:
20.59
5btaC-1ef7A:
20.59
5btaD-1ef7A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 1ef7 CATHEPSIN X
(Homo
sapiens) 		4 / 6 SER A 183
ARG A 138
GLY A 137
GLU A 139
 None
 0.94A 5btaA-1ef7A:
undetectable
5btaB-1ef7A:
undetectable
5btaC-1ef7A:
undetectable		 5btaA-1ef7A:
20.59
5btaB-1ef7A:
21.68
5btaC-1ef7A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1ef7 CATHEPSIN X
(Homo
sapiens) 		4 / 6 SER A 183
ARG A 138
GLY A 137
GLU A 139
 None
 0.91A 5btcA-1ef7A:
0.0
5btcB-1ef7A:
undetectable
5btcC-1ef7A:
0.0		 5btcA-1ef7A:
20.59
5btcB-1ef7A:
21.68
5btcC-1ef7A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_F_GFNF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1ef7 CATHEPSIN X
(Homo
sapiens) 		4 / 7 SER A 183
ARG A 138
GLY A 137
GLU A 139
 None
 0.94A 5btfA-1ef7A:
0.0
5btfB-1ef7A:
undetectable
5btfC-1ef7A:
0.0		 5btfA-1ef7A:
20.59
5btfB-1ef7A:
21.68
5btfC-1ef7A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_2
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 1ef7 CATHEPSIN X
(Homo
sapiens) 		3 / 3 VAL A 242
ARG A   8
PRO A 150
 None
 0.67A 5koxA-1ef7A:
0.0		 5koxA-1ef7A:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR0_A_478A101_2
(PROTEASE E35D-APV)		 1ef7 CATHEPSIN X
(Homo
sapiens) 		6 / 9 LEU A  57
GLY A  87
ALA A  83
ASP A  81
GLY A 130
ILE A 241
 None
 1.37A 5kr0B-1ef7A:
undetectable		 5kr0B-1ef7A:
19.07