SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1efp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_2
(BETA-LACTAMASE)		 1efp PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)
(Paracoccus
denitrificans) 		4 / 5 PRO B 175
LEU B 116
THR B 145
ARG B 161
 None
 1.21A 1i2wA-1efpB:
undetectable		 1i2wA-1efpB:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_B_DESB459_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 1efp PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)
(Paracoccus
denitrificans) 		5 / 12 LEU B  99
LEU B 105
ALA B 106
LEU B 139
VAL B 177
 None
 1.05A 1s9pB-1efpB:
undetectable		 1s9pB-1efpB:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_C_DESC500_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 1efp PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)
(Paracoccus
denitrificans) 		5 / 12 LEU B  99
LEU B 105
ALA B 106
LEU B 139
VAL B 177
 None
 1.07A 1s9pC-1efpB:
undetectable		 1s9pC-1efpB:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SGU_B_MK1B2632_1
(POL POLYPROTEIN)		 1efp PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)
(Paracoccus
denitrificans) 		5 / 8 ALA B 208
ILE B  63
GLY B  64
PRO B 217
ALA B 216
 None
AMP  A 400 (-4.2A)
None
None
None
 1.05A 1sguA-1efpB:
undetectable		 1sguA-1efpB:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN0_B_T44B602_1
(TRANSTHYRETIN)		 1efp PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)
(Paracoccus
denitrificans) 		4 / 7 ALA A 103
LYS B 103
LEU B  99
ALA B 102
 None
 1.14A 1sn0B-1efpA:
0.0
1sn0D-1efpA:
undetectable		 1sn0B-1efpA:
17.43
1sn0D-1efpA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1efp PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)
(Paracoccus
denitrificans) 		5 / 11 TYR B 211
ILE B 104
VAL B 108
ALA B 109
ILE B 117
 None
 1.08A 1uduA-1efpB:
undetectable		 1uduA-1efpB:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 1efp PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)
(Paracoccus
denitrificans) 		5 / 12 ILE A 117
ALA A  25
HIS A  86
PHE A 123
PHE A 145
 None
 1.41A 1y0xX-1efpA:
0.0		 1y0xX-1efpA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_4
(POL POLYPROTEIN)		 1efp PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)
(Paracoccus
denitrificans) 		3 / 3 ARG B 230
VAL A 241
GLY A 199
 None
 0.64A 2avvE-1efpB:
0.0		 2avvE-1efpB:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_A_TRPA601_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1efp PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)
PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)
(Paracoccus
denitrificans;
Paracoccus
denitrificans) 		5 / 12 GLY A 245
GLY A 267
GLN A 240
GLN A 243
PHE B  38
 FAD  A 399 (-4.6A)
None
FAD  A 399 (-3.9A)
None
FAD  A 399 (-4.4A)
 1.26A 2azxA-1efpA:
3.2		 2azxA-1efpA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_B_TRPB603_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1efp PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)
PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)
(Paracoccus
denitrificans;
Paracoccus
denitrificans) 		5 / 12 GLY A 245
GLY A 267
GLN A 240
GLN A 243
PHE B  38
 FAD  A 399 (-4.6A)
None
FAD  A 399 (-3.9A)
None
FAD  A 399 (-4.4A)
 1.29A 2azxB-1efpA:
2.8		 2azxB-1efpA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DR2_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1efp PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)
PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)
(Paracoccus
denitrificans;
Paracoccus
denitrificans) 		5 / 11 GLY A 245
GLY A 267
GLN A 240
GLN A 243
PHE B  38
 FAD  A 399 (-4.6A)
None
FAD  A 399 (-3.9A)
None
FAD  A 399 (-4.4A)
 1.25A 2dr2A-1efpA:
3.9		 2dr2A-1efpA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJG_B_ADNB1502_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 1efp PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)
(Paracoccus
denitrificans) 		4 / 7 ARG A 125
GLU B  97
PRO B  98
ALA B 130
 None
None
AMP  A 400 ( 4.6A)
AMP  A 400 (-4.4A)
 1.28A 2ejgB-1efpA:
undetectable		 2ejgB-1efpA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 1efp PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)
(Paracoccus
denitrificans) 		3 / 3 ALA A 193
GLY A 224
SER A 185
 None
 0.46A 2ivuA-1efpA:
0.0		 2ivuA-1efpA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMY_A_ROCA401_2
(PROTEASE)		 1efp PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)
(Paracoccus
denitrificans) 		5 / 12 ALA B 109
ILE B  59
ILE B  63
ALA B 119
ILE B 117
 None
None
AMP  A 400 (-4.2A)
AMP  A 400 (-3.3A)
None
 0.91A 2nmyB-1efpB:
undetectable		 2nmyB-1efpB:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q5K_A_AB1A201_1
(PROTEASE)		 1efp PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)
(Paracoccus
denitrificans) 		5 / 9 ALA B  89
ASP B  90
VAL B 215
VAL B 101
ILE B  96
 None
None
None
AMP  A 400 ( 4.7A)
None
 0.97A 2q5kA-1efpB:
undetectable		 2q5kA-1efpB:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHC_B_AB1B9001_1
(PROTEASE RETROPEPSIN)		 1efp PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)
(Paracoccus
denitrificans) 		5 / 11 ALA B  89
ASP B  90
VAL B 215
VAL B 101
ILE B  96
 None
None
None
AMP  A 400 ( 4.7A)
None
 1.01A 2qhcA-1efpB:
undetectable		 2qhcA-1efpB:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_B_SAMB206_0
(UPF0217 PROTEIN
MJ1640)		 1efp PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)
(Paracoccus
denitrificans) 		4 / 5 LEU A  14
GLY A  12
GLU A  46
CYH A  36
 None
 1.10A 3aiaA-1efpA:
undetectable
3aiaB-1efpA:
1.0		 3aiaA-1efpA:
22.18
3aiaB-1efpA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AY0_A_ADNA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 1efp PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)
(Paracoccus
denitrificans) 		5 / 10 ASP B 125
ILE A 127
ASN B 126
ALA B 123
LEU B  28
 None
None
AMP  A 400 (-2.5A)
AMP  A 400 (-3.5A)
None
 1.40A 3ay0A-1efpB:
2.3		 3ay0A-1efpB:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJM_A_BJMA1_1
(DIPEPTIDYL PEPTIDASE
4)		 1efp PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)
(Paracoccus
denitrificans) 		5 / 12 ARG B 161
GLU A  71
TYR A  65
ASN A  97
VAL A  98
 None
 1.39A 3bjmA-1efpB:
undetectable		 3bjmA-1efpB:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_0
(PUTATIVE RRNA
METHYLASE)		 1efp PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)
(Paracoccus
denitrificans) 		5 / 12 GLY A 202
ILE A 285
GLY A 260
HIS A 264
LEU A 297
 FAD  A 399 (-3.1A)
None
None
FAD  A 399 (-3.9A)
FAD  A 399 (-3.6A)
 1.17A 3eeyE-1efpA:
2.8		 3eeyE-1efpA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKW_B_DR7B100_1
(PROTEASE)		 1efp PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)
(Paracoccus
denitrificans) 		5 / 10 ALA B 109
ILE B  59
ILE B  63
ALA B 119
ILE B 117
 None
None
AMP  A 400 (-4.2A)
AMP  A 400 (-3.3A)
None
 0.91A 3ekwA-1efpB:
undetectable		 3ekwA-1efpB:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0B_A_T22A800_1
(DIPEPTIDYL PEPTIDASE
4)		 1efp PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)
(Paracoccus
denitrificans) 		5 / 12 ARG B 161
GLU A  71
TYR A  65
ASN A  97
VAL A  98
 None
 1.39A 3g0bA-1efpB:
undetectable		 3g0bA-1efpB:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0B_B_T22B800_1
(DIPEPTIDYL PEPTIDASE
4)		 1efp PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)
(Paracoccus
denitrificans) 		5 / 12 ARG B 161
GLU A  71
TYR A  65
ASN A  97
VAL A  98
 None
 1.40A 3g0bB-1efpB:
2.3		 3g0bB-1efpB:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0B_C_T22C800_1
(DIPEPTIDYL PEPTIDASE
4)		 1efp PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)
(Paracoccus
denitrificans) 		5 / 12 ARG B 161
GLU A  71
TYR A  65
ASN A  97
VAL A  98
 None
 1.42A 3g0bC-1efpB:
undetectable		 3g0bC-1efpB:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0B_D_T22D800_1
(DIPEPTIDYL PEPTIDASE
4)		 1efp PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)
(Paracoccus
denitrificans) 		5 / 12 ARG B 161
GLU A  71
TYR A  65
ASN A  97
VAL A  98
 None
 1.41A 3g0bD-1efpB:
2.4		 3g0bD-1efpB:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_A_SAMA401_0
(O-METHYLTRANSFERASE)		 1efp PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)
PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)
(Paracoccus
denitrificans;
Paracoccus
denitrificans) 		5 / 12 LEU A 190
GLY A 242
GLY A 245
LEU B 182
ALA A 225
 None
FAD  A 399 (-3.1A)
FAD  A 399 (-4.6A)
FAD  A 399 (-4.6A)
None
 1.05A 3i5uA-1efpA:
undetectable		 3i5uA-1efpA:
25.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_0
(O-METHYLTRANSFERASE)		 1efp PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)
PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)
(Paracoccus
denitrificans;
Paracoccus
denitrificans) 		5 / 12 LEU A 190
GLY A 242
GLY A 245
LEU B 182
ALA A 225
 None
FAD  A 399 (-3.1A)
FAD  A 399 (-4.6A)
FAD  A 399 (-4.6A)
None
 1.07A 3i5uB-1efpA:
undetectable		 3i5uB-1efpA:
25.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_1
(GENOME POLYPROTEIN)		 1efp PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)
(Paracoccus
denitrificans) 		5 / 12 GLN A 240
HIS A 264
GLY A 242
GLY A 224
ALA A 255
 FAD  A 399 (-3.9A)
FAD  A 399 (-3.9A)
FAD  A 399 (-3.1A)
None
None
 1.12A 3keeB-1efpA:
undetectable		 3keeB-1efpA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_D_30BD500_1
(GENOME POLYPROTEIN)		 1efp PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)
(Paracoccus
denitrificans) 		5 / 12 GLN A 240
HIS A 264
GLY A 242
GLY A 224
ALA A 255
 FAD  A 399 (-3.9A)
FAD  A 399 (-3.9A)
FAD  A 399 (-3.1A)
None
None
 1.08A 3keeD-1efpA:
undetectable		 3keeD-1efpA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA278_0
(UNIVERSAL STRESS
PROTEIN)		 1efp PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)
(Paracoccus
denitrificans) 		3 / 3 SER A 226
GLY A 200
SER A 232
 FAD  A 399 (-2.7A)
FAD  A 399 (-3.4A)
None
 0.68A 3loqA-1efpA:
3.6		 3loqA-1efpA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_H_BO2H1400_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 1efp PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)
(Paracoccus
denitrificans) 		5 / 11 THR B 160
GLN B 168
ALA B 180
THR B 145
ALA B 144
 None
 1.11A 3mg0H-1efpB:
0.0
3mg0I-1efpB:
0.0		 3mg0H-1efpB:
25.09
3mg0I-1efpB:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A2000_1
(P38A)		 1efp PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)
(Paracoccus
denitrificans) 		5 / 12 ASP B  39
ARG B   9
VAL B  65
ILE B  11
ALA B 123
 AMP  A 400 (-3.0A)
None
None
None
AMP  A 400 (-3.5A)
 1.07A 3ohtA-1efpB:
undetectable
3ohtB-1efpB:
undetectable		 3ohtA-1efpB:
22.42
3ohtB-1efpB:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_C_BEZC264_0
(ECHA1_1)		 1efp PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)
(Paracoccus
denitrificans) 		4 / 5 ALA A  22
GLU A   8
ALA A  91
MET A  99
 None
 1.43A 3r9tC-1efpA:
undetectable		 3r9tC-1efpA:
26.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1efp PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)
(Paracoccus
denitrificans) 		5 / 12 PHE A 145
LEU A  29
ALA A  22
VAL A  34
VAL A   3
 None
 1.02A 3rukA-1efpA:
undetectable		 3rukA-1efpA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1efp PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)
(Paracoccus
denitrificans) 		5 / 12 GLN A 240
HIS A 264
GLY A 242
GLY A 224
ALA A 255
 FAD  A 399 (-3.9A)
FAD  A 399 (-3.9A)
FAD  A 399 (-3.1A)
None
None
 1.08A 3sudA-1efpA:
undetectable		 3sudA-1efpA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1efp PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)
(Paracoccus
denitrificans) 		5 / 12 GLN A 240
HIS A 264
GLY A 242
GLY A 224
ALA A 255
 FAD  A 399 (-3.9A)
FAD  A 399 (-3.9A)
FAD  A 399 (-3.1A)
None
None
 1.13A 3sudB-1efpA:
undetectable		 3sudB-1efpA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1efp PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)
(Paracoccus
denitrificans) 		5 / 12 GLN A 240
HIS A 264
GLY A 242
GLY A 224
ALA A 255
 FAD  A 399 (-3.9A)
FAD  A 399 (-3.9A)
FAD  A 399 (-3.1A)
None
None
 1.13A 3sueB-1efpA:
undetectable		 3sueB-1efpA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1efp PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)
(Paracoccus
denitrificans) 		5 / 12 GLN A 240
HIS A 264
GLY A 242
GLY A 224
ALA A 255
 FAD  A 399 (-3.9A)
FAD  A 399 (-3.9A)
FAD  A 399 (-3.1A)
None
None
 1.07A 3sueD-1efpA:
undetectable		 3sueD-1efpA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1efp PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)
(Paracoccus
denitrificans) 		5 / 11 GLN A 240
HIS A 264
GLY A 242
GLY A 224
ALA A 255
 FAD  A 399 (-3.9A)
FAD  A 399 (-3.9A)
FAD  A 399 (-3.1A)
None
None
 1.14A 3sufC-1efpA:
undetectable		 3sufC-1efpA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		 1efp PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)
(Paracoccus
denitrificans) 		5 / 9 LEU B 219
LEU A 111
GLN A 134
GLU A 124
VAL B 222
 None
 1.22A 3tmzA-1efpB:
0.0		 3tmzA-1efpB:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UR0_C_SVRC516_1
(RNA-DEPENDENT RNA
POLYMERASE)		 1efp PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)
(Paracoccus
denitrificans) 		5 / 9 PRO B   6
GLY B 120
ALA B 119
ALA B 130
LEU B 135
 AMP  A 400 (-4.3A)
AMP  A 400 (-3.5A)
AMP  A 400 (-3.3A)
AMP  A 400 (-4.4A)
None
 1.34A 3ur0C-1efpB:
0.0		 3ur0C-1efpB:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_B_LURB201_1
(TRANSTHYRETIN)		 1efp PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)
(Paracoccus
denitrificans) 		4 / 8 LYS B 158
GLU B 151
THR B 169
ALA B 171
 None
 0.93A 4iizB-1efpB:
undetectable		 4iizB-1efpB:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1A_A_AB1A101_2
(MDR769 HIV-1
PROTEASE)		 1efp PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)
(Paracoccus
denitrificans) 		4 / 6 ARG A  68
ASN A  97
PRO A  72
THR A  73
 None
 1.00A 4l1aB-1efpA:
undetectable		 4l1aB-1efpA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB402_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1efp PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)
(Paracoccus
denitrificans) 		5 / 9 ALA A  70
ILE B 170
VAL B 159
ALA B 176
ALA B 142
 None
 1.09A 4lbgB-1efpA:
2.4		 4lbgB-1efpA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A201_1
(PROTEASE)		 1efp PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)
(Paracoccus
denitrificans) 		4 / 8 ALA B  89
VAL B 215
VAL B 101
ILE B  96
 None
None
AMP  A 400 ( 4.7A)
None
 0.68A 4ll3A-1efpB:
0.0		 4ll3A-1efpB:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)		 1efp PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)
(Paracoccus
denitrificans) 		5 / 11 THR B 160
GLN B 168
ALA B 180
THR B 145
ALA B 144
 None
 1.04A 4qvvH-1efpB:
undetectable		 4qvvH-1efpB:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)		 1efp PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)
(Paracoccus
denitrificans) 		5 / 11 THR B 160
GLN B 168
ALA B 180
THR B 145
ALA B 144
 None
 1.04A 4qvvV-1efpB:
undetectable		 4qvvV-1efpB:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 1efp PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)
(Paracoccus
denitrificans) 		4 / 7 THR A 191
ALA A  18
ALA A  22
THR A  92
 None
 0.89A 4qw0K-1efpA:
undetectable		 4qw0K-1efpA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 1efp PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)
(Paracoccus
denitrificans) 		4 / 7 THR A 191
ALA A  18
ALA A  22
THR A  92
 None
 0.89A 4qw0Y-1efpA:
undetectable		 4qw0Y-1efpA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_A_RBFA201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1efp PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)
(Paracoccus
denitrificans) 		4 / 8 LEU A 111
VAL A  26
LEU A  29
ILE A 117
 None
 0.78A 4r38A-1efpA:
undetectable		 4r38A-1efpA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_D_RBFD201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1efp PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)
(Paracoccus
denitrificans) 		4 / 8 LEU A 111
VAL A  26
LEU A  29
ILE A 117
 None
 0.81A 4r38D-1efpA:
0.0		 4r38D-1efpA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 1efp PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)
(Paracoccus
denitrificans) 		5 / 12 THR B 160
GLN B 168
ALA B 180
THR B 145
ALA B 144
 None
 1.01A 5d0xH-1efpB:
undetectable
5d0xI-1efpB:
undetectable		 5d0xH-1efpB:
23.76
5d0xI-1efpB:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)		 1efp PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)
(Paracoccus
denitrificans) 		5 / 11 THR B 160
GLN B 168
ALA B 180
THR B 145
ALA B 144
 None
 1.00A 5d0xV-1efpB:
undetectable		 5d0xV-1efpB:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWK_A_BEZA301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)		 1efp PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)
(Paracoccus
denitrificans) 		5 / 10 GLY A 202
GLY A 204
SER A 205
LEU A 203
GLU A 207
 FAD  A 399 (-3.1A)
None
None
None
None
 1.37A 5hwkA-1efpA:
0.0		 5hwkA-1efpA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWK_B_BEZB301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)		 1efp PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)
(Paracoccus
denitrificans) 		5 / 10 GLY A 202
GLY A 204
SER A 205
LEU A 203
GLU A 207
 FAD  A 399 (-3.1A)
None
None
None
None
 1.36A 5hwkB-1efpA:
0.0		 5hwkB-1efpA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_B_ACTB713_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 1efp PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)
(Paracoccus
denitrificans) 		3 / 3 GLY A 130
GLN A 243
LYS A 269
 None
 0.86A 5imsB-1efpA:
7.1		 5imsB-1efpA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_A_SAMA401_1
(PAVINE
N-METHYLTRANSFERASE)		 1efp PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)
(Paracoccus
denitrificans) 		4 / 5 PHE A 209
SER A 208
ASN A 278
ASP A 280
 None
None
FAD  A 399 (-2.7A)
FAD  A 399 (-4.8A)
 1.38A 5kpcA-1efpA:
1.6		 5kpcA-1efpA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_0
(METHYLTRANSFERASE)		 1efp PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)
(Paracoccus
denitrificans) 		5 / 12 ALA A  37
GLY A  12
TYR A  65
GLU A  46
ALA A  13
 None
 1.20A 5n5dA-1efpA:
2.1		 5n5dA-1efpA:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OSP_A_ACTA403_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 1efp PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)
(Paracoccus
denitrificans) 		4 / 7 VAL B 150
ILE B 152
VAL B 172
ALA B 157
 None
 0.71A 5ospA-1efpB:
undetectable		 5ospA-1efpB:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QPA613_1
(SERUM ALBUMIN)		 1efp PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)
(Paracoccus
denitrificans) 		4 / 8 ALA A 229
PHE A 298
SER A 208
GLY A 202
 None
None
None
FAD  A 399 (-3.1A)
 1.02A 5v0vA-1efpA:
0.0		 5v0vA-1efpA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X2T_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 1efp PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)
(Paracoccus
denitrificans) 		4 / 8 PRO B  98
ALA B 106
THR B 131
ALA A 103
 AMP  A 400 ( 4.6A)
None
AMP  A 400 (-3.3A)
None
 1.03A 5x2tI-1efpB:
undetectable
5x2tJ-1efpB:
undetectable
5x2tK-1efpB:
undetectable
5x2tL-1efpB:
undetectable		 5x2tI-1efpB:
23.11
5x2tJ-1efpB:
19.43
5x2tK-1efpB:
23.11
5x2tL-1efpB:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_A_SUEA1202_0
(NS3 PROTEASE)		 1efp PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)
(Paracoccus
denitrificans) 		5 / 12 GLN A 240
HIS A 264
GLY A 242
ILE A 212
ALA A 255
 FAD  A 399 (-3.9A)
FAD  A 399 (-3.9A)
FAD  A 399 (-3.1A)
None
None
 1.07A 6c2mA-1efpA:
undetectable		 6c2mA-1efpA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_0
(NS3 PROTEASE)		 1efp PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)
(Paracoccus
denitrificans) 		5 / 12 GLN A 240
HIS A 264
GLY A 242
GLY A 224
ALA A 255
 FAD  A 399 (-3.9A)
FAD  A 399 (-3.9A)
FAD  A 399 (-3.1A)
None
None
 1.15A 6c2mB-1efpA:
0.0		 6c2mB-1efpA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_0
(NS3 PROTEASE)		 1efp PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)
(Paracoccus
denitrificans) 		5 / 12 GLN A 240
HIS A 264
GLY A 242
ILE A 212
ALA A 255
 FAD  A 399 (-3.9A)
FAD  A 399 (-3.9A)
FAD  A 399 (-3.1A)
None
None
 1.13A 6c2mB-1efpA:
0.0		 6c2mB-1efpA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_0
(NS3 PROTEASE)		 1efp PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)
(Paracoccus
denitrificans) 		5 / 12 GLN A 240
HIS A 264
GLY A 242
GLY A 224
ALA A 255
 FAD  A 399 (-3.9A)
FAD  A 399 (-3.9A)
FAD  A 399 (-3.1A)
None
None
 1.06A 6c2mD-1efpA:
undetectable		 6c2mD-1efpA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_0
(NS3 PROTEASE)		 1efp PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)
(Paracoccus
denitrificans) 		5 / 12 GLN A 240
HIS A 264
GLY A 242
ILE A 212
ALA A 255
 FAD  A 399 (-3.9A)
FAD  A 399 (-3.9A)
FAD  A 399 (-3.1A)
None
None
 0.98A 6c2mD-1efpA:
undetectable		 6c2mD-1efpA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_B_HISB402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 1efp PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)
(Paracoccus
denitrificans) 		5 / 9 VAL A 301
LEU A 304
GLY A 292
LEU A 293
VAL A 254
 None
 1.12A 6czmA-1efpA:
0.0
6czmB-1efpA:
0.0		 6czmA-1efpA:
24.54
6czmB-1efpA:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_C_HISC402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 1efp PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)
(Paracoccus
denitrificans) 		5 / 9 VAL A 301
LEU A 304
GLY A 292
LEU A 293
VAL A 254
 None
 1.11A 6czmB-1efpA:
0.0
6czmC-1efpA:
0.4		 6czmB-1efpA:
24.54
6czmC-1efpA:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_E_HISE402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 1efp PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)
(Paracoccus
denitrificans) 		5 / 9 VAL A 301
LEU A 304
GLY A 292
LEU A 293
VAL A 254
 None
 1.10A 6czmD-1efpA:
0.0
6czmE-1efpA:
0.0		 6czmD-1efpA:
24.54
6czmE-1efpA:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_F_HISF402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 1efp PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)
(Paracoccus
denitrificans) 		5 / 10 VAL A 301
LEU A 304
GLY A 292
LEU A 293
VAL A 254
 None
 1.09A 6czmE-1efpA:
0.0
6czmF-1efpA:
0.0		 6czmE-1efpA:
24.54
6czmF-1efpA:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ2_B_AB1B201_0
(HIV-1 PROTEASE)		 1efp PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)
(Paracoccus
denitrificans) 		5 / 10 ALA B  89
ASP B  90
VAL B 215
VAL B 101
ILE B  96
 None
None
None
AMP  A 400 ( 4.7A)
None
 0.98A 6dj2A-1efpB:
undetectable		 6dj2A-1efpB:
18.26