SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1efv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1efv ELECTRON TRANSFER
FLAVOPROTEIN
(Homo
sapiens) 		5 / 10 ALA A 188
ALA A  56
LEU A 119
VAL A 123
ILE A  25
 None
 1.15A 1claA-1efvA:
0.0		 1claA-1efvA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_A_MK1A401_1
(HIV-II PROTEASE)		 1efv ELECTRON TRANSFER
FLAVOPROTEIN
(Homo
sapiens) 		6 / 12 ALA A 305
ASP A 302
ILE A 280
ILE A 315
ILE A 296
ILE A 307
 FAD  A 599 ( 4.2A)
None
FAD  A 599 (-4.3A)
None
None
None
 1.42A 1hshA-1efvA:
undetectable		 1hshA-1efvA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_2
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1efv ELECTRON TRANSFER
FLAVOPROTEIN
(Homo
sapiens) 		3 / 3 LEU A 120
VAL A 123
LEU A 127
 None
 0.47A 1mz9B-1efvA:
undetectable		 1mz9B-1efvA:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_B_RBFB101_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 1efv ELECTRON TRANSFER
FLAVOPROTEIN
(Homo
sapiens) 		5 / 11 ILE A  25
VAL A  24
CYH A  53
LEU A  67
THR A  37
 None
 1.26A 1pkvA-1efvA:
undetectable
1pkvB-1efvA:
undetectable		 1pkvA-1efvA:
14.97
1pkvB-1efvA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_B_GBNB914_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 1efv ELECTRON TRANSFER
FLAVOPROTEIN
(Homo
sapiens) 		5 / 10 TYR A 235
GLY A 228
GLY A 255
ALA A 251
ALA A 254
 None
 1.16A 2ej3B-1efvA:
undetectable		 2ej3B-1efvA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_H_BO2H1400_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 1efv ELECTRON TRANSFER
FLAVOPROTEIN
(Homo
sapiens) 		5 / 11 GLN A  65
ALA A  64
ALA A  71
GLY A 181
ALA A 183
 None
 1.10A 2f16H-1efvA:
undetectable
2f16I-1efvA:
undetectable		 2f16H-1efvA:
23.85
2f16I-1efvA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_V_BO2V1401_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 1efv ELECTRON TRANSFER
FLAVOPROTEIN
(Homo
sapiens) 		5 / 11 GLN A  65
ALA A  64
ALA A  71
GLY A 181
ALA A 183
 None
 1.10A 2f16V-1efvA:
undetectable
2f16W-1efvA:
undetectable		 2f16V-1efvA:
23.85
2f16W-1efvA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EBZ_B_017B201_2
(PROTEASE)		 1efv ELECTRON TRANSFER
FLAVOPROTEIN
(Homo
sapiens) 		5 / 11 GLY A 289
ALA A 288
ILE A 284
GLY A 282
ILE A 280
 None
None
None
None
FAD  A 599 (-4.3A)
 1.05A 3ebzB-1efvA:
undetectable		 3ebzB-1efvA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_0
(PUTATIVE RRNA
METHYLASE)		 1efv ELECTRON TRANSFER
FLAVOPROTEIN
(Homo
sapiens) 		5 / 12 GLY A 224
ILE A 307
GLY A 282
HIS A 286
LEU A 319
 FAD  A 599 (-3.6A)
None
None
FAD  A 599 (-3.8A)
FAD  A 599 (-3.8A)
 1.11A 3eeyE-1efvA:
2.9		 3eeyE-1efvA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_F_SAMF300_0
(PUTATIVE RRNA
METHYLASE)		 1efv ELECTRON TRANSFER
FLAVOPROTEIN
(Homo
sapiens) 		5 / 12 GLY A 224
ILE A 307
GLY A 282
HIS A 286
LEU A 319
 FAD  A 599 (-3.6A)
None
None
FAD  A 599 (-3.8A)
FAD  A 599 (-3.8A)
 1.08A 3eeyF-1efvA:
3.0		 3eeyF-1efvA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_I_SAMI300_0
(PUTATIVE RRNA
METHYLASE)		 1efv ELECTRON TRANSFER
FLAVOPROTEIN
(Homo
sapiens) 		5 / 12 GLY A 224
ILE A 307
GLY A 282
HIS A 286
LEU A 319
 FAD  A 599 (-3.6A)
None
None
FAD  A 599 (-3.8A)
FAD  A 599 (-3.8A)
 1.17A 3eeyI-1efvA:
3.4		 3eeyI-1efvA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_J_SAMJ300_0
(PUTATIVE RRNA
METHYLASE)		 1efv ELECTRON TRANSFER
FLAVOPROTEIN
(Homo
sapiens) 		5 / 12 GLY A 224
ILE A 307
GLY A 282
HIS A 286
LEU A 319
 FAD  A 599 (-3.6A)
None
None
FAD  A 599 (-3.8A)
FAD  A 599 (-3.8A)
 1.13A 3eeyJ-1efvA:
3.0		 3eeyJ-1efvA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM6_A_017A200_1
(PROTEASE)		 1efv ELECTRON TRANSFER
FLAVOPROTEIN
(Homo
sapiens) 		5 / 8 GLY A 255
ALA A 254
ASP A 253
GLY A 222
LEU A 225
 None
None
None
FAD  A 599 (-3.1A)
None
 1.21A 3em6A-1efvA:
undetectable		 3em6A-1efvA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB1_A_IMNA701_1
(LACTOTRANSFERRIN)		 1efv ELECTRON TRANSFER
FLAVOPROTEIN
(Homo
sapiens) 		4 / 4 PRO A  35
THR A  37
GLY A  57
THR A  58
 None
 1.14A 3ib1A-1efvA:
0.0		 3ib1A-1efvA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_1
(GENOME POLYPROTEIN)		 1efv ELECTRON TRANSFER
FLAVOPROTEIN
(Homo
sapiens) 		5 / 12 GLN A 262
HIS A 286
GLY A 264
GLY A 246
ALA A 277
 FAD  A 599 (-3.8A)
FAD  A 599 (-3.8A)
FAD  A 599 (-3.1A)
None
None
 1.08A 3keeB-1efvA:
undetectable		 3keeB-1efvA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_D_30BD500_1
(GENOME POLYPROTEIN)		 1efv ELECTRON TRANSFER
FLAVOPROTEIN
(Homo
sapiens) 		5 / 12 GLN A 262
HIS A 286
GLY A 264
GLY A 246
ALA A 277
 FAD  A 599 (-3.8A)
FAD  A 599 (-3.8A)
FAD  A 599 (-3.1A)
None
None
 1.04A 3keeD-1efvA:
undetectable		 3keeD-1efvA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_A_VORA506_1
(CHOLESTEROL
24-HYDROXYLASE)		 1efv ELECTRON TRANSFER
FLAVOPROTEIN
(Homo
sapiens) 		5 / 9 LEU A  87
ILE A  25
ALA A 110
THR A  37
ALA A  34
 None
 1.13A 3mdtA-1efvA:
0.0		 3mdtA-1efvA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_V_BO2V1401_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 1efv ELECTRON TRANSFER
FLAVOPROTEIN
(Homo
sapiens) 		5 / 11 GLN A  65
ALA A  64
ALA A  71
GLY A 181
ALA A 183
 None
 1.13A 3mg0V-1efvA:
undetectable
3mg0W-1efvA:
undetectable		 3mg0V-1efvA:
23.85
3mg0W-1efvA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1efv ELECTRON TRANSFER
FLAVOPROTEIN
(Homo
sapiens) 		5 / 12 GLN A 262
HIS A 286
GLY A 264
GLY A 246
ALA A 277
 FAD  A 599 (-3.8A)
FAD  A 599 (-3.8A)
FAD  A 599 (-3.1A)
None
None
 1.04A 3sudA-1efvA:
undetectable		 3sudA-1efvA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1efv ELECTRON TRANSFER
FLAVOPROTEIN
(Homo
sapiens) 		5 / 12 GLN A 262
HIS A 286
GLY A 264
GLY A 246
ALA A 277
 FAD  A 599 (-3.8A)
FAD  A 599 (-3.8A)
FAD  A 599 (-3.1A)
None
None
 1.09A 3sudB-1efvA:
undetectable		 3sudB-1efvA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1efv ELECTRON TRANSFER
FLAVOPROTEIN
(Homo
sapiens) 		5 / 12 GLN A 262
HIS A 286
GLY A 264
GLY A 246
ALA A 277
 FAD  A 599 (-3.8A)
FAD  A 599 (-3.8A)
FAD  A 599 (-3.1A)
None
None
 1.09A 3sueB-1efvA:
undetectable		 3sueB-1efvA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1efv ELECTRON TRANSFER
FLAVOPROTEIN
(Homo
sapiens) 		5 / 12 GLN A 262
HIS A 286
GLY A 264
GLY A 246
ALA A 277
 FAD  A 599 (-3.8A)
FAD  A 599 (-3.8A)
FAD  A 599 (-3.1A)
None
None
 1.03A 3sueD-1efvA:
undetectable		 3sueD-1efvA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1efv ELECTRON TRANSFER
FLAVOPROTEIN
(Homo
sapiens) 		5 / 11 GLN A 262
HIS A 286
GLY A 264
GLY A 246
ALA A 277
 FAD  A 599 (-3.8A)
FAD  A 599 (-3.8A)
FAD  A 599 (-3.1A)
None
None
 1.10A 3sufC-1efvA:
undetectable		 3sufC-1efvA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_S_CLMS221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1efv ELECTRON TRANSFER
FLAVOPROTEIN
(Homo
sapiens) 		5 / 12 CYH A  53
PHE A 115
LEU A  67
VAL A  76
VAL A  63
 None
 1.18A 3u9fP-1efvA:
0.0
3u9fS-1efvA:
0.0		 3u9fP-1efvA:
22.15
3u9fS-1efvA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_2
(CYTOCHROME P450 3A4)		 1efv ELECTRON TRANSFER
FLAVOPROTEIN
(Homo
sapiens) 		4 / 7 ILE A  36
PHE A 166
THR A  22
THR A 147
 None
 0.94A 5vc0A-1efvA:
0.0		 5vc0A-1efvA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_0
(REGULATORY PROTEIN
TETR)		 1efv ELECTRON TRANSFER
FLAVOPROTEIN
(Homo
sapiens) 		5 / 12 ALA A 125
LEU A  97
ILE A  96
VAL A 165
TYR A 105
 None
 1.36A 5vlmE-1efvA:
undetectable		 5vlmE-1efvA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA502_1
(CYTOCHROME P450 2C9)		 1efv ELECTRON TRANSFER
FLAVOPROTEIN
(Homo
sapiens) 		5 / 12 ALA A  34
PHE A 115
LEU A  33
GLY A  57
LEU A 119
 None
 1.00A 5x24A-1efvA:
0.0		 5x24A-1efvA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_A_SUEA1202_0
(NS3 PROTEASE)		 1efv ELECTRON TRANSFER
FLAVOPROTEIN
(Homo
sapiens) 		5 / 12 GLN A 262
HIS A 286
GLY A 264
GLY A 246
ALA A 277
 FAD  A 599 (-3.8A)
FAD  A 599 (-3.8A)
FAD  A 599 (-3.1A)
None
None
 1.11A 6c2mA-1efvA:
undetectable		 6c2mA-1efvA:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_0
(NS3 PROTEASE)		 1efv ELECTRON TRANSFER
FLAVOPROTEIN
(Homo
sapiens) 		5 / 12 GLN A 262
HIS A 286
GLY A 264
GLY A 246
ALA A 277
 FAD  A 599 (-3.8A)
FAD  A 599 (-3.8A)
FAD  A 599 (-3.1A)
None
None
 1.11A 6c2mB-1efvA:
undetectable		 6c2mB-1efvA:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_0
(NS3 PROTEASE)		 1efv ELECTRON TRANSFER
FLAVOPROTEIN
(Homo
sapiens) 		5 / 12 GLN A 262
HIS A 286
GLY A 264
GLY A 246
ALA A 277
 FAD  A 599 (-3.8A)
FAD  A 599 (-3.8A)
FAD  A 599 (-3.1A)
None
None
 1.01A 6c2mD-1efvA:
undetectable		 6c2mD-1efvA:
10.16