SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1efy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_A_NCAA700_0
(EXOTOXIN A)		 1efy POLY (ADP-RIBOSE)
POLYMERASE
(Gallus
gallus) 		5 / 7 HIS A 862
GLY A 863
TYR A 896
TYR A 907
GLU A 988
 BZC  A 201 (-4.0A)
BZC  A 201 (-3.9A)
BZC  A 201 (-4.0A)
BZC  A 201 (-3.6A)
BZC  A 201 (-4.0A)
 0.51A 1dmaA-1efyA:
5.8		 1dmaA-1efyA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_B_NCAB700_0
(EXOTOXIN A)		 1efy POLY (ADP-RIBOSE)
POLYMERASE
(Gallus
gallus) 		6 / 6 HIS A 862
GLY A 863
TYR A 896
ALA A 898
TYR A 907
GLU A 988
 BZC  A 201 (-4.0A)
BZC  A 201 (-3.9A)
BZC  A 201 (-4.0A)
BZC  A 201 ( 3.9A)
BZC  A 201 (-3.6A)
BZC  A 201 (-4.0A)
 0.44A 1dmaB-1efyA:
5.6		 1dmaB-1efyA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1efy POLY (ADP-RIBOSE)
POLYMERASE
(Gallus
gallus) 		4 / 5 ILE A 673
LEU A 672
ALA A 905
CYH A 908
 None
 0.96A 1mz9C-1efyA:
0.0		 1mz9C-1efyA:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_A_NCAA1163_0
(TANKYRASE-2)		 1efy POLY (ADP-RIBOSE)
POLYMERASE
(Gallus
gallus) 		7 / 8 HIS A 862
GLY A 863
ALA A 898
LYS A 903
SER A 904
TYR A 907
GLU A 988
 BZC  A 201 (-4.0A)
BZC  A 201 (-3.9A)
BZC  A 201 ( 3.9A)
BZC  A 201 ( 4.8A)
BZC  A 201 (-3.3A)
BZC  A 201 (-3.6A)
BZC  A 201 (-4.0A)
 1.25A 3u9hA-1efyA:
19.0		 3u9hA-1efyA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_A_NCAA1163_0
(TANKYRASE-2)		 1efy POLY (ADP-RIBOSE)
POLYMERASE
(Gallus
gallus) 		7 / 8 HIS A 862
GLY A 863
TYR A 896
ALA A 898
LYS A 903
SER A 904
TYR A 907
 BZC  A 201 (-4.0A)
BZC  A 201 (-3.9A)
BZC  A 201 (-4.0A)
BZC  A 201 ( 3.9A)
BZC  A 201 ( 4.8A)
BZC  A 201 (-3.3A)
BZC  A 201 (-3.6A)
 0.92A 3u9hA-1efyA:
19.0		 3u9hA-1efyA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_B_NCAB1164_0
(TANKYRASE-2)		 1efy POLY (ADP-RIBOSE)
POLYMERASE
(Gallus
gallus) 		7 / 8 HIS A 862
GLY A 863
ALA A 898
LYS A 903
SER A 904
TYR A 907
GLU A 988
 BZC  A 201 (-4.0A)
BZC  A 201 (-3.9A)
BZC  A 201 ( 3.9A)
BZC  A 201 ( 4.8A)
BZC  A 201 (-3.3A)
BZC  A 201 (-3.6A)
BZC  A 201 (-4.0A)
 1.24A 3u9hB-1efyA:
19.0		 3u9hB-1efyA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_B_NCAB1164_0
(TANKYRASE-2)		 1efy POLY (ADP-RIBOSE)
POLYMERASE
(Gallus
gallus) 		7 / 8 HIS A 862
GLY A 863
TYR A 896
ALA A 898
LYS A 903
SER A 904
TYR A 907
 BZC  A 201 (-4.0A)
BZC  A 201 (-3.9A)
BZC  A 201 (-4.0A)
BZC  A 201 ( 3.9A)
BZC  A 201 ( 4.8A)
BZC  A 201 (-3.3A)
BZC  A 201 (-3.6A)
 0.96A 3u9hB-1efyA:
19.0		 3u9hB-1efyA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_A_NCAA1536_0
(DIPHTHERIA TOXIN)		 1efy POLY (ADP-RIBOSE)
POLYMERASE
(Gallus
gallus) 		5 / 6 HIS A 862
GLY A 863
TYR A 896
TYR A 907
GLU A 988
 BZC  A 201 (-4.0A)
BZC  A 201 (-3.9A)
BZC  A 201 (-4.0A)
BZC  A 201 (-3.6A)
BZC  A 201 (-4.0A)
 0.43A 4ae1A-1efyA:
6.4		 4ae1A-1efyA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_B_NCAB1536_0
(DIPHTHERIA TOXIN)		 1efy POLY (ADP-RIBOSE)
POLYMERASE
(Gallus
gallus) 		5 / 5 HIS A 862
GLY A 863
TYR A 896
TYR A 907
GLU A 988
 BZC  A 201 (-4.0A)
BZC  A 201 (-3.9A)
BZC  A 201 (-4.0A)
BZC  A 201 (-3.6A)
BZC  A 201 (-4.0A)
 0.46A 4ae1B-1efyA:
0.1		 4ae1B-1efyA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		 1efy POLY (ADP-RIBOSE)
POLYMERASE
(Gallus
gallus) 		6 / 8 HIS A 862
GLY A 863
ALA A 898
LYS A 903
SER A 904
GLU A 988
 BZC  A 201 (-4.0A)
BZC  A 201 (-3.9A)
BZC  A 201 ( 3.9A)
BZC  A 201 ( 4.8A)
BZC  A 201 (-3.3A)
BZC  A 201 (-4.0A)
 1.30A 4bjcA-1efyA:
18.7		 4bjcA-1efyA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		 1efy POLY (ADP-RIBOSE)
POLYMERASE
(Gallus
gallus) 		6 / 8 HIS A 862
GLY A 863
ALA A 898
SER A 904
TYR A 907
GLU A 988
 BZC  A 201 (-4.0A)
BZC  A 201 (-3.9A)
BZC  A 201 ( 3.9A)
BZC  A 201 (-3.3A)
BZC  A 201 (-3.6A)
BZC  A 201 (-4.0A)
 0.78A 4bjcA-1efyA:
18.7		 4bjcA-1efyA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		 1efy POLY (ADP-RIBOSE)
POLYMERASE
(Gallus
gallus) 		6 / 8 HIS A 862
GLY A 863
TYR A 896
ALA A 898
LYS A 903
SER A 904
 BZC  A 201 (-4.0A)
BZC  A 201 (-3.9A)
BZC  A 201 (-4.0A)
BZC  A 201 ( 3.9A)
BZC  A 201 ( 4.8A)
BZC  A 201 (-3.3A)
 0.91A 4bjcA-1efyA:
18.7		 4bjcA-1efyA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		 1efy POLY (ADP-RIBOSE)
POLYMERASE
(Gallus
gallus) 		6 / 8 HIS A 862
GLY A 863
TYR A 896
ALA A 898
SER A 904
TYR A 907
 BZC  A 201 (-4.0A)
BZC  A 201 (-3.9A)
BZC  A 201 (-4.0A)
BZC  A 201 ( 3.9A)
BZC  A 201 (-3.3A)
BZC  A 201 (-3.6A)
 0.27A 4bjcA-1efyA:
18.7		 4bjcA-1efyA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_A_NCAA1201_0
(TANKYRASE-2)		 1efy POLY (ADP-RIBOSE)
POLYMERASE
(Gallus
gallus) 		7 / 7 HIS A 862
GLY A 863
TYR A 896
ALA A 898
SER A 904
TYR A 907
GLU A 988
 BZC  A 201 (-4.0A)
BZC  A 201 (-3.9A)
BZC  A 201 (-4.0A)
BZC  A 201 ( 3.9A)
BZC  A 201 (-3.3A)
BZC  A 201 (-3.6A)
BZC  A 201 (-4.0A)
 0.58A 4hyfA-1efyA:
19.9		 4hyfA-1efyA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_B_NCAB1201_0
(TANKYRASE-2)		 1efy POLY (ADP-RIBOSE)
POLYMERASE
(Gallus
gallus) 		8 / 8 HIS A 862
GLY A 863
TYR A 896
ALA A 898
LYS A 903
SER A 904
TYR A 907
GLU A 988
 BZC  A 201 (-4.0A)
BZC  A 201 (-3.9A)
BZC  A 201 (-4.0A)
BZC  A 201 ( 3.9A)
BZC  A 201 ( 4.8A)
BZC  A 201 (-3.3A)
BZC  A 201 (-3.6A)
BZC  A 201 (-4.0A)
 0.86A 4hyfB-1efyA:
20.0		 4hyfB-1efyA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_C_NCAC1201_0
(TANKYRASE-2)		 1efy POLY (ADP-RIBOSE)
POLYMERASE
(Gallus
gallus) 		8 / 8 HIS A 862
GLY A 863
TYR A 896
ALA A 898
LYS A 903
SER A 904
TYR A 907
GLU A 988
 BZC  A 201 (-4.0A)
BZC  A 201 (-3.9A)
BZC  A 201 (-4.0A)
BZC  A 201 ( 3.9A)
BZC  A 201 ( 4.8A)
BZC  A 201 (-3.3A)
BZC  A 201 (-3.6A)
BZC  A 201 (-4.0A)
 0.53A 4hyfC-1efyA:
20.0		 4hyfC-1efyA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A201_1
(PROTEASE)		 1efy POLY (ADP-RIBOSE)
POLYMERASE
(Gallus
gallus) 		4 / 8 VAL A 991
GLY A 922
VAL A 994
ILE A 895
 None
 0.74A 4ll3A-1efyA:
undetectable		 4ll3A-1efyA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PE5_C_QELC939_1
(GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 1
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 1efy POLY (ADP-RIBOSE)
POLYMERASE
(Gallus
gallus) 		5 / 10 TYR A 737
THR A 738
LEU A 732
ALA A 709
ILE A 740
 None
 1.31A 4pe5C-1efyA:
0.0
4pe5D-1efyA:
undetectable		 4pe5C-1efyA:
18.59
4pe5D-1efyA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1efy POLY (ADP-RIBOSE)
POLYMERASE
(Gallus
gallus) 		5 / 11 THR A 959
THR A 961
GLY A 974
ALA A 955
THR A 954
 None
 1.21A 4qvlV-1efyA:
undetectable
4qvlb-1efyA:
undetectable		 4qvlV-1efyA:
20.66
4qvlb-1efyA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1efy POLY (ADP-RIBOSE)
POLYMERASE
(Gallus
gallus) 		5 / 11 THR A 959
THR A 961
GLY A 974
ALA A 955
THR A 954
 None
 1.20A 4qvlH-1efyA:
undetectable
4qvlN-1efyA:
undetectable		 4qvlH-1efyA:
20.66
4qvlN-1efyA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1efy POLY (ADP-RIBOSE)
POLYMERASE
(Gallus
gallus) 		5 / 11 THR A 959
THR A 961
GLY A 974
ALA A 955
THR A 954
 None
 1.22A 4qvmV-1efyA:
undetectable
4qvmb-1efyA:
undetectable		 4qvmV-1efyA:
20.66
4qvmb-1efyA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1efy POLY (ADP-RIBOSE)
POLYMERASE
(Gallus
gallus) 		5 / 11 THR A 959
THR A 961
GLY A 974
ALA A 955
THR A 954
 None
 1.21A 4qvmH-1efyA:
undetectable
4qvmN-1efyA:
undetectable		 4qvmH-1efyA:
20.66
4qvmN-1efyA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1efy POLY (ADP-RIBOSE)
POLYMERASE
(Gallus
gallus) 		5 / 12 THR A 959
THR A 961
GLY A 974
ALA A 955
THR A 954
 None
 1.24A 4qvnV-1efyA:
undetectable
4qvnb-1efyA:
undetectable		 4qvnV-1efyA:
20.66
4qvnb-1efyA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1efy POLY (ADP-RIBOSE)
POLYMERASE
(Gallus
gallus) 		5 / 12 THR A 959
THR A 961
GLY A 974
ALA A 955
THR A 954
 None
 1.24A 4qvnH-1efyA:
undetectable
4qvnN-1efyA:
undetectable		 4qvnH-1efyA:
20.66
4qvnN-1efyA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1efy POLY (ADP-RIBOSE)
POLYMERASE
(Gallus
gallus) 		5 / 11 THR A 959
THR A 961
GLY A 974
ALA A 955
THR A 954
 None
 1.23A 4qvpV-1efyA:
undetectable
4qvpb-1efyA:
undetectable		 4qvpV-1efyA:
20.66
4qvpb-1efyA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1efy POLY (ADP-RIBOSE)
POLYMERASE
(Gallus
gallus) 		5 / 11 THR A 959
THR A 961
GLY A 974
ALA A 955
THR A 954
 None
 1.23A 4qvpH-1efyA:
undetectable
4qvpN-1efyA:
undetectable		 4qvpH-1efyA:
20.66
4qvpN-1efyA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1efy POLY (ADP-RIBOSE)
POLYMERASE
(Gallus
gallus) 		5 / 11 THR A 959
THR A 961
GLY A 974
ALA A 955
THR A 954
 None
 1.23A 4qvqV-1efyA:
undetectable
4qvqb-1efyA:
undetectable		 4qvqV-1efyA:
20.66
4qvqb-1efyA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1efy POLY (ADP-RIBOSE)
POLYMERASE
(Gallus
gallus) 		5 / 11 THR A 959
THR A 961
GLY A 974
ALA A 955
THR A 954
 None
 1.24A 4qvqH-1efyA:
undetectable
4qvqN-1efyA:
undetectable		 4qvqH-1efyA:
20.66
4qvqN-1efyA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1efy POLY (ADP-RIBOSE)
POLYMERASE
(Gallus
gallus) 		5 / 11 THR A 959
THR A 961
GLY A 974
ALA A 955
THR A 954
 None
 1.21A 4qvwV-1efyA:
undetectable
4qvwb-1efyA:
undetectable		 4qvwV-1efyA:
20.66
4qvwb-1efyA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1efy POLY (ADP-RIBOSE)
POLYMERASE
(Gallus
gallus) 		5 / 11 THR A 959
THR A 961
GLY A 974
ALA A 955
THR A 954
 None
 1.21A 4qvwH-1efyA:
undetectable
4qvwN-1efyA:
undetectable		 4qvwH-1efyA:
20.66
4qvwN-1efyA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1efy POLY (ADP-RIBOSE)
POLYMERASE
(Gallus
gallus) 		5 / 11 THR A 959
THR A 961
GLY A 974
ALA A 955
THR A 954
 None
 1.20A 4qw0V-1efyA:
undetectable
4qw0b-1efyA:
undetectable		 4qw0V-1efyA:
20.66
4qw0b-1efyA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1efy POLY (ADP-RIBOSE)
POLYMERASE
(Gallus
gallus) 		5 / 11 THR A 959
THR A 961
GLY A 974
ALA A 955
THR A 954
 None
 1.20A 4qw0H-1efyA:
undetectable
4qw0N-1efyA:
undetectable		 4qw0H-1efyA:
20.66
4qw0N-1efyA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1efy POLY (ADP-RIBOSE)
POLYMERASE
(Gallus
gallus) 		5 / 11 THR A 959
THR A 961
GLY A 974
ALA A 955
THR A 954
 None
 1.22A 4qw1V-1efyA:
undetectable
4qw1b-1efyA:
undetectable		 4qw1V-1efyA:
20.66
4qw1b-1efyA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1efy POLY (ADP-RIBOSE)
POLYMERASE
(Gallus
gallus) 		5 / 11 THR A 959
THR A 961
GLY A 974
ALA A 955
THR A 954
 None
 1.22A 4qw1H-1efyA:
undetectable
4qw1N-1efyA:
undetectable		 4qw1H-1efyA:
20.66
4qw1N-1efyA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1efy POLY (ADP-RIBOSE)
POLYMERASE
(Gallus
gallus) 		5 / 11 THR A 959
THR A 961
GLY A 974
ALA A 955
THR A 954
 None
 1.21A 4qw3V-1efyA:
undetectable
4qw3b-1efyA:
undetectable		 4qw3V-1efyA:
20.66
4qw3b-1efyA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1efy POLY (ADP-RIBOSE)
POLYMERASE
(Gallus
gallus) 		5 / 11 THR A 959
THR A 961
GLY A 974
ALA A 955
THR A 954
 None
 1.21A 4qw3H-1efyA:
undetectable
4qw3N-1efyA:
undetectable		 4qw3H-1efyA:
20.66
4qw3N-1efyA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1efy POLY (ADP-RIBOSE)
POLYMERASE
(Gallus
gallus) 		5 / 11 THR A 959
THR A 961
GLY A 974
ALA A 955
THR A 954
 None
 1.24A 4qwuV-1efyA:
undetectable
4qwub-1efyA:
undetectable		 4qwuV-1efyA:
20.66
4qwub-1efyA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1efy POLY (ADP-RIBOSE)
POLYMERASE
(Gallus
gallus) 		5 / 11 THR A 959
THR A 961
GLY A 974
ALA A 955
THR A 954
 None
 1.25A 4qwuH-1efyA:
undetectable
4qwuN-1efyA:
undetectable		 4qwuH-1efyA:
20.66
4qwuN-1efyA:
21.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RV6_A_RPBA1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		 1efy POLY (ADP-RIBOSE)
POLYMERASE
(Gallus
gallus) 		5 / 11 GLN A 763
TYR A 896
ALA A 898
LYS A 903
GLU A 988
 BZC  A 201 (-3.8A)
BZC  A 201 (-4.0A)
BZC  A 201 ( 3.9A)
BZC  A 201 ( 4.8A)
BZC  A 201 (-4.0A)
 0.92A 4rv6A-1efyA:
52.2		 4rv6A-1efyA:
86.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RV6_A_RPBA1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		 1efy POLY (ADP-RIBOSE)
POLYMERASE
(Gallus
gallus) 		9 / 11 HIS A 862
GLY A 863
TYR A 889
TYR A 896
ALA A 898
LYS A 903
SER A 904
TYR A 907
GLU A 988
 BZC  A 201 (-4.0A)
BZC  A 201 (-3.9A)
None
BZC  A 201 (-4.0A)
BZC  A 201 ( 3.9A)
BZC  A 201 ( 4.8A)
BZC  A 201 (-3.3A)
BZC  A 201 (-3.6A)
BZC  A 201 (-4.0A)
 0.50A 4rv6A-1efyA:
52.2		 4rv6A-1efyA:
86.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RV6_B_RPBB1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		 1efy POLY (ADP-RIBOSE)
POLYMERASE
(Gallus
gallus) 		5 / 11 GLN A 763
TYR A 896
ALA A 898
LYS A 903
GLU A 988
 BZC  A 201 (-3.8A)
BZC  A 201 (-4.0A)
BZC  A 201 ( 3.9A)
BZC  A 201 ( 4.8A)
BZC  A 201 (-4.0A)
 0.93A 4rv6B-1efyA:
52.4		 4rv6B-1efyA:
86.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RV6_B_RPBB1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		 1efy POLY (ADP-RIBOSE)
POLYMERASE
(Gallus
gallus) 		9 / 11 HIS A 862
GLY A 863
TYR A 889
TYR A 896
ALA A 898
LYS A 903
SER A 904
TYR A 907
GLU A 988
 BZC  A 201 (-4.0A)
BZC  A 201 (-3.9A)
None
BZC  A 201 (-4.0A)
BZC  A 201 ( 3.9A)
BZC  A 201 ( 4.8A)
BZC  A 201 (-3.3A)
BZC  A 201 (-3.6A)
BZC  A 201 (-4.0A)
 0.49A 4rv6B-1efyA:
52.4		 4rv6B-1efyA:
86.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1efy POLY (ADP-RIBOSE)
POLYMERASE
(Gallus
gallus) 		5 / 11 THR A 959
THR A 961
GLY A 974
ALA A 955
THR A 954
 None
 1.21A 5bxnV-1efyA:
undetectable
5bxnb-1efyA:
undetectable		 5bxnV-1efyA:
20.66
5bxnb-1efyA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1efy POLY (ADP-RIBOSE)
POLYMERASE
(Gallus
gallus) 		5 / 11 THR A 959
THR A 961
GLY A 974
ALA A 955
THR A 954
 None
 1.21A 5bxnH-1efyA:
undetectable
5bxnN-1efyA:
undetectable		 5bxnH-1efyA:
20.66
5bxnN-1efyA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZ7_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1efy POLY (ADP-RIBOSE)
POLYMERASE
(Gallus
gallus) 		5 / 11 THR A 959
THR A 961
GLY A 974
ALA A 955
THR A 954
 None
 1.23A 5cz7H-1efyA:
undetectable
5cz7N-1efyA:
undetectable		 5cz7H-1efyA:
20.66
5cz7N-1efyA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1efy POLY (ADP-RIBOSE)
POLYMERASE
(Gallus
gallus) 		5 / 11 THR A 959
THR A 961
GLY A 974
ALA A 955
THR A 954
 None
 1.21A 5d0xV-1efyA:
undetectable
5d0xb-1efyA:
undetectable		 5d0xV-1efyA:
20.66
5d0xb-1efyA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1efy POLY (ADP-RIBOSE)
POLYMERASE
(Gallus
gallus) 		5 / 11 THR A 959
THR A 961
GLY A 974
ALA A 955
THR A 954
 None
 1.21A 5d0xH-1efyA:
undetectable
5d0xN-1efyA:
undetectable		 5d0xH-1efyA:
20.66
5d0xN-1efyA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_W_BEZW801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1efy POLY (ADP-RIBOSE)
POLYMERASE
(Gallus
gallus) 		4 / 5 PHE A 897
GLY A 922
ILE A 895
LEU A 920
 None
 0.85A 5dzkB-1efyA:
undetectable
5dzkI-1efyA:
undetectable
5dzkW-1efyA:
undetectable		 5dzkB-1efyA:
21.43
5dzkI-1efyA:
18.97
5dzkW-1efyA:
2.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HA9_B_TP0B406_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		 1efy POLY (ADP-RIBOSE)
POLYMERASE
(Gallus
gallus) 		8 / 9 ASP A 770
HIS A 862
SER A 864
ASN A 868
ILE A 872
TYR A 896
SER A 904
TYR A 907
 None
BZC  A 201 (-4.0A)
None
None
None
BZC  A 201 (-4.0A)
BZC  A 201 (-3.3A)
BZC  A 201 (-3.6A)
 0.55A 5ha9B-1efyA:
50.7		 5ha9B-1efyA:
86.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1efy POLY (ADP-RIBOSE)
POLYMERASE
(Gallus
gallus) 		5 / 12 THR A 959
THR A 961
GLY A 974
ALA A 955
THR A 954
 None
 1.23A 5l5zV-1efyA:
undetectable
5l5zb-1efyA:
undetectable		 5l5zV-1efyA:
20.66
5l5zb-1efyA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1efy POLY (ADP-RIBOSE)
POLYMERASE
(Gallus
gallus) 		5 / 12 THR A 959
THR A 961
GLY A 974
ALA A 955
THR A 954
 None
 1.23A 5l5zH-1efyA:
undetectable
5l5zN-1efyA:
undetectable		 5l5zH-1efyA:
20.66
5l5zN-1efyA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1efy POLY (ADP-RIBOSE)
POLYMERASE
(Gallus
gallus) 		5 / 11 THR A 959
THR A 961
GLY A 974
ALA A 955
THR A 954
 None
 1.23A 5l66V-1efyA:
undetectable
5l66b-1efyA:
undetectable		 5l66V-1efyA:
20.66
5l66b-1efyA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1efy POLY (ADP-RIBOSE)
POLYMERASE
(Gallus
gallus) 		5 / 11 THR A 959
THR A 961
GLY A 974
ALA A 955
THR A 954
 None
 1.23A 5l66H-1efyA:
undetectable
5l66N-1efyA:
undetectable		 5l66H-1efyA:
20.66
5l66N-1efyA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_B_ADNB502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 1efy POLY (ADP-RIBOSE)
POLYMERASE
(Gallus
gallus) 		4 / 4 GLU A 968
THR A 962
THR A 821
LEU A 921
 None
 1.44A 5v96B-1efyA:
undetectable		 5v96B-1efyA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_C_ADNC502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 1efy POLY (ADP-RIBOSE)
POLYMERASE
(Gallus
gallus) 		4 / 4 GLU A 968
THR A 962
THR A 821
LEU A 921
 None
 1.45A 5v96C-1efyA:
undetectable		 5v96C-1efyA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_D_ADND502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 1efy POLY (ADP-RIBOSE)
POLYMERASE
(Gallus
gallus) 		4 / 4 GLU A 968
THR A 962
THR A 821
LEU A 921
 None
 1.44A 5v96D-1efyA:
undetectable		 5v96D-1efyA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B94_A_W9TA201_0
(GALECTIN-1)		 1efy POLY (ADP-RIBOSE)
POLYMERASE
(Gallus
gallus) 		4 / 8 ASN A 767
ARG A 865
HIS A 909
GLU A 688
 None
 0.96A 6b94A-1efyA:
undetectable		 6b94A-1efyA:
9.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_1
(TYROSINE-PROTEIN
KINASE ABL1)		 1efy POLY (ADP-RIBOSE)
POLYMERASE
(Gallus
gallus) 		4 / 6 LEU A 797
VAL A 833
PHE A 677
GLY A 871
 None
 0.99A 6hd4B-1efyA:
undetectable		 6hd4B-1efyA:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_B_BO2B201_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-2)		 1efy POLY (ADP-RIBOSE)
POLYMERASE
(Gallus
gallus) 		5 / 12 THR A 959
THR A 961
GLY A 974
ALA A 955
THR A 954
 None
 1.26A 6hwdV-1efyA:
undetectable
6hwdb-1efyA:
undetectable		 6hwdV-1efyA:
12.43
6hwdb-1efyA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_N_BO2N201_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-2)		 1efy POLY (ADP-RIBOSE)
POLYMERASE
(Gallus
gallus) 		5 / 12 THR A 959
THR A 961
GLY A 974
ALA A 955
THR A 954
 None
 1.25A 6hwdH-1efyA:
undetectable
6hwdN-1efyA:
undetectable		 6hwdH-1efyA:
12.43
6hwdN-1efyA:
13.65