SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1eg3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GWR_A_ESTA600_1
(OESTROGEN RECEPTOR)		 1eg3 DYSTROPHIN
(Homo
sapiens) 		5 / 10 LEU A 148
LEU A 179
LEU A  53
ARG A  63
HIS A 136
 None
 1.19A 1gwrA-1eg3A:
0.0		 1gwrA-1eg3A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1eg3 DYSTROPHIN
(Homo
sapiens) 		3 / 3 THR A 108
LEU A 112
LEU A 119
 None
 0.63A 1mz9C-1eg3A:
undetectable		 1mz9C-1eg3A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PCG_A_ESTA1_1
(ESTROGEN RECEPTOR)		 1eg3 DYSTROPHIN
(Homo
sapiens) 		5 / 10 LEU A 148
LEU A 179
LEU A  53
ARG A  63
HIS A 136
 None
 1.18A 1pcgA-1eg3A:
undetectable		 1pcgA-1eg3A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PCG_B_ESTB2_1
(ESTROGEN RECEPTOR)		 1eg3 DYSTROPHIN
(Homo
sapiens) 		5 / 10 LEU A 148
LEU A 179
LEU A  53
ARG A  63
HIS A 136
 None
 1.20A 1pcgB-1eg3A:
undetectable		 1pcgB-1eg3A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKT_A_ESTA600_1
(ESTRADIOL RECEPTOR)		 1eg3 DYSTROPHIN
(Homo
sapiens) 		5 / 10 LEU A 148
LEU A 179
LEU A  53
ARG A  63
HIS A 136
 None
 1.28A 1qktA-1eg3A:
undetectable		 1qktA-1eg3A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGY_A_BRLA503_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 1eg3 DYSTROPHIN
(Homo
sapiens) 		5 / 12 GLY A 202
TYR A 158
LEU A 154
LEU A 133
LEU A 115
 None
 1.42A 1zgyA-1eg3A:
undetectable		 1zgyA-1eg3A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_2
(POL POLYPROTEIN)		 1eg3 DYSTROPHIN
(Homo
sapiens) 		3 / 3 ASP A 187
ILE A  65
VAL A 175
 None
 0.66A 2avvD-1eg3A:
undetectable		 2avvD-1eg3A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1eg3 DYSTROPHIN
(Homo
sapiens) 		5 / 9 GLN A  50
ALA A  64
SER A  66
LEU A 183
ILE A 147
 None
 1.42A 3claA-1eg3A:
0.0		 3claA-1eg3A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ERD_A_DESA600_1
(ESTROGEN RECEPTOR
ALPHA)		 1eg3 DYSTROPHIN
(Homo
sapiens) 		5 / 12 LEU A 148
LEU A 179
LEU A  53
ARG A  63
HIS A 136
 None
 1.17A 3erdA-1eg3A:
undetectable		 3erdA-1eg3A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLS_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 1eg3 DYSTROPHIN
(Homo
sapiens) 		5 / 12 LEU A 148
LEU A 179
LEU A  53
ARG A  63
HIS A 136
 None
 1.21A 3olsB-1eg3A:
undetectable		 3olsB-1eg3A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_B_RITB401_2
(SECRETED ASPARTIC
PROTEASE)		 1eg3 DYSTROPHIN
(Homo
sapiens) 		4 / 7 SER A 205
VAL A 185
ILE A 244
TYR A 158
 None
 1.03A 3tneB-1eg3A:
undetectable		 3tneB-1eg3A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UUD_A_ESTA600_1
(ESTROGEN RECEPTOR)		 1eg3 DYSTROPHIN
(Homo
sapiens) 		5 / 11 LEU A 148
LEU A 179
LEU A  53
ARG A  63
HIS A 136
 None
 1.17A 3uudA-1eg3A:
0.0		 3uudA-1eg3A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAR_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 1eg3 DYSTROPHIN
(Homo
sapiens) 		4 / 7 ILE A 151
THR A 155
VAL A  70
ASP A  84
 None
 1.10A 4iarA-1eg3A:
undetectable		 4iarA-1eg3A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 1eg3 DYSTROPHIN
(Homo
sapiens) 		4 / 7 ASP A 176
LEU A 154
GLN A 149
LEU A 148
 None
 1.10A 4ib4A-1eg3A:
undetectable		 4ib4A-1eg3A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 1eg3 DYSTROPHIN
(Homo
sapiens) 		4 / 7 ASP A 176
THR A  55
GLN A 149
LEU A 148
 None
 0.95A 4ib4A-1eg3A:
undetectable		 4ib4A-1eg3A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXE_A_ESTA1000_1
(ESTROGEN RECEPTOR)		 1eg3 DYSTROPHIN
(Homo
sapiens) 		4 / 8 LEU A 148
LEU A 179
ARG A  63
HIS A 136
 None
 1.01A 5dxeA-1eg3A:
undetectable		 5dxeA-1eg3A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXE_B_ESTB1000_1
(ESTROGEN RECEPTOR)		 1eg3 DYSTROPHIN
(Homo
sapiens) 		5 / 10 LEU A 148
LEU A 179
LEU A  53
ARG A  63
HIS A 136
 None
 1.20A 5dxeB-1eg3A:
0.0		 5dxeB-1eg3A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXG_A_ESTA1000_1
(ESTROGEN RECEPTOR)		 1eg3 DYSTROPHIN
(Homo
sapiens) 		5 / 9 LEU A 148
LEU A 179
LEU A  53
ARG A  63
HIS A 136
 None
 1.19A 5dxgA-1eg3A:
0.0		 5dxgA-1eg3A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 1eg3 DYSTROPHIN
(Homo
sapiens) 		3 / 3 ASP A 146
LEU A  53
ARG A  63
 None
 0.96A 5e8qA-1eg3A:
undetectable		 5e8qA-1eg3A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_C_ACTC1740_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGS
FAD-BINDING SUBUNIT)		 1eg3 DYSTROPHIN
(Homo
sapiens) 		4 / 4 VAL A 263
GLU A 260
GLY A 235
LEU A 238
 None
 1.26A 5g5gC-1eg3A:
0.0		 5g5gC-1eg3A:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HYR_A_ESTA601_1
(ESTROGEN RECEPTOR)		 1eg3 DYSTROPHIN
(Homo
sapiens) 		5 / 10 LEU A 148
LEU A 179
LEU A  53
ARG A  63
HIS A 136
 None
 1.15A 5hyrA-1eg3A:
0.0		 5hyrA-1eg3A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBZ_A_ESTA601_1
(ESTROGEN RECEPTOR)		 1eg3 DYSTROPHIN
(Homo
sapiens) 		4 / 8 LEU A 148
LEU A 179
ARG A  63
HIS A 136
 None
 1.01A 6cbzA-1eg3A:
undetectable		 6cbzA-1eg3A:
19.31