SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1eg7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3004_1
(SERUM ALBUMIN)		 1eg7 FORMYLTETRAHYDROFOLA
TE SYNTHETASE
(Moorella
thermoacetica) 		4 / 6 GLU A1034
LEU A1035
VAL A1019
MET A1020
 None
 1.04A 1hk1A-1eg7A:
0.6		 1hk1A-1eg7A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC1200_1
(PROTEIN (METHIONINE
REPRESSOR))		 1eg7 FORMYLTETRAHYDROFOLA
TE SYNTHETASE
(Moorella
thermoacetica) 		4 / 4 HIS A1280
ALA A1279
PHE A1275
GLY A1281
 None
 1.37A 1mj2D-1eg7A:
undetectable		 1mj2D-1eg7A:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_0
(METHIONINE REPRESSOR)		 1eg7 FORMYLTETRAHYDROFOLA
TE SYNTHETASE
(Moorella
thermoacetica) 		4 / 4 HIS A1280
ALA A1279
PHE A1275
GLY A1281
 None
 1.42A 1mjoA-1eg7A:
undetectable		 1mjoA-1eg7A:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_1
(METHIONINE REPRESSOR)		 1eg7 FORMYLTETRAHYDROFOLA
TE SYNTHETASE
(Moorella
thermoacetica) 		4 / 4 HIS A1280
ALA A1279
PHE A1275
GLY A1281
 None
 1.40A 1mjoD-1eg7A:
undetectable		 1mjoD-1eg7A:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_D_THAD4_1
(LIVER
CARBOXYLESTERASE I)		 1eg7 FORMYLTETRAHYDROFOLA
TE SYNTHETASE
(Moorella
thermoacetica) 		5 / 12 GLY A1521
GLY A1522
VAL A1316
LEU A1485
ILE A1525
 None
 0.94A 1mx1D-1eg7A:
undetectable		 1mx1D-1eg7A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RTS_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 1eg7 FORMYLTETRAHYDROFOLA
TE SYNTHETASE
(Moorella
thermoacetica) 		4 / 7 ILE A1060
ASP A1056
LEU A1292
GLY A1057
 None
 0.87A 1rtsB-1eg7A:
0.0		 1rtsB-1eg7A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_B_GBNB501_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 1eg7 FORMYLTETRAHYDROFOLA
TE SYNTHETASE
(Moorella
thermoacetica) 		5 / 8 TYR A1466
VAL A1513
GLY A1460
THR A1456
ALA A1455
 None
 1.49A 2a1hA-1eg7A:
0.0
2a1hB-1eg7A:
0.0		 2a1hA-1eg7A:
20.35
2a1hB-1eg7A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_A_D16A566_1
(THYMIDYLATE SYNTHASE)		 1eg7 FORMYLTETRAHYDROFOLA
TE SYNTHETASE
(Moorella
thermoacetica) 		5 / 12 LEU A1218
ASP A1132
GLY A1272
VAL A1136
ALA A1135
 None
 1.33A 2kceA-1eg7A:
0.0		 2kceA-1eg7A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_C_SAMC300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 1eg7 FORMYLTETRAHYDROFOLA
TE SYNTHETASE
(Moorella
thermoacetica) 		5 / 12 GLY A1305
GLY A1309
GLY A1281
GLU A1311
HIS A1340
 None
 0.94A 2oxtC-1eg7A:
3.0		 2oxtC-1eg7A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBU_D_ADND504_1
(UNCHARACTERIZED
CONSERVED PROTEIN)		 1eg7 FORMYLTETRAHYDROFOLA
TE SYNTHETASE
(Moorella
thermoacetica) 		3 / 3 PHE A1275
ASN A1277
PHE A1304
 None
None
SO4  A   1 (-4.8A)
 1.04A 2zbuD-1eg7A:
2.4		 2zbuD-1eg7A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_B_CHDB1085_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 1eg7 FORMYLTETRAHYDROFOLA
TE SYNTHETASE
(Moorella
thermoacetica) 		5 / 12 GLY A1415
GLU A1264
THR A1266
THR A1082
GLY A1113
 None
 1.48A 3ag4A-1eg7A:
0.0
3ag4B-1eg7A:
0.0
3ag4T-1eg7A:
0.0		 3ag4A-1eg7A:
23.31
3ag4B-1eg7A:
17.74
3ag4T-1eg7A:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APW_A_DP0A190_2
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 1eg7 FORMYLTETRAHYDROFOLA
TE SYNTHETASE
(Moorella
thermoacetica) 		4 / 4 VAL A1201
ARG A1097
HIS A1280
PHE A1275
 None
SO4  A   1 (-2.9A)
None
None
 1.35A 3apwA-1eg7A:
0.0		 3apwA-1eg7A:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA607_1
(CHITINASE A)		 1eg7 FORMYLTETRAHYDROFOLA
TE SYNTHETASE
(Moorella
thermoacetica) 		5 / 8 VAL A1092
GLY A1080
THR A1082
GLY A1419
ALA A1084
 None
 1.32A 3aruA-1eg7A:
1.9		 3aruA-1eg7A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6R_B_CRNB603_1
(CREATINE KINASE
B-TYPE)		 1eg7 FORMYLTETRAHYDROFOLA
TE SYNTHETASE
(Moorella
thermoacetica) 		4 / 6 THR A1300
VAL A1299
LEU A1061
SER A1078
 None
 1.23A 3b6rB-1eg7A:
0.0		 3b6rB-1eg7A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_A_VD3A701_1
(CYTOCHROME P450 2R1)		 1eg7 FORMYLTETRAHYDROFOLA
TE SYNTHETASE
(Moorella
thermoacetica) 		5 / 12 LEU A1088
ALA A1084
GLY A1403
ILE A1060
THR A1077
 None
 1.07A 3c6gA-1eg7A:
0.0		 3c6gA-1eg7A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_B_V2HB602_0
(CYTOCHROME P450 2R1)		 1eg7 FORMYLTETRAHYDROFOLA
TE SYNTHETASE
(Moorella
thermoacetica) 		5 / 12 VAL A1378
ALA A1377
ALA A1332
ILE A1060
THR A1429
 None
 1.28A 3dl9B-1eg7A:
0.0		 3dl9B-1eg7A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN8_A_DEXA247_2
(GLUCOCORTICOID
RECEPTOR 2)		 1eg7 FORMYLTETRAHYDROFOLA
TE SYNTHETASE
(Moorella
thermoacetica) 		3 / 3 MET A1535
MET A1206
PHE A1197
 None
 1.36A 3gn8A-1eg7A:
0.0		 3gn8A-1eg7A:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1eg7 FORMYLTETRAHYDROFOLA
TE SYNTHETASE
(Moorella
thermoacetica) 		5 / 12 SER A1078
LEU A1096
ALA A1380
GLY A1415
ALA A1117
 None
 1.09A 3ln1D-1eg7A:
0.0		 3ln1D-1eg7A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGL_A_GLYA301_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 1eg7 FORMYLTETRAHYDROFOLA
TE SYNTHETASE
(Moorella
thermoacetica) 		4 / 8 ALA A1070
GLY A1071
THR A1068
THR A1333
 None
 0.93A 3rglA-1eg7A:
undetectable		 3rglA-1eg7A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1eg7 FORMYLTETRAHYDROFOLA
TE SYNTHETASE
(Moorella
thermoacetica) 		5 / 12 HIS A1280
GLY A1281
ILE A1286
GLY A1272
ALA A1212
 None
 1.07A 3sueA-1eg7A:
undetectable		 3sueA-1eg7A:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1eg7 FORMYLTETRAHYDROFOLA
TE SYNTHETASE
(Moorella
thermoacetica) 		5 / 12 HIS A1280
GLY A1281
ILE A1286
GLY A1272
ALA A1212
 None
 1.01A 3sufB-1eg7A:
undetectable		 3sufB-1eg7A:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_A_AZMA229_1
(CARBONIC ANHYDRASE)		 1eg7 FORMYLTETRAHYDROFOLA
TE SYNTHETASE
(Moorella
thermoacetica) 		5 / 10 ASP A1056
VAL A1298
ALA A1291
ALA A1287
THR A1300
 None
 1.15A 3ucjA-1eg7A:
3.9		 3ucjA-1eg7A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_B_AZMB229_2
(CARBONIC ANHYDRASE)		 1eg7 FORMYLTETRAHYDROFOLA
TE SYNTHETASE
(Moorella
thermoacetica) 		5 / 10 ASP A1056
VAL A1298
ALA A1291
ALA A1287
THR A1300
 None
 1.15A 3ucjB-1eg7A:
4.2		 3ucjB-1eg7A:
19.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IOM_A_FOLA608_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 1eg7 FORMYLTETRAHYDROFOLA
TE SYNTHETASE
(Moorella
thermoacetica) 		6 / 7 ALA A1383
PRO A1385
GLU A1389
LEU A1392
TYR A1396
TRP A1412
 None
None
None
None
None
SO4  A   7 (-3.2A)
 0.28A 4iomA-1eg7A:
62.7		 4iomA-1eg7A:
98.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 1eg7 FORMYLTETRAHYDROFOLA
TE SYNTHETASE
(Moorella
thermoacetica) 		4 / 7 ILE A1060
ASP A1056
LEU A1292
GLY A1057
 None
 0.91A 4iqqA-1eg7A:
0.0		 4iqqA-1eg7A:
20.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JJK_A_FOLA601_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 1eg7 FORMYLTETRAHYDROFOLA
TE SYNTHETASE
(Moorella
thermoacetica) 		7 / 8 ASN A1382
ALA A1383
PRO A1385
GLU A1389
LEU A1392
TYR A1396
TRP A1412
 SO4  A   7 (-3.0A)
None
None
None
None
None
SO4  A   7 (-3.2A)
 0.43A 4jjkA-1eg7A:
62.5		 4jjkA-1eg7A:
98.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 1eg7 FORMYLTETRAHYDROFOLA
TE SYNTHETASE
(Moorella
thermoacetica) 		5 / 10 GLY A1080
THR A1077
VAL A1329
ILE A1060
VAL A1062
 None
 1.19A 4jx1B-1eg7A:
0.0		 4jx1B-1eg7A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKT_A_198A1001_1
(ANDROGEN RECEPTOR)		 1eg7 FORMYLTETRAHYDROFOLA
TE SYNTHETASE
(Moorella
thermoacetica) 		5 / 12 LEU A1524
LEU A1485
GLY A1522
VAL A1226
ILE A1278
 None
 1.35A 4oktA-1eg7A:
undetectable		 4oktA-1eg7A:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B6I_A_ADNA302_1
(FLUORINASE)		 1eg7 FORMYLTETRAHYDROFOLA
TE SYNTHETASE
(Moorella
thermoacetica) 		4 / 7 ASP A1240
THR A1237
PRO A1235
THR A1230
 None
 1.29A 5b6iA-1eg7A:
undetectable		 5b6iA-1eg7A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_S_BEZS801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1eg7 FORMYLTETRAHYDROFOLA
TE SYNTHETASE
(Moorella
thermoacetica) 		4 / 6 SER A1284
HIS A1271
MET A1206
LEU A1218
 None
 1.05A 5dzke-1eg7A:
0.7
5dzks-1eg7A:
undetectable		 5dzke-1eg7A:
17.57
5dzks-1eg7A:
1.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_1
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 1eg7 FORMYLTETRAHYDROFOLA
TE SYNTHETASE
(Moorella
thermoacetica) 		6 / 12 GLY A1106
ARG A1097
GLY A1273
VAL A1201
GLY A1110
GLY A1109
 None
SO4  A   1 (-2.9A)
None
None
None
None
 1.03A 5koxA-1eg7A:
undetectable		 5koxA-1eg7A:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_A_BZMA301_0
(ISATIN HYDROLASE A)		 1eg7 FORMYLTETRAHYDROFOLA
TE SYNTHETASE
(Moorella
thermoacetica) 		5 / 12 ILE A1028
LEU A1294
PRO A1257
VAL A1033
ASP A1046
 None
None
None
None
SO4  A   4 (-3.9A)
 1.21A 5nnaA-1eg7A:
undetectable		 5nnaA-1eg7A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_B_BZMB301_0
(ISATIN HYDROLASE A)		 1eg7 FORMYLTETRAHYDROFOLA
TE SYNTHETASE
(Moorella
thermoacetica) 		5 / 12 ILE A1028
LEU A1294
PRO A1257
VAL A1033
ASP A1046
 None
None
None
None
SO4  A   4 (-3.9A)
 1.21A 5nnaB-1eg7A:
0.0		 5nnaB-1eg7A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_C_BZMC301_0
(ISATIN HYDROLASE A)		 1eg7 FORMYLTETRAHYDROFOLA
TE SYNTHETASE
(Moorella
thermoacetica) 		5 / 12 ILE A1028
LEU A1294
PRO A1257
VAL A1033
ASP A1046
 None
None
None
None
SO4  A   4 (-3.9A)
 1.18A 5nnaC-1eg7A:
undetectable		 5nnaC-1eg7A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_D_BZMD301_0
(ISATIN HYDROLASE A)		 1eg7 FORMYLTETRAHYDROFOLA
TE SYNTHETASE
(Moorella
thermoacetica) 		5 / 12 ILE A1028
LEU A1294
PRO A1257
VAL A1033
ASP A1046
 None
None
None
None
SO4  A   4 (-3.9A)
 1.23A 5nnaD-1eg7A:
undetectable		 5nnaD-1eg7A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 1eg7 FORMYLTETRAHYDROFOLA
TE SYNTHETASE
(Moorella
thermoacetica) 		4 / 8 ILE A1060
ASP A1056
LEU A1292
GLY A1057
 None
 0.89A 5nooD-1eg7A:
undetectable		 5nooD-1eg7A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM2_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 1eg7 FORMYLTETRAHYDROFOLA
TE SYNTHETASE
(Moorella
thermoacetica) 		5 / 9 VAL A1426
LEU A1085
ALA A1084
VAL A1299
ILE A1060
 None
 1.20A 5om2A-1eg7A:
undetectable
5om2B-1eg7A:
undetectable		 5om2A-1eg7A:
9.21
5om2B-1eg7A:
6.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_E_D16E402_1
(THYMIDYLATE SYNTHASE)		 1eg7 FORMYLTETRAHYDROFOLA
TE SYNTHETASE
(Moorella
thermoacetica) 		4 / 6 ILE A1060
ASP A1056
LEU A1292
GLY A1057
 None
 0.96A 5x5qE-1eg7A:
0.0		 5x5qE-1eg7A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FOS_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 1eg7 FORMYLTETRAHYDROFOLA
TE SYNTHETASE
(Moorella
thermoacetica) 		4 / 6 MET A1146
ALA A1248
LEU A1250
ALA A1139
 None
 1.23A 6fosB-1eg7A:
undetectable		 6fosB-1eg7A:
8.80