SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1egj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FIQ_C_SALC1335_1
(XANTHINE OXIDASE)		 1egj CYTOKINE RECEPTOR
COMMON BETA CHAIN
PRECURSOR
(Homo
sapiens) 		4 / 8 LEU A 402
VAL A 347
LEU A 356
ALA A 398
 None
 0.90A 1fiqC-1egjA:
0.0		 1fiqC-1egjA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BVA_B_T3B1314_1
(THIOMORPHOLINE-CARBO
XYLATE DEHYDROGENASE)		 1egj CYTOKINE RECEPTOR
COMMON BETA CHAIN
PRECURSOR
(Homo
sapiens) 		5 / 12 ARG A 432
SER A 429
ARG A 411
TRP A 428
GLU A 430
 None
 1.45A 4bvaB-1egjA:
undetectable		 4bvaB-1egjA:
13.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M7K_H_ACTH302_0
(10H10 HEAVY CHAIN)		 1egj ANTIBODY (HEAVY
CHAIN)
(Mus
musculus) 		4 / 5 VAL H   2
TYR H  27
ARG H  94
TYR H 102
 None
 0.34A 4m7kH-1egjH:
27.7		 4m7kH-1egjH:
66.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UGL_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE)		 1egj CYTOKINE RECEPTOR
COMMON BETA CHAIN
PRECURSOR
(Homo
sapiens) 		3 / 3 ARG A 357
THR A 360
TRP A 358
 None
 1.11A 4uglA-1egjA:
undetectable		 4uglA-1egjA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 1egj CYTOKINE RECEPTOR
COMMON BETA CHAIN
PRECURSOR
(Homo
sapiens) 		4 / 5 TYR A 354
PRO A 400
LEU A 356
TYR A 376
 None
 1.42A 4w5qA-1egjA:
undetectable		 4w5qA-1egjA:
8.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 1egj CYTOKINE RECEPTOR
COMMON BETA CHAIN
PRECURSOR
(Homo
sapiens) 		4 / 6 TYR A 354
PRO A 400
LEU A 356
TYR A 376
 None
 1.42A 4z4cA-1egjA:
undetectable		 4z4cA-1egjA:
8.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA902_1
(MRNA CAPPING ENZYME
P5)		 1egj CYTOKINE RECEPTOR
COMMON BETA CHAIN
PRECURSOR
(Homo
sapiens) 		3 / 3 TYR A 354
ASP A 350
ASP A 352
 None
 0.73A 5x6yA-1egjA:
undetectable		 5x6yA-1egjA:
8.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA606_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 1egj ANTIBODY (HEAVY
CHAIN)
(Mus
musculus) 		4 / 5 GLU H 148
PHE H 146
HIS H 210
THR H 110
 None
 1.15A 6b58A-1egjH:
0.0		 6b58A-1egjH:
16.29