SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1egz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DG5_A_TOPA201_1
(DIHYDROFOLATE
REDUCTASE)		 1egz ENDOGLUCANASE Z
(Dickeya
chrysanthemi) 		5 / 11 ILE A 163
ALA A 147
ILE A 143
SER A 171
ILE A 164
 None
 1.17A 1dg5A-1egzA:
undetectable		 1dg5A-1egzA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MOG_A_RBFA200_1
(DODECIN)		 1egz ENDOGLUCANASE Z
(Dickeya
chrysanthemi) 		3 / 3 PHE A  27
TRP A 254
GLU A 220
 None
 1.18A 1mogA-1egzA:
0.0		 1mogA-1egzA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MOG_A_RBFA200_1
(DODECIN)		 1egz ENDOGLUCANASE Z
(Dickeya
chrysanthemi) 		3 / 3 PHE A 243
TRP A 240
GLU A 236
 None
 1.09A 1mogA-1egzA:
0.0		 1mogA-1egzA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_C_REAC503_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1egz ENDOGLUCANASE Z
(Dickeya
chrysanthemi) 		5 / 10 ALA A 117
GLN A 114
PHE A 113
ALA A 153
ILE A  94
 None
 1.18A 2aclC-1egzA:
undetectable		 2aclC-1egzA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_A_ACTA653_0
(ACETYL-COENZYME A
SYNTHETASE)		 1egz ENDOGLUCANASE Z
(Dickeya
chrysanthemi) 		4 / 5 VAL A 224
THR A 223
VAL A 280
GLY A 277
 None
 1.01A 2p2fA-1egzA:
undetectable		 2p2fA-1egzA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_B_ACTB653_0
(ACETYL-COENZYME A
SYNTHETASE)		 1egz ENDOGLUCANASE Z
(Dickeya
chrysanthemi) 		4 / 4 VAL A 224
THR A 223
VAL A 280
GLY A 277
 None
 0.99A 2p2fB-1egzA:
undetectable		 2p2fB-1egzA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q83_A_ADNA1_1
(YTAA PROTEIN)		 1egz ENDOGLUCANASE Z
(Dickeya
chrysanthemi) 		4 / 7 ILE A 214
ILE A 163
LEU A 162
ILE A 164
 None
 0.84A 2q83A-1egzA:
undetectable		 2q83A-1egzA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_A_NBVA1503_1
(GLUCOSYLCERAMIDASE)		 1egz ENDOGLUCANASE Z
(Dickeya
chrysanthemi) 		5 / 12 ASN A 132
GLU A 133
HIS A 192
GLU A 220
TRP A 254
 None
 0.50A 2v3dA-1egzA:
17.3		 2v3dA-1egzA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZ0_B_CLYB900_1
(LINCOSAMIDE
NUCLEOTIDYLTRANSFERA
SE)		 1egz ENDOGLUCANASE Z
(Dickeya
chrysanthemi) 		4 / 8 GLU A   3
TYR A  13
SER A 250
ILE A  55
 None
 1.09A 3jz0B-1egzA:
undetectable		 3jz0B-1egzA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_0
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 1egz ENDOGLUCANASE Z
(Dickeya
chrysanthemi) 		5 / 12 HIS A 192
SER A 171
ILE A  94
LEU A 162
LEU A 216
 None
 1.10A 3lcvB-1egzA:
undetectable		 3lcvB-1egzA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LK0_D_Z80D92_1
(PROTEIN S100-B)		 1egz ENDOGLUCANASE Z
(Dickeya
chrysanthemi) 		3 / 3 HIS A  98
PHE A 112
PHE A 113
 None
 0.45A 3lk0D-1egzA:
undetectable		 3lk0D-1egzA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 1egz ENDOGLUCANASE Z
(Dickeya
chrysanthemi) 		3 / 3 ASP A 180
VAL A 174
ASN A 141
 None
 0.74A 4lmnA-1egzA:
0.0		 4lmnA-1egzA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_A_DAHA304_1
(TYROSINASE)		 1egz ENDOGLUCANASE Z
(Dickeya
chrysanthemi) 		4 / 5 ASN A 132
HIS A  98
GLU A 129
THR A 219
 None
 1.37A 4p6sA-1egzA:
0.1		 4p6sA-1egzA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_D_RBFD201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1egz ENDOGLUCANASE Z
(Dickeya
chrysanthemi) 		4 / 8 ILE A 130
LEU A 216
LEU A 162
ILE A  12
 None
 0.80A 4r38D-1egzA:
undetectable		 4r38D-1egzA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U95_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 1egz ENDOGLUCANASE Z
(Dickeya
chrysanthemi) 		6 / 12 SER A  25
GLY A 166
SER A 171
GLU A 133
ASN A 132
ALA A 147
 None
 1.49A 4u95B-1egzA:
0.8		 4u95B-1egzA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1egz ENDOGLUCANASE Z
(Dickeya
chrysanthemi) 		5 / 12 GLY A  23
VAL A 280
GLN A 285
ALA A 291
MET A  91
 None
 1.18A 5n0xB-1egzA:
undetectable		 5n0xB-1egzA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 1egz ENDOGLUCANASE Z
(Dickeya
chrysanthemi) 		4 / 7 PHE A 113
THR A 190
ILE A 130
GLY A 166
 None
 0.96A 5nzyA-1egzA:
1.4		 5nzyA-1egzA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_B_HFGB1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 1egz ENDOGLUCANASE Z
(Dickeya
chrysanthemi) 		3 / 3 THR A 219
GLU A 129
HIS A  98
 None
 0.87A 5xiqB-1egzA:
undetectable		 5xiqB-1egzA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 1egz ENDOGLUCANASE Z
(Dickeya
chrysanthemi) 		3 / 3 THR A 219
GLU A 129
HIS A  98
 None
 0.89A 5xiqD-1egzA:
undetectable		 5xiqD-1egzA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_D_AM2D301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 1egz ENDOGLUCANASE Z
(Dickeya
chrysanthemi) 		4 / 8 HIS A  98
HIS A 198
GLU A 220
GLU A 261
 None
 1.19A 6mn4D-1egzA:
0.3		 6mn4D-1egzA:
21.09