SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1eh5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_C_TFPC208_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1eh5 PALMITOYL PROTEIN
THIOESTERASE 1
(Bos
taurus) 		4 / 5 LEU A 269
PHE A 282
MET A 227
SER A 138
 None
 1.24A 1wrlC-1eh5A:
undetectable		 1wrlC-1eh5A:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_B_SAMB2002_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 1eh5 PALMITOYL PROTEIN
THIOESTERASE 1
(Bos
taurus) 		5 / 12 TYR A 185
PHE A 201
LEU A 202
ILE A 200
VAL A 181
 None
 1.28A 2g72B-1eh5A:
undetectable		 2g72B-1eh5A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA502_0
(CHORISMATE SYNTHASE)		 1eh5 PALMITOYL PROTEIN
THIOESTERASE 1
(Bos
taurus) 		3 / 3 GLY A  40
ASP A  43
SER A  83
 PLM  A 430 ( 3.8A)
None
None
 0.73A 2qhfA-1eh5A:
0.0		 2qhfA-1eh5A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 1eh5 PALMITOYL PROTEIN
THIOESTERASE 1
(Bos
taurus) 		5 / 10 PHE A 114
LEU A  99
VAL A 124
VAL A  95
LEU A  70
 None
 1.03A 3gwxA-1eh5A:
undetectable		 3gwxA-1eh5A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 1eh5 PALMITOYL PROTEIN
THIOESTERASE 1
(Bos
taurus) 		4 / 5 SER A 157
ASP A 237
ASP A 233
ILE A 235
 None
 1.07A 3uj7B-1eh5A:
2.1		 3uj7B-1eh5A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 1eh5 PALMITOYL PROTEIN
THIOESTERASE 1
(Bos
taurus) 		5 / 12 LEU A 202
HIS A 143
GLY A 245
HIS A 187
GLY A 141
 None
 1.03A 4blvA-1eh5A:
2.3		 4blvA-1eh5A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_B_SAMB1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 1eh5 PALMITOYL PROTEIN
THIOESTERASE 1
(Bos
taurus) 		5 / 12 HIS A 289
HIS A  39
GLY A 113
GLY A 140
LEU A  70
 None
 1.18A 4blvB-1eh5A:
1.3		 4blvB-1eh5A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_A_FOLA301_1
(FOLATE RECEPTOR
ALPHA)		 1eh5 PALMITOYL PROTEIN
THIOESTERASE 1
(Bos
taurus) 		3 / 3 ASP A 233
TRP A 186
SER A 115
 None
None
PLM  A 430 (-1.2A)
 0.85A 4lrhA-1eh5A:
0.0		 4lrhA-1eh5A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN)		 1eh5 PALMITOYL PROTEIN
THIOESTERASE 1
(Bos
taurus) 		5 / 12 SER A  50
ALA A 111
MET A 112
GLY A 113
PHE A 114
 None
 1.24A 4r29B-1eh5A:
undetectable		 4r29B-1eh5A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN)		 1eh5 PALMITOYL PROTEIN
THIOESTERASE 1
(Bos
taurus) 		5 / 12 SER A  50
ALA A 111
MET A 112
GLY A 113
PHE A 114
 None
 1.28A 4r29C-1eh5A:
undetectable		 4r29C-1eh5A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XYZ_A_ACTA103_0
(POLYUBIQUITIN-C)		 1eh5 PALMITOYL PROTEIN
THIOESTERASE 1
(Bos
taurus) 		4 / 4 LEU A 285
ILE A 301
HIS A 300
VAL A 228
 None
 0.84A 4xyzA-1eh5A:
undetectable		 4xyzA-1eh5A:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_0
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 1eh5 PALMITOYL PROTEIN
THIOESTERASE 1
(Bos
taurus) 		5 / 12 LEU A 136
GLY A 141
ASP A  43
SER A  50
VAL A  36
 None
 1.42A 5d0yA-1eh5A:
0.0		 5d0yA-1eh5A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_A_ACTA708_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 1eh5 PALMITOYL PROTEIN
THIOESTERASE 1
(Bos
taurus) 		3 / 3 GLY A 117
GLY A 118
GLN A 142
 None
None
PLM  A 430 (-3.8A)
 0.46A 5imsA-1eh5A:
2.7		 5imsA-1eh5A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 1eh5 PALMITOYL PROTEIN
THIOESTERASE 1
(Bos
taurus) 		4 / 7 THR A 234
PHE A 230
LEU A 290
SER A 138
 None
 1.30A 5uxcA-1eh5A:
undetectable		 5uxcA-1eh5A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCN_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1eh5 PALMITOYL PROTEIN
THIOESTERASE 1
(Bos
taurus) 		5 / 12 LEU A 292
GLY A 113
VAL A  58
ILE A  54
LEU A 222
 None
 0.89A 5ycnA-1eh5A:
undetectable		 5ycnA-1eh5A:
24.06