SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1eh6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOI_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1eh6 O6-ALKYLGUANINE-DNA
ALKYLTRANSFERASE
(Homo
sapiens) 		4 / 5 LEU A 142
PRO A 138
VAL A 139
ILE A 143
 None
 0.83A 2aoiB-1eh6A:
undetectable		 2aoiB-1eh6A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y05_A_RALA802_1
(PROSTAGLANDIN
REDUCTASE 1)		 1eh6 O6-ALKYLGUANINE-DNA
ALKYLTRANSFERASE
(Homo
sapiens) 		4 / 7 ARG A 128
ASN A 157
GLY A 156
VAL A 148
 None
 0.93A 2y05A-1eh6A:
undetectable
2y05B-1eh6A:
undetectable		 2y05A-1eh6A:
21.91
2y05B-1eh6A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 1eh6 O6-ALKYLGUANINE-DNA
ALKYLTRANSFERASE
(Homo
sapiens) 		4 / 6 LYS A  32
ASN A 137
PRO A 140
ARG A   9
 None
 1.41A 4yv5B-1eh6A:
undetectable		 4yv5B-1eh6A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 1eh6 O6-ALKYLGUANINE-DNA
ALKYLTRANSFERASE
(Homo
sapiens) 		4 / 6 LYS A  32
ASN A 137
PRO A 140
ARG A   9
 None
 1.34A 4yv5A-1eh6A:
undetectable		 4yv5A-1eh6A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_0
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 1eh6 O6-ALKYLGUANINE-DNA
ALKYLTRANSFERASE
(Homo
sapiens) 		5 / 12 ALA A 170
GLY A 173
LEU A 168
LEU A 181
GLY A 177
 None
 1.18A 5jglB-1eh6A:
undetectable		 5jglB-1eh6A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQB_B_IBPB706_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)		 1eh6 O6-ALKYLGUANINE-DNA
ALKYLTRANSFERASE
(Homo
sapiens) 		5 / 8 ALA A  64
LEU A  28
LEU A 142
LEU A  12
LEU A  21
 None
 1.38A 5jqbA-1eh6A:
undetectable
5jqbB-1eh6A:
0.0		 5jqbA-1eh6A:
19.23
5jqbB-1eh6A:
16.75