SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ehi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D8C_A_SORA4000_0
(MALATE SYNTHASE G)		 1ehi D-ALANINE:D-LACTATE
LIGASE
(Leuconostoc
mesenteroides) 		3 / 3 GLN A 112
HIS A 130
PRO A 126
 None
 0.98A 1d8cA-1ehiA:
undetectable		 1d8cA-1ehiA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XR2_B_C2FB1201_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 1ehi D-ALANINE:D-LACTATE
LIGASE
(Leuconostoc
mesenteroides) 		4 / 8 LYS A 180
THR A 244
SER A 187
GLU A 216
 ADP  A 781 (-2.6A)
None
ADP  A 781 (-3.5A)
ADP  A 781 (-3.7A)
 1.42A 1xr2B-1ehiA:
0.0		 1xr2B-1ehiA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_2
(POL POLYPROTEIN)		 1ehi D-ALANINE:D-LACTATE
LIGASE
(Leuconostoc
mesenteroides) 		3 / 3 ASP A  18
ILE A  68
VAL A  41
 None
 0.65A 2avvD-1ehiA:
undetectable		 2avvD-1ehiA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBM_A_CAMA517_0
(CYTOCHROME P450-CAM)		 1ehi D-ALANINE:D-LACTATE
LIGASE
(Leuconostoc
mesenteroides) 		4 / 8 PHE A  50
THR A 110
VAL A 101
ILE A   9
 None
 0.96A 2qbmA-1ehiA:
0.0		 2qbmA-1ehiA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_B_ACTB141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 1ehi D-ALANINE:D-LACTATE
LIGASE
(Leuconostoc
mesenteroides) 		3 / 3 PRO A 317
ASN A 318
ARG A 301
 None
MG  A 783 ( 3.3A)
PHY  A 782 (-3.0A)
 0.97A 2qeuB-1ehiA:
undetectable		 2qeuB-1ehiA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_B_TA1B502_1
(TUBULIN BETA CHAIN)		 1ehi D-ALANINE:D-LACTATE
LIGASE
(Leuconostoc
mesenteroides) 		5 / 10 VAL A  19
ASP A  18
LEU A 320
SER A 186
THR A 110
 None
None
None
PHY  A 782 ( 3.8A)
None
 1.14A 3j6gB-1ehiA:
undetectable		 3j6gB-1ehiA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_D_TA1D502_1
(TUBULIN BETA CHAIN)		 1ehi D-ALANINE:D-LACTATE
LIGASE
(Leuconostoc
mesenteroides) 		5 / 10 VAL A  19
ASP A  18
LEU A 320
SER A 186
THR A 110
 None
None
None
PHY  A 782 ( 3.8A)
None
 1.14A 3j6gD-1ehiA:
undetectable		 3j6gD-1ehiA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_F_TA1F502_1
(TUBULIN BETA CHAIN)		 1ehi D-ALANINE:D-LACTATE
LIGASE
(Leuconostoc
mesenteroides) 		5 / 10 VAL A  19
ASP A  18
LEU A 320
SER A 186
THR A 110
 None
None
None
PHY  A 782 ( 3.8A)
None
 1.14A 3j6gF-1ehiA:
undetectable		 3j6gF-1ehiA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_H_TA1H502_1
(TUBULIN BETA CHAIN)		 1ehi D-ALANINE:D-LACTATE
LIGASE
(Leuconostoc
mesenteroides) 		5 / 10 VAL A  19
ASP A  18
LEU A 320
SER A 186
THR A 110
 None
None
None
PHY  A 782 ( 3.8A)
None
 1.14A 3j6gH-1ehiA:
undetectable		 3j6gH-1ehiA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_J_TA1J502_1
(TUBULIN BETA CHAIN)		 1ehi D-ALANINE:D-LACTATE
LIGASE
(Leuconostoc
mesenteroides) 		5 / 10 VAL A  19
ASP A  18
LEU A 320
SER A 186
THR A 110
 None
None
None
PHY  A 782 ( 3.8A)
None
 1.14A 3j6gJ-1ehiA:
undetectable		 3j6gJ-1ehiA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_L_TA1L502_1
(TUBULIN BETA CHAIN)		 1ehi D-ALANINE:D-LACTATE
LIGASE
(Leuconostoc
mesenteroides) 		5 / 10 VAL A  19
ASP A  18
LEU A 320
SER A 186
THR A 110
 None
None
None
PHY  A 782 ( 3.8A)
None
 1.14A 3j6gL-1ehiA:
undetectable		 3j6gL-1ehiA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_N_TA1N502_1
(TUBULIN BETA CHAIN)		 1ehi D-ALANINE:D-LACTATE
LIGASE
(Leuconostoc
mesenteroides) 		5 / 10 VAL A  19
ASP A  18
LEU A 320
SER A 186
THR A 110
 None
None
None
PHY  A 782 ( 3.8A)
None
 1.14A 3j6gN-1ehiA:
undetectable		 3j6gN-1ehiA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_P_TA1P502_1
(TUBULIN BETA CHAIN)		 1ehi D-ALANINE:D-LACTATE
LIGASE
(Leuconostoc
mesenteroides) 		5 / 10 VAL A  19
ASP A  18
LEU A 320
SER A 186
THR A 110
 None
None
None
PHY  A 782 ( 3.8A)
None
 1.14A 3j6gP-1ehiA:
undetectable		 3j6gP-1ehiA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_R_TA1R502_1
(TUBULIN BETA CHAIN)		 1ehi D-ALANINE:D-LACTATE
LIGASE
(Leuconostoc
mesenteroides) 		5 / 10 VAL A  19
ASP A  18
LEU A 320
SER A 186
THR A 110
 None
None
None
PHY  A 782 ( 3.8A)
None
 1.14A 3j6gR-1ehiA:
undetectable		 3j6gR-1ehiA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_1
(PUTATIVE REGULATORY
PROTEIN)		 1ehi D-ALANINE:D-LACTATE
LIGASE
(Leuconostoc
mesenteroides) 		3 / 3 TYR A 153
MET A 302
LEU A 294
 None
 0.85A 3vw1D-1ehiA:
0.0		 3vw1D-1ehiA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L3G_F_ACTF401_0
(METHYLAMINE
DEHYDROGENASE HEAVY
CHAIN)		 1ehi D-ALANINE:D-LACTATE
LIGASE
(Leuconostoc
mesenteroides) 		3 / 3 ARG A 223
LEU A 306
GLU A 224
 None
None
ADP  A 781 (-2.7A)
 0.74A 4l3gF-1ehiA:
0.1		 4l3gF-1ehiA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 1ehi D-ALANINE:D-LACTATE
LIGASE
(Leuconostoc
mesenteroides) 		5 / 12 LYS A 116
ALA A 125
GLY A 124
ARG A 128
ASN A 295
 None
 1.27A 4obwD-1ehiA:
undetectable		 4obwD-1ehiA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UIL_H_QI9H1223_0
(FAB 314.1)		 1ehi D-ALANINE:D-LACTATE
LIGASE
(Leuconostoc
mesenteroides) 		5 / 12 ALA A   7
PHE A 115
GLN A 112
GLY A 106
PRO A  99
 None
 1.21A 4uilH-1ehiA:
2.6
4uilL-1ehiA:
undetectable		 4uilH-1ehiA:
19.85
4uilL-1ehiA:
19.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5BPH_A_ACTA403_0
(D-ALANINE--D-ALANINE
LIGASE)		 1ehi D-ALANINE:D-LACTATE
LIGASE
(Leuconostoc
mesenteroides) 		4 / 6 TYR A 255
LYS A 260
GLY A 322
SER A 327
 None
PHY  A 782 ( 2.6A)
PHY  A 782 (-3.5A)
PHY  A 782 (-2.6A)
 0.77A 5bphA-1ehiA:
36.2		 5bphA-1ehiA:
31.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5BPH_D_ACTD403_0
(D-ALANINE--D-ALANINE
LIGASE)		 1ehi D-ALANINE:D-LACTATE
LIGASE
(Leuconostoc
mesenteroides) 		4 / 6 TYR A 255
LYS A 260
GLY A 322
SER A 327
 None
PHY  A 782 ( 2.6A)
PHY  A 782 (-3.5A)
PHY  A 782 (-2.6A)
 0.72A 5bphD-1ehiA:
35.2		 5bphD-1ehiA:
31.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 1ehi D-ALANINE:D-LACTATE
LIGASE
(Leuconostoc
mesenteroides) 		5 / 12 ALA A 131
THR A 110
GLY A 106
LEU A 105
ALA A 182
 None
 0.99A 5c0oG-1ehiA:
undetectable		 5c0oG-1ehiA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_3_BEZ3801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 1ehi D-ALANINE:D-LACTATE
LIGASE
(Leuconostoc
mesenteroides) 		4 / 4 LEU A 347
ILE A 348
GLY A 124
ILE A  96
 None
 0.85A 5dzk3-1ehiA:
undetectable
5dzkm-1ehiA:
0.0		 5dzk3-1ehiA:
1.69
5dzkm-1ehiA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HJI_A_ADNA401_1
(TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5A)		 1ehi D-ALANINE:D-LACTATE
LIGASE
(Leuconostoc
mesenteroides) 		5 / 11 GLY A 315
ILE A 148
ASN A 150
ASP A 289
PRO A 312
 None
 1.18A 5hjiA-1ehiA:
undetectable		 5hjiA-1ehiA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC0_A_RBFA303_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 1ehi D-ALANINE:D-LACTATE
LIGASE
(Leuconostoc
mesenteroides) 		3 / 3 LYS A  21
LEU A 320
ILE A   9
 None
 0.74A 5kc0A-1ehiA:
0.0		 5kc0A-1ehiA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 1ehi D-ALANINE:D-LACTATE
LIGASE
(Leuconostoc
mesenteroides) 		5 / 10 VAL A  19
ASP A  18
LEU A 320
SER A 186
THR A 110
 None
None
None
PHY  A 782 ( 3.8A)
None
 1.22A 5m5cE-1ehiA:
undetectable		 5m5cE-1ehiA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_A_SAMA501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 1ehi D-ALANINE:D-LACTATE
LIGASE
(Leuconostoc
mesenteroides) 		5 / 12 ILE A  44
GLY A  48
LEU A  88
LEU A 114
LEU A 105
 None
 0.99A 5nfjA-1ehiA:
3.2		 5nfjA-1ehiA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OF1_A_SALA301_1
(SPORE
COAT-ASSOCIATED
PROTEIN N)		 1ehi D-ALANINE:D-LACTATE
LIGASE
(Leuconostoc
mesenteroides) 		4 / 5 ALA A  30
LYS A 330
PHE A 323
ILE A 338
 None
 0.96A 5of1A-1ehiA:
0.2		 5of1A-1ehiA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OF1_B_SALB301_1
(SPORE
COAT-ASSOCIATED
PROTEIN N)		 1ehi D-ALANINE:D-LACTATE
LIGASE
(Leuconostoc
mesenteroides) 		4 / 5 ALA A  30
LYS A 330
PHE A 323
ILE A 338
 None
 0.96A 5of1B-1ehiA:
0.0		 5of1B-1ehiA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0L_B_TA1B502_1
(TUBULIN BETA CHAIN)		 1ehi D-ALANINE:D-LACTATE
LIGASE
(Leuconostoc
mesenteroides) 		5 / 12 VAL A  19
ASP A  18
LEU A 320
SER A 186
THR A 110
 None
None
None
PHY  A 782 ( 3.8A)
None
 1.02A 6b0lB-1ehiA:
0.0		 6b0lB-1ehiA:
13.24