SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ehw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_B_DVAB6_0
(GRAMICIDIN A)		 1ehw NUCLEOSIDE
DIPHOSPHATE KINASE
(Homo
sapiens) 		3 / 3 TRP A  78
ALA A  75
VAL A   9
 None
 0.79A 1c4dA-1ehwA:
undetectable
1c4dB-1ehwA:
undetectable		 1c4dA-1ehwA:
10.66
1c4dB-1ehwA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_C_DVAC6_0
(GRAMICIDIN A)		 1ehw NUCLEOSIDE
DIPHOSPHATE KINASE
(Homo
sapiens) 		3 / 3 ALA A  75
VAL A   9
TRP A  78
 None
 0.90A 1c4dC-1ehwA:
undetectable
1c4dD-1ehwA:
undetectable		 1c4dC-1ehwA:
10.66
1c4dD-1ehwA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_D_DVAD6_0
(GRAMICIDIN A)		 1ehw NUCLEOSIDE
DIPHOSPHATE KINASE
(Homo
sapiens) 		3 / 3 TRP A  78
ALA A  75
VAL A   9
 None
 0.90A 1c4dC-1ehwA:
undetectable
1c4dD-1ehwA:
undetectable		 1c4dC-1ehwA:
10.66
1c4dD-1ehwA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOY_A_HISA1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 1ehw NUCLEOSIDE
DIPHOSPHATE KINASE
(Homo
sapiens) 		5 / 10 ARG A 128
GLY A 125
ALA A 126
HIS A 118
HIS A  51
 None
 1.33A 3boyA-1ehwA:
undetectable
3boyC-1ehwA:
0.0		 3boyA-1ehwA:
20.23
3boyC-1ehwA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOY_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 1ehw NUCLEOSIDE
DIPHOSPHATE KINASE
(Homo
sapiens) 		5 / 10 HIS A 118
HIS A  51
ARG A 128
GLY A 125
ALA A 126
 None
 1.34A 3boyA-1ehwA:
undetectable
3boyB-1ehwA:
0.0		 3boyA-1ehwA:
20.23
3boyB-1ehwA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOY_A_HISA3001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 1ehw NUCLEOSIDE
DIPHOSPHATE KINASE
(Homo
sapiens) 		5 / 10 HIS A 118
HIS A  51
ARG A 128
GLY A 125
ALA A 126
 None
 1.34A 3boyB-1ehwA:
0.0
3boyC-1ehwA:
0.0		 3boyB-1ehwA:
20.23
3boyC-1ehwA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_A_STIA3_2
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 1ehw NUCLEOSIDE
DIPHOSPHATE KINASE
(Homo
sapiens) 		4 / 6 VAL A   9
VAL A  36
ILE A 130
ARG A  31
 None
 1.10A 3pyyA-1ehwA:
undetectable		 3pyyA-1ehwA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK6_A_LURA201_1
(TRANSTHYRETIN)		 1ehw NUCLEOSIDE
DIPHOSPHATE KINASE
(Homo
sapiens) 		4 / 4 LYS A  39
LEU A  41
ALA A  75
VAL A  77
 None
 1.08A 4ik6A-1ehwA:
0.0		 4ik6A-1ehwA:
22.89