SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ehy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_C_DVAC6_0
(GRAMICIDIN A)		 1ehy PROTEIN (SOLUBLE
EPOXIDE HYDROLASE)
(Agrobacterium
tumefaciens) 		3 / 3 ALA A 110
VAL A 104
TRP A  45
 None
 0.85A 1av2C-1ehyA:
undetectable
1av2D-1ehyA:
undetectable		 1av2C-1ehyA:
5.65
1av2D-1ehyA:
5.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_B_KANB559_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 1ehy PROTEIN (SOLUBLE
EPOXIDE HYDROLASE)
(Agrobacterium
tumefaciens) 		4 / 8 LYS A  47
GLU A 194
SER A 184
GLU A 280
 None
 1.15A 1knyA-1ehyA:
0.0
1knyB-1ehyA:
0.0		 1knyA-1ehyA:
20.88
1knyB-1ehyA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS2_A_HAEA874_1
(MACROPHAGE
METALLOELASTASE)		 1ehy PROTEIN (SOLUBLE
EPOXIDE HYDROLASE)
(Agrobacterium
tumefaciens) 		4 / 5 HIS A  36
GLU A  44
HIS A 106
HIS A 275
 None
 1.10A 1os2A-1ehyA:
undetectable		 1os2A-1ehyA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG7_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 1ehy PROTEIN (SOLUBLE
EPOXIDE HYDROLASE)
(Agrobacterium
tumefaciens) 		3 / 3 ILE A 241
ILE A 270
THR A 266
 None
 0.50A 1rg7A-1ehyA:
undetectable		 1rg7A-1ehyA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1ehy PROTEIN (SOLUBLE
EPOXIDE HYDROLASE)
(Agrobacterium
tumefaciens) 		3 / 3 GLU A  70
GLU A  13
LEU A  92
 None
 0.72A 1v8bA-1ehyA:
undetectable		 1v8bA-1ehyA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_B_ADNB1502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1ehy PROTEIN (SOLUBLE
EPOXIDE HYDROLASE)
(Agrobacterium
tumefaciens) 		3 / 3 GLU A  70
GLU A  13
LEU A  92
 None
 0.71A 1v8bB-1ehyA:
undetectable		 1v8bB-1ehyA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_C_DVAC6_0
(GRAMICIDIN D)		 1ehy PROTEIN (SOLUBLE
EPOXIDE HYDROLASE)
(Agrobacterium
tumefaciens) 		3 / 3 ALA A 110
VAL A 104
TRP A  45
 None
 0.86A 1w5uC-1ehyA:
undetectable
1w5uD-1ehyA:
undetectable		 1w5uC-1ehyA:
5.65
1w5uD-1ehyA:
5.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1ehy PROTEIN (SOLUBLE
EPOXIDE HYDROLASE)
(Agrobacterium
tumefaciens) 		4 / 5 ILE A 255
TYR A 265
MET A 240
THR A 239
 None
 1.46A 3abkN-1ehyA:
0.0
3abkW-1ehyA:
undetectable		 3abkN-1ehyA:
20.81
3abkW-1ehyA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_C_TMQC613_1
(DHFR-TS)		 1ehy PROTEIN (SOLUBLE
EPOXIDE HYDROLASE)
(Agrobacterium
tumefaciens) 		5 / 12 ILE A 133
ILE A 111
LEU A 225
ILE A 219
TYR A 152
 None
 0.97A 3clbC-1ehyA:
undetectable		 3clbC-1ehyA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_A_TMQA611_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1ehy PROTEIN (SOLUBLE
EPOXIDE HYDROLASE)
(Agrobacterium
tumefaciens) 		5 / 10 ILE A 133
ILE A 111
LEU A 225
ILE A 219
TYR A 152
 None
 1.10A 3hbbA-1ehyA:
undetectable		 3hbbA-1ehyA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_C_TMQC613_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1ehy PROTEIN (SOLUBLE
EPOXIDE HYDROLASE)
(Agrobacterium
tumefaciens) 		5 / 11 ILE A 133
ILE A 111
LEU A 225
ILE A 219
TYR A 152
 None
 0.99A 3hbbC-1ehyA:
undetectable		 3hbbC-1ehyA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_A_C2FA314_0
(UNCHARACTERIZED
PROTEIN)		 1ehy PROTEIN (SOLUBLE
EPOXIDE HYDROLASE)
(Agrobacterium
tumefaciens) 		5 / 12 VAL A 104
GLY A 105
LEU A 113
ILE A 241
ILE A 284
 None
 1.07A 3ijdA-1ehyA:
undetectable		 3ijdA-1ehyA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB314_0
(UNCHARACTERIZED
PROTEIN)		 1ehy PROTEIN (SOLUBLE
EPOXIDE HYDROLASE)
(Agrobacterium
tumefaciens) 		5 / 12 VAL A 104
GLY A 105
LEU A 113
ILE A 241
ILE A 284
 None
 1.07A 3ijdB-1ehyA:
1.2		 3ijdB-1ehyA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_B_SAMB301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 1ehy PROTEIN (SOLUBLE
EPOXIDE HYDROLASE)
(Agrobacterium
tumefaciens) 		5 / 12 TRP A  38
PHE A 179
ASP A 107
PHE A 108
ASP A 136
 None
 1.26A 3iv6B-1ehyA:
3.1		 3iv6B-1ehyA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB201_1
(PROTEIN S100-A4)		 1ehy PROTEIN (SOLUBLE
EPOXIDE HYDROLASE)
(Agrobacterium
tumefaciens) 		4 / 8 GLY A  37
ILE A 219
PHE A 155
PHE A 179
 None
 1.03A 3ko0B-1ehyA:
0.3
3ko0J-1ehyA:
0.2		 3ko0B-1ehyA:
15.52
3ko0J-1ehyA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK201_1
(PROTEIN S100-A4)		 1ehy PROTEIN (SOLUBLE
EPOXIDE HYDROLASE)
(Agrobacterium
tumefaciens) 		4 / 8 GLY A  37
ILE A 219
PHE A 155
PHE A 179
 None
 0.98A 3ko0K-1ehyA:
0.2
3ko0S-1ehyA:
0.7		 3ko0K-1ehyA:
15.52
3ko0S-1ehyA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L3G_F_ACTF401_0
(METHYLAMINE
DEHYDROGENASE HEAVY
CHAIN)		 1ehy PROTEIN (SOLUBLE
EPOXIDE HYDROLASE)
(Agrobacterium
tumefaciens) 		3 / 3 ARG A 186
LEU A 189
GLU A 188
 None
 0.74A 4l3gF-1ehyA:
0.0		 4l3gF-1ehyA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1W_A_017A104_2
(ASPARTYL PROTEASE)		 1ehy PROTEIN (SOLUBLE
EPOXIDE HYDROLASE)
(Agrobacterium
tumefaciens) 		5 / 10 ALA A  86
ASP A  88
GLY A 105
ILE A 129
VAL A 124
 None
 1.01A 4q1wB-1ehyA:
undetectable		 4q1wB-1ehyA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QDJ_A_SAMA301_1
(MAGNESIUM-PROTOPORPH
YRIN
O-METHYLTRANSFERASE)		 1ehy PROTEIN (SOLUBLE
EPOXIDE HYDROLASE)
(Agrobacterium
tumefaciens) 		4 / 5 HIS A 198
ASP A  62
ASP A  88
TYR A 214
 None
 1.44A 4qdjA-1ehyA:
2.1		 4qdjA-1ehyA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X61_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 1ehy PROTEIN (SOLUBLE
EPOXIDE HYDROLASE)
(Agrobacterium
tumefaciens) 		5 / 12 GLY A 243
GLY A 245
PRO A 135
ARG A 288
LEU A 277
 None
 1.24A 4x61A-1ehyA:
0.4		 4x61A-1ehyA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DLV_B_5D5B927_1
(ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2)		 1ehy PROTEIN (SOLUBLE
EPOXIDE HYDROLASE)
(Agrobacterium
tumefaciens) 		4 / 7 SER A 153
TYR A 152
PHE A 137
HIS A 275
 None
 1.42A 5dlvB-1ehyA:
0.0		 5dlvB-1ehyA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH8_A_ACTA302_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1ehy PROTEIN (SOLUBLE
EPOXIDE HYDROLASE)
(Agrobacterium
tumefaciens) 		3 / 3 CYH A 172
MET A 203
ASN A 207
 None
 1.25A 5qh8A-1ehyA:
0.0		 5qh8A-1ehyA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_B_SAMB301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 1ehy PROTEIN (SOLUBLE
EPOXIDE HYDROLASE)
(Agrobacterium
tumefaciens) 		5 / 12 TYR A 251
PRO A 135
GLY A 243
GLY A 274
GLY A 245
 None
 1.01A 5wyqB-1ehyA:
2.1		 5wyqB-1ehyA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_E_EY4E500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 1ehy PROTEIN (SOLUBLE
EPOXIDE HYDROLASE)
(Agrobacterium
tumefaciens) 		5 / 8 ILE A 117
VAL A 103
PRO A 237
THR A  31
TYR A  56
 None
 1.48A 6cduD-1ehyA:
undetectable
6cduE-1ehyA:
undetectable		 6cduD-1ehyA:
23.02
6cduE-1ehyA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_G_EY4G502_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 1ehy PROTEIN (SOLUBLE
EPOXIDE HYDROLASE)
(Agrobacterium
tumefaciens) 		4 / 8 VAL A 103
PRO A 237
THR A  31
TYR A  56
 None
 1.04A 6cduG-1ehyA:
undetectable
6cduH-1ehyA:
undetectable		 6cduG-1ehyA:
23.02
6cduH-1ehyA:
23.02