SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ei6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 1ei6 PHOSPHONOACETATE
HYDROLASE
(Pseudomonas
fluorescens) 		5 / 12 PHE A 142
ILE A 160
VAL A 123
ALA A 121
ILE A  22
 None
 1.00A 1epbA-1ei6A:
undetectable		 1epbA-1ei6A:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R55_A_097A518_1
(ADAM 33)		 1ei6 PHOSPHONOACETATE
HYDROLASE
(Pseudomonas
fluorescens) 		5 / 10 ALA A 125
THR A 124
VAL A 123
HIS A 155
ALA A 147
 None
 1.09A 1r55A-1ei6A:
undetectable		 1r55A-1ei6A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_C_SHHC2652_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 1ei6 PHOSPHONOACETATE
HYDROLASE
(Pseudomonas
fluorescens) 		5 / 12 GLY A 369
ASP A 241
PHE A  63
ASP A  25
GLY A  26
 None
ZN  A 408 (-2.5A)
None
ZN  A 408 (-2.2A)
ZN  A 408 ( 4.8A)
 1.03A 1zz1C-1ei6A:
undetectable		 1zz1C-1ei6A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_B_SAMB300_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 1ei6 PHOSPHONOACETATE
HYDROLASE
(Pseudomonas
fluorescens) 		5 / 12 ARG A 328
GLY A 343
GLY A 370
ALA A 318
LEU A 259
 None
 1.13A 3dh0B-1ei6A:
undetectable		 3dh0B-1ei6A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_C_CGEC501_1
(CYTOCHROME P450 2B4)		 1ei6 PHOSPHONOACETATE
HYDROLASE
(Pseudomonas
fluorescens) 		5 / 9 ILE A 313
PHE A 309
ALA A 306
VAL A 341
VAL A 316
 None
 1.13A 3me6C-1ei6A:
0.0		 3me6C-1ei6A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_D_CGED501_1
(CYTOCHROME P450 2B4)		 1ei6 PHOSPHONOACETATE
HYDROLASE
(Pseudomonas
fluorescens) 		5 / 9 ILE A 313
PHE A 309
ALA A 306
VAL A 341
VAL A 316
 None
 1.16A 3me6D-1ei6A:
0.0		 3me6D-1ei6A:
23.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3T01_A_PPFA503_1
(PHOSPHONOACETATE
HYDROLASE)		 1ei6 PHOSPHONOACETATE
HYDROLASE
(Pseudomonas
fluorescens) 		7 / 7 PHE A  63
THR A  64
ASN A  85
ASP A 202
HIS A 206
ILE A 278
HIS A 368
 None
ZN  A 408 ( 2.5A)
None
ZN  A 409 (-2.3A)
ZN  A 409 ( 3.3A)
None
ZN  A 409 ( 3.4A)
 0.46A 3t01A-1ei6A:
62.6		 3t01A-1ei6A:
54.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_C_NCTC501_1
(CYTOCHROME P450 2A6)		 1ei6 PHOSPHONOACETATE
HYDROLASE
(Pseudomonas
fluorescens) 		4 / 5 PHE A 226
PHE A 181
ILE A  22
THR A 200
 None
 1.01A 4ejjC-1ei6A:
0.0		 4ejjC-1ei6A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_A_CCSA109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)		 1ei6 PHOSPHONOACETATE
HYDROLASE
(Pseudomonas
fluorescens) 		4 / 8 ASN A 381
PHE A 226
ILE A  20
ALA A 402
 None
 0.90A 4eyzA-1ei6A:
0.0		 4eyzA-1ei6A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_B_CCSB109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)		 1ei6 PHOSPHONOACETATE
HYDROLASE
(Pseudomonas
fluorescens) 		4 / 8 ASN A 381
PHE A 226
ILE A  20
ALA A 402
 None
 0.90A 4eyzB-1ei6A:
0.0		 4eyzB-1ei6A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 1ei6 PHOSPHONOACETATE
HYDROLASE
(Pseudomonas
fluorescens) 		3 / 3 ASP A 397
ASN A 404
SER A  70
 None
 0.81A 4obwA-1ei6A:
undetectable		 4obwA-1ei6A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 1ei6 PHOSPHONOACETATE
HYDROLASE
(Pseudomonas
fluorescens) 		4 / 7 ARG A 335
ILE A 336
PRO A  77
ILE A  82
 None
 0.99A 4w5oA-1ei6A:
0.0		 4w5oA-1ei6A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 1ei6 PHOSPHONOACETATE
HYDROLASE
(Pseudomonas
fluorescens) 		4 / 7 ARG A 335
ILE A 336
PRO A  77
ILE A  82
 None
 0.97A 4z4eA-1ei6A:
0.0		 4z4eA-1ei6A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 1ei6 PHOSPHONOACETATE
HYDROLASE
(Pseudomonas
fluorescens) 		4 / 7 ARG A 335
ILE A 336
PRO A  77
ILE A  82
 None
 0.97A 4z4gA-1ei6A:
2.0		 4z4gA-1ei6A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA302_1
(CHITOSANASE)		 1ei6 PHOSPHONOACETATE
HYDROLASE
(Pseudomonas
fluorescens) 		4 / 7 ASP A 202
ASP A 241
GLY A 243
TYR A  31
 ZN  A 409 (-2.3A)
ZN  A 408 (-2.5A)
None
None
 1.10A 5hwaA-1ei6A:
0.8		 5hwaA-1ei6A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)		 1ei6 PHOSPHONOACETATE
HYDROLASE
(Pseudomonas
fluorescens) 		5 / 12 GLY A 343
GLY A 315
THR A 347
VAL A 319
LEU A 342
 None
 1.19A 5kocB-1ei6A:
undetectable		 5kocB-1ei6A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_D_Z80D401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1ei6 PHOSPHONOACETATE
HYDROLASE
(Pseudomonas
fluorescens) 		5 / 9 ILE A 109
VAL A  21
ASN A 395
ASP A 397
ILE A  71
 None
 1.47A 5lg3D-1ei6A:
0.9		 5lg3D-1ei6A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_D_SAMD501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1ei6 PHOSPHONOACETATE
HYDROLASE
(Pseudomonas
fluorescens) 		5 / 10 ILE A 336
GLY A 337
VAL A 319
LEU A 320
ALA A 325
 None
 0.66A 5o96C-1ei6A:
undetectable
5o96D-1ei6A:
undetectable		 5o96C-1ei6A:
23.59
5o96D-1ei6A:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNM_A_SAMA401_0
(NSP16 PROTEIN)		 1ei6 PHOSPHONOACETATE
HYDROLASE
(Pseudomonas
fluorescens) 		5 / 12 TYR A 219
GLY A  26
ASP A 241
ASN A  67
MET A 244
 None
ZN  A 408 ( 4.8A)
ZN  A 408 (-2.5A)
None
None
 1.33A 5ynmA-1ei6A:
undetectable		 5ynmA-1ei6A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_A_P2EA1201_0
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)		 1ei6 PHOSPHONOACETATE
HYDROLASE
(Pseudomonas
fluorescens) 		5 / 12 GLN A 136
THR A 108
VAL A  72
TYR A 197
LEU A 129
 None
 1.18A 6ak3A-1ei6A:
0.0		 6ak3A-1ei6A:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DCH_A_ACTA401_0
(SCOE PROTEIN)		 1ei6 PHOSPHONOACETATE
HYDROLASE
(Pseudomonas
fluorescens) 		4 / 5 THR A 279
HIS A 368
ASP A 202
HIS A 242
 None
ZN  A 409 ( 3.4A)
ZN  A 409 (-2.3A)
ZN  A 408 ( 2.9A)
 1.09A 6dchA-1ei6A:
undetectable		 6dchA-1ei6A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F7L_B_ACTB505_0
(AMINE OXIDASE LKCE)		 1ei6 PHOSPHONOACETATE
HYDROLASE
(Pseudomonas
fluorescens) 		3 / 3 HIS A 405
ASN A 404
LEU A 403
 None
 0.83A 6f7lB-1ei6A:
undetectable		 6f7lB-1ei6A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_2
(-)		 1ei6 PHOSPHONOACETATE
HYDROLASE
(Pseudomonas
fluorescens) 		4 / 8 VAL A  72
TYR A 197
ASN A  65
CYH A  83
 None
 1.32A 6gneB-1ei6A:
undetectable		 6gneB-1ei6A:
22.89