SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1eif'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA142_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 1eif EUKARYOTIC
TRANSLATION
INITIATION FACTOR 5A
(Methanocaldococc
us
jannaschii) 		4 / 5 GLU A  55
PRO A  27
ILE A  53
GLY A  52
 None
 1.10A 2qeuA-1eifA:
undetectable
2qeuC-1eifA:
undetectable		 2qeuA-1eifA:
22.22
2qeuC-1eifA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA606_1
(CHITINASE A)		 1eif EUKARYOTIC
TRANSLATION
INITIATION FACTOR 5A
(Methanocaldococc
us
jannaschii) 		4 / 7 GLY A   6
LYS A   4
ASP A  75
ARG A  77
 None
 1.01A 3arrA-1eifA:
undetectable		 3arrA-1eifA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA606_1
(CHITINASE A)		 1eif EUKARYOTIC
TRANSLATION
INITIATION FACTOR 5A
(Methanocaldococc
us
jannaschii) 		4 / 7 GLY A   6
LYS A   4
ASP A  75
ARG A  77
 None
 0.96A 3aruA-1eifA:
undetectable		 3aruA-1eifA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_D_017D200_2
(HIV-1 PROTEASE)		 1eif EUKARYOTIC
TRANSLATION
INITIATION FACTOR 5A
(Methanocaldococc
us
jannaschii) 		5 / 10 LEU A  15
VAL A  31
GLY A  52
VAL A  48
ILE A  30
 None
 0.99A 3oxwD-1eifA:
undetectable		 3oxwD-1eifA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QGI_A_ROCA101_2
(PROTEASE)		 1eif EUKARYOTIC
TRANSLATION
INITIATION FACTOR 5A
(Methanocaldococc
us
jannaschii) 		5 / 11 LEU A  15
VAL A  31
GLY A  52
VAL A  48
ILE A  30
 None
 0.91A 4qgiB-1eifA:
undetectable		 4qgiB-1eifA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGL_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1eif EUKARYOTIC
TRANSLATION
INITIATION FACTOR 5A
(Methanocaldococc
us
jannaschii) 		3 / 3 VAL A 131
VAL A 117
GLN A  80
 None
 0.69A 5qglA-1eifA:
0.0		 5qglA-1eifA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHG_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1eif EUKARYOTIC
TRANSLATION
INITIATION FACTOR 5A
(Methanocaldococc
us
jannaschii) 		3 / 3 VAL A 131
VAL A 117
GLN A  80
 None
 0.69A 5qhgA-1eifA:
0.0		 5qhgA-1eifA:
19.29