SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ej6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_A_TESA325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 1ej6 LAMBDA1
(Reovirus
sp.) 		4 / 7 LEU B 599
TYR B 600
THR B 734
TYR B 721
 None
 1.09A 1afsA-1ej6B:
0.0		 1afsA-1ej6B:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_B_TESB325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 1ej6 LAMBDA1
(Reovirus
sp.) 		4 / 7 LEU B 599
TYR B 600
THR B 734
TYR B 721
 None
 1.09A 1afsB-1ej6B:
0.0		 1afsB-1ej6B:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_A_T3A1_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 1ej6 LAMBDA1
(Reovirus
sp.) 		5 / 12 ILE B 743
ALA B 594
LEU B 595
LEU B 886
ILE B 882
 None
 0.83A 1bsxA-1ej6B:
1.3		 1bsxA-1ej6B:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_B_T3B2_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 1ej6 LAMBDA1
(Reovirus
sp.) 		5 / 12 ILE B 743
ALA B 594
LEU B 595
LEU B 886
ILE B 882
 None
 0.83A 1bsxB-1ej6B:
1.3		 1bsxB-1ej6B:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		 1ej6 LAMBDA1
(Reovirus
sp.) 		5 / 11 ALA B 815
LEU B 595
ARG B 592
LEU B 811
LEU B 886
 None
 1.15A 1h9zA-1ej6B:
2.6		 1h9zA-1ej6B:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HA2_A_SWFA3001_1
(SERUM ALBUMIN)		 1ej6 LAMBDA1
(Reovirus
sp.) 		5 / 11 ALA B 815
LEU B 595
LEU B 811
ILE B 882
ALA B 885
 None
 1.04A 1ha2A-1ej6B:
2.8		 1ha2A-1ej6B:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KXH_A_ACRA598_2
(ALPHA-AMYLASE)		 1ej6 LAMBDA1
(Reovirus
sp.) 		3 / 3 TRP B 951
TYR B 948
LEU B 362
 None
 1.04A 1kxhA-1ej6B:
undetectable		 1kxhA-1ej6B:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT2_A_SAMA301_1
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)		 1ej6 LAMBDA1
(Reovirus
sp.) 		3 / 3 THR B 762
GLU B 770
ASP B 777
 None
 0.82A 1nt2A-1ej6B:
undetectable		 1nt2A-1ej6B:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_1
(HEMK PROTEIN)		 1ej6 LAMBDA1
(Reovirus
sp.) 		3 / 3 ASP B1252
PHE B 451
ASN B1237
 None
 0.76A 1sg9B-1ej6B:
2.0		 1sg9B-1ej6B:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_B_DVAB8_0
(GRAMICIDIN A)		 1ej6 LAMBDA1
(Reovirus
sp.) 		4 / 5 VAL B 603
GLY B 602
VAL B 604
TRP B 598
 None
 1.06A 1tkqB-1ej6B:
undetectable		 1tkqB-1ej6B:
1.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_4
(POL POLYPROTEIN)		 1ej6 LAMBDA1
(Reovirus
sp.) 		3 / 3 ARG B 462
VAL B 450
GLY B 377
 None
 0.61A 2avvE-1ej6B:
0.0		 2avvE-1ej6B:
5.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BL9_A_CP6A1240_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1ej6 LAMBDA1
(Reovirus
sp.) 		5 / 12 ILE B 631
ALA B 635
SER B 888
SER B 805
ILE B 803
 None
 1.18A 2bl9A-1ej6B:
undetectable		 2bl9A-1ej6B:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 1ej6 LAMBDA1
(Reovirus
sp.) 		4 / 5 TYR B 407
MET B 406
THR B 453
LEU B 262
 None
 1.20A 2eimJ-1ej6B:
0.0		 2eimJ-1ej6B:
4.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 1ej6 LAMBDA1
(Reovirus
sp.) 		4 / 5 TYR B 407
MET B 406
THR B 453
LEU B 262
 None
 1.25A 2eimW-1ej6B:
0.0		 2eimW-1ej6B:
4.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H77_A_T3A1_1
(THRA PROTEIN)		 1ej6 LAMBDA1
(Reovirus
sp.) 		5 / 12 ILE B 743
ALA B 594
LEU B 595
LEU B 886
ILE B 882
 None
 0.83A 2h77A-1ej6B:
0.0		 2h77A-1ej6B:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H79_A_T3A1_1
(THRA PROTEIN)		 1ej6 LAMBDA1
(Reovirus
sp.) 		5 / 12 ILE B 743
ALA B 594
LEU B 595
LEU B 886
ILE B 882
 None
 0.80A 2h79A-1ej6B:
1.0		 2h79A-1ej6B:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH8_A_VIBA1_1
(MAJOR PRION PROTEIN)		 1ej6 LAMBDA1
(Reovirus
sp.) 		4 / 6 PRO B 326
MET B 324
HIS B 307
ASP B 455
 None
 1.44A 2lh8A-1ej6B:
1.5		 2lh8A-1ej6B:
6.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7U_B_SAMB1299_1
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)		 1ej6 LAMBDA1
(Reovirus
sp.) 		4 / 7 PHE B 365
ASN B 369
SER B 460
ARG B 464
 None
 1.47A 2v7uB-1ej6B:
undetectable		 2v7uB-1ej6B:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1160_1
(ALLERGEN ARG R 1)		 1ej6 LAMBDA1
(Reovirus
sp.) 		4 / 6 SER B1057
VAL B 301
TYR B1150
ASP B1206
 None
 1.34A 2x45A-1ej6B:
0.0		 2x45A-1ej6B:
7.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 1ej6 LAMBDA1
(Reovirus
sp.) 		3 / 3 TYR B 407
GLU B 452
THR B 376
 None
 0.97A 2y7hB-1ej6B:
0.0		 2y7hB-1ej6B:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 1ej6 LAMBDA1
(Reovirus
sp.) 		4 / 5 TYR B 407
MET B 406
THR B 453
LEU B 262
 None
 1.24A 3ag2J-1ej6B:
0.0		 3ag2J-1ej6B:
4.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_C_DXCC576_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 1ej6 LAMBDA1
(Reovirus
sp.) 		4 / 8 PRO B 816
ALA B 820
ALA B 823
ILE B 719
 None
 0.71A 3dtuC-1ej6B:
1.4
3dtuD-1ej6B:
0.0		 3dtuC-1ej6B:
18.72
3dtuD-1ej6B:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWS_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 1ej6 LAMBDA1
(Reovirus
sp.) 		5 / 12 ILE B 743
ALA B 594
LEU B 595
LEU B 886
ILE B 882
 None
 0.81A 3gwsX-1ej6B:
1.4		 3gwsX-1ej6B:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		 1ej6 LAMBDA1
(Reovirus
sp.) 		5 / 12 LEU B 255
ARG B 254
PHE B 316
LEU B 979
ASP B 978
 None
 1.36A 3gwuA-1ej6B:
0.0		 3gwuA-1ej6B:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KHM_A_TPFA501_1
(STEROL 14
ALPHA-DEMETHYLASE)		 1ej6 LAMBDA1
(Reovirus
sp.) 		4 / 8 ALA B 881
ALA B 885
THR B 807
LEU B 549
 None
 0.94A 3khmA-1ej6B:
undetectable		 3khmA-1ej6B:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1ej6 LAMBDA1
(Reovirus
sp.) 		5 / 8 LEU B 988
VAL B 928
LEU B 931
ILE B 520
ARG B 851
 None
 1.22A 3kp6A-1ej6B:
0.0
3kp6B-1ej6B:
0.5		 3kp6A-1ej6B:
8.26
3kp6B-1ej6B:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_A_TPFA490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 1ej6 LAMBDA1
(Reovirus
sp.) 		4 / 8 ALA B 881
ALA B 885
THR B 807
LEU B 549
 None
 0.94A 3l4dA-1ej6B:
undetectable		 3l4dA-1ej6B:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ej6 LAMBDA1
(Reovirus
sp.) 		4 / 8 ARG B1207
LEU B1247
LEU B1253
ILE B1245
 None
 0.95A 3ln1A-1ej6B:
0.0		 3ln1A-1ej6B:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_B_CELB682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ej6 LAMBDA1
(Reovirus
sp.) 		4 / 7 ARG B1207
LEU B1247
LEU B1253
ILE B1245
 None
 0.95A 3ln1B-1ej6B:
0.0		 3ln1B-1ej6B:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA277_0
(UNIVERSAL STRESS
PROTEIN)		 1ej6 LAMBDA1
(Reovirus
sp.) 		3 / 3 ASP B 455
SER B 265
ARG B 462
 None
 0.88A 3loqA-1ej6B:
0.0		 3loqA-1ej6B:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1ej6 LAMBDA1
(Reovirus
sp.) 		5 / 12 LEU B 979
ALA B 927
MET B 922
LEU B 984
ALA B1021
 None
 1.26A 3ou7C-1ej6B:
undetectable		 3ou7C-1ej6B:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_B_017B200_1
(HIV-1 PROTEASE)		 1ej6 LAMBDA1
(Reovirus
sp.) 		5 / 10 LEU B 370
ALA B 976
ASP B 319
VAL B 969
VAL B 366
 None
 1.02A 3oxwA-1ej6B:
undetectable		 3oxwA-1ej6B:
7.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_A_ACRA701_2
(ALPHA-GLUCOSIDASE)		 1ej6 LAMBDA1
(Reovirus
sp.) 		4 / 5 PRO B1153
ILE B1190
TYR B1156
MET B1181
 None
 1.48A 3phaA-1ej6B:
undetectable		 3phaA-1ej6B:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QG2_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1ej6 LAMBDA1
(Reovirus
sp.) 		5 / 10 ILE B 631
ALA B 635
PHE B 630
SER B 805
ILE B 803
 None
 1.37A 3qg2A-1ej6B:
undetectable		 3qg2A-1ej6B:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QG2_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1ej6 LAMBDA1
(Reovirus
sp.) 		5 / 11 ILE B 631
ALA B 635
PHE B 630
SER B 805
ILE B 803
 None
 1.34A 3qg2B-1ej6B:
undetectable		 3qg2B-1ej6B:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGT_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1ej6 LAMBDA1
(Reovirus
sp.) 		6 / 10 ILE B 631
ALA B 635
PHE B 630
SER B 888
SER B 805
ILE B 803
 None
 1.35A 3qgtA-1ej6B:
undetectable		 3qgtA-1ej6B:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGT_B_CP6B609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1ej6 LAMBDA1
(Reovirus
sp.) 		5 / 10 ILE B 631
ALA B 635
SER B 888
SER B 805
ILE B 803
 None
 1.22A 3qgtB-1ej6B:
undetectable		 3qgtB-1ej6B:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_C_9PLC1_1
(CYTOCHROME P450 2A13)		 1ej6 LAMBDA1
(Reovirus
sp.) 		4 / 7 PHE B 977
ALA B 927
THR B 930
LEU B 363
 None
 1.06A 3t3sC-1ej6B:
0.0		 3t3sC-1ej6B:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA1_A_08YA600_1
(CYTOCHROME P450 3A4)		 1ej6 LAMBDA1
(Reovirus
sp.) 		5 / 12 ASP B 921
ARG B 521
ILE B 532
ALA B 596
ALA B 823
 None
 1.35A 3ua1A-1ej6B:
undetectable		 3ua1A-1ej6B:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 1ej6 LAMBDA1
(Reovirus
sp.) 		4 / 8 LEU B 262
TYR B 407
TYR B 403
LEU B 394
 None
 1.00A 3v81A-1ej6B:
0.0		 3v81A-1ej6B:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_D_NCTD501_1
(CYTOCHROME P450 2A13)		 1ej6 LAMBDA1
(Reovirus
sp.) 		4 / 6 PHE B 977
ALA B 927
THR B 930
LEU B 363
 None
 0.99A 4ejgD-1ej6B:
0.0		 4ejgD-1ej6B:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G10_A_ACTA301_0
(GLUTATHIONE
S-TRANSFERASE
HOMOLOG)		 1ej6 LAMBDA1
(Reovirus
sp.) 		4 / 6 PRO B 295
ILE B 268
TYR B1232
PHE B1210
 None
 1.00A 4g10A-1ej6B:
0.0		 4g10A-1ej6B:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IMA_D_ADND604_1
(PYRUVATE KINASE)		 1ej6 LAMBDA1
(Reovirus
sp.) 		3 / 3 ARG B 508
GLU B 478
ASN B 725
 None
 0.85A 4imaD-1ej6B:
undetectable		 4imaD-1ej6B:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IP7_D_ADND604_1
(PYRUVATE KINASE
ISOZYMES L)		 1ej6 LAMBDA1
(Reovirus
sp.) 		3 / 3 ARG B 508
GLU B 478
ASN B 725
 None
 0.89A 4ip7D-1ej6B:
undetectable		 4ip7D-1ej6B:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 1ej6 LAMBDA1
(Reovirus
sp.) 		5 / 12 ILE B 743
ALA B 594
LEU B 595
LEU B 886
ILE B 882
 None
 0.82A 4lnwA-1ej6B:
1.2		 4lnwA-1ej6B:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 1ej6 LAMBDA1
(Reovirus
sp.) 		5 / 12 ILE B 743
ALA B 594
LEU B 595
LEU B 886
ILE B 882
 None
 0.81A 4lnxA-1ej6B:
1.1		 4lnxA-1ej6B:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_D_ADND401_2
(ADENOSINE KINASE)		 1ej6 LAMBDA1
(Reovirus
sp.) 		4 / 5 CYH B 925
LEU B 997
SER B 517
LEU B 987
 None
 1.33A 4n09D-1ej6B:
undetectable		 4n09D-1ej6B:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0U_A_ADNA501_1
(AURORA KINASE A)		 1ej6 LAMBDA1
(Reovirus
sp.) 		4 / 6 ALA B1028
LEU B 359
THR B 930
LEU B 934
 None
 0.78A 4o0uA-1ej6B:
undetectable		 4o0uA-1ej6B:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_2
(TUBULIN BETA-2B
CHAIN)		 1ej6 LAMBDA1
(Reovirus
sp.) 		5 / 12 LEU B 595
ALA B 815
LEU B 549
ALA B 885
ILE B 551
 None
 1.07A 4o2bB-1ej6B:
undetectable		 4o2bB-1ej6B:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJ4_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1ej6 LAMBDA1
(Reovirus
sp.) 		4 / 8 LEU B 362
LEU B 359
VAL B 358
ILE B 952
 None
 0.89A 4oj4A-1ej6B:
1.5		 4oj4A-1ej6B:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_2
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 1ej6 LAMBDA1
(Reovirus
sp.) 		3 / 3 LEU B 802
LEU B 634
ASN B 763
 None
 0.69A 4otwA-1ej6B:
undetectable		 4otwA-1ej6B:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PUO_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 1ej6 LAMBDA1
(Reovirus
sp.) 		4 / 8 LEU B 262
TYR B 407
TYR B 403
LEU B 394
 None
 1.03A 4puoC-1ej6B:
undetectable		 4puoC-1ej6B:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 1ej6 LAMBDA1
(Reovirus
sp.) 		4 / 8 LEU B 262
TYR B 407
TYR B 403
LEU B 394
 None
 1.03A 4pwdA-1ej6B:
0.0		 4pwdA-1ej6B:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 1ej6 LAMBDA1
(Reovirus
sp.) 		4 / 8 PRO B 548
LEU B 895
VAL B 899
TYR B 901
 None
 0.98A 4pwdA-1ej6B:
0.0		 4pwdA-1ej6B:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1ej6 LAMBDA1
(Reovirus
sp.) 		4 / 5 ILE B 708
VAL B 768
PHE B 757
HIS B 710
 None
 1.36A 4rzvA-1ej6B:
0.0		 4rzvA-1ej6B:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA301_0
(THAUMATIN-1)		 1ej6 LAMBDA1
(Reovirus
sp.) 		3 / 3 THR B1212
ASN B1213
SER B1214
 None
 0.78A 4tvtA-1ej6B:
0.0		 4tvtA-1ej6B:
10.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE3_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1ej6 LAMBDA1
(Reovirus
sp.) 		4 / 7 PHE B 831
ILE B 522
PHE B 733
LEU B 864
 None
 0.80A 4ze3A-1ej6B:
0.7		 4ze3A-1ej6B:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESJ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1ej6 LAMBDA1
(Reovirus
sp.) 		4 / 8 PHE B 831
ILE B 522
PHE B 733
LEU B 864
 None
 0.89A 5esjA-1ej6B:
0.0		 5esjA-1ej6B:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_A_032A401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 1ej6 LAMBDA1
(Reovirus
sp.) 		4 / 6 LYS B 773
SER B 564
VAL B 563
ASP B 798
 None
 1.00A 5hesA-1ej6B:
undetectable		 5hesA-1ej6B:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ej6 LAMBDA1
(Reovirus
sp.) 		3 / 3 LEU B1209
TYR B1150
SER B1057
 None
 0.73A 5iktA-1ej6B:
0.0		 5iktA-1ej6B:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ej6 LAMBDA1
(Reovirus
sp.) 		3 / 3 LEU B1209
TYR B1150
SER B1185
 None
 0.68A 5iktA-1ej6B:
0.0		 5iktA-1ej6B:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ITZ_B_LOCB502_1
(TUBULIN BETA-2B
CHAIN)		 1ej6 LAMBDA1
(Reovirus
sp.) 		5 / 12 LEU B 595
ALA B 815
LEU B 549
ALA B 885
ILE B 551
 None
 1.07A 5itzB-1ej6B:
0.0		 5itzB-1ej6B:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KBW_A_RBFA201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 1ej6 LAMBDA1
(Reovirus
sp.) 		5 / 12 ASP B 616
GLY B 617
MET B 655
ASN B 654
LEU B 652
 None
 1.35A 5kbwA-1ej6B:
1.5		 5kbwA-1ej6B:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KBW_A_RBFA201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 1ej6 LAMBDA1
(Reovirus
sp.) 		5 / 12 ASP B 616
GLY B 618
MET B 655
ASN B 654
LEU B 652
 None
 1.02A 5kbwA-1ej6B:
1.5		 5kbwA-1ej6B:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_E_RBFE201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 1ej6 LAMBDA1
(Reovirus
sp.) 		5 / 12 ASP B 616
GLY B 618
MET B 655
ASN B 654
LEU B 652
 None
 1.18A 5kc4E-1ej6B:
0.8		 5kc4E-1ej6B:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_H_6V8H305_0
(PROTEASOME SUBUNIT
BETA TYPE-3
PROTEASOME SUBUNIT
BETA TYPE-7)		 1ej6 LAMBDA1
(Reovirus
sp.) 		5 / 11 THR B 661
GLU B 660
CYH B 687
ALA B 653
LEU B 775
 None
 1.12A 5lf7H-1ej6B:
undetectable
5lf7I-1ej6B:
undetectable		 5lf7H-1ej6B:
11.41
5lf7I-1ej6B:
9.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIO_B_LOCB502_1
(TUBULIN BETA CHAIN)		 1ej6 LAMBDA1
(Reovirus
sp.) 		5 / 12 LEU B 595
ALA B 815
LEU B 549
ALA B 885
ILE B 551
 None
 1.10A 5mioB-1ej6B:
undetectable		 5mioB-1ej6B:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_C_08JC602_1
(CYTOCHROME P450 3A4)		 1ej6 LAMBDA1
(Reovirus
sp.) 		5 / 7 ARG B 765
SER B 805
ALA B 885
ILE B 631
LEU B 581
 None
 1.40A 5te8C-1ej6B:
undetectable		 5te8C-1ej6B:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_1
(CYTOCHROME P450 3A4)		 1ej6 LAMBDA1
(Reovirus
sp.) 		5 / 12 ASP B 921
PHE B 915
PHE B 727
ALA B 487
ALA B 823
 None
 1.20A 5vcgA-1ej6B:
0.0		 5vcgA-1ej6B:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1ej6 LAMBDA1
(Reovirus
sp.) 		4 / 5 TYR B 407
MET B 406
THR B 453
LEU B 262
 None
 1.20A 5x1bW-1ej6B:
0.0		 5x1bW-1ej6B:
4.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1ej6 LAMBDA1
(Reovirus
sp.) 		4 / 5 TYR B 407
MET B 406
THR B 453
LEU B 262
 None
 1.25A 5z86J-1ej6B:
0.0		 5z86J-1ej6B:
4.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FZB_B_SRYB301_1
(STREPTOMYCIN
3''-ADENYLYLTRANSFER
ASE)		 1ej6 LAMBDA1
(Reovirus
sp.) 		5 / 12 ASP B1152
ASP B1224
ASP B1187
HIS B1188
ILE B1220
 None
 1.32A 6fzbB-1ej6B:
0.0		 6fzbB-1ej6B:
5.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		 1ej6 LAMBDA1
(Reovirus
sp.) 		4 / 6 ARG B 355
SER B 954
ALA B 957
ALA B 936
 None
 1.15A 6ma6A-1ej6B:
0.0		 6ma6A-1ej6B:
4.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_W_CHDW102_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1ej6 LAMBDA1
(Reovirus
sp.) 		4 / 5 TYR B 407
MET B 406
THR B 453
LEU B 262
 None
 1.32A 6nknW-1ej6B:
0.0		 6nknW-1ej6B:
4.24