SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ej8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_A_ACTA1122_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 1ej8 LYS7
(Saccharomyces
cerevisiae) 		4 / 7 SER A 132
LYS A 152
SER A 193
VAL A 191
 None
 1.30A 2j9cA-1ej8A:
0.0
2j9cB-1ej8A:
0.0
2j9cC-1ej8A:
0.0		 2j9cA-1ej8A:
20.39
2j9cB-1ej8A:
20.39
2j9cC-1ej8A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDI_A_SAMA601_0
(METHYLTRANSFERASE)		 1ej8 LYS7
(Saccharomyces
cerevisiae) 		5 / 12 GLU A 158
ILE A 157
PHE A 153
THR A 174
ILE A 118
 None
 1.04A 3ndiA-1ej8A:
undetectable		 3ndiA-1ej8A:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 1ej8 LYS7
(Saccharomyces
cerevisiae) 		4 / 6 GLU A 200
GLU A 202
TYR A  90
GLU A 125
 None
 1.44A 4mi4A-1ej8A:
undetectable		 4mi4A-1ej8A:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_E_PARE500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 1ej8 LYS7
(Saccharomyces
cerevisiae) 		5 / 12 SER A 195
LEU A 196
SER A 210
TYR A  90
GLY A 127
 None
 1.41A 4qb9E-1ej8A:
undetectable		 4qb9E-1ej8A:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_2
(CYTOCHROME P450 3A5)		 1ej8 LYS7
(Saccharomyces
cerevisiae) 		4 / 5 PHE A 116
PHE A 175
LEU A 115
LEU A 103
 None
 0.88A 5veuH-1ej8A:
0.0		 5veuH-1ej8A:
16.14