SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ejb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Z_B_ROCB505_1
(PROTEIN (PROTEASE))		 1ejb LUMAZINE SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A  37
ALA A  38
ILE A 121
GLY A 123
ILE A  21
 None
 1.00A 1c6zA-1ejbA:
undetectable		 1c6zA-1ejbA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Z_B_ROCB505_2
(PROTEIN (PROTEASE))		 1ejb LUMAZINE SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A  37
ALA A  38
ILE A 121
GLY A 123
ILE A  21
 None
 0.94A 1c6zB-1ejbA:
undetectable		 1c6zB-1ejbA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G60_B_SAMB501_0
(ADENINE-SPECIFIC
METHYLTRANSFERASE
MBOIIA)		 1ejb LUMAZINE SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 12 ASN A  50
ILE A  85
PRO A  86
GLY A  20
THR A  67
 None
 1.47A 1g60B-1ejbA:
0.0		 1g60B-1ejbA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE9_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		 1ejb LUMAZINE SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 4 LEU A 109
ILE A  31
ARG A  28
TRP A  26
 None
None
None
INJ  A 200 (-3.9A)
 1.44A 1ie9A-1ejbA:
undetectable		 1ie9A-1ejbA:
19.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KYV_A_RBFA501_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1ejb LUMAZINE SYNTHASE
(Saccharomyces
cerevisiae) 		6 / 12 TRP A  26
GLY A  59
SER A  60
GLU A  62
LEU A  90
ILE A 101
 INJ  A 200 (-3.9A)
INJ  A 200 (-3.3A)
INJ  A 200 (-2.8A)
INJ  A 200 (-2.9A)
INJ  A 200 (-4.2A)
INJ  A 200 (-4.5A)
 0.50A 1kyvA-1ejbA:
25.9
1kyvE-1ejbA:
26.0		 1kyvA-1ejbA:
49.10
1kyvE-1ejbA:
49.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KYV_B_RBFB502_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1ejb LUMAZINE SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 11 TRP A  26
GLY A  59
SER A  60
GLU A  62
LEU A  90
 INJ  A 200 (-3.9A)
INJ  A 200 (-3.3A)
INJ  A 200 (-2.8A)
INJ  A 200 (-2.9A)
INJ  A 200 (-4.2A)
 0.25A 1kyvA-1ejbA:
25.9
1kyvB-1ejbA:
26.0		 1kyvA-1ejbA:
49.10
1kyvB-1ejbA:
49.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KYV_C_RBFC503_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1ejb LUMAZINE SYNTHASE
(Saccharomyces
cerevisiae) 		6 / 12 TRP A  26
GLY A  59
SER A  60
GLU A  62
LEU A  90
ILE A 101
 INJ  A 200 (-3.9A)
INJ  A 200 (-3.3A)
INJ  A 200 (-2.8A)
INJ  A 200 (-2.9A)
INJ  A 200 (-4.2A)
INJ  A 200 (-4.5A)
 0.50A 1kyvB-1ejbA:
26.0
1kyvC-1ejbA:
26.1		 1kyvB-1ejbA:
49.10
1kyvC-1ejbA:
49.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KYV_D_RBFD504_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1ejb LUMAZINE SYNTHASE
(Saccharomyces
cerevisiae) 		6 / 12 TRP A  26
GLY A  59
SER A  60
GLU A  62
LEU A  90
ILE A 101
 INJ  A 200 (-3.9A)
INJ  A 200 (-3.3A)
INJ  A 200 (-2.8A)
INJ  A 200 (-2.9A)
INJ  A 200 (-4.2A)
INJ  A 200 (-4.5A)
 0.49A 1kyvC-1ejbA:
26.1
1kyvD-1ejbA:
25.9		 1kyvC-1ejbA:
49.10
1kyvD-1ejbA:
49.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KYV_E_RBFE505_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1ejb LUMAZINE SYNTHASE
(Saccharomyces
cerevisiae) 		6 / 12 TRP A  26
GLY A  59
SER A  60
GLU A  62
LEU A  90
ILE A 101
 INJ  A 200 (-3.9A)
INJ  A 200 (-3.3A)
INJ  A 200 (-2.8A)
INJ  A 200 (-2.9A)
INJ  A 200 (-4.2A)
INJ  A 200 (-4.5A)
 0.49A 1kyvD-1ejbA:
25.9
1kyvE-1ejbA:
26.0		 1kyvD-1ejbA:
49.10
1kyvE-1ejbA:
49.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_B_RITB301_2
(PROTEASE)		 1ejb LUMAZINE SYNTHASE
(Saccharomyces
cerevisiae) 		6 / 11 ARG A  28
GLY A  37
ALA A  38
ILE A 121
GLY A 123
ILE A  21
 None
 1.42A 1n49B-1ejbA:
undetectable		 1n49B-1ejbA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_D_RITD401_1
(PROTEASE)		 1ejb LUMAZINE SYNTHASE
(Saccharomyces
cerevisiae) 		6 / 11 ARG A  28
GLY A  37
ALA A  38
ILE A 121
GLY A 123
ILE A  21
 None
 1.41A 1n49C-1ejbA:
undetectable		 1n49C-1ejbA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T87_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 1ejb LUMAZINE SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 7 THR A 105
LEU A 124
VAL A  57
ILE A  22
 None
 0.92A 1t87B-1ejbA:
0.0		 1t87B-1ejbA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1O_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 1ejb LUMAZINE SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 9 THR A 105
LEU A 124
GLY A  88
VAL A  57
ILE A  22
 None
 1.14A 2a1oB-1ejbA:
undetectable		 2a1oB-1ejbA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q9R_A_BEZA203_0
(PROTEIN OF UNKNOWN
FUNCTION)		 1ejb LUMAZINE SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 5 LEU A  34
GLY A  37
ILE A  21
ILE A  87
 None
 0.83A 2q9rA-1ejbA:
undetectable		 2q9rA-1ejbA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZLC_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		 1ejb LUMAZINE SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 109
ILE A  31
ARG A  28
TRP A  26
 None
None
None
INJ  A 200 (-3.9A)
 1.43A 2zlcA-1ejbA:
undetectable		 2zlcA-1ejbA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH504_3
(PHOSPHOLIPASE A2)		 1ejb LUMAZINE SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 11 VAL A  83
LEU A  81
GLY A  20
ILE A  54
THR A  67
 None
 1.22A 3bjwH-1ejbA:
0.0		 3bjwH-1ejbA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_A_DR7A100_1
(PROTEASE)		 1ejb LUMAZINE SYNTHASE
(Saccharomyces
cerevisiae) 		6 / 11 ARG A  28
GLY A  37
ALA A  38
ILE A 121
LEU A 125
ILE A  21
 None
 1.35A 3em4A-1ejbA:
undetectable		 3em4A-1ejbA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAT_B_BEZB1000_0
(BENZOATE-COENZYME A
LIGASE)		 1ejb LUMAZINE SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 9 ALA A 156
ALA A  38
GLY A 149
ILE A  87
ILE A  21
 None
 1.14A 4eatB-1ejbA:
3.1		 4eatB-1ejbA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_A_STRA604_1
(CYTOCHROME P450
21-HYDROXYLASE)		 1ejb LUMAZINE SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 12 SER A  60
VAL A  35
LEU A  34
ILE A  87
GLY A 123
 INJ  A 200 (-2.8A)
None
None
None
None
 1.01A 4y8wA-1ejbA:
0.0		 4y8wA-1ejbA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_B_STRB603_1
(CYTOCHROME P450
21-HYDROXYLASE)		 1ejb LUMAZINE SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 12 SER A  60
VAL A  35
LEU A  34
ILE A  87
GLY A 123
 INJ  A 200 (-2.8A)
None
None
None
None
 1.01A 4y8wB-1ejbA:
0.0		 4y8wB-1ejbA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBS_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 1ejb LUMAZINE SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 12 VAL A  89
LEU A 125
ALA A 137
ILE A  52
ILE A  87
 None
 1.12A 5hbsA-1ejbA:
undetectable		 5hbsA-1ejbA:
20.45