SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ek2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA154_1
(CALMODULIN)		 1ek2 EPOXIDE HYDROLASE
(Mus
musculus) 		4 / 7 GLU A 314
LEU A 248
MET A 291
MET A 338
 None
 1.09A 1linA-1ek2A:
undetectable		 1linA-1ek2A:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUK_L_ACTL611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 1ek2 EPOXIDE HYDROLASE
(Mus
musculus) 		4 / 6 LEU A 479
LEU A 344
TRP A 509
PHE A 360
 None
 1.44A 1rukH-1ek2A:
undetectable
1rukL-1ek2A:
undetectable		 1rukH-1ek2A:
17.44
1rukL-1ek2A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1ek2 EPOXIDE HYDROLASE
(Mus
musculus) 		3 / 3 SER A 503
ASP A 495
CYH A 521
 None
 1.18A 2br4E-1ek2A:
1.3		 2br4E-1ek2A:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA2_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1ek2 EPOXIDE HYDROLASE
(Mus
musculus) 		5 / 12 PHE A 403
SER A 271
HIS A 263
PHE A 406
TYR A 294
 None
None
None
CDU  A1100 (-4.6A)
None
 1.32A 3adsA-1ek2A:
0.0		 3adsA-1ek2A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_A_IMNA2_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1ek2 EPOXIDE HYDROLASE
(Mus
musculus) 		5 / 12 PHE A 403
SER A 271
HIS A 263
PHE A 406
TYR A 294
 None
None
None
CDU  A1100 (-4.6A)
None
 1.32A 3adxA-1ek2A:
undetectable		 3adxA-1ek2A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_B_478B200_1
(PROTEASE)		 1ek2 EPOXIDE HYDROLASE
(Mus
musculus) 		5 / 8 LEU A 541
GLY A 283
ALA A 282
ILE A 276
ILE A 538
 None
 1.15A 3ekpA-1ek2A:
undetectable		 3ekpA-1ek2A:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FO7_A_IMNA301_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 1ek2 EPOXIDE HYDROLASE
(Mus
musculus) 		4 / 5 HIS A 263
ASP A 290
TYR A 294
PRO A 461
 None
 1.32A 3fo7A-1ek2A:
undetectable		 3fo7A-1ek2A:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN8_A_DEXA247_2
(GLUCOCORTICOID
RECEPTOR 2)		 1ek2 EPOXIDE HYDROLASE
(Mus
musculus) 		3 / 3 MET A 338
MET A 489
PHE A 329
 None
 1.38A 3gn8A-1ek2A:
0.0		 3gn8A-1ek2A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H1X_A_IMNA301_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 1ek2 EPOXIDE HYDROLASE
(Mus
musculus) 		4 / 5 HIS A 263
ASP A 290
TYR A 294
PRO A 461
 None
 1.28A 3h1xA-1ek2A:
undetectable		 3h1xA-1ek2A:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_B_D16B530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1ek2 EPOXIDE HYDROLASE
(Mus
musculus) 		5 / 12 ALA A 109
ILE A 121
ASN A 125
LEU A 143
PHE A 147
 None
 1.24A 3nrrB-1ek2A:
1.9		 3nrrB-1ek2A:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_A_DXCA91_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1ek2 EPOXIDE HYDROLASE
(Mus
musculus) 		3 / 3 PHE A 458
GLN A 382
PHE A 403
 None
CDU  A1100 (-3.5A)
None
 0.84A 3rv5A-1ek2A:
undetectable		 3rv5A-1ek2A:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SM2_A_478A126_2
(GAG-PRO-POL
POLYPROTEIN)		 1ek2 EPOXIDE HYDROLASE
(Mus
musculus) 		5 / 11 HIS A 204
GLY A  12
ALA A  15
LEU A 202
LEU A 210
 None
 1.03A 3sm2B-1ek2A:
undetectable		 3sm2B-1ek2A:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_A_9PLA501_1
(CYTOCHROME P450 2A6)		 1ek2 EPOXIDE HYDROLASE
(Mus
musculus) 		5 / 11 PHE A 406
ILE A 427
THR A 402
LEU A 462
PHE A 265
 CDU  A1100 (-4.6A)
None
None
None
None
 0.93A 3t3rA-1ek2A:
undetectable		 3t3rA-1ek2A:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_D_9PLD1_1
(CYTOCHROME P450 2A13)		 1ek2 EPOXIDE HYDROLASE
(Mus
musculus) 		4 / 8 ALA A 108
PHE A 221
PHE A 117
ALA A   6
 None
 0.85A 3t3sD-1ek2A:
undetectable		 3t3sD-1ek2A:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_A_ADNA401_1
(ADENOSINE KINASE)		 1ek2 EPOXIDE HYDROLASE
(Mus
musculus) 		5 / 12 LEU A 462
GLY A 425
ALA A 421
VAL A 390
LEU A 395
 None
 1.02A 4dc3A-1ek2A:
3.4		 4dc3A-1ek2A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_B_NCTB501_1
(CYTOCHROME P450 2A6)		 1ek2 EPOXIDE HYDROLASE
(Mus
musculus) 		4 / 7 PHE A 385
PHE A 406
THR A 402
PHE A 265
 None
CDU  A1100 (-4.6A)
None
None
 1.00A 4ejjB-1ek2A:
0.0		 4ejjB-1ek2A:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_C_NCTC501_1
(CYTOCHROME P450 2A6)		 1ek2 EPOXIDE HYDROLASE
(Mus
musculus) 		4 / 5 PHE A 385
PHE A 406
ILE A 427
THR A 402
 None
CDU  A1100 (-4.6A)
None
None
 0.98A 4ejjC-1ek2A:
0.0		 4ejjC-1ek2A:
23.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4J03_A_FVSA603_1
(BIFUNCTIONAL EPOXIDE
HYDROLASE 2)		 1ek2 EPOXIDE HYDROLASE
(Mus
musculus) 		8 / 12 ASP A 333
PHE A 379
TYR A 381
PHE A 385
TYR A 465
LEU A 498
HIS A 523
TRP A 524
 CDU  A1100 (-3.2A)
None
CDU  A1100 (-4.4A)
None
CDU  A1100 (-4.2A)
None
CDU  A1100 (-4.1A)
None
 0.45A 4j03A-1ek2A:
50.9		 4j03A-1ek2A:
73.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QE6_A_JN3A1001_1
(BILE ACID RECEPTOR)		 1ek2 EPOXIDE HYDROLASE
(Mus
musculus) 		5 / 12 ALA A 109
MET A 105
ARG A 103
ILE A 101
ILE A 121
 None
 1.44A 4qe6A-1ek2A:
0.0		 4qe6A-1ek2A:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_1
(CYTOCHROME P450 2D6)		 1ek2 EPOXIDE HYDROLASE
(Mus
musculus) 		5 / 12 PHE A 458
LEU A 462
GLY A 426
LEU A 428
ALA A 393
 None
 1.12A 4wnwB-1ek2A:
0.0		 4wnwB-1ek2A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 1ek2 EPOXIDE HYDROLASE
(Mus
musculus) 		5 / 12 GLU A 267
LEU A 395
GLU A 445
GLU A 394
ILE A 427
 None
 1.27A 4xe5A-1ek2A:
undetectable		 4xe5A-1ek2A:
20.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_1
(ESTROGEN RECEPTOR)		 1ek2 EPOXIDE HYDROLASE
(Mus
musculus) 		5 / 12 THR A 358
LEU A 356
LEU A 488
MET A 506
ILE A 510
 None
 1.15A 5gs4A-1ek2A:
undetectable		 5gs4A-1ek2A:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_A_RITA602_2
(CYTOCHROME P450 3A5)		 1ek2 EPOXIDE HYDROLASE
(Mus
musculus) 		3 / 3 ARG A 470
PHE A 265
LEU A 311
 None
 0.87A 5veuA-1ek2A:
0.0		 5veuA-1ek2A:
23.91