SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ek6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4Y_A_TPVA501_2
(PROTEIN (HIV-1
PROTEASE))		 1ek6 UDP-GALACTOSE
4-EPIMERASE
(Homo
sapiens) 		4 / 8 LEU A  68
ALA A  89
ILE A 164
ILE A  67
 None
NAI  A 400 (-3.7A)
None
NAI  A 400 (-3.8A)
 0.69A 1d4yB-1ek6A:
undetectable		 1d4yB-1ek6A:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S8F_B_BEZB1503_0
(RAS-RELATED PROTEIN
RAB-9A)		 1ek6 UDP-GALACTOSE
4-EPIMERASE
(Homo
sapiens) 		4 / 6 VAL A  19
GLU A  24
LEU A  22
ARG A  58
 None
 1.10A 1s8fB-1ek6A:
5.5		 1s8fB-1ek6A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN0_B_T44B602_1
(TRANSTHYRETIN)		 1ek6 UDP-GALACTOSE
4-EPIMERASE
(Homo
sapiens) 		4 / 7 LYS A 257
GLU A 260
ALA A 254
ALA A 314
 TMA  A 950 (-3.5A)
TMA  A 950 (-3.8A)
None
None
 1.11A 1sn0B-1ek6A:
0.0
1sn0D-1ek6A:
0.0		 1sn0B-1ek6A:
14.94
1sn0D-1ek6A:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAY_A_ADNA1001_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 1ek6 UDP-GALACTOSE
4-EPIMERASE
(Homo
sapiens) 		6 / 11 GLY A   9
ALA A  11
ASP A  33
ASP A  66
ALA A  89
VAL A 107
 NAI  A 400 (-3.3A)
NAI  A 400 ( 4.3A)
NAI  A 400 (-2.7A)
NAI  A 400 (-3.1A)
NAI  A 400 (-3.7A)
NAI  A 400 ( 4.7A)
 0.50A 1uayA-1ek6A:
17.7		 1uayA-1ek6A:
25.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAY_B_ADNB1002_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 1ek6 UDP-GALACTOSE
4-EPIMERASE
(Homo
sapiens) 		6 / 10 GLY A   9
ALA A  11
ASP A  33
ASP A  66
ALA A  89
VAL A 107
 NAI  A 400 (-3.3A)
NAI  A 400 ( 4.3A)
NAI  A 400 (-2.7A)
NAI  A 400 (-3.1A)
NAI  A 400 (-3.7A)
NAI  A 400 ( 4.7A)
 0.53A 1uayB-1ek6A:
18.0		 1uayB-1ek6A:
25.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_1
(POL POLYPROTEIN)		 1ek6 UDP-GALACTOSE
4-EPIMERASE
(Homo
sapiens) 		5 / 12 LEU A  68
GLY A  90
ALA A  89
ILE A 164
ILE A  67
 None
NAI  A 400 (-4.1A)
NAI  A 400 (-3.7A)
None
NAI  A 400 (-3.8A)
 0.77A 2avvA-1ek6A:
undetectable		 2avvA-1ek6A:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IDW_B_017B401_2
(PROTEASE)		 1ek6 UDP-GALACTOSE
4-EPIMERASE
(Homo
sapiens) 		5 / 9 LEU A  68
GLY A  90
ALA A  89
ILE A 164
ILE A  67
 None
NAI  A 400 (-4.1A)
NAI  A 400 (-3.7A)
None
NAI  A 400 (-3.8A)
 0.82A 2idwB-1ek6A:
undetectable		 2idwB-1ek6A:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_3
(PROTEASE)		 1ek6 UDP-GALACTOSE
4-EPIMERASE
(Homo
sapiens) 		5 / 12 LEU A  68
GLY A  90
ALA A  89
ILE A 164
ILE A  67
 None
NAI  A 400 (-4.1A)
NAI  A 400 (-3.7A)
None
NAI  A 400 (-3.8A)
 0.83A 2nmzB-1ek6A:
undetectable		 2nmzB-1ek6A:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OMB_A_IPHA2001_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 1ek6 UDP-GALACTOSE
4-EPIMERASE
(Homo
sapiens) 		4 / 5 HIS A 148
PRO A 139
TYR A 141
TYR A 308
 None
 1.36A 2ombA-1ek6A:
undetectable
2ombB-1ek6A:
undetectable		 2ombA-1ek6A:
22.22
2ombB-1ek6A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q8H_A_TF4A438_1
([PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 1)		 1ek6 UDP-GALACTOSE
4-EPIMERASE
(Homo
sapiens) 		4 / 6 LEU A  22
TYR A  27
ILE A  86
ILE A 252
 None
TMA  A 952 ( 3.6A)
None
None
 0.99A 2q8hA-1ek6A:
undetectable		 2q8hA-1ek6A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_A_BEZA1222_0
(PEROXIREDOXIN 6)		 1ek6 UDP-GALACTOSE
4-EPIMERASE
(Homo
sapiens) 		4 / 7 VAL A 212
SER A 213
GLU A 199
PRO A 205
 None
 1.05A 2v2gA-1ek6A:
undetectable
2v2gB-1ek6A:
undetectable		 2v2gA-1ek6A:
22.78
2v2gB-1ek6A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_B_BEZB1220_0
(PEROXIREDOXIN 6)		 1ek6 UDP-GALACTOSE
4-EPIMERASE
(Homo
sapiens) 		4 / 7 PRO A 205
VAL A 212
SER A 213
GLU A 199
 None
 1.04A 2v2gA-1ek6A:
undetectable
2v2gB-1ek6A:
undetectable		 2v2gA-1ek6A:
22.78
2v2gB-1ek6A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_C_BEZC1222_0
(PEROXIREDOXIN 6)		 1ek6 UDP-GALACTOSE
4-EPIMERASE
(Homo
sapiens) 		4 / 7 VAL A 212
SER A 213
GLU A 199
PRO A 205
 None
 1.06A 2v2gC-1ek6A:
undetectable
2v2gD-1ek6A:
undetectable		 2v2gC-1ek6A:
22.78
2v2gD-1ek6A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_D_BEZD1221_0
(PEROXIREDOXIN 6)		 1ek6 UDP-GALACTOSE
4-EPIMERASE
(Homo
sapiens) 		4 / 7 PRO A 205
VAL A 212
SER A 213
GLU A 199
 None
 1.05A 2v2gC-1ek6A:
undetectable
2v2gD-1ek6A:
undetectable		 2v2gC-1ek6A:
22.78
2v2gD-1ek6A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_E_BEZE1222_0
(PEROXIREDOXIN 6.)		 1ek6 UDP-GALACTOSE
4-EPIMERASE
(Homo
sapiens) 		4 / 7 VAL A 212
SER A 213
GLU A 199
PRO A 205
 None
 1.04A 2v41E-1ek6A:
undetectable
2v41F-1ek6A:
undetectable		 2v41E-1ek6A:
22.78
2v41F-1ek6A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BVB_B_017B401_2
(PROTEASE
(RETROPEPSIN))		 1ek6 UDP-GALACTOSE
4-EPIMERASE
(Homo
sapiens) 		5 / 12 LEU A  68
GLY A  90
ALA A  89
ILE A 164
ILE A  67
 None
NAI  A 400 (-4.1A)
NAI  A 400 (-3.7A)
None
NAI  A 400 (-3.8A)
 0.76A 3bvbB-1ek6A:
undetectable		 3bvbB-1ek6A:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_B_478B200_1
(PROTEASE)		 1ek6 UDP-GALACTOSE
4-EPIMERASE
(Homo
sapiens) 		5 / 8 LEU A  68
GLY A  90
ALA A  89
ILE A 164
ILE A  67
 None
NAI  A 400 (-4.1A)
NAI  A 400 (-3.7A)
None
NAI  A 400 (-3.8A)
 0.88A 3ekpA-1ek6A:
0.0		 3ekpA-1ek6A:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_D_017D200_1
(PROTEASE)		 1ek6 UDP-GALACTOSE
4-EPIMERASE
(Homo
sapiens) 		5 / 11 LEU A  68
GLY A  90
ALA A  89
ILE A 164
ILE A  67
 None
NAI  A 400 (-4.1A)
NAI  A 400 (-3.7A)
None
NAI  A 400 (-3.8A)
 0.87A 3ektC-1ek6A:
undetectable		 3ektC-1ek6A:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKV_A_478A200_1
(PROTEASE)		 1ek6 UDP-GALACTOSE
4-EPIMERASE
(Homo
sapiens) 		5 / 10 LEU A  68
GLY A  90
ALA A  89
ILE A 164
ILE A  67
 None
NAI  A 400 (-4.1A)
NAI  A 400 (-3.7A)
None
NAI  A 400 (-3.8A)
 0.86A 3ekvA-1ek6A:
undetectable		 3ekvA-1ek6A:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 1ek6 UDP-GALACTOSE
4-EPIMERASE
(Homo
sapiens) 		5 / 12 ILE A  14
GLY A  15
GLY A  12
ALA A  38
ALA A  89
 NAI  A 400 (-3.9A)
None
NAI  A 400 (-3.3A)
NAI  A 400 (-3.4A)
NAI  A 400 (-3.7A)
 0.92A 3jb2A-1ek6A:
4.5		 3jb2A-1ek6A:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXI_A_CAMA423_0
(CYTOCHROME P450)		 1ek6 UDP-GALACTOSE
4-EPIMERASE
(Homo
sapiens) 		5 / 10 LEU A 247
LEU A 269
GLY A 250
VAL A 128
VAL A 181
 None
 1.31A 3lxiA-1ek6A:
undetectable		 3lxiA-1ek6A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU3_B_478B401_2
(PROTEASE)		 1ek6 UDP-GALACTOSE
4-EPIMERASE
(Homo
sapiens) 		5 / 11 LEU A  68
GLY A  90
ALA A  89
ILE A 164
ILE A  67
 None
NAI  A 400 (-4.1A)
NAI  A 400 (-3.7A)
None
NAI  A 400 (-3.8A)
 0.81A 3nu3B-1ek6A:
undetectable		 3nu3B-1ek6A:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU4_B_478B401_2
(PROTEASE)		 1ek6 UDP-GALACTOSE
4-EPIMERASE
(Homo
sapiens) 		5 / 9 LEU A  68
GLY A  90
ALA A  89
ILE A 164
ILE A  67
 None
NAI  A 400 (-4.1A)
NAI  A 400 (-3.7A)
None
NAI  A 400 (-3.8A)
 0.77A 3nu4B-1ek6A:
undetectable		 3nu4B-1ek6A:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUJ_B_478B401_2
(PROTEASE)		 1ek6 UDP-GALACTOSE
4-EPIMERASE
(Homo
sapiens) 		5 / 9 LEU A  68
GLY A  90
ALA A  89
ILE A 164
ILE A  67
 None
NAI  A 400 (-4.1A)
NAI  A 400 (-3.7A)
None
NAI  A 400 (-3.8A)
 0.74A 3nujB-1ek6A:
undetectable		 3nujB-1ek6A:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUO_B_478B478_2
(PROTEASE)		 1ek6 UDP-GALACTOSE
4-EPIMERASE
(Homo
sapiens) 		5 / 9 LEU A  68
GLY A  90
ALA A  89
ILE A 164
ILE A  67
 None
NAI  A 400 (-4.1A)
NAI  A 400 (-3.7A)
None
NAI  A 400 (-3.8A)
 0.78A 3nuoB-1ek6A:
undetectable		 3nuoB-1ek6A:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3O_A_DLUA399_1
(PFV INTEGRASE)		 1ek6 UDP-GALACTOSE
4-EPIMERASE
(Homo
sapiens) 		4 / 7 PRO A 210
GLN A 214
GLU A 199
ARG A 300
 None
None
None
UPG  A 401 (-2.8A)
 1.28A 3s3oA-1ek6A:
1.0		 3s3oA-1ek6A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S54_B_017B201_1
(PROTEASE)		 1ek6 UDP-GALACTOSE
4-EPIMERASE
(Homo
sapiens) 		5 / 12 LEU A  68
GLY A  90
ALA A  89
VAL A  85
ILE A  67
 None
NAI  A 400 (-4.1A)
NAI  A 400 (-3.7A)
None
NAI  A 400 (-3.8A)
 0.88A 3s54A-1ek6A:
undetectable		 3s54A-1ek6A:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S54_B_017B201_2
(PROTEASE)		 1ek6 UDP-GALACTOSE
4-EPIMERASE
(Homo
sapiens) 		5 / 12 LEU A  68
GLY A  90
ALA A  89
ILE A 164
ILE A  67
 None
NAI  A 400 (-4.1A)
NAI  A 400 (-3.7A)
None
NAI  A 400 (-3.8A)
 0.80A 3s54B-1ek6A:
undetectable		 3s54B-1ek6A:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9P_A_CAMA423_0
(CYTOCHROME P450)		 1ek6 UDP-GALACTOSE
4-EPIMERASE
(Homo
sapiens) 		5 / 9 LEU A 247
LEU A 269
GLY A 250
VAL A 128
VAL A 181
 None
 1.31A 4c9pA-1ek6A:
undetectable		 4c9pA-1ek6A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQF_B_017B101_2
(ASPARTYL PROTEASE)		 1ek6 UDP-GALACTOSE
4-EPIMERASE
(Homo
sapiens) 		5 / 10 LEU A  68
GLY A  90
ALA A  89
ILE A 164
ILE A  67
 None
NAI  A 400 (-4.1A)
NAI  A 400 (-3.7A)
None
NAI  A 400 (-3.8A)
 0.83A 4dqfB-1ek6A:
undetectable		 4dqfB-1ek6A:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_1
(HIV-1 PROTEASE)		 1ek6 UDP-GALACTOSE
4-EPIMERASE
(Homo
sapiens) 		5 / 12 LEU A  68
GLY A  90
ALA A  89
ILE A 164
ILE A  67
 None
NAI  A 400 (-4.1A)
NAI  A 400 (-3.7A)
None
NAI  A 400 (-3.8A)
 0.83A 4jecA-1ek6A:
undetectable		 4jecA-1ek6A:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A201_2
(PROTEASE)		 1ek6 UDP-GALACTOSE
4-EPIMERASE
(Homo
sapiens) 		5 / 10 LEU A  68
GLY A  90
ALA A  89
ILE A 164
ILE A  67
 None
NAI  A 400 (-4.1A)
NAI  A 400 (-3.7A)
None
NAI  A 400 (-3.8A)
 0.86A 4ll3B-1ek6A:
undetectable		 4ll3B-1ek6A:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A202_1
(PROTEASE)		 1ek6 UDP-GALACTOSE
4-EPIMERASE
(Homo
sapiens) 		5 / 10 LEU A  68
GLY A  90
ALA A  89
ILE A 164
ILE A  67
 None
NAI  A 400 (-4.1A)
NAI  A 400 (-3.7A)
None
NAI  A 400 (-3.8A)
 0.88A 4ll3A-1ek6A:
undetectable		 4ll3A-1ek6A:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 1ek6 UDP-GALACTOSE
4-EPIMERASE
(Homo
sapiens) 		4 / 7 ASN A 207
GLU A 199
TYR A 211
ARG A 220
 UPG  A 401 (-3.1A)
None
UPG  A 401 ( 4.7A)
None
 1.18A 4mi4B-1ek6A:
undetectable
4mi4C-1ek6A:
undetectable		 4mi4B-1ek6A:
19.65
4mi4C-1ek6A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD9_A_ADNA501_2
(NUPC FAMILY PROTEIN)		 1ek6 UDP-GALACTOSE
4-EPIMERASE
(Homo
sapiens) 		3 / 3 THR A 232
ASN A 187
PHE A 186
 None
UPG  A 401 (-3.3A)
None
 0.84A 4pd9A-1ek6A:
0.0		 4pd9A-1ek6A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_A_SAMA401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 1ek6 UDP-GALACTOSE
4-EPIMERASE
(Homo
sapiens) 		5 / 11 GLY A   9
GLY A  10
THR A  18
ASP A  33
ASP A  66
 NAI  A 400 (-3.3A)
None
None
NAI  A 400 (-2.7A)
NAI  A 400 (-3.1A)
 0.69A 4pghA-1ek6A:
5.8		 4pghA-1ek6A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_D_SAMD401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 1ek6 UDP-GALACTOSE
4-EPIMERASE
(Homo
sapiens) 		5 / 12 GLY A   9
GLY A  10
THR A  18
ASP A  33
ASP A  66
 NAI  A 400 (-3.3A)
None
None
NAI  A 400 (-2.7A)
NAI  A 400 (-3.1A)
 1.15A 4pghD-1ek6A:
4.7		 4pghD-1ek6A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QD3_A_5AEA201_1
(PEPTIDYL-TRNA
HYDROLASE)		 1ek6 UDP-GALACTOSE
4-EPIMERASE
(Homo
sapiens) 		5 / 9 LEU A  49
GLY A  12
VAL A  31
VAL A  19
LEU A  22
 None
NAI  A 400 (-3.3A)
None
None
None
 1.15A 4qd3A-1ek6A:
2.7		 4qd3A-1ek6A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_B_478B101_2
(HIV-1 PROTEASE)		 1ek6 UDP-GALACTOSE
4-EPIMERASE
(Homo
sapiens) 		5 / 9 LEU A  68
GLY A  90
ALA A  89
ILE A 164
ILE A  67
 None
NAI  A 400 (-4.1A)
NAI  A 400 (-3.7A)
None
NAI  A 400 (-3.8A)
 0.79A 4rvjB-1ek6A:
undetectable		 4rvjB-1ek6A:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_D_478D101_2
(HIV-1 PROTEASE)		 1ek6 UDP-GALACTOSE
4-EPIMERASE
(Homo
sapiens) 		5 / 9 LEU A  68
GLY A  90
ALA A  89
ILE A 164
ILE A  67
 None
NAI  A 400 (-4.1A)
NAI  A 400 (-3.7A)
None
NAI  A 400 (-3.8A)
 0.79A 4rvjD-1ek6A:
undetectable		 4rvjD-1ek6A:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_A_SAMA301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 1ek6 UDP-GALACTOSE
4-EPIMERASE
(Homo
sapiens) 		5 / 12 GLY A   9
GLY A  12
THR A  18
ASP A  33
ILE A  67
 NAI  A 400 (-3.3A)
NAI  A 400 (-3.3A)
None
NAI  A 400 (-2.7A)
NAI  A 400 (-3.8A)
 1.10A 5bw4A-1ek6A:
5.5		 5bw4A-1ek6A:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5K_B_017B201_1
(HIV-1 PROTEASE)		 1ek6 UDP-GALACTOSE
4-EPIMERASE
(Homo
sapiens) 		5 / 12 LEU A  68
GLY A  90
ALA A  89
ILE A 164
ILE A  67
 None
NAI  A 400 (-4.1A)
NAI  A 400 (-3.7A)
None
NAI  A 400 (-3.8A)
 0.80A 5e5kA-1ek6A:
undetectable		 5e5kA-1ek6A:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_1
(CDL2.3A)		 1ek6 UDP-GALACTOSE
4-EPIMERASE
(Homo
sapiens) 		5 / 12 LEU A  76
PHE A  77
LEU A 127
LEU A 116
ALA A  89
 None
None
None
None
NAI  A 400 (-3.7A)
 0.97A 5ieoA-1ek6A:
0.0		 5ieoA-1ek6A:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_1
(CDL2.3B)		 1ek6 UDP-GALACTOSE
4-EPIMERASE
(Homo
sapiens) 		5 / 12 LEU A  76
PHE A  77
LEU A 127
LEU A 116
ALA A  89
 None
None
None
None
NAI  A 400 (-3.7A)
 0.98A 5iepA-1ek6A:
0.0		 5iepA-1ek6A:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T2Z_B_017B201_2
(PROTEASE)		 1ek6 UDP-GALACTOSE
4-EPIMERASE
(Homo
sapiens) 		5 / 12 LEU A  68
GLY A  90
ALA A  89
ILE A 164
ILE A  67
 None
NAI  A 400 (-4.1A)
NAI  A 400 (-3.7A)
None
NAI  A 400 (-3.8A)
 0.78A 5t2zB-1ek6A:
undetectable		 5t2zB-1ek6A:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_B_SALB203_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 1ek6 UDP-GALACTOSE
4-EPIMERASE
(Homo
sapiens) 		4 / 6 PRO A 139
GLY A 137
TYR A 136
VAL A 304
 None
 0.90A 5x80A-1ek6A:
0.0
5x80B-1ek6A:
0.0		 5x80A-1ek6A:
19.53
5x80B-1ek6A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_C_SALC201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 1ek6 UDP-GALACTOSE
4-EPIMERASE
(Homo
sapiens) 		4 / 7 VAL A 304
PRO A 139
GLY A 137
TYR A 136
 None
 1.01A 5x80C-1ek6A:
0.0
5x80D-1ek6A:
undetectable		 5x80C-1ek6A:
19.53
5x80D-1ek6A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCN_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1ek6 UDP-GALACTOSE
4-EPIMERASE
(Homo
sapiens) 		5 / 12 ILE A 113
GLY A 111
LEU A 127
ILE A 164
MET A 167
 None
 1.04A 5ycnA-1ek6A:
0.0		 5ycnA-1ek6A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_K_PACK1_0
(SERINE PROTEASE NS3
PEPTIDE
PAC-DLY-DLY-DAR)		 1ek6 UDP-GALACTOSE
4-EPIMERASE
(Homo
sapiens) 		3 / 3 ALA A 133
VAL A  94
TYR A 157
 UPG  A 401 ( 3.7A)
None
UPG  A 401 ( 4.4A)
 0.70A 5zmqH-1ek6A:
0.0		 5zmqH-1ek6A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3A_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 1ek6 UDP-GALACTOSE
4-EPIMERASE
(Homo
sapiens) 		5 / 12 GLY A   9
GLY A  12
ALA A  38
ASP A  66
ILE A  67
 NAI  A 400 (-3.3A)
NAI  A 400 (-3.3A)
NAI  A 400 (-3.4A)
NAI  A 400 (-3.1A)
NAI  A 400 (-3.8A)
 0.85A 6b3aA-1ek6A:
5.3		 6b3aA-1ek6A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3B_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 1ek6 UDP-GALACTOSE
4-EPIMERASE
(Homo
sapiens) 		5 / 12 GLY A   9
GLY A  12
ALA A  38
ASP A  66
ILE A  67
 NAI  A 400 (-3.3A)
NAI  A 400 (-3.3A)
NAI  A 400 (-3.4A)
NAI  A 400 (-3.1A)
NAI  A 400 (-3.8A)
 0.87A 6b3bA-1ek6A:
5.9		 6b3bA-1ek6A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIF_B_TPVB201_1
(HIV-1 PROTEASE)		 1ek6 UDP-GALACTOSE
4-EPIMERASE
(Homo
sapiens) 		5 / 12 LEU A  68
GLY A  90
ALA A  89
ILE A 164
ILE A  67
 None
NAI  A 400 (-4.1A)
NAI  A 400 (-3.7A)
None
NAI  A 400 (-3.8A)
 0.76A 6difB-1ek6A:
undetectable		 6difB-1ek6A:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIL_B_TPVB201_1
(HIV-1 PROTEASE)		 1ek6 UDP-GALACTOSE
4-EPIMERASE
(Homo
sapiens) 		5 / 12 LEU A  68
GLY A  90
ALA A  89
ILE A 164
ILE A  67
 None
NAI  A 400 (-4.1A)
NAI  A 400 (-3.7A)
None
NAI  A 400 (-3.8A)
 0.74A 6dilB-1ek6A:
undetectable		 6dilB-1ek6A:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QYA_B_FOZB401_0
(THYMIDYLATE SYNTHASE)		 1ek6 UDP-GALACTOSE
4-EPIMERASE
(Homo
sapiens) 		5 / 12 LEU A 247
ILE A  14
LEU A  49
GLY A 198
ALA A  38
 None
NAI  A 400 (-3.9A)
None
None
NAI  A 400 (-3.4A)
 1.45A 6qyaB-1ek6A:
0.0		 6qyaB-1ek6A:
22.43