SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ekb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AQ7_B_AG2B4_1
(TRYPSIN
AERUGINOSIN 98-B)		 1ekb ENTEROPEPTIDASE
(Bos
taurus) 		7 / 8 HIS B  57
ASP B 189
SER B 190
GLN B 192
SER B 195
GLY B 216
GLY B 226
 None
 0.55A 1aq7A-1ekbB:
36.6		 1aq7A-1ekbB:
36.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ETR_H_MITH1_1
(EPSILON-THROMBIN)		 1ekb ENTEROPEPTIDASE
(Bos
taurus) 		5 / 12 HIS B  57
ASP B 189
SER B 195
GLY B 216
GLY B 226
 None
 0.67A 1etrH-1ekbB:
35.6		 1etrH-1ekbB:
35.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 1ekb ENTEROPEPTIDASE
(Bos
taurus) 		5 / 8 ASP B 189
SER B 190
SER B 195
GLY B 216
GLY B 226
 None
 0.36A 1f5lA-1ekbB:
36.4		 1f5lA-1ekbB:
34.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RV7_B_AB1B1001_1
(PROTEASE)		 1ekb ENTEROPEPTIDASE
(Bos
taurus) 		5 / 11 ALA B 158
ILE B 145
VAL B 160
THR B 151
ALA B 152
 None
 1.03A 1rv7A-1ekbB:
0.0
1rv7B-1ekbB:
0.0		 1rv7A-1ekbB:
24.84
1rv7B-1ekbB:
24.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TNL_A_TPAA900_1
(TRYPSIN)		 1ekb ENTEROPEPTIDASE
(Bos
taurus) 		5 / 6 ASP B 189
SER B 190
SER B 195
GLY B 216
GLY B 226
 None
 0.28A 1tnlA-1ekbB:
36.4		 1tnlA-1ekbB:
36.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OTV_A_NCAA1301_0
(CATIONIC TRYPSIN)		 1ekb ENTEROPEPTIDASE
(Bos
taurus) 		5 / 6 ASP B 189
SER B 190
SER B 195
GLY B 216
GLY B 226
 None
 0.27A 2otvA-1ekbB:
36.6		 2otvA-1ekbB:
36.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P16_A_GG2A298_1
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 1ekb ENTEROPEPTIDASE
(Bos
taurus) 		5 / 12 ASP B 189
SER B 195
GLY B 216
GLY B 226
TYR B 228
 None
 0.37A 2p16A-1ekbB:
36.4		 2p16A-1ekbB:
28.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VIN_A_505A1247_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR CHAIN B)		 1ekb ENTEROPEPTIDASE
(Bos
taurus) 		5 / 8 ASP B 189
SER B 190
SER B 195
GLY B 216
GLY B 226
 None
 0.29A 2vinA-1ekbB:
37.2		 2vinA-1ekbB:
34.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		 1ekb ENTEROPEPTIDASE
(Bos
taurus) 		5 / 12 ASP B 189
SER B 195
GLY B 216
GLY B 226
TYR B 228
 None
 0.48A 2w26A-1ekbB:
36.6		 2w26A-1ekbB:
28.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1ekb ENTEROPEPTIDASE
(Bos
taurus) 		4 / 8 ILE B 238
ASN B 100
VAL B 212
GLY B 211
 None
 0.95A 3em0B-1ekbB:
0.0		 3em0B-1ekbB:
21.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GY3_A_PNTA246_0
(CATIONIC TRYPSIN)		 1ekb ENTEROPEPTIDASE
(Bos
taurus) 		7 / 11 HIS B  57
ASP B 189
SER B 190
GLN B 192
SER B 195
GLY B 216
GLY B 226
 None
 0.42A 3gy3A-1ekbB:
36.7		 3gy3A-1ekbB:
36.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_B_486B1_2
(GLUCOCORTICOID
RECEPTOR)		 1ekb ENTEROPEPTIDASE
(Bos
taurus) 		5 / 12 GLY B  19
GLY B  18
GLN B 156
VAL B  17
LEU B 155
 None
 1.28A 3h52B-1ekbB:
undetectable		 3h52B-1ekbB:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_A_KKKA413_1
(FLAVOHEMOGLOBIN)		 1ekb ENTEROPEPTIDASE
(Bos
taurus) 		4 / 8 ILE B 121
GLN B 202
ALA B 210
LEU B 209
 None
 0.82A 3ozwA-1ekbB:
undetectable		 3ozwA-1ekbB:
20.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXF_A_4APA9_1
(CATIONIC TRYPSIN)		 1ekb ENTEROPEPTIDASE
(Bos
taurus) 		4 / 6 SER B 190
SER B 195
GLY B 216
GLY B 226
 None
 0.31A 3rxfA-1ekbB:
14.6		 3rxfA-1ekbB:
36.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)		 1ekb ENTEROPEPTIDASE
(Bos
taurus) 		4 / 5 ASP B 189
SER B 190
SER B 195
GLY B 226
 None
 0.32A 3rxhA-1ekbB:
36.7		 3rxhA-1ekbB:
36.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FU8_A_ACTA302_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 1ekb ENTEROPEPTIDASE
(Bos
taurus) 		4 / 5 HIS B  57
GLN B 192
GLY B 193
SER B 195
 None
 0.86A 4fu8A-1ekbB:
36.6		 4fu8A-1ekbB:
34.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_D_NOVD2000_1
(DNA GYRASE SUBUNIT B)		 1ekb ENTEROPEPTIDASE
(Bos
taurus) 		5 / 12 ASN B  75
SER B  74
ASP B 153
ILE B  80
SER B  77
 None
 1.34A 4uroD-1ekbB:
undetectable		 4uroD-1ekbB:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_D_CVID301_1
(REGULATORY PROTEIN
TETR)		 1ekb ENTEROPEPTIDASE
(Bos
taurus) 		4 / 8 GLN B 156
GLY B  18
ILE B 145
GLN B 219
 None
 1.00A 5vlmD-1ekbB:
undetectable		 5vlmD-1ekbB:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_0
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 1ekb ENTEROPEPTIDASE
(Bos
taurus) 		5 / 12 GLY B 196
ALA B  44
ALA B 229
ALA B  55
ALA B  56
 None
 1.04A 5zw4A-1ekbB:
undetectable		 5zw4A-1ekbB:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC607_0
(ALPHA-AMYLASE)		 1ekb ENTEROPEPTIDASE
(Bos
taurus) 		5 / 6 GLY B 184
ASP B 159
GLY B 186
PRO B 222
GLY B 186
 None
 1.47A 6ag0C-1ekbB:
undetectable		 6ag0C-1ekbB:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_A_EY4A502_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 1ekb ENTEROPEPTIDASE
(Bos
taurus) 		4 / 7 ALA B 221
TYR B 184
GLN B 156
VAL B  17
 None
 0.97A 6cduA-1ekbB:
undetectable
6cduE-1ekbB:
0.0		 6cduA-1ekbB:
19.24
6cduE-1ekbB:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_E_EY4E500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 1ekb ENTEROPEPTIDASE
(Bos
taurus) 		4 / 8 GLN B 156
VAL B  17
ALA B 221
TYR B 184
 None
 0.89A 6cduD-1ekbB:
undetectable
6cduE-1ekbB:
undetectable		 6cduD-1ekbB:
19.24
6cduE-1ekbB:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_H_EY4H500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 1ekb ENTEROPEPTIDASE
(Bos
taurus) 		4 / 7 GLN B 156
VAL B  17
ALA B 221
TYR B 184
 None
 0.94A 6cduH-1ekbB:
0.0
6cduI-1ekbB:
0.0		 6cduH-1ekbB:
19.24
6cduI-1ekbB:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CE2_B_SVRB202_1
()		 1ekb ENTEROPEPTIDASE
(Bos
taurus) 		4 / 8 LEU B 144
LEU B 155
ARG B  23
LYS B  16
 None
 0.90A 6ce2A-1ekbB:
0.0		 6ce2A-1ekbB:
18.36