SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1eke'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_A_NCAA506_0
(NAD-DEPENDENT
DEACETYLASE 2)		 1eke RIBONUCLEASE HII
(Methanocaldococc
us
jannaschii) 		4 / 6 ALA A 113
PHE A 121
ILE A   6
ASP A   7
 None
 1.04A 1yc2A-1ekeA:
undetectable		 1yc2A-1ekeA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_D_NCAD510_0
(NAD-DEPENDENT
DEACETYLASE 2)		 1eke RIBONUCLEASE HII
(Methanocaldococc
us
jannaschii) 		4 / 5 ALA A 113
PHE A 121
ILE A   6
ASP A   7
 None
 1.02A 1yc2D-1ekeA:
undetectable		 1yc2D-1ekeA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1002_0
(ALDEHYDE
DEHYDROGENASE A)		 1eke RIBONUCLEASE HII
(Methanocaldococc
us
jannaschii) 		3 / 3 GLY A  12
ARG A  11
TYR A 184
 None
 0.87A 2opxA-1ekeA:
undetectable		 2opxA-1ekeA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 1eke RIBONUCLEASE HII
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE A 109
ILE A   4
ILE A   6
ILE A 132
PHE A 125
 None
 0.83A 2ygoA-1ekeA:
0.0		 2ygoA-1ekeA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1eke RIBONUCLEASE HII
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A  55
LEU A  33
LEU A  36
VAL A  38
ILE A 160
 None
 1.02A 3adxB-1ekeA:
undetectable		 3adxB-1ekeA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGX_A_SALA102_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 1eke RIBONUCLEASE HII
(Methanocaldococc
us
jannaschii) 		4 / 7 VAL A 154
ILE A 109
TYR A 110
ILE A   6
 None
 1.02A 3hgxA-1ekeA:
undetectable		 3hgxA-1ekeA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_F_LFXF0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 1eke RIBONUCLEASE HII
(Methanocaldococc
us
jannaschii) 		4 / 5 SER A 186
ARG A  11
GLY A  10
GLU A   8
 None
 1.30A 3k9fA-1ekeA:
undetectable
3k9fB-1ekeA:
undetectable
3k9fC-1ekeA:
undetectable		 3k9fA-1ekeA:
20.20
3k9fB-1ekeA:
20.20
3k9fC-1ekeA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1eke RIBONUCLEASE HII
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE A  72
GLY A  16
ILE A 180
ILE A 176
PRO A 205
 None
 0.96A 3mb5A-1ekeA:
undetectable		 3mb5A-1ekeA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJ4_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1eke RIBONUCLEASE HII
(Methanocaldococc
us
jannaschii) 		4 / 8 LEU A  33
LEU A  36
VAL A  38
ILE A 160
 None
 0.92A 4oj4A-1ekeA:
0.0		 4oj4A-1ekeA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2D_F_LFXF102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 1eke RIBONUCLEASE HII
(Methanocaldococc
us
jannaschii) 		3 / 4 ARG A  11
GLY A  10
GLU A   8
 None
 0.62A 4z2dB-1ekeA:
0.0
4z2dC-1ekeA:
undetectable		 4z2dB-1ekeA:
18.05
4z2dC-1ekeA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z3O_F_MFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT
B,PARE30-PARC55
FUSED TOPO IV FROM
S. PNEUMONIAE
E-SITE DNA)		 1eke RIBONUCLEASE HII
(Methanocaldococc
us
jannaschii) 		4 / 5 ARG A  11
GLY A  10
GLU A   8
SER A 186
 None
 1.20A 4z3oA-1ekeA:
undetectable
4z3oB-1ekeA:
undetectable		 4z3oA-1ekeA:
15.08
4z3oB-1ekeA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1eke RIBONUCLEASE HII
(Methanocaldococc
us
jannaschii) 		4 / 7 SER A 186
ARG A  11
GLY A  10
GLU A   8
 None
 1.09A 5btfA-1ekeA:
undetectable
5btfC-1ekeA:
undetectable
5btfD-1ekeA:
undetectable		 5btfA-1ekeA:
18.98
5btfC-1ekeA:
18.98
5btfD-1ekeA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 1eke RIBONUCLEASE HII
(Methanocaldococc
us
jannaschii) 		4 / 5 SER A 186
ARG A  11
GLY A  10
GLU A   8
 None
 0.86A 5btiA-1ekeA:
undetectable
5btiB-1ekeA:
undetectable		 5btiA-1ekeA:
18.98
5btiB-1ekeA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1eke RIBONUCLEASE HII
(Methanocaldococc
us
jannaschii) 		4 / 5 SER A 186
ARG A  11
GLY A  10
GLU A   8
 None
 0.86A 5btiC-1ekeA:
undetectable
5btiD-1ekeA:
undetectable		 5btiC-1ekeA:
18.98
5btiD-1ekeA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_2_BEZ2801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 1eke RIBONUCLEASE HII
(Methanocaldococc
us
jannaschii) 		4 / 4 LEU A  96
ARG A 136
ILE A  97
ILE A 132
 None
 1.30A 5dzk2-1ekeA:
undetectable
5dzkM-1ekeA:
undetectable
5dzkN-1ekeA:
0.0		 5dzk2-1ekeA:
3.57
5dzkM-1ekeA:
21.52
5dzkN-1ekeA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_4_BEZ4801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1eke RIBONUCLEASE HII
(Methanocaldococc
us
jannaschii) 		4 / 5 LEU A  36
PHE A  23
ARG A  29
ILE A  25
 None
 0.92A 5dzk4-1ekeA:
undetectable
5dzkg-1ekeA:
undetectable
5dzkm-1ekeA:
undetectable
5dzkn-1ekeA:
0.0		 5dzk4-1ekeA:
3.57
5dzkg-1ekeA:
22.13
5dzkm-1ekeA:
21.52
5dzkn-1ekeA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_E_PFLE406_1
(PROTON-GATED ION
CHANNEL)		 1eke RIBONUCLEASE HII
(Methanocaldococc
us
jannaschii) 		5 / 10 ILE A   3
ILE A   4
ILE A 111
ILE A 143
ILE A 142
 None
 1.10A 5murE-1ekeA:
0.0		 5murE-1ekeA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_E_PFLE406_1
(PROTON-GATED ION
CHANNEL)		 1eke RIBONUCLEASE HII
(Methanocaldococc
us
jannaschii) 		5 / 10 ILE A   4
ILE A 107
ILE A 142
ILE A 111
ILE A 143
 None
 1.09A 5murE-1ekeA:
0.0		 5murE-1ekeA:
18.37