SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ekj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EKJ_A_ACTA3001_0
(BETA-CARBONIC
ANHYDRASE)		 1ekj BETA-CARBONIC
ANHYDRASE
(Pisum
sativum) 		6 / 8 CYH A 160
ASP A 162
HIS A 220
CYH A 223
GLY A 224
GLY A 225
 ZN  A4001 (-2.2A)
ACT  A3001 (-4.0A)
ZN  A4001 ( 3.2A)
ZN  A4001 ( 2.2A)
ACT  A3001 (-3.4A)
ACT  A3001 (-3.7A)
 0.01A 1ekjA-1ekjA:
34.8
1ekjB-1ekjA:
31.7		 1ekjA-1ekjA:
100.00
1ekjB-1ekjA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EKJ_A_ACTA3003_0
(BETA-CARBONIC
ANHYDRASE)		 1ekj BETA-CARBONIC
ANHYDRASE
(Pisum
sativum) 		5 / 8 CYH A 160
ASP A 162
HIS A 220
CYH A 223
GLY A 225
 ZN  A4001 (-2.2A)
ACT  A3001 (-4.0A)
ZN  A4001 ( 3.2A)
ZN  A4001 ( 2.2A)
ACT  A3001 (-3.7A)
 1.01A 1ekjA-1ekjA:
34.8
1ekjB-1ekjA:
31.7		 1ekjA-1ekjA:
100.00
1ekjB-1ekjA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EKJ_A_ACTA3003_0
(BETA-CARBONIC
ANHYDRASE)		 1ekj BETA-CARBONIC
ANHYDRASE
(Pisum
sativum) 		6 / 8 CYH A 160
ASP A 162
VAL A 184
HIS A 220
CYH A 223
GLY A 224
 ZN  A4001 (-2.2A)
ACT  A3001 (-4.0A)
ACT  A3001 ( 4.9A)
ZN  A4001 ( 3.2A)
ZN  A4001 ( 2.2A)
ACT  A3001 (-3.4A)
 0.24A 1ekjA-1ekjA:
34.8
1ekjB-1ekjA:
31.7		 1ekjA-1ekjA:
100.00
1ekjB-1ekjA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EKJ_B_CUB4_0
(BETA-CARBONIC
ANHYDRASE)		 1ekj BETA-CARBONIC
ANHYDRASE
(Pisum
sativum) 		4 / 6 CYH A 166
PRO A 167
SER A 168
ARG A 182
 None
 0.20A 1ekjA-1ekjA:
34.8
1ekjB-1ekjA:
31.7		 1ekjA-1ekjA:
100.00
1ekjB-1ekjA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EKJ_C_ACTC3004_0
(BETA-CARBONIC
ANHYDRASE)		 1ekj BETA-CARBONIC
ANHYDRASE
(Pisum
sativum) 		4 / 6 CYH A 160
ASP A 162
VAL A 184
GLY A 224
 ZN  A4001 (-2.2A)
ACT  A3001 (-4.0A)
ACT  A3001 ( 4.9A)
ACT  A3001 (-3.4A)
 0.13A 1ekjC-1ekjA:
32.0
1ekjD-1ekjA:
32.9		 1ekjC-1ekjA:
100.00
1ekjD-1ekjA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EKJ_C_ACTC3007_0
(BETA-CARBONIC
ANHYDRASE)		 1ekj BETA-CARBONIC
ANHYDRASE
(Pisum
sativum) 		4 / 6 CYH A 160
ASP A 162
VAL A 184
GLY A 224
 ZN  A4001 (-2.2A)
ACT  A3001 (-4.0A)
ACT  A3001 ( 4.9A)
ACT  A3001 (-3.4A)
 0.11A 1ekjC-1ekjA:
32.0
1ekjD-1ekjA:
32.9		 1ekjC-1ekjA:
100.00
1ekjD-1ekjA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EKJ_E_ACTE3005_0
(BETA-CARBONIC
ANHYDRASE)		 1ekj BETA-CARBONIC
ANHYDRASE
(Pisum
sativum) 		5 / 7 CYH A 160
ASP A 162
HIS A 220
GLY A 224
GLY A 225
 ZN  A4001 (-2.2A)
ACT  A3001 (-4.0A)
ZN  A4001 ( 3.2A)
ACT  A3001 (-3.4A)
ACT  A3001 (-3.7A)
 0.15A 1ekjE-1ekjA:
32.7
1ekjF-1ekjA:
31.8		 1ekjE-1ekjA:
100.00
1ekjF-1ekjA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EKJ_E_ACTE3005_0
(BETA-CARBONIC
ANHYDRASE)		 1ekj BETA-CARBONIC
ANHYDRASE
(Pisum
sativum) 		4 / 7 CYH A 160
ASP A 162
HIS A 220
GLY A 225
 ZN  A4001 (-2.2A)
ACT  A3001 (-4.0A)
ZN  A4001 ( 3.2A)
ACT  A3001 (-3.7A)
 0.86A 1ekjE-1ekjA:
32.7
1ekjF-1ekjA:
31.8		 1ekjE-1ekjA:
100.00
1ekjF-1ekjA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EKJ_F_ACTF3008_0
(BETA-CARBONIC
ANHYDRASE)		 1ekj BETA-CARBONIC
ANHYDRASE
(Pisum
sativum) 		5 / 8 CYH A 160
ASP A 162
VAL A 184
GLY A 224
GLY A 225
 ZN  A4001 (-2.2A)
ACT  A3001 (-4.0A)
ACT  A3001 ( 4.9A)
ACT  A3001 (-3.4A)
ACT  A3001 (-3.7A)
 0.15A 1ekjE-1ekjA:
32.7
1ekjF-1ekjA:
31.8		 1ekjE-1ekjA:
100.00
1ekjF-1ekjA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EKJ_G_ACTG3002_0
(BETA-CARBONIC
ANHYDRASE)		 1ekj BETA-CARBONIC
ANHYDRASE
(Pisum
sativum) 		5 / 8 CYH A 160
ASP A 162
HIS A 220
CYH A 223
GLY A 224
 ZN  A4001 (-2.2A)
ACT  A3001 (-4.0A)
ZN  A4001 ( 3.2A)
ZN  A4001 ( 2.2A)
ACT  A3001 (-3.4A)
 0.97A 1ekjG-1ekjA:
31.6
1ekjH-1ekjA:
32.7		 1ekjG-1ekjA:
100.00
1ekjH-1ekjA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EKJ_G_ACTG3002_0
(BETA-CARBONIC
ANHYDRASE)		 1ekj BETA-CARBONIC
ANHYDRASE
(Pisum
sativum) 		6 / 8 CYH A 160
ASP A 162
HIS A 220
CYH A 223
GLY A 224
GLY A 225
 ZN  A4001 (-2.2A)
ACT  A3001 (-4.0A)
ZN  A4001 ( 3.2A)
ZN  A4001 ( 2.2A)
ACT  A3001 (-3.4A)
ACT  A3001 (-3.7A)
 0.15A 1ekjG-1ekjA:
31.6
1ekjH-1ekjA:
32.7		 1ekjG-1ekjA:
100.00
1ekjH-1ekjA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EKJ_G_CUG2_0
(BETA-CARBONIC
ANHYDRASE)		 1ekj BETA-CARBONIC
ANHYDRASE
(Pisum
sativum) 		4 / 5 CYH A 166
PRO A 167
SER A 168
ARG A 182
 None
 0.87A 1ekjG-1ekjA:
31.6
1ekjH-1ekjA:
32.7		 1ekjG-1ekjA:
100.00
1ekjH-1ekjA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EKJ_H_ACTH3006_0
(BETA-CARBONIC
ANHYDRASE)		 1ekj BETA-CARBONIC
ANHYDRASE
(Pisum
sativum) 		5 / 6 CYH A 160
ASP A 162
VAL A 184
HIS A 220
CYH A 223
 ZN  A4001 (-2.2A)
ACT  A3001 (-4.0A)
ACT  A3001 ( 4.9A)
ZN  A4001 ( 3.2A)
ZN  A4001 ( 2.2A)
 0.12A 1ekjG-1ekjA:
31.6
1ekjH-1ekjA:
32.7		 1ekjG-1ekjA:
100.00
1ekjH-1ekjA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		 1ekj BETA-CARBONIC
ANHYDRASE
(Pisum
sativum) 		4 / 8 LEU A 282
LEU A 300
VAL A 291
VAL A 188
 None
 0.81A 2bdmA-1ekjA:
0.0		 2bdmA-1ekjA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_C_GBNC1414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 1ekj BETA-CARBONIC
ANHYDRASE
(Pisum
sativum) 		5 / 8 GLU A 204
GLY A 200
THR A 199
ALA A 202
ALA A 201
 None
None
CL  A2007 (-4.1A)
None
None
 1.40A 2ej3C-1ekjA:
undetectable		 2ej3C-1ekjA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_A_AZMA229_1
(CARBONIC ANHYDRASE)		 1ekj BETA-CARBONIC
ANHYDRASE
(Pisum
sativum) 		5 / 10 ASP A 162
HIS A 220
CYH A 223
GLY A 225
ALA A 185
 ACT  A3001 (-4.0A)
ZN  A4001 ( 3.2A)
ZN  A4001 ( 2.2A)
ACT  A3001 (-3.7A)
None
 1.22A 3ucjA-1ekjA:
21.9		 3ucjA-1ekjA:
28.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_A_AZMA229_1
(CARBONIC ANHYDRASE)		 1ekj BETA-CARBONIC
ANHYDRASE
(Pisum
sativum) 		5 / 10 CYH A 160
ASP A 162
HIS A 220
CYH A 223
GLY A 225
 ZN  A4001 (-2.2A)
ACT  A3001 (-4.0A)
ZN  A4001 ( 3.2A)
ZN  A4001 ( 2.2A)
ACT  A3001 (-3.7A)
 1.09A 3ucjA-1ekjA:
21.9		 3ucjA-1ekjA:
28.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_A_AZMA229_1
(CARBONIC ANHYDRASE)		 1ekj BETA-CARBONIC
ANHYDRASE
(Pisum
sativum) 		6 / 10 CYH A 160
ASP A 162
VAL A 184
HIS A 220
CYH A 223
GLY A 224
 ZN  A4001 (-2.2A)
ACT  A3001 (-4.0A)
ACT  A3001 ( 4.9A)
ZN  A4001 ( 3.2A)
ZN  A4001 ( 2.2A)
ACT  A3001 (-3.4A)
 0.34A 3ucjA-1ekjA:
21.9		 3ucjA-1ekjA:
28.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_A_AZMA229_2
(CARBONIC ANHYDRASE)		 1ekj BETA-CARBONIC
ANHYDRASE
(Pisum
sativum) 		3 / 3 GLN A 151
PHE A 179
TYR A 205
 ACT  A3003 (-3.9A)
ACT  A3003 (-4.9A)
ACT  A3003 (-3.6A)
 0.50A 3ucjB-1ekjA:
22.5		 3ucjB-1ekjA:
28.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_B_AZMB229_1
(CARBONIC ANHYDRASE)		 1ekj BETA-CARBONIC
ANHYDRASE
(Pisum
sativum) 		3 / 3 GLN A 151
PHE A 179
TYR A 205
 ACT  A3003 (-3.9A)
ACT  A3003 (-4.9A)
ACT  A3003 (-3.6A)
 0.54A 3ucjA-1ekjA:
21.9		 3ucjA-1ekjA:
28.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_B_AZMB229_2
(CARBONIC ANHYDRASE)		 1ekj BETA-CARBONIC
ANHYDRASE
(Pisum
sativum) 		5 / 10 ASP A 162
HIS A 220
CYH A 223
GLY A 225
ALA A 185
 ACT  A3001 (-4.0A)
ZN  A4001 ( 3.2A)
ZN  A4001 ( 2.2A)
ACT  A3001 (-3.7A)
None
 1.20A 3ucjB-1ekjA:
22.5		 3ucjB-1ekjA:
28.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_B_AZMB229_2
(CARBONIC ANHYDRASE)		 1ekj BETA-CARBONIC
ANHYDRASE
(Pisum
sativum) 		5 / 10 CYH A 160
ASP A 162
HIS A 220
CYH A 223
GLY A 225
 ZN  A4001 (-2.2A)
ACT  A3001 (-4.0A)
ZN  A4001 ( 3.2A)
ZN  A4001 ( 2.2A)
ACT  A3001 (-3.7A)
 1.10A 3ucjB-1ekjA:
22.5		 3ucjB-1ekjA:
28.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_B_AZMB229_2
(CARBONIC ANHYDRASE)		 1ekj BETA-CARBONIC
ANHYDRASE
(Pisum
sativum) 		6 / 10 CYH A 160
ASP A 162
VAL A 184
HIS A 220
CYH A 223
GLY A 224
 ZN  A4001 (-2.2A)
ACT  A3001 (-4.0A)
ACT  A3001 ( 4.9A)
ZN  A4001 ( 3.2A)
ZN  A4001 ( 2.2A)
ACT  A3001 (-3.4A)
 0.36A 3ucjB-1ekjA:
22.5		 3ucjB-1ekjA:
28.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 1ekj BETA-CARBONIC
ANHYDRASE
(Pisum
sativum) 		4 / 4 ASN A 183
VAL A 217
THR A 199
ILE A 203
 None
None
CL  A2007 (-4.1A)
None
 1.31A 4retA-1ekjA:
undetectable		 4retA-1ekjA:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 1ekj BETA-CARBONIC
ANHYDRASE
(Pisum
sativum) 		4 / 4 ASN A 183
VAL A 217
THR A 199
ILE A 203
 None
None
CL  A2007 (-4.1A)
None
 1.31A 4retC-1ekjA:
undetectable		 4retC-1ekjA:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_A_ACTA403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 1ekj BETA-CARBONIC
ANHYDRASE
(Pisum
sativum) 		3 / 3 VAL A 291
LEU A 300
VAL A 207
 None
 0.63A 4wq4A-1ekjA:
0.6		 4wq4A-1ekjA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_H_FFOH403_0
(THYMIDYLATE SYNTHASE)		 1ekj BETA-CARBONIC
ANHYDRASE
(Pisum
sativum) 		5 / 12 PHE A 232
TRP A 246
ASN A 183
TYR A 196
GLY A 250
 None
 1.24A 6r2eH-1ekjA:
0.0		 6r2eH-1ekjA:
18.93