SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ekz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_B_GBNB501_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 1ekz MATERNAL EFFECT
PROTEIN (STAUFEN)
(Drosophila
melanogaster) 		4 / 8 VAL A  46
GLY A  53
THR A  42
ALA A  43
 None
 0.82A 2a1hA-1ekzA:
undetectable
2a1hB-1ekzA:
undetectable		 2a1hA-1ekzA:
11.01
2a1hB-1ekzA:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		 1ekz MATERNAL EFFECT
PROTEIN (STAUFEN)
(Drosophila
melanogaster) 		3 / 3 LEU A  76
VAL A  13
ARG A  20
 None
 0.78A 3b0wB-1ekzA:
undetectable		 3b0wB-1ekzA:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_A_SALA303_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 1ekz MATERNAL EFFECT
PROTEIN (STAUFEN)
(Drosophila
melanogaster) 		4 / 4 ARG A  64
VAL A  60
LYS A  63
GLU A  67
 None
 0.86A 3deuA-1ekzA:
undetectable		 3deuA-1ekzA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_B_SALB304_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 1ekz MATERNAL EFFECT
PROTEIN (STAUFEN)
(Drosophila
melanogaster) 		4 / 4 ARG A  64
VAL A  60
LYS A  63
GLU A  67
 None
 0.93A 3deuB-1ekzA:
0.0		 3deuB-1ekzA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 1ekz MATERNAL EFFECT
PROTEIN (STAUFEN)
(Drosophila
melanogaster) 		3 / 3 SER A  11
ASP A   5
ASP A   2
 None
 0.86A 3uj7A-1ekzA:
undetectable		 3uj7A-1ekzA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 1ekz MATERNAL EFFECT
PROTEIN (STAUFEN)
(Drosophila
melanogaster) 		3 / 3 SER A  11
ASP A   5
ASP A   2
 None
 0.81A 4mwzA-1ekzA:
undetectable		 4mwzA-1ekzA:
17.43