SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1elj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Y_B_MK1B524_1
(PROTEIN (PROTEASE))		 1elj MALTODEXTRIN-BINDING
PROTEIN
(Pyrococcus
furiosus) 		5 / 11 LEU A 356
ILE A 190
GLY A 192
ILE A 166
ILE A 355
 None
 0.87A 1c6yA-1eljA:
undetectable		 1c6yA-1eljA:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPK_A_ACAA80_1
(PLASMINOGEN)		 1elj MALTODEXTRIN-BINDING
PROTEIN
(Pyrococcus
furiosus) 		4 / 6 PRO A 157
ASP A 234
ASN A 233
TYR A 210
 None
None
None
GLC  A1001 ( 4.2A)
 1.45A 1hpkA-1eljA:
0.0		 1hpkA-1eljA:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPV_B_478B200_1
(HIV-1 PROTEASE)		 1elj MALTODEXTRIN-BINDING
PROTEIN
(Pyrococcus
furiosus) 		5 / 9 LEU A 356
ILE A 190
GLY A 192
ILE A 166
ILE A 355
 None
 0.95A 1hpvA-1eljA:
0.0		 1hpvA-1eljA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB504_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 1elj MALTODEXTRIN-BINDING
PROTEIN
(Pyrococcus
furiosus) 		4 / 7 LEU A 368
ILE A 364
ALA A 351
ILE A 158
 None
 0.73A 1oniB-1eljA:
0.0
1oniC-1eljA:
0.0		 1oniB-1eljA:
15.75
1oniC-1eljA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_0
(SUN PROTEIN)		 1elj MALTODEXTRIN-BINDING
PROTEIN
(Pyrococcus
furiosus) 		5 / 12 ALA A 351
GLY A 347
GLY A 346
ILE A 364
GLY A 192
 None
 1.04A 1sqfA-1eljA:
undetectable		 1sqfA-1eljA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V2X_A_SAMA400_0
(TRNA (GM18)
METHYLTRANSFERASE)		 1elj MALTODEXTRIN-BINDING
PROTEIN
(Pyrococcus
furiosus) 		5 / 12 PHE A 325
GLY A 326
ILE A 120
LEU A 247
ALA A 119
 None
 1.00A 1v2xA-1eljA:
undetectable		 1v2xA-1eljA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_A_SAMA301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 1elj MALTODEXTRIN-BINDING
PROTEIN
(Pyrococcus
furiosus) 		5 / 12 THR A 117
ILE A 166
GLU A 199
PHE A 195
PRO A 248
 None
 1.25A 1vq1A-1eljA:
undetectable		 1vq1A-1eljA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_B_1UNB900_1
(PROTEASE)		 1elj MALTODEXTRIN-BINDING
PROTEIN
(Pyrococcus
furiosus) 		5 / 9 LEU A 356
ILE A 190
GLY A 192
ILE A 166
ILE A 355
 None
 1.09A 2r5qA-1eljA:
undetectable		 2r5qA-1eljA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_D_1UND900_1
(PROTEASE)		 1elj MALTODEXTRIN-BINDING
PROTEIN
(Pyrococcus
furiosus) 		5 / 9 LEU A 356
ILE A 190
GLY A 192
ILE A 166
ILE A 355
 None
 1.08A 2r5qC-1eljA:
undetectable		 2r5qC-1eljA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3V_A_TOPA1169_1
(DIHYDROFOLATE
REDUCTASE)		 1elj MALTODEXTRIN-BINDING
PROTEIN
(Pyrococcus
furiosus) 		5 / 12 ILE A 364
PHE A 196
LEU A 356
ILE A 163
TYR A 174
 None
 1.13A 2w3vA-1eljA:
undetectable		 2w3vA-1eljA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA1_0
(FERROCHELATASE)		 1elj MALTODEXTRIN-BINDING
PROTEIN
(Pyrococcus
furiosus) 		5 / 11 LEU A 247
MET A 137
ILE A 163
PRO A 223
VAL A 127
 None
 1.45A 3aqiA-1eljA:
undetectable		 3aqiA-1eljA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_A_SAMA300_0
(PUTATIVE RRNA
METHYLASE)		 1elj MALTODEXTRIN-BINDING
PROTEIN
(Pyrococcus
furiosus) 		5 / 12 THR A 117
GLY A 264
GLY A 326
GLN A 327
LEU A 334
 None
 0.98A 3eeyA-1eljA:
undetectable		 3eeyA-1eljA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_H_SAMH300_0
(PUTATIVE RRNA
METHYLASE)		 1elj MALTODEXTRIN-BINDING
PROTEIN
(Pyrococcus
furiosus) 		5 / 12 THR A 117
GLY A 264
GLY A 326
GLN A 327
LEU A 334
 None
 0.95A 3eeyH-1eljA:
undetectable		 3eeyH-1eljA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPC_A_SAMA1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 1elj MALTODEXTRIN-BINDING
PROTEIN
(Pyrococcus
furiosus) 		5 / 11 ASP A 319
VAL A 244
ILE A 121
ASN A 233
ILE A 232
 None
 1.19A 3kpcA-1eljA:
0.0		 3kpcA-1eljA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_B_SAMB1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 1elj MALTODEXTRIN-BINDING
PROTEIN
(Pyrococcus
furiosus) 		5 / 12 ASP A 319
VAL A 244
ILE A 121
ASN A 233
ILE A 232
 None
 1.19A 3kpdB-1eljA:
0.0		 3kpdB-1eljA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RFM_A_CFFA330_1
(ADENOSINE RECEPTOR
A2A)		 1elj MALTODEXTRIN-BINDING
PROTEIN
(Pyrococcus
furiosus) 		4 / 7 PHE A 196
MET A 204
LEU A 356
ILE A 352
 None
 1.01A 3rfmA-1eljA:
0.0		 3rfmA-1eljA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_B_9PLB1_1
(CYTOCHROME P450 2A13)		 1elj MALTODEXTRIN-BINDING
PROTEIN
(Pyrococcus
furiosus) 		4 / 6 PHE A  40
PHE A 283
ALA A 284
THR A 288
 None
 1.10A 3t3sB-1eljA:
undetectable		 3t3sB-1eljA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A202_2
(POL POLYPROTEIN)		 1elj MALTODEXTRIN-BINDING
PROTEIN
(Pyrococcus
furiosus) 		5 / 9 GLY A  77
ALA A  76
GLY A  71
ILE A  70
LEU A  50
 None
 1.06A 3u7sB-1eljA:
undetectable		 3u7sB-1eljA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_F_5FWF1001_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 1elj MALTODEXTRIN-BINDING
PROTEIN
(Pyrococcus
furiosus) 		4 / 6 GLU A 136
LYS A 132
PRO A 249
GLU A 256
 None
 1.45A 4a7tF-1eljA:
0.0		 4a7tF-1eljA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HB6_A_DXCA75_0
(PPCA)		 1elj MALTODEXTRIN-BINDING
PROTEIN
(Pyrococcus
furiosus) 		4 / 8 ILE A 364
LEU A 368
ILE A 163
GLY A 172
 None
 0.74A 4hb6A-1eljA:
undetectable		 4hb6A-1eljA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HB8_A_DXCA75_0
(PPCA)		 1elj MALTODEXTRIN-BINDING
PROTEIN
(Pyrococcus
furiosus) 		4 / 8 ILE A 364
LEU A 368
ILE A 163
GLY A 172
 None
 0.60A 4hb8A-1eljA:
undetectable		 4hb8A-1eljA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1N_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1elj MALTODEXTRIN-BINDING
PROTEIN
(Pyrococcus
furiosus) 		5 / 11 ILE A 163
ALA A 165
PHE A 193
LYS A 194
LEU A 368
 None
None
None
SO4  A1102 (-4.6A)
None
 1.41A 4i1nA-1eljA:
undetectable		 4i1nA-1eljA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM0_B_CP6B201_1
(DIHYDROFOLATE
REDUCTASE)		 1elj MALTODEXTRIN-BINDING
PROTEIN
(Pyrococcus
furiosus) 		5 / 12 ILE A 166
ILE A 364
PHE A 196
LEU A 356
ILE A 163
 None
 1.12A 4km0B-1eljA:
undetectable		 4km0B-1eljA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM0_B_CP6B201_1
(DIHYDROFOLATE
REDUCTASE)		 1elj MALTODEXTRIN-BINDING
PROTEIN
(Pyrococcus
furiosus) 		5 / 12 ILE A 364
PHE A 196
LEU A 356
ILE A 163
TYR A 174
 None
 1.09A 4km0B-1eljA:
undetectable		 4km0B-1eljA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UAC_A_ACRA501_1
(CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT1 FAMILY
(TC 3.A.1.1.-))		 1elj MALTODEXTRIN-BINDING
PROTEIN
(Pyrococcus
furiosus) 		5 / 12 ALA A  66
ASP A  68
ASN A 159
TRP A 230
LYS A 266
 GLC  A1002 (-3.2A)
GLC  A1003 (-2.8A)
GLC  A1002 ( 3.3A)
GLC  A1001 ( 3.8A)
GLC  A1001 ( 2.6A)
 0.87A 4uacA-1eljA:
33.9		 4uacA-1eljA:
27.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 1elj MALTODEXTRIN-BINDING
PROTEIN
(Pyrococcus
furiosus) 		5 / 12 ILE A 352
ALA A 351
PHE A 197
LEU A 368
GLY A 208
 None
 1.33A 5i71A-1eljA:
undetectable		 5i71A-1eljA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JI0_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1elj MALTODEXTRIN-BINDING
PROTEIN
(Pyrococcus
furiosus) 		5 / 11 GLN A  23
LEU A  19
PHE A  22
LEU A  25
ALA A  26
 None
 1.08A 5ji0A-1eljA:
undetectable		 5ji0A-1eljA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_A_CVIA609_0
(ACETYLCHOLINESTERASE)		 1elj MALTODEXTRIN-BINDING
PROTEIN
(Pyrococcus
furiosus) 		4 / 6 TYR A 104
TYR A 109
ASP A 100
HIS A  67
 None
 1.41A 5ov9A-1eljA:
undetectable		 5ov9A-1eljA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB603_0
(ACETYLCHOLINESTERASE)		 1elj MALTODEXTRIN-BINDING
PROTEIN
(Pyrococcus
furiosus) 		4 / 7 TYR A 104
TYR A 109
ASP A 100
HIS A  67
 None
 1.44A 5ov9B-1eljA:
undetectable		 5ov9B-1eljA:
21.49