SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1em2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG7_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 1em2 MLN64 PROTEIN
(Homo
sapiens) 		3 / 3 ILE A 284
ILE A 274
THR A 270
 None
 0.55A 1rg7A-1em2A:
undetectable		 1rg7A-1em2A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG7_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 1em2 MLN64 PROTEIN
(Homo
sapiens) 		3 / 3 ILE A 389
ILE A 405
THR A 401
 None
 0.62A 1rg7A-1em2A:
undetectable		 1rg7A-1em2A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SGU_B_MK1B2632_1
(POL POLYPROTEIN)		 1em2 MLN64 PROTEIN
(Homo
sapiens) 		5 / 8 ALA A 247
ILE A 365
GLY A 364
GLY A 386
ILE A 405
 None
 1.13A 1sguA-1em2A:
undetectable		 1sguA-1em2A:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T86_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 1em2 MLN64 PROTEIN
(Homo
sapiens) 		4 / 8 THR A 408
THR A 313
LEU A 406
VAL A 314
 None
 0.87A 1t86A-1em2A:
0.0		 1t86A-1em2A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1em2 MLN64 PROTEIN
(Homo
sapiens) 		5 / 10 GLU A 237
ARG A 240
ILE A 239
GLY A 242
ARG A 351
 None
 1.28A 3adsA-1em2A:
0.0		 3adsA-1em2A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1em2 MLN64 PROTEIN
(Homo
sapiens) 		5 / 10 GLU A 354
ILE A 389
GLY A 387
LEU A 434
ILE A 301
 None
 1.05A 3adsA-1em2A:
0.0		 3adsA-1em2A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RZE_A_D7VA1201_1
(HISTAMINE H1
RECEPTOR, LYSOZYME
CHIMERA)		 1em2 MLN64 PROTEIN
(Homo
sapiens) 		5 / 12 THR A 282
ILE A 405
ASN A 407
TRP A 404
PHE A 347
 None
 1.40A 3rzeA-1em2A:
undetectable		 3rzeA-1em2A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_A_LURA201_1
(TRANSTHYRETIN)		 1em2 MLN64 PROTEIN
(Homo
sapiens) 		3 / 3 LYS A 372
LEU A 320
ALA A 371
 None
 0.77A 4iizA-1em2A:
0.0		 4iizA-1em2A:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4USW_A_ACTA1470_0
(ADENYLATE CYCLASE
TYPE 10)		 1em2 MLN64 PROTEIN
(Homo
sapiens) 		4 / 6 LEU A 289
LEU A 391
VAL A 390
PHE A 288
 None
 1.14A 4uswA-1em2A:
0.7		 4uswA-1em2A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_1
(METHYLTRANSFERASE)		 1em2 MLN64 PROTEIN
(Homo
sapiens) 		4 / 7 LEU A 434
PHE A 430
ILE A 284
ASP A 269
 None
 1.06A 5n5dA-1em2A:
undetectable		 5n5dA-1em2A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B201_2
(ENDO-1,4-BETA-XYLANA
SE A)		 1em2 MLN64 PROTEIN
(Homo
sapiens) 		3 / 3 ARG A 380
PRO A 373
TYR A 378
 None
 1.01A 5tzoB-1em2A:
undetectable		 5tzoB-1em2A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_2
(CYTOCHROME P450 3A4)		 1em2 MLN64 PROTEIN
(Homo
sapiens) 		3 / 3 ARG A 352
ARG A 355
ARG A 351
 None
 1.00A 5vcgA-1em2A:
undetectable		 5vcgA-1em2A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_A_CVIA301_1
(REGULATORY PROTEIN
TETR)		 1em2 MLN64 PROTEIN
(Homo
sapiens) 		4 / 8 GLY A 387
TRP A 259
GLN A 255
VAL A 249
 None
 0.88A 5vlmA-1em2A:
0.1		 5vlmA-1em2A:
23.63