SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1em8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX2_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1em8 DNA POLYMERASE III
CHI SUBUNIT
(Escherichia
coli) 		4 / 7 VAL A  21
ARG A 130
VAL A 114
PHE A   6
 None
 1.25A 3jx2A-1em8A:
0.0
3jx2B-1em8A:
0.0		 3jx2A-1em8A:
18.05
3jx2B-1em8A:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX4_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1em8 DNA POLYMERASE III
CHI SUBUNIT
(Escherichia
coli) 		4 / 6 VAL A  21
ARG A 130
VAL A 114
PHE A   6
 None
 1.29A 3jx4A-1em8A:
0.0
3jx4B-1em8A:
0.2		 3jx4A-1em8A:
18.05
3jx4B-1em8A:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX4_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1em8 DNA POLYMERASE III
CHI SUBUNIT
(Escherichia
coli) 		4 / 7 PHE A   6
VAL A  21
ARG A 130
VAL A 114
 None
 1.30A 3jx4A-1em8A:
0.0
3jx4B-1em8A:
0.2		 3jx4A-1em8A:
18.05
3jx4B-1em8A:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX5_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1em8 DNA POLYMERASE III
CHI SUBUNIT
(Escherichia
coli) 		4 / 7 PHE A   6
VAL A  21
ARG A 130
VAL A 114
 None
 1.33A 3jx5A-1em8A:
0.0
3jx5B-1em8A:
0.2		 3jx5A-1em8A:
18.05
3jx5B-1em8A:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX6_B_H4BB761_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1em8 DNA POLYMERASE III
CHI SUBUNIT
(Escherichia
coli) 		4 / 7 PHE A   6
VAL A  21
ARG A 130
VAL A 114
 None
 1.31A 3jx6A-1em8A:
0.0
3jx6B-1em8A:
0.7		 3jx6A-1em8A:
18.05
3jx6B-1em8A:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLJ_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1em8 DNA POLYMERASE III
CHI SUBUNIT
(Escherichia
coli) 		4 / 7 VAL A  21
ARG A 130
VAL A 114
PHE A   6
 None
 1.25A 3nljA-1em8A:
0.0
3nljB-1em8A:
0.0		 3nljA-1em8A:
18.05
3nljB-1em8A:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLP_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1em8 DNA POLYMERASE III
CHI SUBUNIT
(Escherichia
coli) 		4 / 7 VAL A  21
ARG A 130
VAL A 114
PHE A   6
 None
 1.28A 3nlpA-1em8A:
0.0
3nlpB-1em8A:
0.0		 3nlpA-1em8A:
18.05
3nlpB-1em8A:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_D_QELD2_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 1em8 DNA POLYMERASE III
CHI SUBUNIT
(Escherichia
coli) 		4 / 5 TYR A   7
THR A 143
PHE A   6
LEU A   9
 None
 1.39A 3qelC-1em8A:
4.3		 3qelC-1em8A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROX_A_TEPA266_1
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)		 1em8 DNA POLYMERASE III
PSI SUBUNIT
(Escherichia
coli) 		4 / 8 ALA B  60
VAL B  57
ASP B  56
LEU B  53
 None
 0.79A 3roxA-1em8B:
undetectable		 3roxA-1em8B:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_B_ROCB203_1
(PROTEASE)		 1em8 DNA POLYMERASE III
PSI SUBUNIT
(Escherichia
coli) 		4 / 7 LEU B  98
LEU B  79
PRO B  34
ILE B  33
 None
 0.70A 3s56B-1em8B:
undetectable		 3s56B-1em8B:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADD_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1em8 DNA POLYMERASE III
CHI SUBUNIT
(Escherichia
coli) 		4 / 6 VAL A  21
ARG A 130
VAL A 114
PHE A   6
 None
 1.32A 5addA-1em8A:
0.0
5addB-1em8A:
0.2		 5addA-1em8A:
18.05
5addB-1em8A:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADE_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1em8 DNA POLYMERASE III
CHI SUBUNIT
(Escherichia
coli) 		4 / 6 VAL A  21
ARG A 130
VAL A 114
PHE A   6
 None
 1.32A 5adeA-1em8A:
0.0
5adeB-1em8A:
0.0		 5adeA-1em8A:
18.05
5adeB-1em8A:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADE_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1em8 DNA POLYMERASE III
CHI SUBUNIT
(Escherichia
coli) 		4 / 7 PHE A   6
VAL A  21
ARG A 130
VAL A 114
 None
 1.33A 5adeA-1em8A:
0.0
5adeB-1em8A:
0.0		 5adeA-1em8A:
18.05
5adeB-1em8A:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G0P_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1em8 DNA POLYMERASE III
CHI SUBUNIT
(Escherichia
coli) 		4 / 7 VAL A  21
ARG A 130
VAL A 114
PHE A   6
 None
 1.29A 5g0pA-1em8A:
0.0
5g0pB-1em8A:
0.0		 5g0pA-1em8A:
18.05
5g0pB-1em8A:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G0P_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1em8 DNA POLYMERASE III
CHI SUBUNIT
(Escherichia
coli) 		4 / 7 PHE A   6
VAL A  21
ARG A 130
VAL A 114
 None
 1.33A 5g0pA-1em8A:
0.0
5g0pB-1em8A:
0.0		 5g0pA-1em8A:
18.05
5g0pB-1em8A:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGY_A_ERYA403_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 1em8 DNA POLYMERASE III
CHI SUBUNIT
DNA POLYMERASE III
PSI SUBUNIT
(Escherichia
coli;
Escherichia
coli) 		5 / 12 GLY A  77
GLU A  54
PHE A  64
ALA B  60
ILE A  41
 None
 1.21A 5igyA-1em8A:
0.0		 5igyA-1em8A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 1em8 DNA POLYMERASE III
CHI SUBUNIT
DNA POLYMERASE III
PSI SUBUNIT
(Escherichia
coli;
Escherichia
coli) 		5 / 12 GLY A  77
GLU A  54
PHE A  64
ALA B  60
ILE A  41
 None
 1.13A 5ih0A-1em8A:
0.0		 5ih0A-1em8A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_C_SALC201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 1em8 DNA POLYMERASE III
CHI SUBUNIT
DNA POLYMERASE III
PSI SUBUNIT
(Escherichia
coli) 		4 / 7 ARG B  59
ARG A  32
VAL A  39
GLY A  36
 None
 0.90A 5x80C-1em8B:
undetectable
5x80D-1em8B:
undetectable		 5x80C-1em8B:
28.48
5x80D-1em8B:
28.48