SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ems'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I00_A_D16A315_1
(THYMIDYLATE SYNTHASE)		 1ems NIT-FRAGILE
HISTIDINE TRIAD
FUSION PROTEIN
(Caenorhabditis
elegans) 		5 / 9 GLU A  48
ILE A 161
ASP A 263
LEU A 264
GLY A  13
 None
 1.45A 1i00A-1emsA:
0.0		 1i00A-1emsA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2200_0
(PROTEIN (METHIONINE
REPRESSOR))		 1ems NIT-FRAGILE
HISTIDINE TRIAD
FUSION PROTEIN
(Caenorhabditis
elegans) 		5 / 12 ALA A 352
PHE A 355
LEU A 346
GLU A 350
HIS A 288
 None
 1.27A 1mj2A-1emsA:
undetectable
1mj2B-1emsA:
undetectable		 1mj2A-1emsA:
12.44
1mj2B-1emsA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC2199_0
(PROTEIN (METHIONINE
REPRESSOR))		 1ems NIT-FRAGILE
HISTIDINE TRIAD
FUSION PROTEIN
(Caenorhabditis
elegans) 		5 / 12 ALA A 352
PHE A 355
LEU A 346
GLU A 350
HIS A 288
 None
 1.27A 1mj2C-1emsA:
undetectable
1mj2D-1emsA:
undetectable		 1mj2C-1emsA:
12.44
1mj2D-1emsA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_A_SAMA200_0
(METHIONINE REPRESSOR)		 1ems NIT-FRAGILE
HISTIDINE TRIAD
FUSION PROTEIN
(Caenorhabditis
elegans) 		5 / 11 LEU A 346
GLU A 350
HIS A 288
ALA A 352
PHE A 355
 None
 1.30A 1mjqA-1emsA:
undetectable
1mjqB-1emsA:
undetectable		 1mjqA-1emsA:
12.44
1mjqB-1emsA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_C_SAMC199_0
(METHIONINE REPRESSOR)		 1ems NIT-FRAGILE
HISTIDINE TRIAD
FUSION PROTEIN
(Caenorhabditis
elegans) 		5 / 10 LEU A 346
GLU A 350
HIS A 288
ALA A 352
PHE A 355
 None
 1.36A 1mjqC-1emsA:
undetectable
1mjqD-1emsA:
undetectable		 1mjqC-1emsA:
12.44
1mjqD-1emsA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_I_SAMI199_0
(METHIONINE REPRESSOR)		 1ems NIT-FRAGILE
HISTIDINE TRIAD
FUSION PROTEIN
(Caenorhabditis
elegans) 		5 / 11 LEU A 346
GLU A 350
HIS A 288
ALA A 352
PHE A 355
 None
 1.36A 1mjqI-1emsA:
undetectable
1mjqJ-1emsA:
undetectable		 1mjqI-1emsA:
12.44
1mjqJ-1emsA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B7P_A_SPMA501_1
(SPERMIDINE SYNTHASE)		 1ems NIT-FRAGILE
HISTIDINE TRIAD
FUSION PROTEIN
(Caenorhabditis
elegans) 		5 / 12 TYR A 125
ASP A 171
GLU A 291
PRO A 156
ILE A 154
 None
 1.46A 3b7pA-1emsA:
undetectable		 3b7pA-1emsA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O1C_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 1ems NIT-FRAGILE
HISTIDINE TRIAD
FUSION PROTEIN
(Caenorhabditis
elegans) 		5 / 10 PHE A 301
ILE A 306
LEU A 333
HIS A 392
HIS A 394
 None
None
None
None
NA  A 459 (-3.9A)
 0.59A 3o1cA-1emsA:
11.0		 3o1cA-1emsA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O1X_A_ADNA1450_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 1ems NIT-FRAGILE
HISTIDINE TRIAD
FUSION PROTEIN
(Caenorhabditis
elegans) 		5 / 10 PHE A 301
ILE A 306
LEU A 333
HIS A 392
HIS A 394
 None
None
None
None
NA  A 459 (-3.9A)
 0.57A 3o1xA-1emsA:
10.9		 3o1xA-1emsA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGZ_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 1ems NIT-FRAGILE
HISTIDINE TRIAD
FUSION PROTEIN
(Caenorhabditis
elegans) 		5 / 10 PHE A 301
ILE A 306
LEU A 333
HIS A 392
HIS A 394
 None
None
None
None
NA  A 459 (-3.9A)
 0.57A 3qgzA-1emsA:
11.0		 3qgzA-1emsA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_A_ADNA501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 1ems NIT-FRAGILE
HISTIDINE TRIAD
FUSION PROTEIN
(Caenorhabditis
elegans) 		4 / 5 GLN A 250
THR A 199
HIS A 203
LEU A 207
 None
 1.39A 4lvcA-1emsA:
undetectable		 4lvcA-1emsA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_C_ADNC501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 1ems NIT-FRAGILE
HISTIDINE TRIAD
FUSION PROTEIN
(Caenorhabditis
elegans) 		4 / 5 GLN A 250
THR A 199
HIS A 203
LEU A 207
 None
 1.38A 4lvcC-1emsA:
undetectable		 4lvcC-1emsA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_D_RBFD201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1ems NIT-FRAGILE
HISTIDINE TRIAD
FUSION PROTEIN
(Caenorhabditis
elegans) 		4 / 8 LEU A  94
LEU A 166
ILE A 114
PHE A 191
 None
None
None
NA  A 457 ( 4.7A)
 0.89A 4r38D-1emsA:
0.0		 4r38D-1emsA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_ACTA608_0
(SERUM ALBUMIN)		 1ems NIT-FRAGILE
HISTIDINE TRIAD
FUSION PROTEIN
(Caenorhabditis
elegans) 		3 / 3 LYS A 231
ARG A 232
HIS A 228
 None
 1.18A 4zbrA-1emsA:
undetectable		 4zbrA-1emsA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_1_BEZ1801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1ems NIT-FRAGILE
HISTIDINE TRIAD
FUSION PROTEIN
(Caenorhabditis
elegans) 		3 / 3 LEU A 333
PHE A 312
ILE A 395
 None
 0.73A 5dzk1-1emsA:
undetectable
5dzkF-1emsA:
2.4
5dzkM-1emsA:
0.0		 5dzk1-1emsA:
7.14
5dzkF-1emsA:
20.87
5dzkM-1emsA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA612_0
(NADH DEHYDROGENASE,
PUTATIVE)		 1ems NIT-FRAGILE
HISTIDINE TRIAD
FUSION PROTEIN
(Caenorhabditis
elegans) 		3 / 3 LYS A 382
ASP A 383
ARG A 342
 None
 0.80A 5jwaA-1emsA:
0.7
5jwaH-1emsA:
0.5		 5jwaA-1emsA:
20.48
5jwaH-1emsA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM8_B_L8PB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 1ems NIT-FRAGILE
HISTIDINE TRIAD
FUSION PROTEIN
(Caenorhabditis
elegans) 		4 / 8 ALA A 384
GLN A 386
HIS A 392
HIS A 394
 None
None
None
NA  A 459 (-3.9A)
 1.07A 5km8A-1emsA:
11.8
5km8B-1emsA:
11.6		 5km8A-1emsA:
16.82
5km8B-1emsA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM9_B_ADNB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 1ems NIT-FRAGILE
HISTIDINE TRIAD
FUSION PROTEIN
(Caenorhabditis
elegans) 		6 / 12 PHE A 301
ILE A 306
LEU A 333
VAL A 388
HIS A 392
HIS A 394
 None
None
None
None
None
NA  A 459 (-3.9A)
 0.50A 5km9B-1emsA:
11.7		 5km9B-1emsA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UVM_B_ADNB207_1
(HISTIDINE TRIAD
(HIT) PROTEIN)		 1ems NIT-FRAGILE
HISTIDINE TRIAD
FUSION PROTEIN
(Caenorhabditis
elegans) 		7 / 12 PHE A 301
ILE A 306
LEU A 333
THR A 387
VAL A 388
HIS A 392
HIS A 394
 None
None
None
None
None
None
NA  A 459 (-3.9A)
 0.60A 5uvmB-1emsA:
11.3		 5uvmB-1emsA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 1ems NIT-FRAGILE
HISTIDINE TRIAD
FUSION PROTEIN
(Caenorhabditis
elegans) 		3 / 3 LYS A 127
ASN A 110
SER A 147
 EMC  A 451 (-3.0A)
EMC  A 453 (-3.2A)
EMC  A 453 (-3.4A)
 1.26A 5yw0A-1emsA:
0.0		 5yw0A-1emsA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BTX_A_EDTA503_0
(SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER))		 1ems NIT-FRAGILE
HISTIDINE TRIAD
FUSION PROTEIN
(Caenorhabditis
elegans) 		4 / 7 SER A  93
HIS A 112
GLY A  95
LEU A 164
 None
 1.02A 6btxA-1emsA:
0.0		 6btxA-1emsA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_A_ADNA501_2
(-)		 1ems NIT-FRAGILE
HISTIDINE TRIAD
FUSION PROTEIN
(Caenorhabditis
elegans) 		4 / 5 GLN A 250
THR A 199
HIS A 203
LEU A 207
 None
 1.40A 6gbnA-1emsA:
undetectable		 6gbnA-1emsA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_D_ADND501_2
(-)		 1ems NIT-FRAGILE
HISTIDINE TRIAD
FUSION PROTEIN
(Caenorhabditis
elegans) 		4 / 5 GLN A 250
THR A 199
HIS A 203
LEU A 207
 None
 1.41A 6gbnD-1emsA:
undetectable		 6gbnD-1emsA:
22.92