SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1en4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AZM_A_AZMA262_1
(CARBONIC ANHYDRASE I)		 1en4 MANGANESE SUPEROXIDE
DISMUTASE
(Escherichia
coli) 		4 / 8 PHE A  18
HIS A  26
HIS A  81
TRP A 128
 None
MN  A 501 (-3.4A)
MN  A 501 (-3.4A)
None
 1.04A 1azmA-1en4A:
undetectable		 1azmA-1en4A:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_A_DVAA8_0
(GRAMICIDIN A)		 1en4 MANGANESE SUPEROXIDE
DISMUTASE
(Escherichia
coli) 		4 / 4 GLY A  87
VAL A 192
TRP A 128
GLY A 165
 None
 1.33A 1ng8A-1en4A:
undetectable		 1ng8A-1en4A:
7.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_B_DVAB8_0
(GRAMICIDIN A)		 1en4 MANGANESE SUPEROXIDE
DISMUTASE
(Escherichia
coli) 		4 / 4 GLY A  87
VAL A 192
TRP A 128
GLY A 165
 None
 1.33A 1ng8B-1en4A:
undetectable		 1ng8B-1en4A:
7.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_P_CHDP304_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1en4 MANGANESE SUPEROXIDE
DISMUTASE
(Escherichia
coli) 		4 / 6 HIS A  26
ASP A  12
TYR A   9
HIS A  30
 MN  A 501 (-3.4A)
None
None
None
 1.49A 2dysN-1en4A:
0.4
2dysP-1en4A:
0.9		 2dysN-1en4A:
18.27
2dysP-1en4A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_A_CHDA525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1en4 MANGANESE SUPEROXIDE
DISMUTASE
(Escherichia
coli) 		4 / 6 HIS A  26
ASP A  12
TYR A   9
HIS A  30
 MN  A 501 (-3.4A)
None
None
None
 1.48A 2eimA-1en4A:
0.3
2eimC-1en4A:
0.9		 2eimA-1en4A:
18.27
2eimC-1en4A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 1en4 MANGANESE SUPEROXIDE
DISMUTASE
(Escherichia
coli) 		5 / 10 THR A 143
VAL A 141
PHE A 116
VAL A 168
GLY A 127
 None
 1.39A 2x2iD-1en4A:
0.0		 2x2iD-1en4A:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_A_9PLA501_1
(CYTOCHROME P450 2A6)		 1en4 MANGANESE SUPEROXIDE
DISMUTASE
(Escherichia
coli) 		5 / 10 VAL A 192
PHE A 188
ALA A 197
ILE A 102
PHE A 112
 None
 1.34A 3t3qA-1en4A:
undetectable		 3t3qA-1en4A:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_B_T1CB392_1
(TETX2 PROTEIN)		 1en4 MANGANESE SUPEROXIDE
DISMUTASE
(Escherichia
coli) 		5 / 11 ARG A  72
HIS A 146
GLY A 127
PRO A 149
GLY A 152
 None
 1.47A 4a6nB-1en4A:
undetectable		 4a6nB-1en4A:
19.45