SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ep2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HBP_A_RTLA184_0
(RETINOL BINDING
PROTEIN)		 1ep2 DIHYDROOROTATE
DEHYDROGENASE B
(PYRK SUBUNIT)
(Lactococcus
lactis) 		5 / 11 LEU B  98
ALA B  90
MET B   8
MET B  23
LEU B  29
 None
 1.19A 1hbpA-1ep2B:
0.0		 1hbpA-1ep2B:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3004_1
(SERUM ALBUMIN)		 1ep2 DIHYDROOROTATE
DEHYDROGENASE B
(PYRK SUBUNIT)
(Lactococcus
lactis) 		4 / 7 PHE B 102
ALA B 129
LEU B 132
MET B 139
 None
 0.93A 1hk2A-1ep2B:
0.0		 1hk2A-1ep2B:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IIU_A_RTLA176_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 1ep2 DIHYDROOROTATE
DEHYDROGENASE B
(PYRK SUBUNIT)
(Lactococcus
lactis) 		5 / 11 LEU B  98
ALA B  90
MET B   8
MET B  23
LEU B  29
 None
 1.26A 1iiuA-1ep2B:
0.0		 1iiuA-1ep2B:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_A_RBFA100_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 1ep2 DIHYDROOROTATE
DEHYDROGENASE B
(PYRK SUBUNIT)
(Lactococcus
lactis) 		5 / 11 SER B  58
THR B  68
ILE B  73
THR B  80
ILE B  20
 None
None
None
FAD  B 503 (-2.7A)
None
 1.11A 1pkvA-1ep2B:
10.0
1pkvB-1ep2B:
10.1		 1pkvA-1ep2B:
18.15
1pkvB-1ep2B:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_B_RBFB101_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 1ep2 DIHYDROOROTATE
DEHYDROGENASE B
(PYRK SUBUNIT)
(Lactococcus
lactis) 		5 / 11 ILE B  20
SER B  58
THR B  68
ILE B  73
THR B  80
 None
None
None
None
FAD  B 503 (-2.7A)
 1.09A 1pkvA-1ep2B:
10.0
1pkvB-1ep2B:
10.1		 1pkvA-1ep2B:
18.15
1pkvB-1ep2B:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 1ep2 DIHYDROOROTATE
DEHYDROGENASE B
(PYRK SUBUNIT)
(Lactococcus
lactis) 		4 / 5 TYR B  71
MET B  23
THR B  68
LEU B  25
 None
 1.42A 2eimJ-1ep2B:
0.0		 2eimJ-1ep2B:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA502_0
(FERROCHELATASE)		 1ep2 DIHYDROOROTATE
DEHYDROGENASE B
(PYRK SUBUNIT)
(Lactococcus
lactis) 		4 / 8 MET B 220
PRO B 124
SER B  56
GLY B 118
 None
None
FAD  B 503 (-3.2A)
None
 1.02A 2qd3A-1ep2B:
3.5		 2qd3A-1ep2B:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA502_0
(FERROCHELATASE)		 1ep2 DIHYDROOROTATE
DEHYDROGENASE B
(PYRK SUBUNIT)
(Lactococcus
lactis) 		4 / 8 MET B 220
PRO B 124
SER B  56
GLY B 119
 None
None
FAD  B 503 (-3.2A)
None
 1.02A 2qd3A-1ep2B:
3.5		 2qd3A-1ep2B:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_B_SAMB1267_0
(NON-STRUCTURAL
PROTEIN 5)		 1ep2 DIHYDROOROTATE
DEHYDROGENASE B
(PYRK SUBUNIT)
(Lactococcus
lactis) 		6 / 12 SER B  56
GLY B  37
GLY B 117
GLY B 121
GLU B 221
VAL B 180
 FAD  B 503 (-3.2A)
None
None
None
FAD  B 503 (-3.7A)
None
 1.17A 2wa2B-1ep2B:
4.2		 2wa2B-1ep2B:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 1ep2 DIHYDROOROTATE
DEHYDROGENASE B
(PYRK SUBUNIT)
(Lactococcus
lactis) 		4 / 5 TYR B  71
MET B  23
THR B  68
LEU B  25
 None
 1.43A 3ag1J-1ep2B:
0.0		 3ag1J-1ep2B:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 1ep2 DIHYDROOROTATE
DEHYDROGENASE B
(PYRK SUBUNIT)
(Lactococcus
lactis) 		4 / 5 TYR B  71
MET B  23
THR B  68
LEU B  25
 None
 1.43A 3ag2J-1ep2B:
undetectable		 3ag2J-1ep2B:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 1ep2 DIHYDROOROTATE
DEHYDROGENASE B
(PYRK SUBUNIT)
(Lactococcus
lactis) 		4 / 5 TYR B  71
MET B  23
THR B  68
LEU B  25
 None
 1.43A 3ag4J-1ep2B:
0.0		 3ag4J-1ep2B:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_B_478B200_1
(PROTEASE)		 1ep2 DIHYDROOROTATE
DEHYDROGENASE B
(PYRK SUBUNIT)
(Lactococcus
lactis) 		5 / 8 LEU B 153
GLY B 121
VAL B 150
ILE B  55
ILE B 152
 None
None
None
FAD  B 503 (-4.3A)
None
 1.13A 3ekpA-1ep2B:
0.0		 3ekpA-1ep2B:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_A_STIA3_2
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 1ep2 DIHYDROOROTATE
DEHYDROGENASE B
(PYRK SUBUNIT)
(Lactococcus
lactis) 		4 / 6 TYR B  71
VAL B  30
VAL B  94
ILE B  57
 None
 1.09A 3pyyA-1ep2B:
undetectable		 3pyyA-1ep2B:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1ep2 DIHYDROOROTATE
DEHYDROGENASE B
(PYRK SUBUNIT)
(Lactococcus
lactis) 		4 / 8 MET B 220
PRO B 124
SER B  56
GLY B 119
 None
None
FAD  B 503 (-3.2A)
None
 1.03A 4mk4A-1ep2B:
3.0		 4mk4A-1ep2B:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA502_1
(PENTALENIC ACID
SYNTHASE)		 1ep2 DIHYDROOROTATE
DEHYDROGENASE B
(PYRK SUBUNIT)
(Lactococcus
lactis) 		5 / 9 ARG B 215
VAL B 107
LEU B 216
LEU B 132
ILE B 115
 None
 1.29A 4ubsA-1ep2B:
0.0		 4ubsA-1ep2B:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 1ep2 DIHYDROOROTATE
DEHYDROGENASE B
(PYRK SUBUNIT)
(Lactococcus
lactis) 		4 / 6 LEU B 143
ILE B 218
THR B 196
MET B 220
 None
 1.40A 5ljeA-1ep2B:
0.1		 5ljeA-1ep2B:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_J_CHDJ101_1
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1ep2 DIHYDROOROTATE
DEHYDROGENASE B
(PYRK SUBUNIT)
(Lactococcus
lactis) 		4 / 5 TYR B  71
MET B  23
THR B  68
LEU B  25
 None
 1.37A 5wauJ-1ep2B:
0.0		 5wauJ-1ep2B:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1ep2 DIHYDROOROTATE
DEHYDROGENASE B
(PYRK SUBUNIT)
(Lactococcus
lactis) 		4 / 5 TYR B  71
MET B  23
THR B  68
LEU B  25
 None
 1.42A 5x19J-1ep2B:
undetectable		 5x19J-1ep2B:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1ep2 DIHYDROOROTATE
DEHYDROGENASE B
(PYRK SUBUNIT)
(Lactococcus
lactis) 		4 / 5 TYR B  71
MET B  23
THR B  68
LEU B  25
 None
 1.41A 5x1bJ-1ep2B:
0.0		 5x1bJ-1ep2B:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1ep2 DIHYDROOROTATE
DEHYDROGENASE B
(PYRK SUBUNIT)
(Lactococcus
lactis) 		4 / 5 TYR B  71
MET B  23
THR B  68
LEU B  25
 None
 1.35A 5x1bW-1ep2B:
0.0		 5x1bW-1ep2B:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1ep2 DIHYDROOROTATE
DEHYDROGENASE B
(PYRK SUBUNIT)
(Lactococcus
lactis) 		4 / 5 TYR B  71
MET B  23
THR B  68
LEU B  25
 None
 1.34A 5x1fW-1ep2B:
0.0		 5x1fW-1ep2B:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_J_CHDJ102_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1ep2 DIHYDROOROTATE
DEHYDROGENASE B
(PYRK SUBUNIT)
(Lactococcus
lactis) 		4 / 5 TYR B  71
MET B  23
THR B  68
LEU B  25
 None
 1.44A 6nknJ-1ep2B:
undetectable		 6nknJ-1ep2B:
17.79