SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ep5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1ep5 CAPSID PROTEIN C
(Venezuelan
equine
encephalitis
virus) 		4 / 8 ILE B 157
PRO B 181
ASN B 183
VAL B 142
 None
 0.95A 3em0B-1ep5B:
0.3		 3em0B-1ep5B:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_A_30BA500_1
(GENOME POLYPROTEIN)		 1ep5 CAPSID PROTEIN C
(Venezuelan
equine
encephalitis
virus) 		5 / 12 HIS B 152
ASP B 174
LYS B 223
GLY B 224
SER B 226
 None
 1.07A 3keeA-1ep5B:
6.5		 3keeA-1ep5B:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_1
(GENOME POLYPROTEIN)		 1ep5 CAPSID PROTEIN C
(Venezuelan
equine
encephalitis
virus) 		5 / 12 HIS B 152
ASP B 174
LYS B 223
GLY B 224
SER B 226
 None
 1.01A 3keeB-1ep5B:
12.2		 3keeB-1ep5B:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_C_30BC500_1
(GENOME POLYPROTEIN)		 1ep5 CAPSID PROTEIN C
(Venezuelan
equine
encephalitis
virus) 		5 / 12 HIS B 152
ASP B 174
LYS B 223
GLY B 224
SER B 226
 None
 1.08A 3keeC-1ep5B:
11.7		 3keeC-1ep5B:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_D_30BD500_1
(GENOME POLYPROTEIN)		 1ep5 CAPSID PROTEIN C
(Venezuelan
equine
encephalitis
virus) 		5 / 12 HIS B 152
ASP B 174
LYS B 223
GLY B 224
SER B 226
 None
 0.98A 3keeD-1ep5B:
12.2		 3keeD-1ep5B:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_A_SAMA226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1ep5 CAPSID PROTEIN C
(Venezuelan
equine
encephalitis
virus) 		5 / 12 GLY B 243
VAL B 255
PRO B 269
ALA B 222
GLY B 221
 None
 0.92A 3ku1A-1ep5B:
undetectable		 3ku1A-1ep5B:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_C_SAMC226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1ep5 CAPSID PROTEIN C
(Venezuelan
equine
encephalitis
virus) 		5 / 12 GLY B 243
VAL B 255
PRO B 269
ALA B 222
GLY B 221
 None
 0.92A 3ku1C-1ep5B:
undetectable		 3ku1C-1ep5B:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1ep5 CAPSID PROTEIN C
(Venezuelan
equine
encephalitis
virus) 		5 / 12 HIS B 152
ASP B 174
LYS B 223
GLY B 224
SER B 226
 None
 1.01A 3sueA-1ep5B:
10.9		 3sueA-1ep5B:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1ep5 CAPSID PROTEIN C
(Venezuelan
equine
encephalitis
virus) 		5 / 12 HIS B 152
ASP B 174
LYS B 223
GLY B 224
SER B 226
 None
 0.82A 3sueB-1ep5B:
10.9		 3sueB-1ep5B:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU8_A_ACTA304_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 1ep5 CAPSID PROTEIN C
(Venezuelan
equine
encephalitis
virus) 		3 / 3 ARG B 228
HIS B 203
TYR B 139
 None
URE  B 946 (-4.7A)
None
 0.91A 4fu8A-1ep5B:
4.0		 4fu8A-1ep5B:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU8_A_ACTA304_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 1ep5 CAPSID PROTEIN C
(Venezuelan
equine
encephalitis
virus) 		3 / 3 ARG B 228
HIS B 204
TYR B 139
 None
URE  B 946 (-4.3A)
None
 1.07A 4fu8A-1ep5B:
4.0		 4fu8A-1ep5B:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU9_A_ACTA312_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 1ep5 CAPSID PROTEIN C
(Venezuelan
equine
encephalitis
virus) 		3 / 3 ARG B 228
HIS B 203
TYR B 139
 None
URE  B 946 (-4.7A)
None
 0.98A 4fu9A-1ep5B:
9.2		 4fu9A-1ep5B:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU9_A_ACTA312_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 1ep5 CAPSID PROTEIN C
(Venezuelan
equine
encephalitis
virus) 		3 / 3 ARG B 228
HIS B 204
TYR B 139
 None
URE  B 946 (-4.3A)
None
 0.97A 4fu9A-1ep5B:
9.2		 4fu9A-1ep5B:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_C_SUEC1203_0
(NS3 PROTEASE)		 1ep5 CAPSID PROTEIN C
(Venezuelan
equine
encephalitis
virus) 		5 / 12 HIS B 152
ASP B 174
GLY B 224
SER B 226
VAL B 245
 None
 0.70A 6c2mC-1ep5B:
11.0		 6c2mC-1ep5B:
19.44