SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ept'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AQ7_B_AG2B4_1
(TRYPSIN
AERUGINOSIN 98-B)		 1ept PORCINE E-TRYPSIN
(Sus
scrofa) 		5 / 8 ASP C 189
SER C 190
GLN C 192
SER C 195
GLY C 219
 None
 1.39A 1aq7A-1eptC:
12.7		 1aq7A-1eptC:
81.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AQ7_B_AG2B4_1
(TRYPSIN
AERUGINOSIN 98-B)		 1ept PORCINE E-TRYPSIN
(Sus
scrofa) 		8 / 8 HIS A  57
ASP C 189
SER C 190
GLN C 192
SER C 195
VAL C 213
GLY C 216
GLY C 226
 None
 0.47A 1aq7A-1eptA:
3.0		 1aq7A-1eptA:
90.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)		 1ept PORCINE E-TRYPSIN
(Sus
scrofa) 		6 / 9 ASP C 189
SER C 195
VAL C 213
TRP C 215
GLY C 216
GLY C 226
 None
 0.41A 1bcuH-1eptC:
10.3		 1bcuH-1eptC:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DWC_H_MITH1_1
(ALPHA-THROMBIN
(LARGE SUBUNIT))		 1ept PORCINE E-TRYPSIN
(Sus
scrofa) 		5 / 9 HIS A  57
ASP C 189
SER C 195
TRP C 215
GLY C 226
 None
 0.34A 1dwcH-1eptA:
2.2		 1dwcH-1eptA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_A_IBPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 1ept PORCINE E-TRYPSIN
(Sus
scrofa) 		6 / 9 VAL A  52
LEU B  67
ILE B  63
ALA B  85
SER B 109
LEU B 108
 None
 1.17A 1eqgA-1eptA:
undetectable		 1eqgA-1eptA:
5.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_B_IBPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 1ept PORCINE E-TRYPSIN
(Sus
scrofa) 		6 / 11 VAL A  52
LEU B  67
ILE B  63
ALA B  85
SER B 109
LEU B 108
 None
 1.16A 1eqgB-1eptA:
undetectable		 1eqgB-1eptA:
5.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_A_FLPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 1ept PORCINE E-TRYPSIN
(Sus
scrofa) 		6 / 12 VAL A  52
LEU B  67
ILE B  63
ALA B  85
SER B 109
LEU B 108
 None
 1.19A 1eqhA-1eptA:
undetectable		 1eqhA-1eptA:
5.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_B_FLPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 1ept PORCINE E-TRYPSIN
(Sus
scrofa) 		6 / 12 VAL A  52
LEU B  67
ILE B  63
ALA B  85
SER B 109
LEU B 108
 None
 1.18A 1eqhB-1eptA:
undetectable		 1eqhB-1eptA:
5.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETR_H_MITH1_1
(EPSILON-THROMBIN)		 1ept PORCINE E-TRYPSIN
(Sus
scrofa) 		8 / 12 HIS A  57
LEU B  99
ASP C 189
SER C 195
VAL C 213
TRP C 215
GLY C 216
GLY C 226
 None
 0.51A 1etrH-1eptA:
2.2		 1etrH-1eptA:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 1ept PORCINE E-TRYPSIN
(Sus
scrofa) 		6 / 8 ASP C 189
SER C 190
SER C 195
VAL C 213
GLY C 216
GLY C 226
 None
 0.37A 1f5lA-1eptC:
12.5		 1f5lA-1eptC:
24.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TNL_A_TPAA900_1
(TRYPSIN)		 1ept PORCINE E-TRYPSIN
(Sus
scrofa) 		6 / 6 ASP C 189
SER C 190
SER C 195
VAL C 213
GLY C 216
GLY C 226
 None
 0.23A 1tnlA-1eptC:
16.1		 1tnlA-1eptC:
81.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTF_A_2TNA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 1ept PORCINE E-TRYPSIN
(Sus
scrofa) 		4 / 5 LEU C 155
ILE B  73
SER A  32
GLY A  43
 None
 0.92A 2otfA-1eptC:
undetectable		 2otfA-1eptC:
24.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OTV_A_NCAA1301_0
(CATIONIC TRYPSIN)		 1ept PORCINE E-TRYPSIN
(Sus
scrofa) 		6 / 6 ASP C 189
SER C 190
SER C 195
VAL C 213
GLY C 216
GLY C 226
 None
 0.24A 2otvA-1eptC:
16.2		 2otvA-1eptC:
81.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P16_A_GG2A298_1
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 1ept PORCINE E-TRYPSIN
(Sus
scrofa) 		7 / 12 ASP C 189
SER C 195
VAL C 213
TRP C 215
GLY C 216
GLY C 226
TYR C 228
 None
 0.38A 2p16A-1eptC:
14.2		 2p16A-1eptC:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VIN_A_505A1247_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR CHAIN B)		 1ept PORCINE E-TRYPSIN
(Sus
scrofa) 		6 / 8 ASP C 189
SER C 190
SER C 195
VAL C 213
GLY C 216
GLY C 226
 None
 0.28A 2vinA-1eptC:
12.9		 2vinA-1eptC:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		 1ept PORCINE E-TRYPSIN
(Sus
scrofa) 		8 / 12 ASP C 189
SER C 195
VAL C 213
TRP C 215
GLY C 216
GLY C 219
GLY C 226
TYR C 228
 None
 0.46A 2w26A-1eptC:
12.7		 2w26A-1eptC:
20.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GY3_A_PNTA246_0
(CATIONIC TRYPSIN)		 1ept PORCINE E-TRYPSIN
PORCINE E-TRYPSIN
PORCINE E-TRYPSIN
(Sus
scrofa;
Sus
scrofa;
Sus
scrofa) 		9 / 11 HIS A  57
LEU B  99
ASP C 189
SER C 190
GLN C 192
SER C 195
TRP C 215
GLY C 216
GLY C 226
 None
 0.41A 3gy3A-1eptA:
4.4		 3gy3A-1eptA:
90.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GY3_A_PNTA246_0
(CATIONIC TRYPSIN)		 1ept PORCINE E-TRYPSIN
PORCINE E-TRYPSIN
PORCINE E-TRYPSIN
(Sus
scrofa;
Sus
scrofa;
Sus
scrofa) 		9 / 11 HIS A  57
LEU B  99
GLN C 175
ASP C 189
SER C 190
SER C 195
TRP C 215
GLY C 216
GLY C 226
 None
 0.55A 3gy3A-1eptA:
4.4		 3gy3A-1eptA:
90.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD8_0
(GRAMICIDIN D)		 1ept PORCINE E-TRYPSIN
(Sus
scrofa) 		3 / 3 VAL C 227
VAL C 213
TRP C 215
 None
 0.97A 3l8lC-1eptC:
undetectable
3l8lD-1eptC:
undetectable		 3l8lC-1eptC:
14.81
3l8lD-1eptC:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1ept PORCINE E-TRYPSIN
PORCINE E-TRYPSIN
PORCINE E-TRYPSIN
(Sus
scrofa;
Sus
scrofa;
Sus
scrofa) 		5 / 12 ILE C 212
VAL C 213
GLY A  44
ALA A  55
ILE B  73
 None
 0.97A 3mb5A-1eptC:
undetectable		 3mb5A-1eptC:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_C_FLPC701_1
(CYCLOOXYGENASE-2)		 1ept PORCINE E-TRYPSIN
(Sus
scrofa) 		5 / 12 VAL A  52
LEU B  67
ALA B  85
SER B 109
LEU B 108
 None
 0.95A 3pghC-1eptA:
undetectable		 3pghC-1eptA:
6.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ept PORCINE E-TRYPSIN
(Sus
scrofa) 		5 / 12 VAL A  52
LEU B  67
ALA B  85
SER B 109
LEU B 108
 None
 1.06A 3rr3A-1eptA:
undetectable		 3rr3A-1eptA:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_B_FLRB700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ept PORCINE E-TRYPSIN
(Sus
scrofa) 		5 / 12 VAL A  52
LEU B  67
ALA B  85
SER B 109
LEU B 108
 None
 1.06A 3rr3B-1eptA:
undetectable		 3rr3B-1eptA:
7.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXF_A_4APA9_1
(CATIONIC TRYPSIN)		 1ept PORCINE E-TRYPSIN
(Sus
scrofa) 		6 / 6 SER C 190
SER C 195
VAL C 213
TRP C 215
GLY C 216
GLY C 226
 None
 0.29A 3rxfA-1eptC:
13.0		 3rxfA-1eptC:
81.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)		 1ept PORCINE E-TRYPSIN
(Sus
scrofa) 		5 / 5 ASP C 189
SER C 190
SER C 195
VAL C 213
GLY C 226
 None
 0.25A 3rxhA-1eptC:
16.3		 3rxhA-1eptC:
81.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V1N_A_BEZA288_0
(2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE)		 1ept PORCINE E-TRYPSIN
PORCINE E-TRYPSIN
(Sus
scrofa;
Sus
scrofa) 		5 / 8 GLY C 197
GLY C 196
ILE B 103
LEU B 105
VAL C 231
 None
 1.09A 3v1nA-1eptC:
undetectable		 3v1nA-1eptC:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF512_1
(HEMOLYTIC LECTIN
CEL-III)		 1ept PORCINE E-TRYPSIN
(Sus
scrofa) 		4 / 6 THR B 144
ASN B 143
GLY C 193
ILE B  73
 None
 0.85A 3w9tF-1eptB:
undetectable		 3w9tF-1eptB:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU8_A_ACTA302_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 1ept PORCINE E-TRYPSIN
PORCINE E-TRYPSIN
(Sus
scrofa;
Sus
scrofa) 		5 / 5 HIS A  57
TYR C 151
GLN C 192
GLY C 193
SER C 195
 None
 1.00A 4fu8A-1eptA:
3.1		 4fu8A-1eptA:
8.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_B_15UB402_1
(PROTHROMBIN)		 1ept PORCINE E-TRYPSIN
(Sus
scrofa) 		5 / 12 HIS A  57
LEU B  99
ASP C 189
GLY C 216
GLY C 226
 None
 0.41A 4hfpB-1eptA:
2.2		 4hfpB-1eptA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		 1ept PORCINE E-TRYPSIN
(Sus
scrofa) 		6 / 12 HIS A  57
LEU B  99
ASP C 189
VAL C 213
TRP C 215
GLY C 226
 None
 0.42A 4hfpD-1eptA:
2.2		 4hfpD-1eptA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_A_IBPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ept PORCINE E-TRYPSIN
(Sus
scrofa) 		5 / 10 VAL A  52
LEU B  67
ALA B  85
SER B 109
LEU B 108
 None
 0.97A 4ph9A-1eptA:
undetectable		 4ph9A-1eptA:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_B_IBPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ept PORCINE E-TRYPSIN
(Sus
scrofa) 		5 / 10 VAL A  52
LEU B  67
ALA B  85
SER B 109
LEU B 108
 None
 0.95A 4ph9B-1eptA:
undetectable		 4ph9B-1eptA:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		 1ept PORCINE E-TRYPSIN
(Sus
scrofa) 		6 / 12 HIS A  57
LEU B  99
VAL C 213
TRP C 215
GLY C 216
GLY C 226
 None
 0.41A 4rn6B-1eptA:
undetectable		 4rn6B-1eptA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_C_REAC602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 1ept PORCINE E-TRYPSIN
(Sus
scrofa) 		5 / 10 GLY A  44
GLN C 239
ASN A  48
LEU A  46
LEU B  67
 None
 1.31A 5fhzC-1eptA:
undetectable		 5fhzC-1eptA:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_1
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1ept PORCINE E-TRYPSIN
PORCINE E-TRYPSIN
(Sus
scrofa;
Sus
scrofa) 		3 / 3 SER C 214
SER C 195
PHE B  94
 None
 0.92A 5mugA-1eptC:
undetectable		 5mugA-1eptC:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_E_DVAE7_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 1ept PORCINE E-TRYPSIN
(Sus
scrofa) 		3 / 3 TYR C 217
SER C 171
TRP C 215
 None
 0.90A 5n8jB-1eptC:
0.0		 5n8jB-1eptC:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_O_DVAO7_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 1ept PORCINE E-TRYPSIN
(Sus
scrofa) 		3 / 3 TYR C 217
SER C 171
TRP C 215
 None
 0.85A 5n8jA-1eptC:
0.0		 5n8jA-1eptC:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_P_DVAP5_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 1ept PORCINE E-TRYPSIN
(Sus
scrofa) 		3 / 3 TYR C 217
SER C 171
TRP C 215
 None
 0.86A 5n8jD-1eptC:
0.0		 5n8jD-1eptC:
23.12