SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1epv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DG5_A_TOPA201_1
(DIHYDROFOLATE
REDUCTASE)		 1epv ALANINE RACEMASE
(Geobacillus
stearothermophil
us) 		5 / 11 ILE A  34
ALA A  54
ILE A  17
PHE A 220
LEU A 241
 None
 0.94A 1dg5A-1epvA:
undetectable		 1dg5A-1epvA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_A_NCAA700_0
(EXOTOXIN A)		 1epv ALANINE RACEMASE
(Geobacillus
stearothermophil
us) 		4 / 7 HIS A  45
GLY A  44
ALA A  42
TYR A  43
 None
None
None
DCS  A1001 (-4.3A)
 0.87A 1dmaA-1epvA:
undetectable		 1dmaA-1epvA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRQ_A_STRA501_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 1epv ALANINE RACEMASE
(Geobacillus
stearothermophil
us) 		5 / 11 GLU A 153
VAL A 149
ILE A 152
HIS A 200
LEU A  83
 None
 1.35A 1mrqA-1epvA:
5.3		 1mrqA-1epvA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPO_H_TESH1010_1
(ANTI-TESTOSTERONE
(HEAVY CHAIN)
ANTI-TESTOSTERONE
(LIGHT CHAIN))		 1epv ALANINE RACEMASE
(Geobacillus
stearothermophil
us) 		5 / 12 SER A 204
ALA A 228
TYR A 354
LEU A 241
VAL A  37
 DCS  A1001 (-1.9A)
None
DCS  A1001 (-4.4A)
None
None
 1.25A 1vpoH-1epvA:
0.0
1vpoL-1epvA:
0.0		 1vpoH-1epvA:
20.90
1vpoL-1epvA:
20.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XQL_A_4AXA605_1
(ALANINE RACEMASE)		 1epv ALANINE RACEMASE
(Geobacillus
stearothermophil
us) 		4 / 8 LYS A  39
TYR A  43
ARG A 136
TYR A 354
 DCS  A1001 (-2.2A)
DCS  A1001 (-4.3A)
DCS  A1001 (-3.1A)
DCS  A1001 (-4.4A)
 0.40A 1xqlA-1epvA:
60.2
1xqlB-1epvA:
59.1		 1xqlA-1epvA:
99.74
1xqlB-1epvA:
99.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XQL_B_4AXB505_1
(ALANINE RACEMASE)		 1epv ALANINE RACEMASE
(Geobacillus
stearothermophil
us) 		4 / 8 LYS A  39
TYR A  43
ARG A 136
TYR A 354
 DCS  A1001 (-2.2A)
DCS  A1001 (-4.3A)
DCS  A1001 (-3.1A)
DCS  A1001 (-4.4A)
 0.43A 1xqlA-1epvA:
60.2
1xqlB-1epvA:
59.1		 1xqlA-1epvA:
99.74
1xqlB-1epvA:
99.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_D_IMND476_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 1epv ALANINE RACEMASE
(Geobacillus
stearothermophil
us) 		5 / 12 THR A 359
CYH A 358
PRO A 357
ILE A 342
VAL A 345
 None
 1.20A 1z9hD-1epvA:
0.0		 1z9hD-1epvA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9W_A_PAUA6002_0
(PANTOTHENATE KINASE)		 1epv ALANINE RACEMASE
(Geobacillus
stearothermophil
us) 		4 / 8 ARG A 184
THR A 165
GLY A 133
THR A 169
 None
 0.76A 2f9wA-1epvA:
undetectable
2f9wB-1epvA:
undetectable		 2f9wA-1epvA:
21.68
2f9wB-1epvA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_2
(CYTOCHROME P450 2C8)		 1epv ALANINE RACEMASE
(Geobacillus
stearothermophil
us) 		5 / 8 ILE A 306
ILE A 317
ARG A 250
ILE A 310
VAL A 329
 None
 1.29A 2nniA-1epvA:
0.0		 2nniA-1epvA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1104_0
(FERROCHELATASE)		 1epv ALANINE RACEMASE
(Geobacillus
stearothermophil
us) 		3 / 3 LEU A 319
PRO A 320
LEU A 323
 None
 0.49A 2qd5B-1epvA:
undetectable		 2qd5B-1epvA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 1epv ALANINE RACEMASE
(Geobacillus
stearothermophil
us) 		5 / 12 ALA A  54
SER A 204
ALA A 228
PRO A 229
GLY A 226
 None
DCS  A1001 (-1.9A)
None
None
None
 1.20A 2zifB-1epvA:
undetectable		 2zifB-1epvA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1epv ALANINE RACEMASE
(Geobacillus
stearothermophil
us) 		4 / 8 ILE A 317
LEU A 319
VAL A 325
GLY A 326
 None
 0.85A 3w1wA-1epvA:
undetectable		 3w1wA-1epvA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM2_A_TOPA202_1
(DIHYDROFOLATE
REDUCTASE)		 1epv ALANINE RACEMASE
(Geobacillus
stearothermophil
us) 		5 / 12 ILE A  34
ALA A  54
ILE A  17
PHE A 220
LEU A 208
 None
 0.94A 4km2A-1epvA:
undetectable		 4km2A-1epvA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM2_B_TOPB202_1
(DIHYDROFOLATE
REDUCTASE)		 1epv ALANINE RACEMASE
(Geobacillus
stearothermophil
us) 		5 / 12 ILE A  34
ALA A  54
ILE A  17
PHE A 220
LEU A 208
 None
 1.02A 4km2B-1epvA:
undetectable		 4km2B-1epvA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_1
(DIHYDROFOLATE
REDUCTASE)		 1epv ALANINE RACEMASE
(Geobacillus
stearothermophil
us) 		5 / 12 ILE A  34
ALA A  54
ILE A  17
PHE A 220
LEU A 241
 None
 0.97A 4m2xA-1epvA:
undetectable		 4m2xA-1epvA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVP_B_GBMB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 1epv ALANINE RACEMASE
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A 128
VAL A 149
ILE A 152
HIS A 200
LEU A  83
 KCX  A 129 ( 3.6A)
None
None
None
None
 1.32A 4yvpB-1epvA:
5.6		 4yvpB-1epvA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MTH_A_ACTA301_0
(ANTIBODY FAB HEAVY
CHAIN)		 1epv ALANINE RACEMASE
(Geobacillus
stearothermophil
us) 		4 / 4 THR A  32
VAL A 218
PRO A 211
THR A 214
 None
 1.03A 5mthA-1epvA:
0.0
5mthH-1epvA:
0.0		 5mthA-1epvA:
19.72
5mthH-1epvA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_2
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 1epv ALANINE RACEMASE
(Geobacillus
stearothermophil
us) 		4 / 4 VAL A  64
LEU A  67
ASN A  41
ASP A  47
 None
 1.32A 5vcyA-1epvA:
undetectable		 5vcyA-1epvA:
20.92