SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1epx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_CCSB381_0
(ESTROGEN RECEPTOR)		 1epx FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE
(Leishmania
mexicana) 		3 / 3 GLU A 221
ALA A 172
SER A 169
 None
 0.65A 1errB-1epxA:
0.0		 1errB-1epxA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_F_REAF177_1
(RETINOL BINDING
PROTEIN)		 1epx FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE
(Leishmania
mexicana) 		5 / 11 LEU A 238
ALA A 224
VAL A 277
LEU A 307
MET A 270
 None
 1.16A 1rlbF-1epxA:
undetectable		 1rlbF-1epxA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TV8_A_SAMA1501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 1epx FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE
(Leishmania
mexicana) 		4 / 7 TYR A 161
THR A 265
THR A 269
VAL A 173
 None
 1.23A 1tv8A-1epxA:
2.8		 1tv8A-1epxA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA501_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 1epx FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE
(Leishmania
mexicana) 		5 / 9 GLY A  38
SER A  83
LEU A  39
PHE A 306
LEU A 237
 None
 1.41A 1y7iA-1epxA:
undetectable		 1y7iA-1epxA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_A_ACTA653_0
(ACETYL-COENZYME A
SYNTHETASE)		 1epx FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE
(Leishmania
mexicana) 		4 / 5 VAL A 223
VAL A 231
GLY A 230
TRP A 233
 None
 0.91A 2p2fA-1epxA:
2.3		 2p2fA-1epxA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 1epx FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE
(Leishmania
mexicana) 		5 / 11 LEU A 106
LEU A  73
ILE A 195
MET A 278
ILE A  82
 None
 1.22A 2uxoB-1epxA:
0.0		 2uxoB-1epxA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W1B_A_DXCA2034_0
(ACRIFLAVIN
RESISTANCE PROTEIN B)		 1epx FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE
(Leishmania
mexicana) 		3 / 3 PHE A 154
SER A 310
LEU A  40
 None
 0.71A 2w1bA-1epxA:
0.0		 2w1bA-1epxA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_A_IBPA1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 1epx FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE
(Leishmania
mexicana) 		4 / 7 LEU A 186
GLY A 139
GLY A 136
THR A 117
 None
 0.81A 2wd9A-1epxA:
2.4		 2wd9A-1epxA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GVU_A_STIA1001_2
(TYROSINE-PROTEIN
KINASE ABL2)		 1epx FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE
(Leishmania
mexicana) 		4 / 5 LYS A 239
VAL A  85
ILE A 195
TYR A 305
 None
 1.28A 3gvuA-1epxA:
undetectable		 3gvuA-1epxA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_B_SAMB220_0
(16S RRNA METHYLASE)		 1epx FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE
(Leishmania
mexicana) 		5 / 12 GLY A 191
PRO A 194
VAL A 193
ALA A 184
LEU A  17
 None
 0.93A 3mteB-1epxA:
undetectable		 3mteB-1epxA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_2
(P38A)		 1epx FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE
(Leishmania
mexicana) 		3 / 3 GLU A 197
LEU A 280
LEU A  40
 None
 0.76A 3ohtA-1epxA:
undetectable		 3ohtA-1epxA:
25.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_2
(P38A)		 1epx FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE
(Leishmania
mexicana) 		3 / 3 GLU A 197
LEU A 280
LEU A  40
 None
 0.72A 3ohtB-1epxA:
undetectable		 3ohtB-1epxA:
25.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_0
(16S RRNA METHYLASE)		 1epx FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE
(Leishmania
mexicana) 		5 / 12 GLY A 191
PRO A 194
VAL A 193
ALA A 184
LEU A  17
 None
 0.89A 3p2kC-1epxA:
undetectable		 3p2kC-1epxA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_D_SAMD6735_0
(16S RRNA METHYLASE)		 1epx FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE
(Leishmania
mexicana) 		5 / 12 GLY A 191
PRO A 194
VAL A 193
ALA A 184
LEU A  17
 None
 0.93A 3p2kD-1epxA:
undetectable		 3p2kD-1epxA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_A_TPVA100_2
(HIV-1 PROTEASE)		 1epx FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE
(Leishmania
mexicana) 		4 / 7 ALA A 253
GLY A 246
ILE A 202
THR A 262
 None
 0.86A 3spkB-1epxA:
undetectable		 3spkB-1epxA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX5_B_MIYB1103_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 1epx FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE
(Leishmania
mexicana) 		5 / 12 GLY A 246
ASP A 209
ILE A 208
ALA A 253
VAL A 258
 None
 1.14A 4dx5B-1epxA:
0.0		 4dx5B-1epxA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1epx FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE
(Leishmania
mexicana) 		4 / 7 VAL A 112
PHE A  78
ILE A  82
PHE A 337
 None
 0.77A 4fglC-1epxA:
0.5		 4fglC-1epxA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6T_A_SAMA201_0
(RNA POLYMERASE
II-ASSOCIATED FACTOR
1 HOMOLOG, LINKER,
RNA
POLYMERASE-ASSOCIATE
D PROTEIN LEO1)		 1epx FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE
(Leishmania
mexicana) 		4 / 4 ILE A 296
VAL A 243
VAL A 263
ARG A 303
 None
 1.36A 4m6tA-1epxA:
0.0		 4m6tA-1epxA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U8V_B_MIYB1103_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 1epx FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE
(Leishmania
mexicana) 		5 / 12 GLY A 246
ASP A 209
ILE A 208
ALA A 253
VAL A 258
 None
 1.13A 4u8vB-1epxA:
0.0		 4u8vB-1epxA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U95_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 1epx FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE
(Leishmania
mexicana) 		5 / 12 GLY A 246
ASP A 209
ILE A 208
ALA A 253
VAL A 258
 None
 1.14A 4u95B-1epxA:
0.0		 4u95B-1epxA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_A_QI9A602_0
(CYTOCHROME P450 2D6)		 1epx FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE
(Leishmania
mexicana) 		5 / 9 PHE A 337
LEU A 338
GLU A  79
VAL A  85
LEU A 106
 None
 1.24A 4wnvA-1epxA:
0.0		 4wnvA-1epxA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_A_HISA302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 1epx FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE
(Leishmania
mexicana) 		6 / 10 GLY A  84
VAL A 111
GLU A  79
VAL A  85
MET A  72
LEU A  73
 None
 1.41A 4yb6A-1epxA:
0.0
4yb6E-1epxA:
0.0		 4yb6A-1epxA:
24.22
4yb6E-1epxA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_B_HISB302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 1epx FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE
(Leishmania
mexicana) 		6 / 10 GLY A  84
VAL A 111
GLU A  79
VAL A  85
MET A  72
LEU A  73
 None
 1.40A 4yb6B-1epxA:
0.0
4yb6C-1epxA:
0.0		 4yb6B-1epxA:
24.22
4yb6C-1epxA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_C_HISC302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 1epx FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE
(Leishmania
mexicana) 		5 / 10 GLY A  84
GLU A  79
VAL A  85
MET A  72
LEU A  73
 None
 1.33A 4yb6C-1epxA:
0.0
4yb6F-1epxA:
0.0		 4yb6C-1epxA:
24.22
4yb6F-1epxA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_D_HISD302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 1epx FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE
(Leishmania
mexicana) 		5 / 10 MET A  72
LEU A  73
GLY A  84
GLU A  79
VAL A  85
 None
 1.31A 4yb6A-1epxA:
0.0
4yb6D-1epxA:
0.0		 4yb6A-1epxA:
24.22
4yb6D-1epxA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_E_HISE302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 1epx FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE
(Leishmania
mexicana) 		5 / 10 MET A  72
LEU A  73
GLY A  84
GLU A  79
VAL A  85
 None
 1.33A 4yb6D-1epxA:
0.0
4yb6E-1epxA:
0.0		 4yb6D-1epxA:
24.22
4yb6E-1epxA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_F_HISF302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 1epx FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE
(Leishmania
mexicana) 		5 / 10 MET A  72
LEU A  73
VAL A 111
GLU A  79
VAL A  85
 None
 1.28A 4yb6B-1epxA:
0.0
4yb6F-1epxA:
0.0		 4yb6B-1epxA:
24.22
4yb6F-1epxA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNM_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 1epx FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE
(Leishmania
mexicana) 		5 / 12 GLY A 136
HIS A  88
TYR A 147
CYH A 155
ILE A 115
 None
 1.36A 4ynmA-1epxA:
undetectable		 4ynmA-1epxA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNM_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 1epx FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE
(Leishmania
mexicana) 		5 / 12 GLY A 136
HIS A  88
TYR A 147
CYH A 155
ILE A 115
 None
 1.33A 4ynmB-1epxA:
undetectable		 4ynmB-1epxA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMI_B_EF2B151_1
(CEREBLON ISOFORM 4)		 1epx FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE
(Leishmania
mexicana) 		4 / 8 ASN A 241
PRO A 240
PHE A 279
SER A 281
 None
 1.39A 5amiB-1epxA:
undetectable		 5amiB-1epxA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_A_SAMA801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 1epx FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE
(Leishmania
mexicana) 		5 / 12 ILE A  86
THR A 117
ASP A 118
CYH A 155
LEU A  39
 None
 0.95A 5hw4A-1epxA:
undetectable		 5hw4A-1epxA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_C_SAMC801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 1epx FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE
(Leishmania
mexicana) 		5 / 12 ILE A  86
THR A 117
ASP A 118
CYH A 155
LEU A  39
 None
 0.92A 5hw4C-1epxA:
undetectable		 5hw4C-1epxA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 1epx FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE
(Leishmania
mexicana) 		5 / 10 VAL A 200
HIS A 206
THR A 252
GLY A 283
LEU A 284
 None
 1.23A 5m5cE-1epxA:
undetectable		 5m5cE-1epxA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA303_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1epx FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE
(Leishmania
mexicana) 		3 / 3 GLU A 104
TYR A 105
ARG A 109
 None
 0.62A 5uunA-1epxA:
0.0		 5uunA-1epxA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA309_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1epx FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE
(Leishmania
mexicana) 		4 / 4 LEU A  25
GLY A 191
SER A 190
SER A 187
 None
 1.35A 5uunA-1epxA:
0.0		 5uunA-1epxA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB305_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1epx FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE
(Leishmania
mexicana) 		3 / 3 GLU A 104
TYR A 105
ARG A 109
 None
 0.57A 5uunB-1epxA:
0.0		 5uunB-1epxA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YSI_A_NCAA1001_0
(UBIQUITINATING/DEUBI
QUITINATING ENZYME
SDEA)		 1epx FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE
(Leishmania
mexicana) 		4 / 6 GLY A 235
SER A  23
THR A  28
VAL A 193
 None
 0.98A 5ysiA-1epxA:
0.0		 5ysiA-1epxA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0C_D_TA1D502_1
(TUBULIN BETA CHAIN)		 1epx FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE
(Leishmania
mexicana) 		6 / 12 VAL A 200
GLU A 199
HIS A 206
THR A 252
GLY A 283
LEU A 284
 None
 1.38A 6b0cD-1epxA:
undetectable		 6b0cD-1epxA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B54_A_OAQA302_0
(SULFOTRANSFERASE)		 1epx FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE
(Leishmania
mexicana) 		5 / 12 ASP A 138
LEU A 137
LEU A 125
PHE A 175
THR A 179
 None
 1.17A 6b54A-1epxA:
undetectable		 6b54A-1epxA:
21.93