SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1epz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_A_BEZA1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 1epz DTDP-6-DEOXY-D-XYLO-
4-HEXULOSE
3,5-EPIMERASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 7 VAL A 131
SER A  53
ARG A  61
HIS A  64
 None
None
TYD  A2187 (-3.7A)
TYD  A2187 (-4.3A)
 0.89A 2f78A-1epzA:
undetectable		 2f78A-1epzA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1001_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 1epz DTDP-6-DEOXY-D-XYLO-
4-HEXULOSE
3,5-EPIMERASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 6 VAL A 131
SER A  53
ARG A  61
HIS A  64
 None
None
TYD  A2187 (-3.7A)
TYD  A2187 (-4.3A)
 0.82A 2f8dA-1epzA:
0.0		 2f8dA-1epzA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UYQ_A_SAMA1311_0
(HYPOTHETICAL PROTEIN
ML2640)		 1epz DTDP-6-DEOXY-D-XYLO-
4-HEXULOSE
3,5-EPIMERASE
(Methanothermobac
ter
thermautotrophic
us) 		6 / 7 ALA A 119
GLY A 121
VAL A  85
ASP A  88
LEU A  89
ARG A  90
 None
 1.33A 2uyqA-1epzA:
undetectable		 2uyqA-1epzA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1epz DTDP-6-DEOXY-D-XYLO-
4-HEXULOSE
3,5-EPIMERASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 7 ILE A 114
GLY A 101
VAL A 131
LEU A  63
 None
 0.87A 3elzA-1epzA:
0.0		 3elzA-1epzA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_A_EVPA1_1
(DNA TOPOISOMERASE
2-BETA)		 1epz DTDP-6-DEOXY-D-XYLO-
4-HEXULOSE
3,5-EPIMERASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 5 GLY A  62
ASP A 172
ARG A  61
GLN A  66
 None
TYD  A2187 ( 4.4A)
TYD  A2187 (-3.7A)
None
 1.29A 3qx3A-1epzA:
undetectable		 3qx3A-1epzA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_D_EVPD1_1
(DNA TOPOISOMERASE
2-BETA)		 1epz DTDP-6-DEOXY-D-XYLO-
4-HEXULOSE
3,5-EPIMERASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 5 GLY A  62
ASP A 172
ARG A  61
GLN A  66
 None
TYD  A2187 ( 4.4A)
TYD  A2187 (-3.7A)
None
 1.32A 3qx3B-1epzA:
0.0		 3qx3B-1epzA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFG_B_LEUB289_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 1epz DTDP-6-DEOXY-D-XYLO-
4-HEXULOSE
3,5-EPIMERASE
(Methanothermobac
ter
thermautotrophic
us) 		3 / 3 PHE A 122
SER A  53
SER A  55
 None
 1.00A 3ufgB-1epzA:
0.5		 3ufgB-1epzA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 1epz DTDP-6-DEOXY-D-XYLO-
4-HEXULOSE
3,5-EPIMERASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 7 GLU A  98
TYR A  96
GLY A 117
ARG A  90
 None
 1.02A 4fgzA-1epzA:
undetectable		 4fgzA-1epzA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A602_1
(SERUM ALBUMIN)		 1epz DTDP-6-DEOXY-D-XYLO-
4-HEXULOSE
3,5-EPIMERASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 7 VAL A  56
ALA A 124
PHE A 122
TYR A 133
 None
 0.87A 4lb2A-1epzA:
undetectable		 4lb2A-1epzA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		 1epz DTDP-6-DEOXY-D-XYLO-
4-HEXULOSE
3,5-EPIMERASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 5 LEU A 178
ASP A 153
TYR A 184
LEU A  89
 None
 1.25A 4wozF-1epzA:
undetectable
4wozH-1epzA:
undetectable		 4wozF-1epzA:
18.75
4wozH-1epzA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_1
(TUBULIN BETA CHAIN)		 1epz DTDP-6-DEOXY-D-XYLO-
4-HEXULOSE
3,5-EPIMERASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 VAL A  85
ASP A  84
ASP A 172
LEU A 166
LEU A 125
 None
None
TYD  A2187 ( 4.4A)
None
None
 1.20A 6ew0F-1epzA:
undetectable		 6ew0F-1epzA:
17.03