SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1eq9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_A_FLPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 1eq9 CHYMOTRYPSIN
(Solenopsis
invicta) 		5 / 12 VAL A  59
VAL A  52
ILE A 212
GLY A 197
LEU A  33
 None
 0.84A 1eqhA-1eq9A:
0.0		 1eqhA-1eq9A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_B_FLPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 1eq9 CHYMOTRYPSIN
(Solenopsis
invicta) 		5 / 12 VAL A  59
VAL A  52
ILE A 212
GLY A 197
LEU A  33
 None
 0.87A 1eqhB-1eq9A:
0.0		 1eqhB-1eq9A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 1eq9 CHYMOTRYPSIN
(Solenopsis
invicta) 		4 / 8 VAL A  59
VAL A  52
ILE A 212
LEU A  33
 None
 0.71A 1igxA-1eq9A:
undetectable		 1igxA-1eq9A:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CL5_B_SAMB1217_1
(CATECHOL
O-METHYLTRANSFERASE)		 1eq9 CHYMOTRYPSIN
(Solenopsis
invicta) 		4 / 6 SER A 233
TYR A 228
GLN A 167
ASP A 127
 None
 1.20A 2cl5B-1eq9A:
0.0		 2cl5B-1eq9A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_D_SAMD300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 1eq9 CHYMOTRYPSIN
(Solenopsis
invicta) 		6 / 12 GLY A 142
GLY A 196
GLY A 193
THR A  54
LEU A  53
VAL A  31
 None
None
PMS  A1201 (-4.0A)
None
None
None
 1.34A 2oxtD-1eq9A:
undetectable		 2oxtD-1eq9A:
20.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2P16_A_GG2A298_1
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 1eq9 CHYMOTRYPSIN
(Solenopsis
invicta) 		5 / 12 ALA A 190
SER A 195
VAL A 213
GLY A 216
TYR A 228
 PMS  A1201 (-3.6A)
PMS  A1201 (-1.5A)
None
PMS  A1201 ( 4.5A)
None
 0.43A 2p16A-1eq9A:
12.9		 2p16A-1eq9A:
34.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		 1eq9 CHYMOTRYPSIN
(Solenopsis
invicta) 		5 / 12 ALA A 190
SER A 195
VAL A 213
GLY A 216
TYR A 228
 PMS  A1201 (-3.6A)
PMS  A1201 (-1.5A)
None
PMS  A1201 ( 4.5A)
None
 0.37A 2w26A-1eq9A:
11.8		 2w26A-1eq9A:
34.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D2T_B_1FLB500_1
(TRANSTHYRETIN)		 1eq9 CHYMOTRYPSIN
(Solenopsis
invicta) 		4 / 6 ALA A  44
SER A 195
THR A  54
VAL A 106
 None
PMS  A1201 (-1.5A)
None
None
 1.01A 3d2tB-1eq9A:
0.0		 3d2tB-1eq9A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_I_SAMI228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 1eq9 CHYMOTRYPSIN
(Solenopsis
invicta) 		5 / 12 LYS A  16
GLY A 197
ILE A 212
ALA A  55
ASP A 194
 None
 0.98A 3nvkI-1eq9A:
undetectable		 3nvkI-1eq9A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_D_MIYD392_1
(TETX2 PROTEIN)		 1eq9 CHYMOTRYPSIN
(Solenopsis
invicta) 		4 / 5 HIS A  57
SER A 195
SER A 214
VAL A 213
 PMS  A1201 ( 4.6A)
PMS  A1201 (-1.5A)
None
None
 1.38A 4a99D-1eq9A:
undetectable		 4a99D-1eq9A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_B_LURB201_1
(TRANSTHYRETIN)		 1eq9 CHYMOTRYPSIN
(Solenopsis
invicta) 		4 / 8 LEU A 155
GLU A 157
THR A 137
VAL A 200
 None
 0.89A 4iizB-1eq9A:
undetectable		 4iizB-1eq9A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK6_B_LURB201_1
(TRANSTHYRETIN)		 1eq9 CHYMOTRYPSIN
(Solenopsis
invicta) 		4 / 8 LEU A 155
GLU A 157
THR A 137
VAL A 200
 None
 0.88A 4ik6B-1eq9A:
undetectable		 4ik6B-1eq9A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 1eq9 CHYMOTRYPSIN
(Solenopsis
invicta) 		5 / 12 GLU A 159
LEU A 184
GLU A 157
GLY A 189
ALA A 221
 None
 1.19A 4xe5A-1eq9A:
undetectable		 4xe5A-1eq9A:
12.18