SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1eqc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_A_DVAA8_0
(GRAMICIDIN A)		 1eqc EXO-(B)-(1,3)-GLUCAN
ASE
(Candida
albicans) 		3 / 4 VAL A  14
TRP A 131
TRP A 360
 None
 1.03A 1gmkA-1eqcA:
undetectable
1gmkB-1eqcA:
undetectable		 1gmkA-1eqcA:
4.33
1gmkB-1eqcA:
4.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_C_DVAC8_0
(GRAMICIDIN A)		 1eqc EXO-(B)-(1,3)-GLUCAN
ASE
(Candida
albicans) 		3 / 4 VAL A  14
TRP A 131
TRP A 360
 None
 1.23A 1gmkC-1eqcA:
undetectable
1gmkD-1eqcA:
undetectable		 1gmkC-1eqcA:
4.33
1gmkD-1eqcA:
4.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_A_NBVA1503_1
(GLUCOSYLCERAMIDASE)		 1eqc EXO-(B)-(1,3)-GLUCAN
ASE
(Candida
albicans) 		6 / 12 ASN A 191
GLU A 192
HIS A 253
TYR A 255
GLU A 292
TRP A 363
 CTS  A 401 (-3.1A)
CTS  A 401 (-3.3A)
None
CTS  A 401 (-3.7A)
CTS  A 401 (-2.8A)
CTS  A 401 (-3.5A)
 0.69A 2v3dA-1eqcA:
16.5		 2v3dA-1eqcA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_B_NBVB1504_1
(GLUCOSYLCERAMIDASE)		 1eqc EXO-(B)-(1,3)-GLUCAN
ASE
(Candida
albicans) 		5 / 11 ASN A 191
GLU A 192
TYR A 255
GLU A 292
TRP A 363
 CTS  A 401 (-3.1A)
CTS  A 401 (-3.3A)
CTS  A 401 (-3.7A)
CTS  A 401 (-2.8A)
CTS  A 401 (-3.5A)
 0.77A 2v3dB-1eqcA:
13.9		 2v3dB-1eqcA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_A_DVAA8_0
(GRAMICIDIN A)		 1eqc EXO-(B)-(1,3)-GLUCAN
ASE
(Candida
albicans) 		3 / 3 VAL A  25
TRP A  74
TRP A  23
 None
 1.00A 2xdcA-1eqcA:
undetectable
2xdcB-1eqcA:
undetectable		 2xdcA-1eqcA:
4.33
2xdcB-1eqcA:
4.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_B_DVAB8_0
(GRAMICIDIN A)		 1eqc EXO-(B)-(1,3)-GLUCAN
ASE
(Candida
albicans) 		3 / 3 TRP A  23
VAL A  25
TRP A  74
 None
 0.99A 2xdcA-1eqcA:
undetectable
2xdcB-1eqcA:
undetectable		 2xdcA-1eqcA:
4.33
2xdcB-1eqcA:
4.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_C_DVAC8_0
(GRAMICIDIN A)		 1eqc EXO-(B)-(1,3)-GLUCAN
ASE
(Candida
albicans) 		3 / 3 VAL A  25
TRP A  74
TRP A  23
 None
 1.32A 2xdcC-1eqcA:
undetectable
2xdcD-1eqcA:
undetectable		 2xdcC-1eqcA:
4.33
2xdcD-1eqcA:
4.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1eqc EXO-(B)-(1,3)-GLUCAN
ASE
(Candida
albicans) 		4 / 7 GLN A 110
ILE A  95
TYR A 108
TYR A  97
 None
 1.26A 2xz5D-1eqcA:
0.0
2xz5E-1eqcA:
0.0		 2xz5D-1eqcA:
18.53
2xz5E-1eqcA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y5M_A_DVAA8_0
(VAL-GRAMICIDIN A)		 1eqc EXO-(B)-(1,3)-GLUCAN
ASE
(Candida
albicans) 		3 / 3 VAL A  25
TRP A  74
TRP A  23
 None
 0.97A 2y5mA-1eqcA:
undetectable
2y5mB-1eqcA:
undetectable		 2y5mA-1eqcA:
4.33
2y5mB-1eqcA:
4.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_A_DVAA8_0
(VAL-GRAMICIDIN A)		 1eqc EXO-(B)-(1,3)-GLUCAN
ASE
(Candida
albicans) 		3 / 3 VAL A  25
TRP A  74
TRP A  23
 None
 0.97A 2y6nA-1eqcA:
undetectable
2y6nB-1eqcA:
undetectable		 2y6nA-1eqcA:
4.33
2y6nB-1eqcA:
4.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_B_DVAB8_0
(VAL-GRAMICIDIN A)		 1eqc EXO-(B)-(1,3)-GLUCAN
ASE
(Candida
albicans) 		3 / 3 TRP A  23
VAL A  25
TRP A  74
 None
 0.98A 2y6nA-1eqcA:
undetectable
2y6nB-1eqcA:
undetectable		 2y6nA-1eqcA:
4.33
2y6nB-1eqcA:
4.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_1
(MODIFICATION
METHYLASE HHAI)		 1eqc EXO-(B)-(1,3)-GLUCAN
ASE
(Candida
albicans) 		3 / 3 GLU A 179
SER A 219
VAL A 220
 None
 0.78A 3eeoA-1eqcA:
undetectable		 3eeoA-1eqcA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW4_A_TICA600_1
(CYTOCHROME P450 2B4)		 1eqc EXO-(B)-(1,3)-GLUCAN
ASE
(Candida
albicans) 		5 / 11 ILE A 224
ILE A  15
VAL A 289
VAL A 361
GLY A  17
 None
 0.95A 3kw4A-1eqcA:
undetectable		 3kw4A-1eqcA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF512_1
(HEMOLYTIC LECTIN
CEL-III)		 1eqc EXO-(B)-(1,3)-GLUCAN
ASE
(Candida
albicans) 		4 / 6 THR A 377
ASN A 381
GLY A 382
ILE A 347
 None
 0.74A 3w9tF-1eqcA:
undetectable		 3w9tF-1eqcA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_A_DVAA8_0
(VAL-GRAMICIDIN A)		 1eqc EXO-(B)-(1,3)-GLUCAN
ASE
(Candida
albicans) 		3 / 3 VAL A  25
TRP A  74
TRP A  23
 None
 1.19A 3zq8A-1eqcA:
undetectable
3zq8B-1eqcA:
undetectable		 3zq8A-1eqcA:
4.33
3zq8B-1eqcA:
4.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_C_DVAC8_0
(VAL-GRAMICIDIN A)		 1eqc EXO-(B)-(1,3)-GLUCAN
ASE
(Candida
albicans) 		4 / 4 VAL A  25
TRP A  74
TRP A  23
TRP A  98
 None
 1.36A 3zq8C-1eqcA:
undetectable
3zq8D-1eqcA:
undetectable		 3zq8C-1eqcA:
4.33
3zq8D-1eqcA:
4.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA7_A_P2ZA301_1
(MAJOR PRION PROTEIN)		 1eqc EXO-(B)-(1,3)-GLUCAN
ASE
(Candida
albicans) 		4 / 8 VAL A  25
TYR A  52
VAL A 163
THR A 164
 None
 0.74A 4ma7A-1eqcA:
0.0		 4ma7A-1eqcA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_MTLA501_1
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 1eqc EXO-(B)-(1,3)-GLUCAN
ASE
(Candida
albicans) 		3 / 3 GLU A 292
TYR A  29
GLU A  27
 CTS  A 401 (-2.8A)
CTS  A 401 (-4.6A)
CTS  A 401 (-2.7A)
 0.65A 4ryaA-1eqcA:
0.0		 4ryaA-1eqcA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_B_BQ1B1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 1eqc EXO-(B)-(1,3)-GLUCAN
ASE
(Candida
albicans) 		4 / 8 ALA A  62
ALA A  63
ILE A  66
LEU A  34
 None
 0.64A 4v1fA-1eqcA:
undetectable
4v1fB-1eqcA:
undetectable		 4v1fA-1eqcA:
11.08
4v1fB-1eqcA:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_D_ADND303_1
(5'/3'-NUCLEOTIDASE
SURE)		 1eqc EXO-(B)-(1,3)-GLUCAN
ASE
(Candida
albicans) 		5 / 10 LEU A 189
GLY A 210
TYR A 211
SER A 213
ILE A 225
 None
 1.11A 4xj7C-1eqcA:
undetectable
4xj7D-1eqcA:
undetectable		 4xj7C-1eqcA:
19.81
4xj7D-1eqcA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_E_Z80E401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1eqc EXO-(B)-(1,3)-GLUCAN
ASE
(Candida
albicans) 		5 / 12 ILE A  15
VAL A 289
ASN A 191
ASP A 133
ILE A 224
 None
None
CTS  A 401 (-3.1A)
None
None
 1.00A 5lg3E-1eqcA:
0.0		 5lg3E-1eqcA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_J_Z80J401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1eqc EXO-(B)-(1,3)-GLUCAN
ASE
(Candida
albicans) 		5 / 12 ILE A  15
VAL A 289
ASN A 191
ASP A 133
ILE A 224
 None
None
CTS  A 401 (-3.1A)
None
None
 0.97A 5lg3J-1eqcA:
undetectable		 5lg3J-1eqcA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNW_D_GCSD302_1
(25 KDA PROTEIN
ELICITOR)		 1eqc EXO-(B)-(1,3)-GLUCAN
ASE
(Candida
albicans) 		4 / 7 GLY A 359
ASP A 251
HIS A 254
ASN A 288
 None
 1.06A 5nnwD-1eqcA:
0.0		 5nnwD-1eqcA:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NO9_D_95ZD302_1
(25 KDA PROTEIN
ELICITOR)		 1eqc EXO-(B)-(1,3)-GLUCAN
ASE
(Candida
albicans) 		4 / 7 GLY A 359
ASP A 251
HIS A 254
ASN A 288
 None
 1.08A 5no9D-1eqcA:
0.0		 5no9D-1eqcA:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8F_A_ACTA803_0
(UNCHARACTERIZED
PROTEIN)		 1eqc EXO-(B)-(1,3)-GLUCAN
ASE
(Candida
albicans) 		3 / 3 GLU A 117
LEU A 120
ARG A 124
 None
 0.73A 6d8fA-1eqcA:
1.6		 6d8fA-1eqcA:
19.77