SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1eqf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1eqf RNA POLYMERASE II
TRANSCRIPTION
INITIATION FACTOR
(Homo
sapiens) 		3 / 3 VAL A1505
ALA A1506
HIS A1610
 None
 0.78A 1q23L-1eqfA:
0.0		 1q23L-1eqfA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1eqf RNA POLYMERASE II
TRANSCRIPTION
INITIATION FACTOR
(Homo
sapiens) 		3 / 3 LYS A1454
ASP A1549
ASP A1571
 None
 0.97A 2br4A-1eqfA:
undetectable		 2br4A-1eqfA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTR_A_LQZA90_1
(LACTOTRANSFERRIN)		 1eqf RNA POLYMERASE II
TRANSCRIPTION
INITIATION FACTOR
(Homo
sapiens) 		3 / 3 PRO A1404
THR A1402
LEU A1427
 None
 0.75A 3ttrA-1eqfA:
undetectable		 3ttrA-1eqfA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUZ_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		 1eqf RNA POLYMERASE II
TRANSCRIPTION
INITIATION FACTOR
(Homo
sapiens) 		3 / 3 LYS A1534
PRO A1538
LYS A1419
 None
 1.48A 4duzL-1eqfA:
undetectable		 4duzL-1eqfA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1eqf RNA POLYMERASE II
TRANSCRIPTION
INITIATION FACTOR
(Homo
sapiens) 		4 / 7 ASP A1549
ASN A1556
GLU A1447
ASP A1571
 None
 1.08A 4feuB-1eqfA:
0.0		 4feuB-1eqfA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K36_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 1eqf RNA POLYMERASE II
TRANSCRIPTION
INITIATION FACTOR
(Homo
sapiens) 		5 / 12 ASN A1455
SER A1456
LEU A1466
ILE A1469
LEU A1399
 None
 1.30A 4k36A-1eqfA:
undetectable		 4k36A-1eqfA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K37_B_SAMB504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 1eqf RNA POLYMERASE II
TRANSCRIPTION
INITIATION FACTOR
(Homo
sapiens) 		5 / 11 ASN A1455
SER A1456
LEU A1466
ILE A1469
LEU A1399
 None
 1.29A 4k37B-1eqfA:
undetectable		 4k37B-1eqfA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K39_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 1eqf RNA POLYMERASE II
TRANSCRIPTION
INITIATION FACTOR
(Homo
sapiens) 		5 / 12 ASN A1455
SER A1456
LEU A1466
ILE A1469
LEU A1399
 None
 1.29A 4k39A-1eqfA:
undetectable		 4k39A-1eqfA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PBE_A_TYLA2001_1
(BROMODOMAIN ADJACENT
TO ZINC FINGER
DOMAIN PROTEIN 2B)		 1eqf RNA POLYMERASE II
TRANSCRIPTION
INITIATION FACTOR
(Homo
sapiens) 		5 / 6 PRO A1404
VAL A1409
VAL A1414
TYR A1417
ASN A1460
 None
 0.61A 5pbeA-1eqfA:
14.3		 5pbeA-1eqfA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PBE_A_TYLA2001_1
(BROMODOMAIN ADJACENT
TO ZINC FINGER
DOMAIN PROTEIN 2B)		 1eqf RNA POLYMERASE II
TRANSCRIPTION
INITIATION FACTOR
(Homo
sapiens) 		4 / 6 PRO A1527
VAL A1532
TYR A1540
ASN A1583
 None
 0.84A 5pbeA-1eqfA:
14.3		 5pbeA-1eqfA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PBE_A_TYLA2001_1
(BROMODOMAIN ADJACENT
TO ZINC FINGER
DOMAIN PROTEIN 2B)		 1eqf RNA POLYMERASE II
TRANSCRIPTION
INITIATION FACTOR
(Homo
sapiens) 		4 / 6 VAL A1532
VAL A1537
TYR A1540
ASN A1583
 None
 0.51A 5pbeA-1eqfA:
14.3		 5pbeA-1eqfA:
23.57