SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1erz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4H_A_REAA500_1
(NUCLEAR RECEPTOR
ROR-BETA)		 1erz N-CARBAMYL-D-AMINO
ACID AMIDOHYDROLASE
(Agrobacterium
sp.
KNK712) 		5 / 11 ILE A 190
ALA A 228
MET A 183
ARG A 181
LEU A 113
 None
 1.11A 1n4hA-1erzA:
0.0		 1n4hA-1erzA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_B_ADNB1246_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1erz N-CARBAMYL-D-AMINO
ACID AMIDOHYDROLASE
(Agrobacterium
sp.
KNK712) 		4 / 8 GLY A   9
VAL A 268
GLU A 267
ILE A  42
 None
 0.90A 1pk7B-1erzA:
undetectable		 1pk7B-1erzA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXD_A_DR7A102_2
(POL PROTEIN)		 1erz N-CARBAMYL-D-AMINO
ACID AMIDOHYDROLASE
(Agrobacterium
sp.
KNK712) 		4 / 7 ALA A 164
ASP A 160
GLY A 167
ILE A 191
 None
 0.70A 2fxdB-1erzA:
undetectable		 2fxdB-1erzA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_A_ACTA544_0
(ACETYLCHOLINESTERASE)		 1erz N-CARBAMYL-D-AMINO
ACID AMIDOHYDROLASE
(Agrobacterium
sp.
KNK712) 		5 / 8 GLY A 194
GLY A 193
ALA A 233
PHE A 169
HIS A 215
 None
 1.35A 2ha4A-1erzA:
undetectable		 2ha4A-1erzA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_B_ACTB601_0
(ACETYLCHOLINESTERASE)		 1erz N-CARBAMYL-D-AMINO
ACID AMIDOHYDROLASE
(Agrobacterium
sp.
KNK712) 		5 / 7 GLY A 194
GLY A 193
ALA A 233
PHE A 169
HIS A 215
 None
 1.39A 2ha4B-1erzA:
undetectable		 2ha4B-1erzA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CSJ_B_CBLB211_0
(GLUTATHIONE
S-TRANSFERASE P)		 1erz N-CARBAMYL-D-AMINO
ACID AMIDOHYDROLASE
(Agrobacterium
sp.
KNK712) 		5 / 9 PHE A 156
PRO A 157
GLY A 184
ARG A 181
GLY A 167
 None
 1.26A 3csjB-1erzA:
undetectable		 3csjB-1erzA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEG_A_DAHA416_1
(PHENYLALANYL-TRNA
SYNTHETASE,
MITOCHONDRIAL)		 1erz N-CARBAMYL-D-AMINO
ACID AMIDOHYDROLASE
(Agrobacterium
sp.
KNK712) 		5 / 12 GLN A  11
PHE A  91
PHE A  44
GLY A  94
ALA A  48
 None
 1.12A 3tegA-1erzA:
undetectable		 3tegA-1erzA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A81_A_DXCA1161_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 1erz N-CARBAMYL-D-AMINO
ACID AMIDOHYDROLASE
(Agrobacterium
sp.
KNK712) 		5 / 12 ILE A  14
GLY A  12
ASP A 266
VAL A  43
ASN A 109
 None
 1.17A 4a81A-1erzA:
undetectable		 4a81A-1erzA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_A_DM2A1106_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 1erz N-CARBAMYL-D-AMINO
ACID AMIDOHYDROLASE
(Agrobacterium
sp.
KNK712) 		5 / 11 PHE A  81
PHE A  91
ASN A  92
LEU A  93
ALA A   7
 None
 1.44A 4dx7A-1erzA:
0.0		 4dx7A-1erzA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L78_A_ACTA1327_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)		 1erz N-CARBAMYL-D-AMINO
ACID AMIDOHYDROLASE
(Agrobacterium
sp.
KNK712) 		4 / 4 VAL A  99
THR A  70
GLU A  97
GLU A  69
 None
 1.19A 4l78A-1erzA:
0.0		 4l78A-1erzA:
13.21