SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1es6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P2Y_A_NCTA440_1
(CYTOCHROME P450-CAM)
1es6 MATRIX PROTEIN VP40
(Ebola
virus
sp.)
4 / 7 VAL A 100
GLY A  99
ASP A 253
ILE A 252
None
0.77A 1p2yA-1es6A:
undetectable
1p2yA-1es6A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SGU_B_MK1B2632_1
(POL POLYPROTEIN)
1es6 MATRIX PROTEIN VP40
(Ebola
virus
sp.)
5 / 8 ASP A 296
ILE A 258
GLY A 260
ILE A 261
PRO A 317
None
1.29A 1sguA-1es6A:
undetectable
1sguA-1es6A:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN)
1es6 MATRIX PROTEIN VP40
(Ebola
virus
sp.)
5 / 12 ILE A 115
THR A 112
ASP A  56
ILE A 258
LEU A 288
None
1.09A 1tw4A-1es6A:
0.7
1tw4A-1es6A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)
1es6 MATRIX PROTEIN VP40
(Ebola
virus
sp.)
3 / 3 LYS A 236
ASP A 194
ASN A 220
None
1.14A 2bm9A-1es6A:
undetectable
2bm9A-1es6A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)
1es6 MATRIX PROTEIN VP40
(Ebola
virus
sp.)
5 / 12 ILE A 115
THR A 112
ASP A  56
ILE A 258
LEU A 288
None
1.16A 2jn3A-1es6A:
0.6
2jn3A-1es6A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4N_A_TPVA300_1
(PROTEASE)
1es6 MATRIX PROTEIN VP40
(Ebola
virus
sp.)
6 / 12 ASP A 296
ILE A 258
GLY A 260
ILE A 261
PRO A 317
LEU A 213
None
1.34A 2o4nA-1es6A:
undetectable
2o4nA-1es6A:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)
1es6 MATRIX PROTEIN VP40
(Ebola
virus
sp.)
5 / 12 ILE A 142
LEU A 150
GLY A 153
ARG A  52
ALA A 114
None
0.94A 2oc8A-1es6A:
undetectable
2oc8A-1es6A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_A_KKKA413_1
(FLAVOHEMOGLOBIN)
1es6 MATRIX PROTEIN VP40
(Ebola
virus
sp.)
4 / 8 ILE A 252
GLN A 282
LEU A 186
LEU A 288
None
0.83A 3ozwA-1es6A:
undetectable
3ozwA-1es6A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_0
(METHYLTRANSFERASE
WBDD)
1es6 MATRIX PROTEIN VP40
(Ebola
virus
sp.)
5 / 12 ALA A 318
ILE A 216
LEU A 288
VAL A 287
ILE A 261
None
1.07A 4aztA-1es6A:
undetectable
4aztA-1es6A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)
1es6 MATRIX PROTEIN VP40
(Ebola
virus
sp.)
4 / 5 ILE A  82
LEU A  88
ASP A  45
VAL A 162
None
1.01A 4nkxB-1es6A:
undetectable
4nkxB-1es6A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_1
(ESTROGEN RECEPTOR)
1es6 MATRIX PROTEIN VP40
(Ebola
virus
sp.)
5 / 12 LEU A  75
LEU A 149
GLY A 139
LEU A 138
PRO A  53
None
1.03A 4xi3B-1es6A:
undetectable
4xi3B-1es6A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_A_CELA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)
1es6 MATRIX PROTEIN VP40
(Ebola
virus
sp.)
4 / 6 VAL A 162
SER A 316
ARG A 214
ILE A 216
None
0.95A 5jw1A-1es6A:
0.0
5jw1A-1es6A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_B_CELB602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)
1es6 MATRIX PROTEIN VP40
(Ebola
virus
sp.)
4 / 6 VAL A 162
SER A 316
ARG A 214
ILE A 216
None
0.95A 5jw1B-1es6A:
0.0
5jw1B-1es6A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_2
(PROTEIN CYP51)
1es6 MATRIX PROTEIN VP40
(Ebola
virus
sp.)
4 / 7 VAL A  69
PRO A  97
LEU A  96
LEU A 288
None
1.03A 6aycA-1es6A:
undetectable
6aycA-1es6A:
13.99