SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1esc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1esc ESTERASE
(Streptomyces
scabiei) 		4 / 5 ILE A 291
LEU A 245
VAL A 243
ALA A 240
 None
 0.96A 1mz9C-1escA:
0.0		 1mz9C-1escA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_C_ADNC1503_1
(CLASS B ACID
PHOSPHATASE)		 1esc ESTERASE
(Streptomyces
scabiei) 		4 / 8 PHE A 145
LEU A 154
TRP A 153
GLY A 109
 None
 0.91A 1rmtC-1escA:
2.1		 1rmtC-1escA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_C_SAMC604_0
(HYPOTHETICAL PROTEIN)		 1esc ESTERASE
(Streptomyces
scabiei) 		5 / 12 THR A  16
GLY A 101
SER A 102
VAL A 296
VAL A   9
 None
 1.25A 2yvlC-1escA:
2.0		 2yvlC-1escA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB501_2
(PHOSPHOLIPASE A2)		 1esc ESTERASE
(Streptomyces
scabiei) 		5 / 11 VAL A 243
LEU A 245
GLY A 185
SER A  14
THR A  16
 None
 1.17A 3bjwB-1escA:
0.0		 3bjwB-1escA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE503_1
(PHOSPHOLIPASE A2)		 1esc ESTERASE
(Streptomyces
scabiei) 		5 / 11 VAL A 243
LEU A 245
GLY A 185
SER A  14
THR A  16
 None
 1.23A 3bjwE-1escA:
0.0		 3bjwE-1escA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_3
(PHOSPHOLIPASE A2)		 1esc ESTERASE
(Streptomyces
scabiei) 		5 / 12 VAL A 243
LEU A 245
GLY A 185
SER A  14
THR A  16
 None
 1.28A 3bjwF-1escA:
undetectable		 3bjwF-1escA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH504_3
(PHOSPHOLIPASE A2)		 1esc ESTERASE
(Streptomyces
scabiei) 		5 / 11 VAL A 243
LEU A 245
GLY A 185
SER A  14
THR A  16
 None
 1.25A 3bjwH-1escA:
0.0		 3bjwH-1escA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_0
(2'-O-METHYL
TRANSFERASE)		 1esc ESTERASE
(Streptomyces
scabiei) 		5 / 12 ASN A 106
GLY A  12
SER A  14
GLY A 104
ASN A  40
 None
 1.32A 3r24A-1escA:
2.7		 3r24A-1escA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V1N_A_BEZA288_0
(2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE)		 1esc ESTERASE
(Streptomyces
scabiei) 		5 / 8 GLY A 148
GLY A 150
GLY A 142
ILE A 113
VAL A 219
 None
 1.17A 3v1nA-1escA:
3.2		 3v1nA-1escA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_I_IPHI101_0
(INSULIN)		 1esc ESTERASE
(Streptomyces
scabiei) 		5 / 12 VAL A 161
LEU A 169
ILE A  69
LEU A 183
ALA A 235
 None
 0.96A 4p65B-1escA:
undetectable
4p65D-1escA:
undetectable
4p65I-1escA:
undetectable
4p65J-1escA:
undetectable		 4p65B-1escA:
12.24
4p65D-1escA:
12.24
4p65I-1escA:
5.59
4p65J-1escA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_K_IPHK101_0
(INSULIN)		 1esc ESTERASE
(Streptomyces
scabiei) 		5 / 12 LEU A 169
VAL A 161
ILE A  69
LEU A 183
ALA A 235
 None
 1.01A 4p65F-1escA:
undetectable
4p65H-1escA:
undetectable
4p65K-1escA:
undetectable
4p65L-1escA:
undetectable		 4p65F-1escA:
12.24
4p65H-1escA:
12.24
4p65K-1escA:
5.59
4p65L-1escA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTR_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 1esc ESTERASE
(Streptomyces
scabiei) 		5 / 11 GLY A 250
ASN A 285
TYR A  41
PRO A 187
TYR A 246
 None
 1.47A 4rtrA-1escA:
undetectable		 4rtrA-1escA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_V_MFXV2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 1esc ESTERASE
(Streptomyces
scabiei) 		4 / 5 ARG A 160
GLY A 162
GLU A 164
ARG A 226
 None
 1.17A 5cdqR-1escA:
undetectable
5cdqS-1escA:
1.1
5cdqT-1escA:
undetectable		 5cdqR-1escA:
20.29
5cdqS-1escA:
18.82
5cdqT-1escA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXG_B_ESTB601_1
(ESTROGEN RECEPTOR)		 1esc ESTERASE
(Streptomyces
scabiei) 		5 / 11 LEU A 265
ALA A 282
LEU A 189
LEU A 220
GLY A 105
 None
 1.19A 5dxgB-1escA:
undetectable		 5dxgB-1escA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUM_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 1esc ESTERASE
(Streptomyces
scabiei) 		5 / 8 VAL A   6
ILE A  54
LEU A  56
ILE A 300
ILE A 303
 None
 1.33A 5numA-1escA:
undetectable		 5numA-1escA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1esc ESTERASE
(Streptomyces
scabiei) 		4 / 6 ILE A 113
ILE A  69
LEU A  68
PHE A  11
 None
 1.03A 5vkqB-1escA:
0.0
5vkqC-1escA:
0.0		 5vkqB-1escA:
10.76
5vkqC-1escA:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1esc ESTERASE
(Streptomyces
scabiei) 		4 / 6 ILE A 113
ILE A  69
LEU A  68
PHE A  11
 None
 1.03A 5vkqC-1escA:
0.0
5vkqD-1escA:
0.0		 5vkqC-1escA:
10.76
5vkqD-1escA:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_1
(REGULATORY PROTEIN
TETR)		 1esc ESTERASE
(Streptomyces
scabiei) 		4 / 7 GLY A 109
GLN A  88
ASP A  13
TYR A  15
 None
 1.16A 5vlmG-1escA:
undetectable		 5vlmG-1escA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA608_0
(ALPHA-AMYLASE)		 1esc ESTERASE
(Streptomyces
scabiei) 		4 / 6 PHE A  11
GLY A 101
THR A  16
TYR A 186
 None
 1.20A 6ag0A-1escA:
undetectable		 6ag0A-1escA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC606_0
(ALPHA-AMYLASE)		 1esc ESTERASE
(Streptomyces
scabiei) 		4 / 6 PHE A  11
GLY A 101
THR A  16
TYR A 186
 None
 1.23A 6ag0C-1escA:
undetectable		 6ag0C-1escA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CE2_B_SVRB202_2
(-)		 1esc ESTERASE
(Streptomyces
scabiei) 		5 / 12 LEU A 220
LEU A 217
GLY A 263
ARG A 260
PRO A 191
 None
 1.06A 6ce2B-1escA:
undetectable		 6ce2B-1escA:
18.09