SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1et6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_4
(PROTEASE RETROPEPSIN)		 1et6 SUPERANTIGEN SMEZ-2
(Streptococcus
pyogenes) 		3 / 3 ASP A 198
ASN A 196
THR A  92
 None
 0.76A 2q63B-1et6A:
0.0		 2q63B-1et6A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_PCFA1179_1
(WNT INHIBITORY
FACTOR 1)		 1et6 SUPERANTIGEN SMEZ-2
(Streptococcus
pyogenes) 		4 / 5 ILE A  16
PHE A  69
PRO A  72
VAL A 105
 None
 1.20A 2ygnA-1et6A:
0.0		 2ygnA-1et6A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_2
(RENIN)		 1et6 SUPERANTIGEN SMEZ-2
(Streptococcus
pyogenes) 		4 / 4 VAL A  83
TYR A  86
PRO A  72
PHE A  46
 None
 1.44A 3d91B-1et6A:
0.0		 3d91B-1et6A:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_C_VIBC223_1
(THIAMINE
PYROPHOSPHOKINASE)		 1et6 SUPERANTIGEN SMEZ-2
(Streptococcus
pyogenes) 		4 / 8 TYR A 154
LEU A 174
LEU A 141
SER A 149
 None
 0.96A 3lm8A-1et6A:
undetectable
3lm8C-1et6A:
undetectable		 3lm8A-1et6A:
19.92
3lm8C-1et6A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_A_ADNA401_2
(PUTATIVE ADENOSINE
KINASE)		 1et6 SUPERANTIGEN SMEZ-2
(Streptococcus
pyogenes) 		4 / 4 LEU A 135
ALA A 130
PHE A 172
ASN A 192
 None
 1.49A 3vasA-1et6A:
undetectable		 3vasA-1et6A:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJE_A_C2FA300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 1et6 SUPERANTIGEN SMEZ-2
(Streptococcus
pyogenes) 		5 / 12 ASN A   5
PHE A 175
ASP A   4
GLY A 151
SER A 152
 None
 1.40A 4djeA-1et6A:
undetectable		 4djeA-1et6A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CB4_A_BEZA501_0
(CANAVALIN)		 1et6 SUPERANTIGEN SMEZ-2
(Streptococcus
pyogenes) 		4 / 8 ASN A   6
LEU A   9
LEU A 147
ILE A 207
 None
 0.84A 6cb4A-1et6A:
undetectable		 6cb4A-1et6A:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA811_0
(GEPHYRIN)		 1et6 SUPERANTIGEN SMEZ-2
(Streptococcus
pyogenes) 		3 / 3 LEU A 141
LEU A 174
ARG A 138
 None
 0.63A 6fgcA-1et6A:
undetectable		 6fgcA-1et6A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA810_0
(GEPHYRIN)		 1et6 SUPERANTIGEN SMEZ-2
(Streptococcus
pyogenes) 		3 / 3 LEU A 141
LEU A 174
ARG A 138
 None
 0.65A 6fgdA-1et6A:
undetectable		 6fgdA-1et6A:
18.89