SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1etz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JTV_A_TESA500_1 (17 BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1)	1etz	FAB NC10.14 - HEAVY CHAIN (Mus musculus)	4 / 8	VAL H 149 LEU H 151 PRO H 197 SER H 169	None	1.17A	1jtvA-1etzH: undetectable	1jtvA-1etzH: 21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3AQI_B_CHDB5_0 (FERROCHELATASE)	1etz	FAB NC10.14 - HEAVY CHAIN (Mus musculus)	3 / 3	PRO H 9 LEU H 122 ARG H 40	None	0.81A	3aqiB-1etzH: undetectable	3aqiB-1etzH: 20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3G1U_B_ADNB438_2 (ADENOSYLHOMOCYSTEINA SE)	1etz	FAB NC10.14 - HEAVY CHAIN (Mus musculus)	3 / 3	THR H 123 GLU H 161 HIS H 212	None	0.75A	3g1uB-1etzH: undetectable	3g1uB-1etzH: 20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ECK_B_FOLB703_0 (BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE)	1etz	FAB NC10.14 - HEAVY CHAIN (Mus musculus)	5 / 12	PHE H 27 SER H 25 LEU H 4 VAL H 36 THR H 31	None	1.09A	4eckB-1etzH: undetectable	4eckB-1etzH: 15.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4M93_B_ACTB305_0 (S25-26 FAB (IGG1K) HEAVY CHAIN)	1etz	FAB NC10.14 - HEAVY CHAIN (Mus musculus)	4 / 4	SER H 19 THR H 21 PHE H 81 LYS H 83	None	0.47A	4m93B-1etzH: 23.0	4m93B-1etzH: 65.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4O2B_D_LOCD503_1 (TUBULIN ALPHA-1B CHAIN TUBULIN BETA-2B CHAIN)	1etz	FAB NC10.14 - HEAVY CHAIN (Mus musculus)	3 / 3	SER H 216 ALA H 211 VAL H 210	None	0.62A	4o2bC-1etzH: undetectable	4o2bC-1etzH: 18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4X1I_B_LOCB502_1 (TUBULIN ALPHA CHAIN TUBULIN BETA CHAIN)	1etz	FAB NC10.14 - HEAVY CHAIN (Mus musculus)	3 / 3	SER H 216 ALA H 211 VAL H 210	None	0.60A	4x1iA-1etzH: undetectable	4x1iA-1etzH: 19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EYP_B_LOCB502_1 (TUBULIN ALPHA CHAIN TUBULIN BETA CHAIN)	1etz	FAB NC10.14 - HEAVY CHAIN (Mus musculus)	3 / 3	SER H 216 ALA H 211 VAL H 210	None	0.55A	5eypA-1etzH: undetectable	5eypA-1etzH: 18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5N8J_E_DVAE7_0 (GLY-DTY-GLY-DLE-DAL- DSG-DVA-DAS-DGL-DSN- DSN-GLY STREPTAVIDIN)	1etz	FAB NC10.14 - HEAVY CHAIN (Mus musculus)	3 / 3	TYR H 111 SER H 103 TRP H 54	GAS H 229 (-3.5A) None GAS H 229 ( 4.3A)	0.83A	5n8jB-1etzH: 0.0	5n8jB-1etzH: 23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5N8J_O_DVAO7_0 (GLY-DTY-GLY-DLE-DAL- DSG-DVA-DAS-DGL-DSN- DSN-GLY STREPTAVIDIN)	1etz	FAB NC10.14 - HEAVY CHAIN (Mus musculus)	3 / 3	TYR H 111 SER H 103 TRP H 54	GAS H 229 (-3.5A) None GAS H 229 ( 4.3A)	0.85A	5n8jA-1etzH: 0.0	5n8jA-1etzH: 23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5N8J_P_DVAP5_0 (GLY-DTY-GLY-DLE-DAL- DSG-DVA-DAS-DGL-DSN- DSN-GLY STREPTAVIDIN)	1etz	FAB NC10.14 - HEAVY CHAIN (Mus musculus)	3 / 3	TYR H 111 SER H 103 TRP H 54	GAS H 229 (-3.5A) None GAS H 229 ( 4.3A)	0.89A	5n8jD-1etzH: 0.0	5n8jD-1etzH: 23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5QGL_A_ACTA301_0 (PEROXISOMAL COENZYME A DIPHOSPHATASE NUDT7)	1etz	FAB NC10.14 - HEAVY CHAIN (Mus musculus)	3 / 3	VAL H 149 VAL H 196 GLN H 204	None	0.66A	5qglA-1etzH: 0.0	5qglA-1etzH: 17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIW_D_LOCD503_1 (TUBULIN ALPHA-1B CHAIN TUBULIN BETA CHAIN)	1etz	FAB NC10.14 - HEAVY CHAIN (Mus musculus)	3 / 3	SER H 216 ALA H 211 VAL H 210	None	0.46A	5xiwC-1etzH: undetectable	5xiwC-1etzH: 15.21

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1JTV_A_TESA500_1","17 BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1","1etz","FAB NC10.14 - HEAVY CHAIN","Mus musculus",4,"VAL H 149;LEU H 151;PRO H 197;SER H 169","None","1.17A","1jtvA-1etzH:undetectable","1jtvA-1etzH:21.51"],["3AQI_B_CHDB5_0","FERROCHELATASE","1etz","FAB NC10.14 - HEAVY CHAIN","Mus musculus",3,"PRO H   9;LEU H 122;ARG H  40","None","0.81A","3aqiB-1etzH:undetectable","3aqiB-1etzH:20.53"],["3G1U_B_ADNB438_2","ADENOSYLHOMOCYSTEINASE","1etz","FAB NC10.14 - HEAVY CHAIN","Mus musculus",3,"THR H 123;GLU H 161;HIS H 212","None","0.75A","3g1uB-1etzH:undetectable","3g1uB-1etzH:20.51"],["4ECK_B_FOLB703_0","BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","1etz","FAB NC10.14 - HEAVY CHAIN","Mus musculus",5,"PHE H  27;SER H  25;LEU H   4;VAL H  36;THR H  31","None","1.09A","4eckB-1etzH:undetectable","4eckB-1etzH:15.45"],["4M93_B_ACTB305_0","S25-26 FAB (IGG1K) HEAVY CHAIN","1etz","FAB NC10.14 - HEAVY CHAIN","Mus musculus",4,"SER H  19;THR H  21;PHE H  81;LYS H  83","None","0.47A","4m93B-1etzH:23.0","4m93B-1etzH:65.49"],["4O2B_D_LOCD503_1","TUBULIN ALPHA-1B CHAIN;TUBULIN BETA-2B CHAIN","1etz","FAB NC10.14 - HEAVY CHAIN","Mus musculus",3,"SER H 216;ALA H 211;VAL H 210","None","0.62A","4o2bC-1etzH:undetectable","4o2bC-1etzH:18.69"],["4X1I_B_LOCB502_1","TUBULIN ALPHA CHAIN;TUBULIN BETA CHAIN","1etz","FAB NC10.14 - HEAVY CHAIN","Mus musculus",3,"SER H 216;ALA H 211;VAL H 210","None","0.60A","4x1iA-1etzH:undetectable","4x1iA-1etzH:19.32"],["5EYP_B_LOCB502_1","TUBULIN ALPHA CHAIN;TUBULIN BETA CHAIN","1etz","FAB NC10.14 - HEAVY CHAIN","Mus musculus",3,"SER H 216;ALA H 211;VAL H 210","None","0.55A","5eypA-1etzH:undetectable","5eypA-1etzH:18.69"],["5N8J_E_DVAE7_0","GLY-DTY-GLY-DLE-DAL-DSG-DVA-DAS-DGL-DSN-DSN-GLY;STREPTAVIDIN","1etz","FAB NC10.14 - HEAVY CHAIN","Mus musculus",3,"TYR H 111;SER H 103;TRP H  54","GAS H 229 (-3.5A);None;GAS H 229 ( 4.3A)","0.83A","5n8jB-1etzH:0.0","5n8jB-1etzH:23.02"],["5N8J_O_DVAO7_0","GLY-DTY-GLY-DLE-DAL-DSG-DVA-DAS-DGL-DSN-DSN-GLY;STREPTAVIDIN","1etz","FAB NC10.14 - HEAVY CHAIN","Mus musculus",3,"TYR H 111;SER H 103;TRP H  54","GAS H 229 (-3.5A);None;GAS H 229 ( 4.3A)","0.85A","5n8jA-1etzH:0.0","5n8jA-1etzH:23.02"],["5N8J_P_DVAP5_0","GLY-DTY-GLY-DLE-DAL-DSG-DVA-DAS-DGL-DSN-DSN-GLY;STREPTAVIDIN","1etz","FAB NC10.14 - HEAVY CHAIN","Mus musculus",3,"TYR H 111;SER H 103;TRP H  54","GAS H 229 (-3.5A);None;GAS H 229 ( 4.3A)","0.89A","5n8jD-1etzH:0.0","5n8jD-1etzH:23.02"],["5QGL_A_ACTA301_0","PEROXISOMAL COENZYME A DIPHOSPHATASE NUDT7","1etz","FAB NC10.14 - HEAVY CHAIN","Mus musculus",3,"VAL H 149;VAL H 196;GLN H 204","None","0.66A","5qglA-1etzH:0.0","5qglA-1etzH:17.21"],["5XIW_D_LOCD503_1","TUBULIN ALPHA-1B CHAIN;TUBULIN BETA CHAIN","1etz","FAB NC10.14 - HEAVY CHAIN","Mus musculus",3,"SER H 216;ALA H 211;VAL H 210","None","0.46A","5xiwC-1etzH:undetectable","5xiwC-1etzH:15.21"]]