SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1eu8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_B_DMEB996_1
(ACETYLCHOLINESTERASE)		 1eu8 TREHALOSE/MALTOSE
BINDING PROTEIN
(Thermococcus
litoralis) 		4 / 6 TYR A 128
GLU A 186
TYR A 259
GLY A 262
 None
None
TRE  A 563 (-4.1A)
None
 1.10A 1maaB-1eu8A:
undetectable
1maaD-1eu8A:
undetectable		 1maaB-1eu8A:
24.35
1maaD-1eu8A:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OLT_A_SAMA501_0
(OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE)		 1eu8 TREHALOSE/MALTOSE
BINDING PROTEIN
(Thermococcus
litoralis) 		5 / 12 GLU A  47
ASP A  70
ARG A 364
ILE A 377
ALA A 402
 None
TRE  A 563 (-2.8A)
TRE  A 563 (-2.8A)
None
None
 1.33A 1oltA-1eu8A:
0.2		 1oltA-1eu8A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 1eu8 TREHALOSE/MALTOSE
BINDING PROTEIN
(Thermococcus
litoralis) 		3 / 3 ASN A 265
TRP A 261
GLN A 247
 None
 1.36A 1xoqA-1eu8A:
undetectable		 1xoqA-1eu8A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_B_SAMB2002_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 1eu8 TREHALOSE/MALTOSE
BINDING PROTEIN
(Thermococcus
litoralis) 		5 / 12 GLN A  42
PHE A  28
ILE A  25
VAL A  24
VAL A 316
 None
 1.20A 2g72B-1eu8A:
undetectable		 2g72B-1eu8A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA142_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 1eu8 TREHALOSE/MALTOSE
BINDING PROTEIN
(Thermococcus
litoralis) 		4 / 5 GLU A  17
PRO A  15
ILE A  18
GLY A  13
 TRE  A 563 (-2.9A)
None
None
TRE  A 563 (-3.1A)
 1.14A 2qeuA-1eu8A:
0.0
2qeuC-1eu8A:
0.0		 2qeuA-1eu8A:
16.54
2qeuC-1eu8A:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_L_ASDL1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1eu8 TREHALOSE/MALTOSE
BINDING PROTEIN
(Thermococcus
litoralis) 		4 / 7 PHE A 253
LEU A 133
ALA A 252
PHE A 167
 None
 0.94A 2vcvL-1eu8A:
0.8		 2vcvL-1eu8A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1009_1
(SERUM ALBUMIN)		 1eu8 TREHALOSE/MALTOSE
BINDING PROTEIN
(Thermococcus
litoralis) 		4 / 8 TYR A 177
GLU A 178
SER A 374
GLN A 378
 TRE  A 563 (-4.7A)
None
None
None
 0.82A 3b9lA-1eu8A:
0.4		 3b9lA-1eu8A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_J_ACHJ323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 1eu8 TREHALOSE/MALTOSE
BINDING PROTEIN
(Thermococcus
litoralis) 		4 / 8 GLU A 148
GLU A 151
TYR A 139
LEU A 134
 None
 1.10A 3rqwF-1eu8A:
0.0
3rqwJ-1eu8A:
0.0		 3rqwF-1eu8A:
19.19
3rqwJ-1eu8A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U88_A_CHDA611_0
(MENIN)		 1eu8 TREHALOSE/MALTOSE
BINDING PROTEIN
(Thermococcus
litoralis) 		3 / 3 SER A 318
PHE A 325
LYS A 323
 None
None
CL  A 413 (-3.4A)
 1.02A 3u88A-1eu8A:
0.0		 3u88A-1eu8A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UR0_B_SVRB516_1
(RNA-DEPENDENT RNA
POLYMERASE)		 1eu8 TREHALOSE/MALTOSE
BINDING PROTEIN
(Thermococcus
litoralis) 		5 / 7 PRO A 333
GLY A 330
ALA A 326
ALA A 343
ASP A 341
 None
None
None
CL  A 413 (-3.0A)
None
 1.41A 3ur0B-1eu8A:
0.0		 3ur0B-1eu8A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UR0_C_SVRC516_1
(RNA-DEPENDENT RNA
POLYMERASE)		 1eu8 TREHALOSE/MALTOSE
BINDING PROTEIN
(Thermococcus
litoralis) 		5 / 9 PRO A 333
GLY A 330
ALA A 326
ALA A 343
ASP A 341
 None
None
None
CL  A 413 (-3.0A)
None
 1.48A 3ur0C-1eu8A:
0.0		 3ur0C-1eu8A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1eu8 TREHALOSE/MALTOSE
BINDING PROTEIN
(Thermococcus
litoralis) 		4 / 6 PHE A 315
TYR A  20
VAL A  11
PHE A 325
 None
 1.21A 4a97E-1eu8A:
0.0		 4a97E-1eu8A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZV_A_SAMA1474_1
(WBDD)		 1eu8 TREHALOSE/MALTOSE
BINDING PROTEIN
(Thermococcus
litoralis) 		4 / 6 TYR A 121
ARG A  49
GLN A 322
GLU A  27
 TRE  A 563 (-4.5A)
TRE  A 563 (-3.9A)
None
None
 1.08A 4azvA-1eu8A:
undetectable		 4azvA-1eu8A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJE_A_C2FA300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 1eu8 TREHALOSE/MALTOSE
BINDING PROTEIN
(Thermococcus
litoralis) 		5 / 12 PHE A  28
ASP A  65
LEU A  57
GLY A 298
ILE A 299
 None
 1.45A 4djeA-1eu8A:
undetectable		 4djeA-1eu8A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FE1_A_PQNA846_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 1eu8 TREHALOSE/MALTOSE
BINDING PROTEIN
(Thermococcus
litoralis) 		5 / 10 SER A 288
ALA A 278
LEU A 126
GLY A 125
ALA A 343
 None
None
None
None
CL  A 413 (-3.0A)
 1.29A 4fe1A-1eu8A:
undetectable
4fe1J-1eu8A:
0.0		 4fe1A-1eu8A:
19.10
4fe1J-1eu8A:
9.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P7N_A_GCSA702_1
(POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE)		 1eu8 TREHALOSE/MALTOSE
BINDING PROTEIN
(Thermococcus
litoralis) 		3 / 3 ASP A 123
TYR A 121
TRP A 257
 TRE  A 563 (-3.5A)
TRE  A 563 (-4.5A)
TRE  A 563 (-3.5A)
 1.36A 4p7nA-1eu8A:
undetectable		 4p7nA-1eu8A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PUO_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 1eu8 TREHALOSE/MALTOSE
BINDING PROTEIN
(Thermococcus
litoralis) 		5 / 8 LEU A 207
VAL A 181
VAL A 188
TRP A 203
LEU A 373
 None
 1.35A 4puoC-1eu8A:
1.7		 4puoC-1eu8A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EML_A_SAMA701_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 1eu8 TREHALOSE/MALTOSE
BINDING PROTEIN
(Thermococcus
litoralis) 		4 / 6 TYR A 187
GLY A 179
GLU A 239
ASP A  45
 None
TRE  A 563 (-3.5A)
TRE  A 563 (-2.9A)
None
 1.00A 5emlA-1eu8A:
undetectable		 5emlA-1eu8A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWZ_B_BEZB301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 1eu8 TREHALOSE/MALTOSE
BINDING PROTEIN
(Thermococcus
litoralis) 		3 / 3 MET A 245
GLN A 248
ARG A 243
 PT  A 415 (-3.2A)
None
None
 1.11A 5ewzB-1eu8A:
undetectable		 5ewzB-1eu8A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNC_D_ACTD305_0
(CARBONIC ANHYDRASE 4)		 1eu8 TREHALOSE/MALTOSE
BINDING PROTEIN
(Thermococcus
litoralis) 		4 / 5 PRO A 391
ALA A 394
ALA A 384
ILE A 389
 None
 0.74A 5jncD-1eu8A:
0.0		 5jncD-1eu8A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M35_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 1eu8 TREHALOSE/MALTOSE
BINDING PROTEIN
(Thermococcus
litoralis) 		3 / 3 MET A 245
GLN A 248
ARG A 243
 PT  A 415 (-3.2A)
None
None
 1.05A 5m35B-1eu8A:
0.0		 5m35B-1eu8A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M36_A_BEZA303_0
(14-3-3 PROTEIN
ZETA/DELTA)		 1eu8 TREHALOSE/MALTOSE
BINDING PROTEIN
(Thermococcus
litoralis) 		3 / 3 MET A 245
GLN A 248
ARG A 243
 PT  A 415 (-3.2A)
None
None
 1.03A 5m36A-1eu8A:
undetectable		 5m36A-1eu8A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWW_A_ACAA18_2
(SCRFP-TAG,GP41)		 1eu8 TREHALOSE/MALTOSE
BINDING PROTEIN
(Thermococcus
litoralis) 		3 / 3 LYS A 347
TRP A 261
SER A 346
 CL  A 414 (-3.0A)
None
None
 1.18A 5nwwA-1eu8A:
0.0		 5nwwA-1eu8A:
8.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_B_SAMB901_0
(MRNA CAPPING ENZYME
P5)		 1eu8 TREHALOSE/MALTOSE
BINDING PROTEIN
(Thermococcus
litoralis) 		5 / 10 VAL A 188
GLY A 193
GLU A 211
ALA A 215
ASN A 208
 None
 1.11A 5x6yB-1eu8A:
undetectable		 5x6yB-1eu8A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XPR_A_K86A1201_1
(ENDOTHELIN B
RECEPTOR,ENDOLYSIN,E
NDOTHELIN B RECEPTOR)		 1eu8 TREHALOSE/MALTOSE
BINDING PROTEIN
(Thermococcus
litoralis) 		5 / 12 HIS A 296
LEU A  53
LEU A  83
ILE A  78
ALA A 117
 None
 1.45A 5xprA-1eu8A:
0.0		 5xprA-1eu8A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FN9_A_BEZA302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 1eu8 TREHALOSE/MALTOSE
BINDING PROTEIN
(Thermococcus
litoralis) 		3 / 3 MET A 245
GLN A 248
ARG A 243
 PT  A 415 (-3.2A)
None
None
 1.09A 6fn9A-1eu8A:
undetectable		 6fn9A-1eu8A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNA_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 1eu8 TREHALOSE/MALTOSE
BINDING PROTEIN
(Thermococcus
litoralis) 		3 / 3 MET A 245
GLN A 248
ARG A 243
 PT  A 415 (-3.2A)
None
None
 1.06A 6fnaB-1eu8A:
0.0		 6fnaB-1eu8A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNB_A_BEZA301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 1eu8 TREHALOSE/MALTOSE
BINDING PROTEIN
(Thermococcus
litoralis) 		3 / 3 MET A 245
GLN A 248
ARG A 243
 PT  A 415 (-3.2A)
None
None
 1.08A 6fnbA-1eu8A:
0.0		 6fnbA-1eu8A:
19.46